Edinburgh Research Explorer

Andrew Leigh-Brown

Professor of Evolutionary Genetics

  1. 2020
  2. The Molecular Epidemiology and Transmission Dynamics of HIV Type 1 in a General Population Cohort in Uganda

    Ssemwanga, D., Bbosa, N., Nsubuga, R. N., Ssekagiri, A., Kapaata, A., Nannyonjo, M., Nassolo, F., Karabarinde, A., Mugisha, J., Seeley, J., Yebra, G., Leigh Brown, A. & Kaleebu, P., 10 Nov 2020, In: Viruses. 12, 11

    Research output: Contribution to journalArticlepeer-review

  3. Pervasive and non-random recombination in near full-length HIV genomes from Uganda

    Grant, H., Hodcroft, E., Ssemwanga, D., Kitayimbwa, J., Yebra, G., Esquivel Gomez, L. R., Frampton, D., Gall, A., Kellam, P., de Oliveira, T., Bbosa, N., Nsubuga, R. N., Kibengo, F., Kwan, T. H., Lycett, S., Kao, R., Robertson, D., Ratmann, O., Fraser, C., Pillay, D. & 2 others, Kaleebu, P. & Leigh-Brown, A., 11 Feb 2020, In: Virus Evolution. 6, 1, veaa004.

    Research output: Contribution to journalArticlepeer-review

  4. 2019
  5. Inferring HIV-1 transmission networks and sources of epidemic spread in Africa with deep-sequence phylogenetic analysis

    Ratmann, O., Grabowski, M. K., Hall, M., Golubchik, T., Wymant, C., Abeler-Dörner, L., Bonsall, D., Hoppe, A., Brown, A. L., de Oliveira, T., Gall, A., Kellam, P., Pillay, D., Kagaayi, J., Kigozi, G., Quinn, T. C., Wawer, M. J., Laeyendecker, O., Serwadda, D., Gray, R. H. & 1 others, Fraser, C., 29 Mar 2019, In: Nature Communications. 10, 1411.

    Research output: Contribution to journalArticlepeer-review

  6. Phylogeography of HIV-1 suggests that Ugandan fishing communities are a sink for, not a source of, virus from general populations

    Bbosa, N., Ssemwanga, D., Nsubuga, R. N., Salazar-Gonzalez, J. F., Salazar, M. G., Nanyonjo, M., Kuteesa, M., Seeley, J., Kiwanuka, N., Bagaya, B. S., Yebra, G., Leigh-Brown, A. & Kaleebu, P., 31 Jan 2019, In: Scientific Reports. 9, 1, 8 p., 1051.

    Research output: Contribution to journalArticlepeer-review

  7. HIV-1 DNA is Maintained in Antigen-Specific CD4+ T Cell Subsets in Patients on Long-Term Antiretroviral Therapy Regardless of Recurrent Antigen Exposure

    Hey-Nguyen, W., Bailey, M., Xu, Y., Suzuki, K., van Bockel, D., Finlayson, R., Leigh Brown, A., Carr, A., Cooper, D. A., Kelleher, A. D., Koelsch, K. K. & Zaunders, J., 11 Jan 2019, In: Aids research and human retroviruses. 35, 1, p. 112-120 9 p.

    Research output: Contribution to journalArticlepeer-review

  8. 2018
  9. Recent and rapid transmission of HIV among people who inject drugs in Scotland revealed through phylogenetic analysis

    Ragonnet-Cronin, M., Jackson, C., Bradley-Stewart, A., Aitken, C., McAuley, A., Palmateer, N., Gunson, R., Goldberg, D. J., Milosevic, C. & Leigh Brown, A. J., 15 Jun 2018, In: The Journal of Infectious Diseases. 217, 12, p. 1875-1882 8 p.

    Research output: Contribution to journalArticlepeer-review

  10. Non-disclosed men who have sex with men in UK HIV transmission networks: Phylogenetic analysis of surveillance data

    Ragonnet-Cronin, M., Hué, S., Hodcroft, E. B., Tostevin, A., Dunn, D., Fawcett, T., Pozniak, A., Brown, A. E., Delpech, V. & Leigh-Brown, A., 1 Jun 2018, In: Lancet HIV. 5, 6, p. e309–e316 8 p.

    Research output: Contribution to journalArticlepeer-review

  11. A high HIV-1 strain variability in London, UK, revealed by full-genome analysis: Results from the ICONIC project

    Yebra, G., Frampton, D., Gallo Cassarino, T., Raffle, J., Hubb, J., Ferns, R. B., Waters, L., Tong, C. Y. W., Kozlakidis, Z., Hayward, A., Kellam, P., Pillay, D., Clark, D. A., Nastouli, E., Leigh Brown, A. J. & ICONIC Consortium, 1 Feb 2018, In: PLoS ONE. 13, 2, p. e0192081

    Research output: Contribution to journalArticlepeer-review

  12. HIV-TRACE (Transmission Cluster Engine): a tool for large scale molecular epidemiology of HIV-1 and other rapidly evolving pathogens

    Kosakovsky Pond, S. L., Weaver, S., Leigh Brown, A. J. & Wertheim, J. O., 31 Jan 2018, In: Molecular Biology and Evolution. 16 p., msy016.

    Research output: Contribution to journalArticlepeer-review

  13. 2017
  14. Recent trends and patterns in HIV-1 transmitted drug resistance in the United Kingdom

    Tostevin, A., White, E., Dunn, D., Croxford, S., Delpech, V., Williams, I., Asboe, D., Pozniak, A., Churchill, D., Geretti, A., Pillay, D., Sabin, C., Leigh-Brown, A. & Smit, E., Mar 2017, In: HIV Medicine.

