Edinburgh Research Explorer

Anna Williams

Personal chair of Regenerative neurology

  1. Comparative assessment of phototherapy protocols for reduction of oxidative stress in partially transected spinal cord slices undergoing secondary degeneration

    Ashworth, B. E., Stephens, E., Bartlett, C. A., Serghiou, S., Giacci, M. K., Williams, A., Hart, N. S. & Fitzgerald, M., 18 May 2016, In: BMC Neuroscience.

    Research output: Contribution to journalArticlepeer-review

  2. Association between endothelial cell stabilizing medication and small vessel disease stroke: a case-control study

    Becker, C. E., Quinn, T. & Williams, A., 25 Sep 2019, In: Frontiers in Neurology.

    Research output: Contribution to journalArticlepeer-review

  3. Correlated Heterospectral Lipidomics for Biomolecular Profiling of Remyelination in Multiple Sclerosis

    Bergholt, M. S., Serio, A., McKenzie, J. S., Boyd, A., Soares, R. F., Tillner, J., Chiappini, C., Wu, V., Dannhorn, A., Takats, Z., Williams, A. & Stevens, M. M., 27 Dec 2017, In: ACS Central Science. 4, 1, p. 39-51 13 p.

    Research output: Contribution to journalArticlepeer-review

  4. Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models

    Boyd, A., Zhang, H. & Williams, A., Jun 2013, In: Acta Neuropathologica. p. 1-19 19 p.

    Research output: Contribution to journalArticlepeer-review

  5. A systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis

    Cunniffe, N., Vuong, K. A., Ainslie, D., Baker, D., Beveridge, J., Bickley, S. R. B., Camilleri, P., Craner, M., Fitzgerald, D. C., De La Fuente, A. G., Giovannoni, G., Gray, E., Hazlehurst, L., Kapoor, R., Kaur, R., Kozlowski, D., Lumicisi, B., Mahad, D., Neumann, B., Palmer, A. & 9 others, Peruzzotti-Jametti, L., Pluchino, S., Robertson, J., Rothaul, A., Shellard, L., Smith, K. J., Wilkins, A., Williams, A. C. & Coles, A. J., 12 Nov 2020, In: Journal of Neurology, Neurosurgery & Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  6. Activin receptors regulate the oligodendrocyte lineage in health and disease

    Dillenburg, A., Ireland, G., Holloway, R. K., Davies, C. L., Evans, F. L., Swire, M., Bechler, M. E., Soong, D., Yuen, T. J., Su, G. H., Becher, J-C., Smith, C., Williams, A. & Miron, V. E., 3 Feb 2018, In: Acta Neuropathologica.

    Research output: Contribution to journalArticlepeer-review

  7. Regulatory T cells promote myelin regeneration in the central nervous system

    Dombrowski, Y., O'Hagan, T., Dittmer, M., Penalva, R., Mayoral, S. R., Bankhead, P., Fleville, S., Eleftheriadis, G., Zhao, C., Naughton, M., Hassan, R., Moffat, J., Falconer, J., Boyd, A., Hamilton, P., Allen, I. V., Kissenpfennig, A., Moynagh, P. N., Evergren, E., Perbal, B. & 5 others, Williams, A. C., Ingram, R. J., Chan, J. R., Franklin, R. J. M. & Fitzgerald, D. C., 13 Mar 2017, In: Nature Neuroscience. 20, 5, p. 674-680 7 p.

    Research output: Contribution to journalArticlepeer-review

  8. Cryogel scaffolds for regionally constrained delivery of lysophosphatidylcholine to central nervous system slice cultures: a model of focal demyelination for multiple sclerosis research

    Eigel, D., Zoupi, L., Sekizar, S., Welzel, P., Werner, C., Williams, A. & Newland, B., Oct 2019, In: Acta Biomaterialia.

