Edinburgh Research Explorer

Bill Earnshaw

Professor of Chromosome Dynamics

  1. 3D-CLEM reveals that a major portion of mitotic chromosomes is not Chromatin

    Booth, D., Beckett, A. J., Molina, O., Samejima, I., Masumoto, H., Kouprina, N., Larionov, V., Prior, I. A. & Earnshaw, W., 17 Nov 2016, In: Molecular Cell. 64, 4, p. 790-802 13 p.

    Research output: Contribution to journalArticlepeer-review

  2. De novo formation and epigenetic maintenance of centromere chromatin

    Ohzeki, J., Larionov, V., Earnshaw, W. C. & Masumoto, H., 1 Jun 2019, In: Current opinion in cell biology. 58, p. 15-25 11 p.

    Research output: Contribution to journalReview articlepeer-review

  3. In vitro BioID: Mapping the CENP-A microenvironment with high temporal and spatial resolution

    Remnant, L., Booth, D. G., Vargiu, G., Spanos, C., Kerr, A. R. W. & Earnshaw, W. C., 20 Mar 2019, In: Molecular Biology of the Cell. 30, 11, p. 1314-1325 12 p.

    Research output: Contribution to journalArticlepeer-review

  4. A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

    Ladds, M. J. G. W., van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A-L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 16 Mar 2018, In: Nature Communications. 9, 1, 14 p., 1107 (2018).

    Research output: Contribution to journalArticlepeer-review

  5. A Human Artificial Chromosome (HAC) with a conditional centromere

    Masumoto, H., Ohzeki, J., Nakano, M., Bergmann, J., Noskov, V., Kouprina, N., Earnshaw, W. & Larionov, V., Dec 2010, In: Genes & genetic systems. 85, 6, p. 458-458 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  6. A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells

    Lee, H-S., Lee, N. C. O., Samoshkin, A., Kononenko, A. V., Kouprina, N., Larionov, V., Grimes, B. R., Bansal, R., Masumoto, H. & Earnshaw, W. C., 22 May 2013, In: BMC Cancer. 13, 12 p., 252.

    Research output: Contribution to journalArticlepeer-review

  7. A new generation of human artificial chromosomes for functional genomics and gene therapy

    Kouprina, N., Larionov, V., Earnshaw, W. C. & Masumoto, H., 1 Apr 2013, In: Cellular and Molecular Life Sciences. 70, 7, p. 1135-1148 14 p.

    Research output: Contribution to journalArticlepeer-review

  8. A novel assay to screen siRNA libraries identifies protein kinases as required for chromosome transmission

    Liskovykh, M., Goncharov, N. V., Petrov, N., Aksenova, V., Pegoraro, G., Ozbun, L. L., Reinhold, W. C., Varma, S., Dasso, M., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 12 Sep 2019, In: Genome Research. 29, 9

    Research output: Contribution to journalArticlepeer-review

  9. A pathway for mitotic chromosome formation

    Gibcus, J. H., Samejima, K., Goloborodko, A., Samejima, I., Naumova, N., Nuebler, J., Kanemaki, M. T., Xie, L., Paulson, J. R., Earnshaw, W. C., Mirny, L. A. & Dekker, J., 9 Feb 2018, In: Science. 359, 6376, 14 p., eaao6135.

    Research output: Contribution to journalArticlepeer-review

  10. A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function

    Kononenko, A. V., Bansal, R., Lee, N. C. O., Grimes, B. R., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 1 Dec 2014, In: Nucleic Acids Research. 42, 21, e164.

    Research output: Contribution to journalArticlepeer-review

  11. A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes

    Samejima, K., Ogawa, H., Cooke, C. A., Hudson, D., MacIsaac, F., Ribeiro, S. A., Vagnarelli, P., Cardinale, S., Kerr, A., Lai, F. & Earnshaw, B., 2008, In: Proceedings of the National Academy of Sciences. 105, 7, p. 2457-2462 1 p.