    Research output: Contribution to journalArticlepeer-review

  15. Quantifying predictors for the spatial diffusion of avian influenza virus in China

    Lu, L., Leigh-Brown, A. & Lycett, S., 13 Jan 2017, In: BMC Evolutionary Biology. 17, 1, 16.

    Research output: Contribution to journalArticlepeer-review

  16. Phylogenetic Tools for Generalized HIV-1 Epidemics: Findings from the PANGEA-HIV Methods Comparison

    Ratmann, O., Hodcroft, E., Pickles, M., Cori, A., Hall, M., Lycett, S., Colijn, C., Leigh Brown, A. & Fraser, C., Jan 2017, In: Molecular Biology and Evolution. 34, 10, p. 185-203 31 p.

    Research output: Contribution to journalArticlepeer-review

  17. 2016
  18. Reconstructing the HIV-1 CRF02_AG and CRF06_cpx Epidemics in Burkina Faso and West Africa using early samples

    Yebra, G., Kalish, M. L. & Leigh Brown, A. J., Dec 2016, In: Infection, Genetics and Evolution. 46, p. 209-218 10 p.

    Research output: Contribution to journalArticlepeer-review

  19. A Direct Comparison of Two Densely Sampled HIV Epidemics: The UK and Switzerland

    Ragonnet-Cronin, M. L., Shilaih, M., Günthard, H. F., Hodcroft, E. B., Böni, J., Fearnhill, E., Dunn, D., Yerly, S., Klimkait, T., Aubert, V., Yang, W-L., Brown, A. E., Lycett, S. J., Kouyos, R. & Leigh Brown, A., 19 Sep 2016, In: Scientific Reports. 6, 32251.

    Research output: Contribution to journalArticlepeer-review

  20. 2015
  21. Transmission of non-B HIV subtypes in the UK is increasingly driven by large non-heterosexual clusters

    Ragonnet-Cronin, M., Lycett, S., Hodcroft, E., Hué, S., Fearnhill, E., Brown, A. E., Delpech, V., Dunn, D., Leigh Brown, A. J. & UK HIV Drug Resistance Database, 23 Dec 2015, In: The Journal of Infectious Diseases. 213, 9, p. 1410-1418

    Research output: Contribution to journalArticlepeer-review

  22. Analysis of the History and Spread of HIV-1 in Uganda using phylodynamics

    Yebra, G., Ragonnet-Cronin, M., Ssemwanga, D., Parry, C. M., Logue, C. H., Cane, P. A., Kaleebu, P. & Leigh-Brown, A. J., 1 Jul 2015, In: Journal of General Virology. 96, p. 1890–1898

    Research output: Contribution to journalArticlepeer-review

  23. PANGEA-HIV: phylogenetics for generalised epidemics in Africa

    Pillay, D., Herbeck, J., Cohen, M. S., de Oliveira, T., Fraser, C., Ratmann, O., Brown, A. L., Kellam, P. & PANGEA-HIV Consortium, Mar 2015, In: The Lancet Infectious Diseases. 15, 3, p. 259-61 3 p.

    Research output: Contribution to journalComment/debatepeer-review

  24. 2014
  25. Phylogenetic studies of transmission dynamics in generalized HIV epidemics: An essential tool where the burden is greatest?

    Dennis, A. M., Herbeck, J. T., Leigh Brown, A., Kellam, P., de Oliveira, T., Pillay, D., Fraser, C. & Cohen, M. S., 1 Oct 2014, In: Journal of Acquired Immune Deficiency Syndromes. 67, 2, p. 181-95 15 p.

    Research output: Contribution to journalArticlepeer-review

  26. Determining the Phylogenetic and Phylogeographic Origin of Highly Pathogenic Avian Influenza (H7N3) in Mexico

    Lu, L., Lycett, S. J. & Leigh Brown, A. J., 16 Sep 2014, In: PLoS ONE. 9, 9, 13 p., e107330.

    Research output: Contribution to journalArticlepeer-review

  27. Phylogenetic analyses reveal HIV-1 infections between men misclassified as heterosexual transmissions

    Hué, S., Brown, A. E., Ragonnet-Cronin, M., Lycett, S. J., Dunn, D. T., Fearnhill, E., Dolling, D. I., Pozniak, A., Pillay, D., Delpech, V. C. & Leigh Brown, A. J., 24 Aug 2014, In: AIDS. 28, 13, p. 1967-75 9 p.

    Research output: Contribution to journalArticlepeer-review

  28. Intercontinental dispersal of HIV-1 subtype B associated with transmission among men who have sex with men in Japan

    on behalf of the UK Collaborative Group on HIV Drug Resistance, 18 Jun 2014, In: Journal of Virology. 88, 17, p. 9864-9876 13 p.

    Research output: Contribution to journalArticlepeer-review

  29. The Contribution of Viral Genotype to Plasma Viral Set-Point in HIV Infection

    Hodcroft, E., Hadfield, J. D., Fearnhill, E., Phillips, A., Dunn, D., O'Shea, S., Pillay, D., Leigh Brown, A. J. & on behalf of the UK HIV Drug Resistance Database and the UK CHIC Study, May 2014, In: Plos Pathogens. 10, 5, e1004112.