    Research output: Contribution to journalArticlepeer-review

  9. Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease

    Ferrari Bardile, C., Garcia-Miralles, M., Caron, N. S., Rayan, N. A., Langley, S. R., Harmston, N., Rondelli, A. M., Teo, R. T. Y., Waltl, S., Anderson, L. M., Bae, H-G., Jung, S., Williams, A., Prabhakar, S., Petretto, E., Hayden, M. R. & Pouladi, M. A., 7 May 2019, In: Proceedings of the National Academy of Sciences of the United States of America.

    Research output: Contribution to journalArticlepeer-review

  10. A mutation in periaxin is responsible for CMT4F, an autosomal recessive form of Charcot-Marie-Tooth disease

    Guilbot, A., Williams, A., Ravisé, N., Verny, C., Brice, A., Sherman, D. L., Brophy, P. J., LeGuern, E., Delague, V., Bareil, C., Mégarbané, A. & Claustres, M., 15 Feb 2001, In: Human Molecular Genetics. 10, 4, p. 415-21 7 p.

    Research output: Contribution to journalArticlepeer-review

  11. Loss of PRMT1 in the CNS induces reactive astrocytes and microglia during postnatal brain development

    Hashimoto, M., Kumabe, A., Kim, J-D., Murata, K., Sekizar, S., Williams, A. C., Lu, W., Ishida, J., Nakagawa, T., Endo, M., Minami, Y. & Fukamizu, A., 16 Aug 2020, In: Journal of Neurochemistry.

    Research output: Contribution to journalArticlepeer-review

  12. 'Small vessels, dementia and chronic diseases -molecular mechanisms and pathophysiology' Workshop proceedings

    Horsburgh, K., Wardlaw, J., Van Agtmael, T., Allan, S., Ashford, M., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davies, J. B., Duncombe, J., Farr, T. D., Fowler, J., Goense, J., Granata, A., Hall, C., Hainsworth, A., Harvey, A., Hawkes, C. & 26 others, Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., MacLeod, M., Macrae, M., Markus, H. S., McCabe, C., McColl, B., Meakin, P. J., Miller, A. A., Nedergaard, M., O'Sullivan, M., Quinn, T., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R., Trueman, R., Wang, T., Williams, A., Williams, S. & Work, L. M., 30 Apr 2018, In: Clinical science. 132, 8, p. 851-868

    Research output: Contribution to journalReview articlepeer-review

  13. Retinoid X receptor gamma signaling accelerates CNS remyelination

    Huang, J. K., Jarjour, A. A., Oumesmar, B. N., Kerninon, C., Williams, A., Krezel, W., Kagechika, H., Bauer, J., Zhao, C., Baron-Van Evercooren, A., Chambon, P., Ffrench-Constant, C. & Franklin, R. J. M., Jan 2011, In: Nature Neuroscience. 14, 1, p. 45-53 9 p.

    Research output: Contribution to journalArticlepeer-review

  14. What Have Advances in Transcriptomic Technologies Taught us About Human White Matter Pathologies?

    Jaekel, S. & Williams, A. C., 4 Aug 2020, In: Frontiers in Cellular Neuroscience.

    Research output: Contribution to journalReview articlepeer-review

  15. The Polarity Protein Scribble Regulates Myelination and Remyelination in the Central Nervous System

    Jarjour, A. A., Boyd, A., Dow, L. E., Holloway, R. K., Goebbels, S., Humbert, P. O., Williams, A. & Ffrench-Constant, C., 25 Mar 2015, In: PLoS Biology. 13, 3, e1002107.

    Research output: Contribution to journalArticlepeer-review

  16. Promoting remyelination in multiple sclerosis-recent advances

    Jolanda Münzel, E. & Williams, A., Dec 2013, In: Drugs. 73, 18, p. 2017-29 13 p.

    Research output: Contribution to journalArticlepeer-review

  17. Altered human oligodendrocyte heterogeneity in multiple sclerosis

    Jäkel, S., Agirre, E., Falcão, A. M., van Bruggen, D., Lee, K. W., Knuesel, I., Malhotra, D., ffrench-Constant, C., Williams, A. & Castelo-Branco, G., 28 Feb 2019, In: Nature. 566, 7745, p. 543–547 5 p.

