Edinburgh Research Explorer

Dr Barry McColl

Senior Research Fellow

  1. 2019
  2. Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence

    McCulloch, L., McColl, B., Allan, S. M., Emsley, H. C. A. & Smith, C. J., 16 Oct 2019, In : F1000Research. v2.

    Research output: Contribution to journalArticle

  3. Myeloid Cell and Transcriptome Signatures Associated With Inflammation Resolution in a Model of Self-Limiting Acute Brain Inflammation

    Davies, C. L., Patir, A. & McColl, B. W., 17 May 2019, In : Frontiers in Immunology. 10, p. 1048

    Research output: Contribution to journalArticle

  4. Regional molecular mapping of primate synapses during normal healthy ageing

    Graham, L. C., Naldrett, M. J., Kohama, S. G., Smith, C., Lamont, D. J., Mccoll, B. W., Gillingwater, T. H., Skehel, P., Urbanski, H. F. & Wishart, T. M., 23 Apr 2019, In : Cell Reports. 27, 4, p. 1018-1026.e4

    Research output: Contribution to journalArticle

  5. 2018
  6. Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing

    Stevenson, A., McCartney, D. L., Harris, S., Taylor, A., Redmond, P., Starr, J., Zhang, Q., McRae, A. F., Wray, N. R., Spires-Jones, T., McColl, B., McIntosh, A., Deary, I. & Marioni, R., 20 Dec 2018, In : Clinical epigenetics.

    Research output: Contribution to journalArticle

  7. Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury

    Greenhalgh, A. D., Zarruk, J. G., Healy, L. M., Baskar Jesudasan, S. J., Jhelum, P., Salmon, C. K., Formanek, A., Russo, M. V., Antel, J. P., McGavern, D. B., McColl, B. W. & David, S., 17 Oct 2018, In : PLoS Biology. 16, 10, p. e2005264

    Research output: Contribution to journalArticle

  8. Neutrophil infiltration to the brain is platelet-dependent, and is reversed by blockade of platelet GPIbα

    Giles, J. A., Greenhalgh, A. D., Denes, A., Nieswandt, B., Coutts, G., McColl, B. W. & Allan, S. M., Jun 2018, In : Immunology . 154, 2, p. 322-328 7 p.

    Research output: Contribution to journalArticle

  9. Experimental stroke differentially affects discrete subpopulations of splenic macrophages

    McCulloch, L., Alfieri, A. & McColl, B., 22 May 2018, In : Frontiers in Immunology.

    Research output: Contribution to journalArticle

  10. Isolation and Phenotyping of Adult Mouse Microglial Cells

    Grabert, K. & McColl, B. W., 15 May 2018, Macrophages: Methods and Protocols, Methods in Molecular Biology, vol. 1784,. Springer, Vol. 1784. p. 77-86 10 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  11. 'Small vessels, dementia and chronic diseases -molecular mechanisms and pathophysiology' Workshop proceedings

    Horsburgh, K., Wardlaw, J., Van Agtmael, T., Allan, S., Ashford, M., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davies, J. B., Duncombe, J., Farr, T. D., Fowler, J., Goense, J., Granata, A., Hall, C., Hainsworth, A., Harvey, A., Hawkes, C. & 26 others, Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., MacLeod, M., Macrae, M., Markus, H. S., McCabe, C., McColl, B., Meakin, P. J., Miller, A. A., Nedergaard, M., O'Sullivan, M., Quinn, T., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R., Trueman, R., Wang, T., Williams, A., Williams, S. & Work, L. M., 30 Apr 2018, In : Clinical science. 132, 8, p. 851-868

    Research output: Contribution to journalReview article

  12. Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease

    Manso Sanz, Y., Holland, P., Kitamura, A., Szymkowiak, S., Duncombe, J., Hennessy, E., Searcy, J., Marangoni, M., Randall, A. D., Brown, J., McColl, B. & Horsburgh, K., Jan 2018, In : Glia. 66, 1, p. 34-46

    Research output: Contribution to journalArticle

  13. 2017
  14. The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments

    Percie du Sert, N., Alfieri, A., Allan, S. M., Carswell, H. V. O., Deuchar, G. A., Farr, T. D., Flecknell, P., Gallagher, L., Gibson, C., Haley, M. J., MacLeod, M., McColl, B., McCabe, C., Morancho, A., Moon, L., O'Neill, M., Perez de Puig, I., Planas, A., Ragan, I., Rosell, A. & 10 others, Roy, L., Ryder, K., Simats, A., Sena, E., Sutherland, B., Tricklebank, M., Trueman, R., Whitfield, L., Wong, R. & Macrae, M., Nov 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 11, p. 3488-3517 30 p., 271678X17709185.