    Research output: Contribution to journalArticlepeer-review

  30. Dynamics of the emergence and establishment of a newly dominant genotype of Japanese encephalitis virus throughout Asia

    Schuh, A. J., Ward, M. J., Leigh Brown, A. J. & Barrett, A. D. T., 5 Feb 2014, In: Journal of Virology. p. 4522-4532

    Research output: Contribution to journalArticlepeer-review

  31. Reassortment patterns of avian influenza virus internal segments among different subtypes

    Lu, L., Lycett, S. J. & Leigh Brown, A. J., 24 Jan 2014, In: BMC Evolutionary Biology. 14, 1, 15 p., 16.

    Research output: Contribution to journalArticlepeer-review

  32. Novel HIV-1 Recombinants Spreading across Multiple Risk Groups in the United Kingdom: The Identification and Phylogeography of Circulating Recombinant Form (CRF) 50_A1D

    Foster, G. M., Ambrose, J. C., Hué, S., Delpech, V. C., Fearnhill, E., Abecasis, A. B., Leigh Brown, A. J., Geretti, A. M. & UK HIV Drug Resistance Database, 15 Jan 2014, In: PLoS ONE. 9, 1, e83337.

    Research output: Contribution to journalArticlepeer-review

  33. The global transmission network of HIV-1

    Wertheim, J. O., Leigh Brown, A. J., Hepler, N. L., Mehta, S. R., Richman, D. D., Smith, D. M. & Kosakovsky Pond, S. L., 15 Jan 2014, In: The Journal of Infectious Diseases. 209, 2, p. 304-313 10 p.

    Research output: Contribution to journalArticlepeer-review

  34. 2013
  35. The evolutionary dynamics of influenza A virus adaptation to mammalian hosts

    Bhatt, S., Lam, T. T., Lycett, S. J., Leigh Brown, A. J., Bowden, T. A., Holmes, E. C., Guan, Y., Wood, J. L. N., Brown, I. H., Kellam, P., Pybus, O. G. & Combating Swine Influenza Consortium, Mar 2013, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 368, 1614, 20120382.

    Research output: Contribution to journalArticlepeer-review

  36. Estimating the rate of intersubtype recombination in early HIV-1 group M strains

    Ward, M. J., Lycett, S. J., Kalish, M. L., Rambaut, A. & Leigh Brown, A., Feb 2013, In: Journal of Virology. 87, 4, p. 1967-1973 7 p.

    Research output: Contribution to journalArticlepeer-review

  37. Automated analysis of phylogenetic clusters

    Ragonnet-Cronin, M., Hodcroft, E., Hué, S., Fearnhill, E., Delpech, V., Leigh Brown, A., Lycett, S. & UK HIV Drug Resistance Database, 2013, In: BMC Bioinformatics. 14, 317.

    Research output: Contribution to journalArticlepeer-review

  38. Evolutionary interactions between haemagglutinin and neuraminidase in avian influenza

    Ward, M. J., Lycett, S. J., Avila, D., Bollback, J. P. & Leigh Brown, A. J., 2013, In: BMC Evolutionary Biology. 13, 222.

    Research output: Contribution to journalArticlepeer-review

  39. Phylogeography of Japanese encephalitis virus: genotype is associated with climate

    Schuh, A. J., Ward, M. J., Leigh Brown, A. & Barrett, A. D. T., 2013, In: PLoS Neglected Tropical Diseases. 7, 8, e2411.

    Research output: Contribution to journalArticlepeer-review

  40. 2012
  41. Simple Epidemiological Dynamics Explain Phylogenetic Clustering of HIV from Patients with Recent Infection

    Volz, E. M., Koopman, J. S., Ward, M. J., Brown, A. L. & Frost, S. D. W., 28 Jun 2012, In: PLoS Computational Biology. 8, 6, e1002552.

    Research output: Contribution to journalArticlepeer-review

  42. Origin and Fate of A/H1N1 Influenza in Scotland during 2009

    Lycett, S., McLeish, N. J., Robertson, C., Carman, W., Baillie, G., McMenamin, J., Rambaut, A., Simmonds, P., Woolhouse, M. & Leigh Brown, A. J., Jun 2012, In: Journal of General Virology. 93, 6, p. 1253-1260 8 p.

    Research output: Contribution to journalArticlepeer-review

  43. Immune responses in pigs vaccinated with adjuvanted and non-adjuvanted A(H1N1)pdm/09 influenza vaccines used in human immunization programmes

    Lefevre, E. A., Carr, B. V., Inman, C. F., Prentice, H., Brown, I. H., Brookes, S. M., Garcon, F., Hill, M. L., Iqbal, M., Elderfield, R. A., Barclay, W. S., Gubbins, S., Bailey, M., Charleston, B., COSI, Leigh Brown, A., Woolhouse, M. & Archibald, A., 9 Mar 2012, In: PLoS ONE. 7, 3, p. e32400

    Research output: Contribution to journalArticlepeer-review

  44. Estimating reassortment rates in co-circulating Eurasian swine influenza viruses

    Combating Swine Influenza Initiative (COSI) Consortium, 2012, In: Journal of General Virology. 93, 11, p. 2326-2336

    Research output: Contribution to journalArticlepeer-review

  45. The HIV Epidemic: High-Income Countries

    Vermund, SH. & Leigh Brown, AJ., 2012, In: Cold spring harbor perspectives in medicine. 2, 5

    Research output: Contribution to journalArticlepeer-review

  46. Time trends in drug resistant HIV-1 infections in the United Kingdom up to 2009: multicentre observational study

    Dolling, D., Sabin, C., Delpech, V., Smit, E., Pozniak, A., Asboe, D., Brown, A. L., Churchill, D., Williams, I., Geretti, A. M., Phillips, A., Mackie, N., Murphy, G., Castro, H., Pillay, D., Cane, P., Dunn, D. & UK Collaborative Group on HIV Drug Resistance, 2012, In: British Medical Journal (BMJ). 345, p. e5253

    Research output: Contribution to journalArticlepeer-review

  47. 2011
  48. Transmission Network Parameters Estimated From HIV Sequences for a Nationwide Epidemic

    Leigh Brown, A. J., Lycett, S. J., Weinert, L., Hughes, G. J., Fearnhill, E. & Dunn, D. T., Nov 2011, In: The Journal of Infectious Diseases. 204, 9, p. 1463-1469 7 p.