    Research output: Contribution to journalArticlepeer-review

  18. Calcitriol modulates the CD46 pathway by controlling its expression and function on T cells

    Kickler, K., Choileain, S. N., Williams, A., Richards, A. & Astier, A. L., Sep 2012, In: Immunology . 137, p. 469-469 1 p.

    Research output: Contribution to journalMeeting abstract

  19. Vitamin D / CD46 crosstalk in human T cells in multiple sclerosis

    Killick, J., Hay, J., Morandi, E., Vermeren, S., Kari, S., Angles, T., Williams, A. C., Damoiseaux, J. & Astier, A., 24 Nov 2020, In: Frontiers in Immunology.

    Research output: Contribution to journalArticlepeer-review

  20. Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9

    Lindner, M., Thümmler, K., Arthur, A., Brunner, S., Elliott, C., McElroy, D., Mohan, H., Williams, A., Edgar, J. M., Schuh, C., Stadelmann, C., Barnett, S. C., Lassmann, H., Mücklisch, S., Mudaliar, M., Schaeren-Wiemers, N., Meinl, E. & Linington, C., 23 Apr 2015, In: Brain. 138, p. 1875-1893

    Research output: Contribution to journalArticlepeer-review

  21. Central nervous system regeneration is driven by microglia necroptosis and repopulation

    Lloyd, A. F., Davies, C. L., Holloway, R. K., Labrak, Y., Ireland, G., Carradori, D., Dillenburg, A., Borger, E., Soong, D., Richardson, J. C., Kuhlmann, T., Williams, A., Pollard, J. W., des Rieux, A., Priller, J. & Miron, V. E., 31 Jul 2019, In: Nature Neuroscience. 22, 7, p. 1046–1052 7 p.

    Research output: Contribution to journalArticlepeer-review

  22. Remyelination in multiple sclerosis: from basic science to clinical translation

    Lubetzki, C., Zalc, B., Williams, A., Stadelmann, C. & Stankoff, B., 1 Aug 2020, In: Lancet Neurology.

    Research output: Contribution to journalArticlepeer-review

  23. Stochastic spatial modelling of the remyelination process in multiple sclerosis lesions

    Luisa Vissat, L., Hillston, J. & Williams, A., 12 Jun 2019, Automated Reasoning for Systems Biology and Medicine. Liò, P. & Zuliani, P. (eds.). Springer, p. 299-326 28 p. (Computational Biology; vol. 30).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

  24. Most neurologists in Scotland do not use the mcdonald 2010 criteria to diagnose multiple sclerosis

    Lumley, R., Davenport, R. & Williams, A., Nov 2013, In: Journal of Neurology, Neurosurgery & Psychiatry. 84, 11, p. e2

    Research output: Contribution to journalArticlepeer-review

  25. Most Scottish neurologists do not apply the 2010 McDonald criteria when diagnosing multiple sclerosis

    Lumley, R., Davenport, R. & Williams, A., Mar 2015, In: Journal of the Royal College of Physicians of Edinburgh. 45, 1, p. 23-6 4 p.

    Research output: Contribution to journalArticlepeer-review

  26. Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulphate production

    Macchi, M., Magalon, K., Zimmer, C., Peeva, E., El Waly, B., Brousse, B., Jaekel, S., Grobe, K., Kiefer, F., Williams, A. C., Cayre, M. & Durbec, P., 22 Jun 2020, In: eLIFE.

    Research output: Contribution to journalArticlepeer-review

  27. Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

    Macchi, M., Magalon, K., Zimmer, C., Peeva, E., El Waly, B., Brousse, B., Jaekel, S., Grobe, K., Kiefer, F., Williams, A., Cayre, M. & Durbec, P., 9 Jun 2020, In: eLIFE. 9

    Research output: Contribution to journalArticlepeer-review

  28. Biomass fuel flexibility in future conventional power generation

    Mason, P. E., Riaza, J., Chalmers, H., Darvell, L. I., Jones, J. M. & Williams, A., 1 Jan 2016.