    Research output: Contribution to journalArticle

  15. Corrigendum: Adrenergic-mediated loss of splenic marginal zone B cells contributes to infection susceptibility after stroke

    McCulloch, L., Smith, C. J. & McColl, B. W., 18 Aug 2017, In : Nature Communications. 8, p. 16151

    Research output: Contribution to journalComment/debate

  16. Minocycline reduces microgliosis and improves subcortical white matter function in a model of chronic cerebral vascular disease

    Duncombe, J., Manso, Y., Holland, P., Kitamura, A., Searcy, L., Marangoni, M., Szymkowiak, S., Randall, A., Brown, J., McColl, B. & Horsburgh, K., Jun 2017, In : Glia. 65, S1, p. E345-E345 1 p.

    Research output: Contribution to journalMeeting abstract

  17. Adrenergic-mediated loss of splenic innate-like B cells contributes to infection susceptibility after stroke

    McCulloch, L., Smith, C. J. & McColl, B., 19 Apr 2017, In : Nature Communications. 8, 15051.

    Research output: Contribution to journalArticle

  18. Adrenergic-mediated loss of splenic innate-like B cells contributes to infection susceptibility after stroke

    McCulloch, L., Smith, C. J. & McColl, B., 1 Apr 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 1 Suppt., p. 48 Abstract BS11-3.

    Research output: Contribution to journalMeeting abstract

  19. Triggering receptor expressed on myeloid cells 2 (TREM2) controls subacute injury resolution and myeloid cell reactivity after experimental stroke

    Alfieri, A. & McColl, B., 1 Apr 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 1 Suppt., p. 4 Abstract BS01-1.

    Research output: Contribution to journalMeeting abstract

  20. Divergent neuroinflammatory regulation of microglial TREM expression and involvement of NF-κB

    Owens, R., Grabert, K., Davies, C., Alfieri, A., Antel, J. P., Healy, L. M. & McColl, B., 2 Mar 2017, In : Frontiers in Cellular Neuroscience. 11, 14 p., 56.

    Research output: Contribution to journalArticle

  21. 2016
  22. Assessing the disease-modifying role of TREM2 in a prion model of neurodegeneration

    Manson, J. C., Alfieri, A., Carpanini, S. M., Boyle, A., Piccardo, P. & McColl, B. W., 18 Apr 2016, In : Prion. 10, Suppt. 1, p. S92-S93 2 p., P-112.

    Research output: Contribution to journalMeeting abstract

  23. Defining the microglia response during the time course of chronic neurodegeneration

    Vincenti, J. E., Murphy, L., Renault, K., McColl, B. W., Cancellotti, E., Freeman, T. C. & Manson, J. C., Mar 2016, In : Journal of Virology. 90, 6, p. 3003-3017

    Research output: Contribution to journalArticle

  24. Microglial brain region−dependent diversity and selective regional sensitivities to aging

    Renault, K., Michoel, T., Karavolos, M., Clohisey, S., Baillie, J., Stevens, M., Freeman, T., Summers, K. & McColl, B., Mar 2016, In : Nature Neuroscience. 19, 3, p. 504-516

    Research output: Contribution to journalArticle

  25. 2015
  26. Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity

    Giles, J. A., Greenhalgh, A. D., Davies, C., Denes, A., Shaw, T., Coutts, G., Rothwell, N. J., McColl, B. W. & Allan, S. M., Feb 2015, In : European Journal of Immunology. 45, 2, p. 525-530