    Research output: Contribution to journalArticlepeer-review

  49. Sero-Prevalence and Incidence of A/H1N1 2009 Influenza Infection in Scotland in Winter 2009-2010

    McLeish, N. J., Simmonds, P., Robertson, C., Handel, I., McGilchrist, M., Singh, B. K., Kerr, S., Chase-Topping, M. E., Sinka, K., Bronsvoort, M., Porteous, D. J., Carman, W., McMenamin, J., Leigh-Brown, A. & Woolhouse, M. E. J., 8 Jun 2011, In: PLoS ONE. 6, 6, p. - 8 p., e20358.

    Research output: Contribution to journalArticlepeer-review

  50. 2009
  51. Phylodynamics of Infectious Disease Epidemics

    Volz, E. M., Pond, S. L. K., Ward, M. J., Leigh Brown, A. J. & Frost, S. D. W., Dec 2009, In: Genetics. 183, 4, p. 1421-1430 10 p.

    Research output: Contribution to journalArticlepeer-review

  52. Detection of Mammalian Virulence Determinants in Highly Pathogenic Avian Influenza H5N1 Viruses: Multivariate Analysis of Published Data

    Lycett, S. J., Ward, M. J., Lewis, F. I., Poon, A. F. Y., Pond, S. L. K. & Leigh Brown, A., Oct 2009, In: Journal of Virology. 83, 19, p. 9901-9910 10 p.

    Research output: Contribution to journalArticlepeer-review

  53. Molecular Phylodynamics of the Heterosexual HIV Epidemic in the United Kingdom

    Hughes, G. J., Fearnhill, E., Dunn, D., Lycett, S. J., Rambaut, A. & Leigh Brown, A. J., Sep 2009, In: Plos Pathogens. 5, 9, 8 p., e1000590.

    Research output: Contribution to journalArticlepeer-review

  54. An Evolutionary Model-Based Algorithm for Accurate Phylogenetic Breakpoint Mapping and Subtype Prediction in HIV-1

    Pond, S. L. K., Posada, D., Stawiski, E., Chappey, C., Poon, A. F. Y., Hughes, G., Fearnhill, E., Gravenor, M. B., Leigh Brown, A. J. & Frost, S. D. W., 2009, In: PLoS Computational Biology. 5, 11, p. 1-21 21 p., e1000581.

    Research output: Contribution to journalArticlepeer-review

  55. 2008
  56. A maximum likelihood method for detecting directional evolution in protein sequences and its application to influenza a virus

    Pond, S. L. K., Poon, A. F. Y., Leigh Brown, A. J. & Frost, S. D. W., Oct 2008, In: Molecular Biology and Evolution. 25, 9, p. 1809-1824 16 p.

    Research output: Contribution to journalArticlepeer-review

  57. Genetic basis of variation in tenofovir drug susceptibility in HIV-1

    Murray, R. J., Lewis, F. I., Miller, M. D. & Leigh Brown, A. J., Jun 2008, In: AIDS. 22, 10, p. 1113-1123 11 p.

    Research output: Contribution to journalArticlepeer-review

  58. Episodic sexual transmission of HIV revealed by molecular phylodynamics

    Lewis, F., Hughes, G. J., Rambaut, A., Pozniak, A. & Leigh Brown, A. J., Mar 2008, In: PLoS Medicine. 5, 3, p. 0392-0402 11 p., e50.

    Research output: Contribution to journalArticlepeer-review

  59. Estimating selection pressures on HIV-1 using phylogenetic likelihood models

    Pond, S. L. K., Poon, A. F. Y., Zarate, S., Smith, D. M., Little, S. J., Pillai, S. K., Ellis, R. J., Wong, J. K., Leigh Brown, A., Richman, D. D. & Frost, S. D. W., 2008, In: STATISTICS IN MEDICINE. 27, 23, SI, p. 4779-4789 11 p.

    Research output: Contribution to journalArticlepeer-review

  60. 2007
  61. Adaptation to human populations is revealed by within-host polymorphisms in HIV-1 and hepatitis C virus

    Poon, A. F. Y., Pond, S. L. K., Bennett, P., Richman, D. D., Leigh Brown, A. J. & Frost, S. D. W., Apr 2007, In: Plos Pathogens. 3, 3

    Research output: Contribution to journalArticlepeer-review

  62. Evidence of a decline in transmitted HIV-1 drug resistance in the United Kingdom

    Burns, S., Cameron, S., Cane, P., Down, P., Chrystie, I., Churchill, D., Delpech, V., Pillay, D., Dunn, D., Fearnhill, E., Green, H., Porter, K., Easterbrook, P., Zuckerman, M., Geretti, A. M., Gifford, R., Kellam, P., Phillips, A., Sabin, C., Goldberg, D. & 32 others, Gompels, M., Hale, A., Kaye, S., Leigh Brown, A., Orkin, C., Pozniak, A., Robb, G., Smit, E., Tilston, P., Williams, I., Ainsworth, J., Anderson, J., Babiker, A., Fisher, M., Gazzard, B., Gilson, R., Hill, T., Johnson, M., Leen, C., Sadiq, T., Schwenk, A., Walsh, J., Brettle, R., Darbyshire, J., Fidler, S., Hawkins, D., Jaffe, H., Johnson, A., McLean, K., Resistance, UK. C. G. HIV. D., Comm, UK. CHIC. S. & Ste, UK. R. HIV. S., 2007, In: AIDS. 21, 8, p. 1035-1039 5 p.