    Research output: Contribution to conferencePaperpeer-review

  29. Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors

    Matjusaitis, M., Wagstaff, L. J., Martella, A., Baranowski, B., Blin, C., Gogolok, S., Williams, A. & Pollard, S. M., 7 Nov 2019, In: Stem Cell Reports.

    Research output: Contribution to journalArticlepeer-review

  30. The Lysosomal Transcription Factor TFEB represses myelination downstream of the Rag-Ragulator complex

    Meireles, A. M., Shen, K., Zoupi, L., Iyer, H., Bouchard, E. L., Williams, A. & Talbot, W. S., 5 Nov 2018, In: Developmental Cell.

    Research output: Contribution to journalArticlepeer-review

  31. Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

    Mendanha Falcão, A., van Bruggen, D., Marques, S., Meijer, M., Jaekel, S., Agirre, E., Samudyata, Floriddia, E. M., Vanichkina, D. P., ffrench-Constant, C., Williams, A., Ortlieb Guerreiro-Cacais, A. & Castelo-Branco, G., 31 Dec 2018, In: Nature Medicine. 24, 12, p. 1837–1844 8 p.

    Research output: Contribution to journalArticlepeer-review

  32. Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination

    Milbreta, U., Lin, J., Pinese, C., Ong, W., Chin, J. S., Shirahama, H., Mi, R., Williams, A., Bechler, M. E., Wang, J., Ffrench-Constant, C., Hoke, A. & Chew, S. Y., 6 Feb 2019, In: Molecular Therapy. 27, 2

    Research output: Contribution to journalArticlepeer-review

  33. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

    Miron, V. E., Boyd, A., Zhao, J-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M. & Ffrench-Constant, C., 2013, In: Nature Neuroscience. 16, 9, p. 1211 - 1218 10 p.

    Research output: Contribution to journalArticlepeer-review

  34. Opening the floodgates to the brain

    Moss, J. & Williams, A., 13 Mar 2020, Science.

    Research output: Book/ReportCommissioned report

  35. Claudin k is specifically expressed in cells that form myelin during development of the nervous system and regeneration of the optic nerve in adult zebrafish

    Muenzel, E. J., Schaefer, K., Obirei, B., Kremmer, E., Burton, E. A., Kuscha, V., Becker, C. G., Broesamle, C., Williams, A. & Becker, T., Feb 2012, In: Glia. 60, 2, p. 253-270 18 p.

    Research output: Contribution to journalArticlepeer-review

  36. CLAUDIN K IS SPECIFICALLY EXPRESSED IN MYELIN OF DEVELOPING AND ADULT ZEBRAFISH

    Muenzel, J., Schaefer, K., Obirei, B., Broesamle, C., Burton, E. A., Kuscha, V., Becker, C. G., Williams, A. & Becker, T., Oct 2011, In: Glia. 59, p. S63-S63 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  37. Relapsing-remitting multiple sclerosis and chronic idiopathic neutropenia: a challenging combination

    Münzel, E. J., Wimperis, J. Z. & Williams, A., 2013, In: BMJ Case Reports. 2013

    Research output: Contribution to journalArticlepeer-review

  38. Zebrafish regenerate full thickness optic nerve myelin after demyelination, but this fails with increasing age

    Münzel, E., Becker, C. G., Becker, T. & Williams, A., 15 Jul 2014, In: Acta Neuropathologica Communications. 2, 1, p. 77

    Research output: Contribution to journalArticlepeer-review

  39. TCR-stimulated changes in cell surface CD46 expression generate type 1 regulatory T cells

    Ni Choileain, S., Hay, J., Thomas, J., Williams, A., Vermeren, M. M., Benezech, C., Gomez-salazar, M., Hugues, O. R., Vermeren, S., Howie, S. E. M., Dransfield, I. & Astier, A. L., 24 Oct 2017, In: Science Signaling. 10, 502, p. eaah6163

    Research output: Contribution to journalArticlepeer-review

  40. Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis

    Nicaise, A. M., Wagstaff, L. J., Willis, C. M., Paisie, C., Chandok, H., Robson, P., Fossati, V., Williams, A. & Crocker, S. J., Apr 2019, In: Proceedings of the National Academy of Sciences. 116, 18, p. 9030-9039 10 p.