    Research output: Contribution to journalArticlepeer-review

  12. A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, (2457-2462) DOI: 10.1073/pnas. 0712083105)

    Samejima, K., Ogawa, H., Cooke, C. A., Hudson, D. F., MacIsaac, F., Ribeiro, S. A., Vagnarelli, P., Cardinale, S., Kerr, A., Lai, F., Ruchaud, S., Yue, Z. & Earnshaw, W. C., 8 Apr 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5650 1 p.

    Research output: Contribution to journalComment/debatepeer-review

  13. A super-resolution map of the vertebrate kinetochore

    Ribeiro, S. A., Vagnarelli, P., Dong, Y., Hori, T., McEwen, B. F., Fukagawa, T., Flors, C. & Earnshaw, W. C., 8 Jun 2010, In: Proceedings of the National Academy of Sciences. 107, 23, p. 10484-10489 6 p.

    Research output: Contribution to journalArticlepeer-review

  14. APC/CCdh1 is required for the termination of CPC activity upon mitotic exit

    Tsunematsu, T., Arakaki, R., Kawai, H., Ruppert, J., Tsuneyama, K., Earnshaw, W. C., Pagano, M. & Kudo, Y., 15 Sep 2020, In: Journal of Cell Science.

    Research output: Contribution to journalArticlepeer-review

  15. Acetylation of core histones in response to HDAC inhibitors is diminished in mitotic HeLa cells

    Patzlaff, J. S., Terrenoire, E., Turner, B. M., Earnshaw, W. C. & Paulson, J. R., 1 Aug 2010, In: Experimental Cell Research. 316, 13, p. 2123-2135 13 p.

    Research output: Contribution to journalArticlepeer-review

  16. An intrinsic S/G checkpoint enforced by ATR

    Saldivar, J. C., Hamperl, S., Bocek, M. J., Chung, M., Bass, T. E., Cisneros-Soberanis, F., Samejima, K., Xie, L., Paulson, J. R., Earnshaw, W. C., Cortez, D., Meyer, T. & Cimprich, K. A., 24 Aug 2018, In: Science. 361, 6404, p. 806-810 5 p.

    Research output: Contribution to journalArticlepeer-review

  17. Analysis of complex DNA rearrangements during early stages of HAC formation

    Pesenti, E., Liskovykh, M., Okazaki, K., Mallozzi, A., Reid, C., Abad, M. A., Jeyaprakash, A. A., Kouprina, N., Larionov, V., Masumoto, H. & Earnshaw, W. C., 18 Dec 2020, In: ACS Synthetic Biology. 9, 12, p. 3267-3287 20 p.

    Research output: Contribution to journalArticlepeer-review

  18. Apoptosis-associated caspase activation assays

    Kaufmann, S. H., Meng, X. W., Loegering, D. A., Kottke, T. J., Lee, S-H., Henzing, A. J., Ruchaud, S., Samejima, K. & Earnshaw, W. C., 1 Mar 2008, In: Methods. 44, 3, p. 262-272 11 p.

    Research output: Contribution to journalArticlepeer-review

  19. Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development

    González-Loyola, A., Fernández-Miranda, G., Trakala, M., Partida, D., Samejima, K., Ogawa, H., Cañamero, M., de Martino, A., Martínez-Ramírez, Á., de Cárcer, G., de Castro., I. P., Earnshaw, W. C. & Malumbres, M., 3 Aug 2015, In: Molecular and Cellular Biology. 35, 20, p. 3566-3578 13 p.

    Research output: Contribution to journalArticlepeer-review

  20. Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide module

    Samejima, K., Ogawa, H., Ageichik, A. V., Peterson, K. L., Kaufmann, S. H., Kanemaki, M. T. & Earnshaw, W. C., 7 Nov 2014, In: Journal of Biological Chemistry. 289, 45, p. 31617-31623 7 p.