    Research output: Contribution to journalArticlepeer-review

  63. HIV phylogenetics: Criminal convictions relying solely on this to establish transmission are unsafe

    Pillay, D., Rambaut, A., Geretti, A. M. & Leigh Brown, A. J., 2007, In: British Medical Journal (BMJ). 335, 7618, p. 460-461 2 p.

    Research output: Contribution to journalArticlepeer-review

  64. 2006
  65. Adaptation to Different Human Populations by HIV-1 Revealed by Codon-Based Analyses

    Kosakovsky Pond, S. L., Frost, S. D. W., Grossman, Z., Gravenor, M. B., Richman, D. D. & Leigh Brown, A. J., Jun 2006, In: PLoS Computational Biology. 2, 6, p. 530-538 9 p., e62.

    Research output: Contribution to journalArticlepeer-review

  66. Bayesian graphical models in the analysis of HIV drug resistance data from the UK HIV Drug Resistance Database

    Lewis, F., Fearnhill, E., Murray, R., Pillay, D., Dunn, D., Leigh Brown, A. & Collaboration, UK. D. R., 2006, In: Antiviral Therapy. 11, 5

    Research output: Contribution to journalArticlepeer-review

  67. 2005
  68. Phenotypic hypersusceptibility to multiple protease inhibitors and low replicative capacity in patients who are chronically infected with human immunodeficiency virus type 1

    Martinez-Picado, J., Wrin, T., Frost, SDW., Clotet, B., Ruiz, L., Leigh Brown, AJ., Petropoulos, CJ. & Parkin, NT., May 2005, In: Journal of Virology. 79, 10, p. 5907-5913 7 p.

    Research output: Contribution to journalArticlepeer-review

  69. Human immunodeficiency virus type 1 clade B superinfection: Evidence for differential immune containment of distinct clade B strains

    Yang, OO., Daar, ES., Jamieson, BD., Balamurugan, A., Smith, DM., Pitt, JA., Petropoulos, CJ., Richman, DD., Little, SJ. & Leigh Brown, AJ., Jan 2005, In: Journal of Virology. 79, 2, p. 860-868 9 p.

    Research output: Contribution to journalArticlepeer-review

  70. Estimating HIV-1 drug resistance in antiretroviral-treated individuals in the United Kingdom

    Pillay, D., Green, H., Matthias, R., Dunn, D., Phillips, A., Sabin, C., Evans, B., Cane, P., Burns, S., Cameron, S., Chrystie, I., Churchill, D., Clarke, J., Easterbrook, P., Zuckerman, M., Goldberg, D., Gompels, M., Hale, T., Robb, G., Leigh Brown, A. & 9 others, Geretti, AM., Kellam, P., Porter, K., Orkin, C., Pozniak, A., Smit, R., Tilston, P., Williams, I. & Res, UK. C. G. HIV. D., 2005, In: The Journal of Infectious Diseases. 192, 6, p. 967-973 7 p.

    Research output: Contribution to journalArticlepeer-review

  71. Long term probability of detection of HIV-1 drug resistance after starting antiretroviral therapy in routine clinical practice

    Blackham, J., Burns, S., Cameron, S., Cane, P., Chrystie, I., Churchill, D., Clarke, J., Easterbrook, P., Zuckerman, M., Goldberg, D., Gompels, M., Hale, T., Lazarus, L., Leigh Brown, A., Loveday, C., Geretti, AM., Pillay, D., Phillips, A., Sabin, C., Hill, T. & 43 others, Kellam, P., Dunn, D., Porter, K., Green, H., Matthias, R., Pozniak, A., Tilston, P., Williams, I., Babiker, A., Fisher, M., Gilson, R., Johnson, M., Mortimer, J., Peters, B., Scullard, G., Gazzard, B., Bansi, L., Smith, C., Waters, A., Crates, D., Morgan, N., Perry, N., Pullin, A., Harris, W., Bulbeck, S., Mandalia, S., Dodds, J., Fudge, N., Rider, A., Sinka, K., Evans, B., Delpech, V., Larbalestier, N., Gray, K., Youle, M., Lampe, F., Gumley, H., Chaloner, C., Puradiredja, J., Weber, J., Owens, C., Resist, UK. C. G. HIV. D. & Grp, UK. CHIC. S., 2005, In: AIDS. 19, 5, p. 487-494 8 p.

    Research output: Contribution to journalArticlepeer-review

  72. Using mixtures of amino acids to detect individual- and population-level selection of HIV-1 protease

    Frost, SDW., Pond, SLK., Smith, DM., Richman, DD. & Leigh Brown, AJ., 2005, In: Antiviral Therapy. 10, 4

    Research output: Contribution to journalArticlepeer-review

  73. 2004
  74. Activation by malaria antigens renders mononuclear cells susceptible to HIV infection and re-activates replication of endogenous HIV in cells from HIV-infected adults

    Froebel, K., Howard, W., Schafer, JR., Howie, F., Whitworth, J., Kaleebu, P., Leigh Brown, AJ. & Riley, E., May 2004, In: Parasite Immunology. 26, 5, p. 213-217 5 p.