    Research output: Contribution to journalArticlepeer-review

  41. Class 3 semaphorins influence oligodendrocyte precursor recruitment and remyelination in adult central nervous system

    Piaton, G., Aigrot, M-S., Williams, A., Moyon, S., Tepavcevic, V., Moutkine, I., Gras, J., Matho, K. S., Schmitt, A., Soellner, H., Huber, A. B., Ravassard, P. & Lubetzki, C., Apr 2011, In: Brain. 134, 4, p. 1156-1167 12 p.

    Research output: Contribution to journalArticlepeer-review

  42. A vessel for change: endothelial dysfunction in cerebral small vessel disease

    Quick, S., Moss, J., Rajani, R. M. & Williams, A. C., 8 Dec 2020, In: Trends in Neurosciences.

    Research output: Contribution to journalArticlepeer-review

  43. Endothelial cell-oligodendrocyte interactions in small vessel disease and aging

    Rajani, R. M. & Williams, A., Mar 2017, In: Clinical science. 131, 5, p. 369-379 11 p.

    Research output: Contribution to journalArticlepeer-review

  44. Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

    Rajani, R. M., Quick, S., Ruigrok, S. R., Graham, D., Harris, S. E., Verhaaren, B. F. J., Fornage, M., Seshadri, S., Atanur, S. S., Dominiczak, A. F., Smith, C., Wardlaw, J. M. & Williams, A., 4 Jul 2018, In: Science Translational Medicine. 10, 448, 12 p., eaam9507.

    Research output: Contribution to journalArticlepeer-review

  45. Myelin repair in vivo is increased by targeting oligodendrocyte precursor cells with nanoparticles encapsulating leukaemia inhibitory factor (LIF)

    Rittchen, S., Boyd, A., Burns, A., Park, J., Fahmy, T. M., Metcalfe, S. & Williams, A., Jun 2015, In: Biomaterials. 56

    Research output: Contribution to journalArticlepeer-review

  46. Imaging central nervous system myelin by positron emission tomography in multiple sclerosis using [methyl-11C]-2-(4′-methylaminophenyl)- 6-hydroxybenzothiazole

    Stankoff, B., Freeman, L., Aigrot, M-S., Chardain, A., Dolle, F., Williams, A., Galanaud, D., Armand, L., Lehericy, S., Lubetzki, C., Zalc, B. & Bottlaender, M., Apr 2011, In: Annals of Neurology. 69, 4, p. 673-680 8 p.

    Research output: Contribution to journalArticlepeer-review

  47. Raman Imaging of Nanocarriers for Drug Delivery

    Vanden-Hehir, S., Tipping, W. J., Lee, M., Brunton, V. G., Williams, A. & Hulme, A. N., 3 Mar 2019, In: Nanomaterials. 9, 3

    Research output: Contribution to journalReview articlepeer-review

  48. Alkyne-tagged PLGA allows direct visualisation of nanoparticles in vitro and ex vivo by stimulated Raman scattering microscopy

    Vanden-hehir, S., Cairns, S. A., Lee, M., Zoupi, L., Shaver, M. P., Brunton, V. G., Williams, A. & Hulme, A. N., 13 Aug 2019, In: Biomacromolecules.

    Research output: Contribution to journalArticlepeer-review

  49. Central nervous system regeneration--where are we?

    Williams, A., May 2014, In: QJM: An International Journal of Medicine. 107, 5, p. 335-9 5 p.

    Research output: Contribution to journalLiterature reviewpeer-review

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