Edinburgh Research Explorer

Andrew McKechanie

Senior Clinical Research Fellow

Profile photo

Education/Academic qualification

Doctor of Philosophy (PhD), The University of Edinburgh
Bachelor of Medicine and Bachelor of Surgery, The University of Edinburgh

Professional Qualifications

Fellow of the Royal College of Psychiatrists, FRCPsych
Member of The Royal Society of Edinburgh Young Academy of Scotland


Andrew McKechanie is a senior clinical research fellow at The Patrick Wild Centre for Research into Autism, Fragile X and Intellectual Disabilities.

The Patrick Wild Centre

His clinical work is as a consultant psychiatrist for the NHS Lothian Learning Disability Services in East Lothian.

He also serves as a board member of Scottish Autism, a national charity which provides autism-specific services to autistic children and adults, along with support and information for their families, carers and professionals.

Scottish Autism

My research in a nutshell

My research interests primarily relate to intellectual disabilities, the autism spectrum and related neurodevelopmental disorders. While our understanding of these conditions has increased dramatically in recent years, in many cases this has yet to be translated into meaningful clinical benefits for individuals affected by them. I have a particular interest in the methods that can be used to bring fundamental and clinical research more closely together; particularly through the use of translational measures of cognition, imaging and development.

Current Research Interests

  • Functional brain imaging in individuals with intellectual disabilities, autism and fragile X syndrome.
  • The genetics of neuropsychiatric disorders in individuals with an intellectual disability.
  • The neuropsychiatric phenotype of individuals with genetic variants in SYNGAP1.
  • Translational measures of development and cognition, to bridge the gap between pre-clinical and clinical research.
  • Development of novel, objective outcome measures for use in clinical trials with individuals with neurodevelopmental disorders.
  • Glucocorticoid metabolism in Down syndrome.

Highlighted research outputs

  1. The Never-Changing Face of Fragile X?

    Research output: Contribution to journalLetter

  2. Autism in fragile X syndrome; a functional MRI study of facial emotion-processing

    Research output: Contribution to journalArticlepeer-review

  3. Fragile X-associated conditions: Implications for the whole family

    Research output: Contribution to journalArticlepeer-review

  4. Links between autism spectrum disorder diagnostic status and family quality of life

    Research output: Contribution to journalArticlepeer-review

  5. The UK10K project identifies rare variants in health and disease

    Research output: Contribution to journalArticlepeer-review

  6. Synaptic scaffold evolution generated components of vertebrate cognitive complexity

    Research output: Contribution to journalArticlepeer-review

View all (50) »

Research activities & awards

  1. BJPsych Open (Journal)

    Activity: Publication peer-review and editorial work typesPublication peer-review

  2. European Journal of Human Genetics (Journal)

    Activity: Publication peer-review and editorial work typesPublication peer-review

  3. Navigator Trust CIO (External organisation)

    Activity: Membership typesMembership of board

View all (42) »

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