    Research output: Contribution to journalArticlepeer-review

  75. Genetic basis of hypersusceptibility to protease inhibitors and low replicative capacity of human immunodeficiency virus type 1 strains in primary infection

    Leigh Brown, AJ., Frost, SDW., Good, B., Daar, ES., Simon, V., Markowitz, M., Collier, AC., Connick, E., Conway, B., Margolick, JB., Routy, JP., Corbeil, J., Hellmann, NS., Richman, DD. & Little, SJ., Mar 2004, In: Journal of Virology. 78, 5, p. 2242-2246 5 p.

    Research output: Contribution to journalArticlepeer-review

  76. 2003
  77. Effects of amino acid and synonymous polymorphisms in HIV-1 protease on viral fitness

    Frost, SDW., Kosakovsky Pond, S., Grossman, Z., Daar, E., Condra, J., Richman, DD., Little, SJ. & Leigh Brown, AJ., Jun 2003, In: Antiviral Therapy. 8, 3

    Research output: Contribution to journalArticlepeer-review

  78. Changing transmission fitness of drug-resistant human immunodeficiency virus against a background of evolving antiretroviral therapy - Reply

    Leigh Brown, AJ., Frost, SDW., Mathews, WC., Dawson, K., Hellmann, NS., Daar, ES., Richman, DD. & Little, SJ., 2003, In: The Journal of Infectious Diseases. 188, 8, p. 1258-1259 2 p.

    Research output: Contribution to journalArticlepeer-review

  79. Clade BHIV-1 superinfection with wild-type virus after primary infection with drug-resistant clade B virus

    Koelsch, KK., Smith, DM., Little, SJ., Ignacio, CC., Macaranas, TR., Leigh Brown, AJ., Petropoulos, CJ., Richman, DD. & Wong, JK., 2003, In: AIDS. 17, 7, p. F11-F16

    Research output: Contribution to journalArticlepeer-review

  80. Differences in HIV-1 pol sequences from female genital tract and blood during antiretroviral therapy

    De Pasquale, MP., Leigh Brown, AJ., Uvin, SC., Allega-Ingersoll, J., Caliendo, AM., Sutton, L., Donahue, S. & D'Aquila, RT., 2003, In: Journal of Acquired Immune Deficiency Syndromes. 34, 1, p. 37-44 8 p.

    Research output: Contribution to journalArticlepeer-review

  81. Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: Intrinsic stability predicts lifelong persistence

    Strain, MC., Gunthard, HF., Havlir, DV., Ignacio, CC., Smith, DM., Leigh Brown, AJ., Macaranas, TR., Lam, RY., Daly, OA., Fischer, M., Opravil, M., Levine, H., Bacheler, L., Spina, CA., Richman, DD. & Wong, JK., 2003, In: Proceedings of the National Academy of Sciences (PNAS). 100, 8, p. 4819-4824 6 p.

    Research output: Contribution to journalArticlepeer-review

  82. Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population

    Leigh Brown, AJ., Frost, SDW., Mathews, WC., Dawson, K., Hellmann, NS., Daar, ES., Richman, DD. & Little, SJ., 2003, In: The Journal of Infectious Diseases. 187, 4, p. 683-686 4 p.

    Research output: Contribution to journalArticlepeer-review

  83. 2002
  84. Association of antiretroviral resistance genotypes with response to therapy--comparison of three models

    Nicol, M., Frost, SDW., McDonagh, S., Burns, SM., Clutterbuck, D., McMillan, A., Leen, CS. & Leigh Brown, AJ., Oct 2002, In: Antiviral Therapy. 7, 3, p. 151-157 7 p.

    Research output: Contribution to journalArticlepeer-review

  85. Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection

    Frost, SDW., Martinez-Picado, J., Ruiz, L., Clotet, B. & Leigh Brown, AJ., Feb 2002, In: Journal of Virology. 76, 3, p. 968-979 12 p.

    Research output: Contribution to journalArticlepeer-review

  86. An individual-based epidemiological model for the transmission of drug resistant HIV

    Leigh Brown, AJ., Frost, SD., Daar, E., Perrin, L., Richman, DD. & Little, SJ., 2002, In: Antiviral Therapy. 7, 1

    Research output: Contribution to journalArticlepeer-review

  87. Analysing the genotypic basis of hypersusceptibility to amprenavir in HIV from antiretroviral-naive patients

    Leigh Brown, AJ., Good, B., Frost, SD., Collier, AC., Connick, E., Conway, B., Daar, E., Kilby, M., Routy, JP., Margolick, JB., Markowitz, M., Dawson, K., Hellmann, N., Richman, DD. & Little, SJ., 2002, In: Antiviral Therapy. 7, 1

    Research output: Contribution to journalArticlepeer-review

  88. Human macrophages accumulate HIV-1 particles in MHC II compartments

    Raposo, G., Moore, M., Innes, D., Leijendekker, R., Leigh Brown, A., Benaroch, P. & Geuze, H., 2002, In: Traffic. 3, 10, p. 718-729 12 p.

    Research output: Contribution to journalArticlepeer-review

  89. 2001
  90. Criminalisation of HIV transmission: implications for public health in Scotland

    Bird, SM. & Leigh Brown, AJ., 2001, In: British Medical Journal (BMJ). 323, 7322, p. 1174-1177 4 p.

