Edinburgh Research Explorer

Dr Barry Bradford

Core Scientist (Research Fellow)

Education/Academic qualification

1998Bachelor of Science (Honours), University of Edinburgh
2016Doctor of Philosophy (PhD), University of Edinburgh
The role of CXCR5 expressing dendritic cells in transmissible spongiform encephalopathy pathogenesis
2007Master of Science, University of Edinburgh
The role of Schwann cells in transmissible spongiform encephalopathy neuroinvasion

Research Interests

The immunopathogenesis and neuropathogenesis of infectious diseases.

I work within a group that aims to understand the pathogenesis of infectious diseases within the immune system. Particular interests include understanding host-pathogen interactions within the mucosal immune system, especially prion diseases and other gastrointestinal pathogens such as Salmonella and nematodes. Studies are also focused on the effects of host age on the function of the immune system and how this influences susceptibility to gastrointestinal pathogens.

Current Research Interests

Prion Disease (transmissible spongiform encephalopathies):

  • The role of the immune system in peripheral prion pathogenesis 
  • Glial responses and prion neuropathogenesis
  • Prion strain typing using molecular markers
  • Neurobehavioural outcomes during prion infection

B-cell follicle homing chemokine CXCR5, application of conditional CXCR5fl mice to immune system function

  • Dendritic cells and Th2 responses

Biography

Following completion my BSc with Neuroscience (Hons), I joined the Institute for Animal Health Neuropathogenesis Unit (IAH-NPU) Edinburgh, UK in 2000. Initially working within the Mouse Genetics Group on transgenic mouse models of conditional prion gene expression and prion protein glycosylation mutant models.

I have over 18 years of experience studying the neuropathology and immunopathogenesis of transmissible spongiform encephalopathy (prion disease) as well as other models of infectious disease and parasitic infections.

I am currently employed as a Post Doctoral Research Scientist within the Mucosal Host Pathogen Interactions & Prion Research and Neuropathology Groups as well as managing the Histology Facility at The Roslin Institute & Royal (Dick) School of Veterinary Sciences, The University of Edinburgh, Edinburgh, UK

Memberships:

International Society for Mucosal Immunology

Collaborative Activity

Current:

FIRE-KO mice

Dr. Clare Pridans, Centre for Inflammation Research, The University of Edinburgh

CXCR5-conditional mice

Dr. Dirk Baumjohann, Institute for Immunology, Ludwig-Maximillians University, Munich.

Dr. Botond Igyarto, Baylor Institute for Immunology Research, Dallas, Texas.

 

 

Previous:

CXCR5-conditional mice

Dr. Michelle Linterman, Babraham Institute, Cambridge, UK.

Dr. Matthew Hepworth, University of Manchester

Trichurs Muris infection studies

Prof. Kathryn Else & Dr. Ruth Forman, The University of Manchester

CXCR5-deficient mice

Dr David Withers, Institute of Immunology and Immunotherapy Wellcome Trust Research Fellow, University of Birmingham

The role of sialoadhesin (Siglec-1/CD169) in prion disease pathogenesis

Prof. Paul R. Crocker, College of Life Sciences, University of Dundee

Conditional Neuronal PrP knockout models

Prof. V. Hugh Perry, Centre for Biological Sciences, The University of Southampton

Dr. Pedro Piccardo, Centre for Biologics Evaluation and Research, US Food and Drug Administration

Prof. Alan R. Clarke, Cardiff School of Biosciences, Cardiff University

The role of Schwann cells in TSE pathogenesis

Dr. M. Laura Feltri, San Raffaele Scientific Institute, Milan

Prof. Peter Brophy, Centre for neuroregeneration, The University of Edinburgh

Conditional Cre/LoxP Prnp models

Prof. Alan R. Clarke, Cardiff School of Biosciences, Cardiff University

 

Research students

2012 - Matthew Helsby

Undergraduate Honours Project: Characterising CXCR5-specific knockout in antigen presenting cells

2012-2013 - Kah Yap

Immunology Honours Project: Effect of B cell-specific CXCR5-deficiency on lymphoid tissue organogenesis and microarchitecture.

2013 - Mark Laloo

Wellcome Trust Studentship Project: The effect of early prion pathogenesis on gut homeostasis.

2014 - Lester Thoo

Project: Identification of novel genes expressed by B-cell subsets.

2015 - Caroline Wood

Project: IgA synthesis and intestinal homeostasis: CXCR5 gene deficient mice have altered mucosal immunity.

2016 - Laura Tetlow

Project: Effect of the host gut microbiota on prion disease pathogenesis in the brain.

2019 - Danica Ariyadasa-Sáez

Immunology honours project: Intestinal mononuclear phagocyte status in Csf1r-FIRE-deficient mice

2019 - Christianus Arie Wisnu Wijaya

Infectious Diseases One Health student internship project: The influence of prion strain on glial cell responses during CNS prion disease

 

Highlighted research outputs

  1. Type I interferon induces CXCL13 to support ectopic germinal center formation

    Research output: Contribution to journalArticle

  2. Prion disease pathogenesis in the absence of the commensal microbiota

    Research output: Contribution to journalArticle

  3. Prion pathogenesis is unaltered following down-regulation of SIGN-R1

    Research output: Contribution to journalArticle

  4. The good, the bad and the ugly of dendritic cells during prion disease

    Research output: Contribution to journalLiterature review

  5. Aging and the mucosal immune system in the intestine

    Research output: Contribution to journalArticle

  6. Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.

    Research output: Contribution to journalArticle

  7. Prion Disease and the Innate Immune System

    Research output: Contribution to journalArticle

View all (55) »

Research activities & awards

  1. BMC Veterinary Research (Journal)

    Activity: Publication peer-review and editorial work typesPublication peer-review

  2. Journal of Animal Science and Biotechnology (Journal)

    Activity: Publication peer-review and editorial work typesPublication peer-review

View all (25) »

Research projects

  1. British Society for Immunology Travel Award

    Project: Research Collaboration with external organisation

View all (1) »

ID: 169476