    Research output: Contribution to journalArticle

  27. Culturing adult mouse microglia

    Greenhalgh, A., Renault, K., McColl, B. & David, S., 2015, In : Glia. 63, Suppt. S1, p. E332-E332

    Research output: Contribution to journalMeeting abstract

  28. Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke

    Maysami, S., Haley, M. J., Gorenkova, N., Krishnan, S., McColl, B. W. & Lawrence, C. B., 2015, In : Journal of neuroinflammation. 12, p. 140

    Research output: Contribution to journalArticle

  29. 2014
  30. Functional cellular imaging of immune responses during ageing using intravital multiphoton microscopy

    Pattison, M., Mabbott, N. & McColl, B., Dec 2014, In : Immunology . 143, S2, p. 121-121 1 p., 702.

    Research output: Contribution to journalMeeting abstract

  31. 2013
  32. Refining Methods for Studying Microglial Diversity in the Healthy and Ageing Brain

    Renault, K., Vincenti, J., Summers, K. & McColl, B., Jul 2013, In : Glia. 61, S1, p. S110 1 p.

    Research output: Contribution to journalMeeting abstract

  33. 2012
  34. Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats

    Pradillo, J. M., Denes, A., Greenhalgh, A. D., Boutin, H., Drake, C., McColl, B. W., Barton, E., Proctor, S. D., Russell, J. C., Rothwell, N. J. & Allan, S. M., Sep 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, 9, p. 1810-9 10 p.

    Research output: Contribution to journalArticle

  35. Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis

    Denes, A., Drake, C., Stordy, J., Chamberlain, J., McColl, B. W., Gram, H., Crossman, D., Francis, S., Allan, S. M. & Rothwell, N. J., 2012, In : Journal of the American Heart Association. 1, 3, 11 p., e002006.

    Research output: Contribution to journalArticle

  36. Neutrophil Cerebrovascular Transmigration Triggers Rapid Neurotoxicity through Release of Proteases Associated with Decondensed DNA

    Allen, C., Thornton, P., Denes, A., McColl, B. W., Pierozynski, A., Monestier, M., Pinteaux, E., Rothwell, N. J. & Allan, S. M., 2012, In : Journal of Immunology. 189, 1, p. 381-392

    Research output: Contribution to journalArticle

  37. 2011
  38. Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

    Small, B. G., McColl, B. W., Allmendinger, R., Pahle, J., Lopez-Castejon, G., Rothwell, N. J., Knowles, J., Mendes, P., Brough, D. & Kell, D. B., Dec 2011, In : Nature Chemical Biology. 7, 12, p. 902-908 7 p.

    Research output: Contribution to journalArticle

  39. Interleukin-1 and platelets as key drivers of cerebrovascular inflammation

    Giles, J. A., Greenhalgh, A. D., Denes, A., Thornton, P. P., Rothwell, N. J., McColl, B. W. & Allan, S. M., Dec 2011, p. 1.

    Research output: Contribution to conferenceAbstract

  40. Letter by McColl et al Regarding Article, "Influenza Virus Infection Aggravates Stroke Outcome"

    McColl, B. W., Allan, S. M., Denes, A. & Lawrence, C. B., Aug 2011, In : Stroke. 42, 8, p. E416-E416 1 p.

    Research output: Contribution to journalLetter

  41. Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses

    Denes, A., McColl, B. W., Leow-Dyke, S. F., Chapman, K. Z., Humphreys, N. E., Grencis, R. K., Allan, S. M. & Rothwell, N. J., Apr 2011, In : Journal of Cerebral Blood Flow and Metabolism. 4, 31, p. 1036-1050 15 p.

    Research output: Contribution to journalArticle

  42. Brain inflammation is induced by co-morbidities and risk factors for stroke

    Drake, C., Boutin, H., Jones, M. S., Denes, A., McColl, B. W., Selvarajah, J. R., Hulme, S., Georgiou, R. F., Hinz, R., Gerhard, A., Vail, A., Prenant, C., Julyan, P., Maroy, R., Brown, G., Smigova, A., Herholz, K., Kassiou, M., Crossman, D., Francis, S. & 6 others, Proctor, S. D., Russell, J. C., Hopkins, S. J., Tyrrell, P. J., Rothwell, N. J. & Allan, S. M., 2011, In : Brain, Behavior, and Immunity. 25, 6, p. 1113-1122 10 p.

