Edinburgh Research Explorer

Dr Andrew Finch

Co-Manager of the IGMM Mass Spec Facility

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Research Interests

Ribosome biogenesis is the process of generation of new ribosomes, involving four rRNAs, some 80 core ribosomal proteins (in eukaryotes) and over 200 transacting factors. It is a costly exercise for the cell in terms of energy and biosynthetic precursors and, as such, is tightly regulated at many stages. Unsurprisingly, many of the major oncogenes and tumour suppressor genes impinge on the regulation of ribosome biogenesis in several ways. Deregulation (both overactivation and impairment) of ribosome biogenesis leads to activation of tumour suppressive responses that a nascent tumour must circumvent in order to progress.

We are primarily interested in homeostatic models of regulation of ribosome biogenesis i.e. the activation of stress responses and consequent feedback mechanisms. Using this conceptual framework, we are trying to understand how deregulation of ribosome biogenesis leads to activation of tumour suppressive responses and what mechanisms cancer cells use to circumvent them. In addition, we are trying to see if we can interfere with ribosome biogenesis and elicit stress responses to try to therapeutically target cancer cells.

ID: 7481084