    Research output: Contribution to journalArticlepeer-review

  91. Evidence for positive selection driving the evolution of HIV-1 env under potent antiviral therapy

    Frost, SDW., Gunthard, HF., Wong, JK., Havlir, D., Richman, DD. & Leigh Brown, AJ., 2001, In: Virology. 284, 2, p. 250-258 9 p.

    Research output: Contribution to journalArticlepeer-review

  92. Genetic drift and within-host metapopulation dynamics of HIV-1 infection

    Frost, SDW., Dumaurier, MJ., Wain-Hobson, S. & Leigh Brown, AJ., 2001, In: Proceedings of the National Academy of Sciences (PNAS). 98, 12, p. 6975-6980 6 p.

    Research output: Contribution to journalArticlepeer-review

  93. Mismatched human leukocyte antigen alleles protect against heterosexual HIV transmission

    Lockett, SF., Robertson, JR., Brettle, RP., Yap, PL., Middleton, D. & Leigh Brown, AJ., 2001, In: Journal of Acquired Immune Deficiency Syndromes. 27, 3, p. 277-280 4 p.

    Research output: Contribution to journalArticlepeer-review

  94. Residual human immunodeficiency virus (HIV) type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 years

    Gunthard, HF., Havlir, DV., Fiscus, S., Zhang, ZQ., Eron, J., Mellors, J., Gulick, R., Frost, SDW., Leigh Brown, AJ., Schleif, W., Valentine, F., Jonas, L., Meibohm, A., Ignacio, CC., Isaacs, R., Gamagami, R., Emini, E., Haase, A., Richman, DD. & Wong, JK., 2001, In: The Journal of Infectious Diseases. 183, 9, p. 1318-1327 10 p.

    Research output: Contribution to journalArticlepeer-review

  95. Soluble recombinant HTLV-1 surface glycoprotein competitively inhibits syncytia formation and viral infection of cells

    Jassal, SR., Lairmore, MD., Leigh Brown, AJ. & Brighty, DW., 2001, In: Virus Research. 78, 1-2, p. 17-34 18 p.

    Research output: Contribution to journalArticlepeer-review

  96. 2000
  97. Evolution of lamivudine resistance in human immunodeficiency virus type 1-infected individuals: the relative roles of drift and selection

    Frost, SDW., Nijhuis, M., Schuurman, R., Boucher, CAB. & Leigh Brown, AJ., Jul 2000, In: Journal of Virology. 74, 14, p. 6262-6268 7 p.

    Research output: Contribution to journalArticlepeer-review

  98. Patterns of resistance mutations selected by treatment of human immunodeficiency virus type 1 infection with zidovudine, didanosine, and nevirapine

    Hanna, GJ., Johnson, VA., Kuritzkes, DR., Richman, DD., Leigh Brown, AJ., Savara, AV., Hazelwood, JD. & D'Aquila, RT., Mar 2000, In: The Journal of Infectious Diseases. 181, 3, p. 904-911 8 p.

    Research output: Contribution to journalArticlepeer-review

  99. Molecular evidence for genetic mixing of Arctic and Antarctic subpolar populations of planktonic foraminifers

    Darling, K., Wade, C. M., Stewart, I. A., Kroon, D., Dingle, R. & Leigh Brown, A., 2000, In: Nature. 405, 6782, p. 43-47 5 p.

    Research output: Contribution to journalArticlepeer-review

  100. Multiple sites in HIV-1 reverse transcriptase associated with virological response to combination therapy

    Precious, HM., Gunthard, HF., Wong, JK., D'Aquila, RT., Johnson, VA., Kuritzkes, DR., Richman, DD. & Leigh Brown, AJ., 2000, In: AIDS. 14, 1, p. 31-36 6 p.

    Research output: Contribution to journalArticlepeer-review

  101. Transmission and fitness of drug resistant strains of HIV

    Leigh Brown, AJ., Frost, SDW., Whitcomb, JM., McLean, AR., Hellmann, NS., Leen, CS., Brettle, RP., Havlir, DV., Mathews, WC., Richman, DD. & Little, SJ., 2000, In: AIDS. 14, 4

    Research output: Contribution to journalArticlepeer-review

  102. 1999
  103. Associations between amino acids in the evolution of HIV type 1 protease sequences under indinavir therapy

    Leigh Brown, AJ., Korber, BT. & Condra, JH., 1999, In: Aids research and human retroviruses. 15, 3, p. 247-253 7 p.

    Research output: Contribution to journalArticlepeer-review

  104. Completing the molecular investigation into the HIV outbreak at Glenochil prison

    Yirrell, DL., Hutchinson, SJ., Griffin, M., Gore, SM., Leigh Brown, AJ. & Goldberg, DJ., 1999, In: Epidemiology and Infection. 123, 2, p. 277-282 6 p.

    Research output: Contribution to journalArticlepeer-review

  105. Evolution of envelope sequences of human immunodeficiency virus type 1 in cellular reservoirs in the setting of potent antiviral therapy

    Gunthard, HF., Frost, SDW., Leigh Brown, AJ., Ignacio, CC., Kee, K., Perelson, AS., Spina, CA., Havlir, DV., Hezareh, M., Looney, DJ., Richman, DD. & Wong, JK., 1999, In: Journal of Virology. 73, 11, p. 9404-9412 9 p.

    Research output: Contribution to journalArticlepeer-review

  106. Higher selection pressure from antiretroviral drugs in vivo results in increased evolutionary distance in HIV-1 pol

    Gunthard, HF., Leigh Brown, AJ., D'Aquila, RT., Johnson, VA., Kuritzkes, DR., Richman, DD. & Wong, JK., 1999, In: Virology. 259, 1, p. 154-165 12 p.