    Research output: Contribution to journalArticle

  43. Changes in glutamate transporter expression in mouse forebrain areas following focal ischemia

    Ketheeswaranathan, P., Turner, N. A., Spary, E. J., Batten, T. F., McColl, B. W. & Saha, S., 2011, In : Brain Research. 1418, p. 93-103

    Research output: Contribution to journalArticle

  44. Defining the role of mis-folded protein in neurodegeneration

    Alibhai, J., McColl, B., Perry, H. & Manson, J., 2011.

    Research output: Contribution to conferenceAbstract

  45. Endovascular inflammation may occur via tissue-specific mechanisms

    Giles, J., Greenhalgh, A., Denes, A., Thornton, P., Rothwell, N., McColl, B. & Allan, S., 2011, In : European Heart Journal. 97, 20, p. 17 1 p.

    Research output: Contribution to journalArticle

  46. 2010
  47. Platelet interleukin-1alpha drives cerebrovascular inflammation

    Thornton, P., McColl, B. W., Greenhalgh, A., Denes, A., Allan, S. M. & Rothwell, N. J., Apr 2010, In : Blood. 115, 17, p. 3632-3639 8 p.

    Research output: Contribution to journalArticle

  48. Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke

    McColl, B. W., Rose, N., Robson, F. H., Rothwell, N. J. & Lawrence, C. B., Feb 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 2, p. 267-272 6 p.

    Research output: Contribution to journalArticle

  49. Alteration of the nuclear pore complex in Ca(2+)-mediated cell death

    Bano, D., Dinsdale, D., Cabrera-Socorro, A., Maida, S., Lambacher, N., Mccoll, B., Ferrando-May, E., Hengartner, M. O. & Nicotera, P., Jan 2010, In : Cell Death and Differentiation. 17, 1, p. 119-133 15 p.

    Research output: Contribution to journalArticle

  50. Interleukin-1 drives cerebrovascular inflammation via MAP kinase-independent pathways

    Thornton, P., McColl, B. W., Cooper, L., Rothwell, N. J. & Allan, S. M., 2010, In : Current Neurovascular Research. 7, 4, p. 330-40 11 p.

    Research output: Contribution to journalArticle

  51. Interleukin-1 receptor antagonist in animal models of stroke: a fair summing up?

    Parry-Jones, A., Boutin, H., Denes, A., McColl, B., Hopkins, S., Allan, S. & Tyrrell, P., 2010, In : Journal of Stroke and Cerebrovascular Diseases. 19, 6, p. 512-3 2 p.

    Research output: Contribution to journalLetter

  52. Modeling risk factors and confounding effects in stroke

    McColl, B. W., Howells, D., Rothwell, N. J. & Denes, A., 2010, Rodent models of stroke. Dirnagl, U. (ed.). New Jersey: Humana Press, p. 93-119 27 p. (Neuromethods; vol. 47).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  53. 2009
  54. A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke

    Chapman, K. Z., Dale, V. Q., Dénes, A., Bennett, G., Rothwell, N. J., Allan, S. M. & McColl, B. W., Nov 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 11, p. 1764-1768 5 p.

    Research output: Contribution to journalArticle

  55. Nuclear retention of IL-1 alpha by necrotic cells: A mechanism to dampen sterile inflammation

    Luheshi, N. M., McColl, B. W. & Brough, D., Nov 2009, In : European Journal of Immunology. 39, 11, p. 2973-2980 8 p.

    Research output: Contribution to journalArticle

  56. Systemic infection, inflammation and acute ischemic stroke

    McColl, B. W., Allan, S. M. & Rothwell, N. J., 6 Feb 2009, In : Neuroscience. 158, 3, p. 1049-1061 13 p.

    Research output: Contribution to journalLiterature review

  57. 2008
  58. Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice

    McColl, B. W., Rothwell, N. J. & Allan, S. M., 17 Sep 2008, In : Journal of Neuroscience. 28, 38, p. 9451-9462 12 p.

    Research output: Contribution to journalArticle

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