    Research output: Contribution to journalArticlepeer-review

  107. Method used to identify previously undiagnosed infections in the HIV outbreak at Glenochil prison

    Hutchinson, SJ., Gore, SM., Goldberg, DJ., Yirrell, DL., McGregor, J., Bird, AG. & Leigh Brown, AJ., 1999, In: Epidemiology and Infection. 123, 2, p. 271-275 5 p.

    Research output: Contribution to journalArticlepeer-review

  108. Sequence clusters in human immunodeficiency virus type 1 reverse transcriptase are associated with subsequent virological response to antiretroviral therapy

    Leigh Brown, AJ., Gunthard, HF., Wong, JK., D'Aquila, RT., Johnson, VA., Kuritzkes, DR. & Richman, DD., 1999, In: The Journal of Infectious Diseases. 180, 4, p. 1043-1049 7 p.

    Research output: Contribution to journalArticlepeer-review

  109. 1998
  110. Analysis of human immunodeficiency virus type 1 env and gag sequence variants derived from a mother and two vertically infected children provides evidence for the transmission of multiple sequence variants

    Wade, CM., Lobidel, D. & Leigh Brown, AJ., May 1998, In: Journal of General Virology. 79, 5, p. 1055-1068 14 p.

    Research output: Contribution to journalArticlepeer-review

  111. Molecular epidemiological analysis of HIV in sexual networks in Uganda

    Yirrell, DL., Pickering, H., Palmarini, G., Hamilton, L., Rutemberwa, A., Biryahwaho, B., Whitworth, J. & Leigh Brown, AJ., 1998, In: AIDS. 12, 3, p. 285-290 6 p.

    Research output: Contribution to journalArticlepeer-review

  112. 1997
  113. Evolution of human immunodeficiency virus type 1 in perinatally infected infants with rapid and slow progression to disease

    Salvatori, F., Masiero, S., Giaquinto, C., Wade, CM., Leigh Brown, AJ., ChiecoBianchi, L. & DeRossi, A., Jun 1997, In: Journal of Virology. 71, 6, p. 4694-4706 13 p.

    Research output: Contribution to journalArticlepeer-review

  114. Genetic and molecular analysts of smooth, a quantitative trait locus affecting bristle number in Drosophila melanogaster

    zurLage, P., Shrimpton, AD., Flavell, AJ., Mackay, TFC. & Leigh Brown, AJ., Jun 1997, In: Genetics. 146, 2, p. 607-618 12 p.

    Research output: Contribution to journalArticlepeer-review

  115. Mutations associated with zidovudine resistance in HIV-1 among recent seroconvertors

    Quigg, M., Rebus, S., France, A. J., McMenamin, J., Darby, G. & Leigh Brown, A. J., May 1997, In: AIDS. 11, 6, p. 835-836 2 p.

    Research output: Contribution to journalArticlepeer-review

  116. Planktic foraminiferal molecular evolution and their polyphyletic origins from benthic taxa

    Darling, K., Wade, C. M., Kroon, D. & Leigh Brown, A., Apr 1997, In: Marine Micropaleontology. 30, 4, p. 251-266 16 p.

    Research output: Contribution to journalArticlepeer-review

  117. HIV-1: Gambling on the evolution of drug resistance?

    Leigh Brown, AJ. & Richman, DD., Mar 1997, In: Nature Medicine. 3, 3, p. 268-271 4 p.

    Research output: Contribution to journalArticlepeer-review

  118. Analysis of HIV-1 env gene sequences reveals evidence for a low effective number in the viral population

    Leigh Brown, AJ., 1997, In: Proceedings of the National Academy of Sciences (PNAS). 94, 5, p. 1862-1865 4 p.

    Research output: Contribution to journalArticlepeer-review

  119. Molecular investigation into outbreak of HIV in a Scottish prison

    Yirrell, DI., Robertson, P., Goldberg, DJ., McMenamin, J., Cameron, S. & Leigh Brown, AJ., 1997, In: British Medical Journal (BMJ). 314, 7092, p. 1446-1450 5 p.

    Research output: Contribution to journalArticlepeer-review

  120. 1996
  121. Early evolutionary origin of the planktic foraminifera inferred from small subunit rDNA sequence comparisons

    Wade, C. M., Darling, K., Kroon, D. & Leigh Brown, A., Dec 1996, In: Journal of molecular evolution. 43, 6, p. 672-677 6 p.

    Research output: Contribution to journalArticlepeer-review

  122. Independent evolution of the env and pol genes of HIV-1 during zidovudine therapy

    Leigh Brown, AJ. & Cleland, A., Oct 1996, In: AIDS. 10, 10, p. 1067-1073 7 p.

    Research output: Contribution to journalArticlepeer-review

  123. Evolution of zidovudine resistance-associated genotypes in human immunodeficiency virus type 1-infected patients

    Cleland, A., Watson, HG., Robertson, P., Ludlam, CA. & Leigh Brown, AJ., 1996, In: Journal of Acquired Immune Deficiency Syndromes. 12, 1, p. 6-18 13 p.

    Research output: Contribution to journalArticlepeer-review

  124. Molecular phylogeny of the planktic foraminifera

    Darling, K., Kroon, D., Wade, C. M. & Leigh Brown, A., 1996, In: Journal of foraminiferal research. 26, 4, p. 324-330 7 p.

    Research output: Contribution to journalArticlepeer-review

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