    Research output: Contribution to journalArticlepeer-review

  21. Auxin/AID versus conventional knockouts: Distinguishing the roles of CENP-T/W in mitotic kinetochore assembly and stability

    Wood, L., Booth, D. G., Vargiu, G., Ohta, S., deLima Alves, F., Samejima, K., Fukagawa, T., Rappsilber, J. & Earnshaw, W. C., 20 Jan 2016, In: Open Biology. 6, 1, 150230.

    Research output: Contribution to journalArticlepeer-review

  22. Borealin–nucleosome interaction secures chromosome association of the chromosomal passenger complex

    Abad, M. A., Ruppert, J., Buzuk, L., Wear, M., Zou, J., Webb, K., Kelly, D., Voigt, P., Rappsilber, J., Earnshaw, W. & Arulanandam, A., 30 Sep 2019, In: Journal of Cell Biology. 218, 12, p. 3912–3925 13 p.

    Research output: Contribution to journalArticlepeer-review

  23. Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly

    Ohzeki, J-I., Nakano, M., Masumoto, H., Kouprina, N., Noskov, V. N., Larionov, V., Bergmann, J. H., Earnshaw, W. C. & Kimura, H., 16 May 2012, In: EMBO Journal. 31, 10, p. 2391-2402 12 p.

    Research output: Contribution to journalArticlepeer-review

  24. Building mitotic chromosomes

    Ohta, S., Wood, L., Bukowski-Wills, J-C., Rappsilber, J. & Earnshaw, W. C., Feb 2011, In: Current opinion in cell biology. 23, 1, p. 114-121 8 p.

    Research output: Contribution to journalArticlepeer-review

  25. CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly

    Ohta, S., Wood, L., Toramoto, I., Yagyu, K. I., Fukagawa, T. & Earnshaw, W. C., 15 Apr 2015, In: Molecular Biology of the Cell. 26, 7, p. 1225-1237 13 p.

    Research output: Contribution to journalArticlepeer-review

  26. CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly

    Otake, K., Ohzeki, J., Shono, N., Kugou, K., Okazaki, K., Nagase, T., Yamakawa, H., Kouprina, N., Larionov, V., Kimura, H., Earnshaw, W. C. & Masumoto, H., 11 Aug 2020, In: Journal of Cell Science. 133, jcs.243303.

    Research output: Contribution to journalArticlepeer-review

  27. CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly

    Shono, N., Ohzeki, J. I., Otake, K., Martins, N. M. C., Nagase, T., Kimura, H., Larionov, V., Earnshaw, W. C. & Masumoto, H., 2015, In: Journal of Cell Science. 128, 24, p. 4572-4587 16 p.

    Research output: Contribution to journalArticlepeer-review

  28. CENP-V is required for centromere organization, chromosome alignment and cytokinesis

    Tadeu, A. M. B., Ribeiro, S., Johnston, J., Goldberg, I., Gerloff, D. & Earnshaw, W. C., 8 Oct 2008, In: EMBO Journal. 27, 19, p. 2510-2522 13 p.

    Research output: Contribution to journalArticlepeer-review

  29. Cell Biology: Third Edition

    Pollard, T. D., Earnshaw, W. C., Lippincott-Schwartz, J. & Johnson, G. T., 30 Nov 2016, Elsevier Inc. 882 p.

    Research output: Book/ReportBook

  30. Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1

    Papini, D., Fant, X., Ogawa, H., Desban, N., Samejima, K., Feizbakhsh, O., Askin, B., Ly, T., Earnshaw, W. C. & Ruchaud, S., 6 Nov 2019, In: Journal of Cell Science. jcs.234401.

    Research output: Contribution to journalArticlepeer-review

  31. Chromokinesin KIF4A teams up with Stathmin 1 to regulate abscission in a SUMO-dependent manner

    Cuijpers, S., Willemstein, E., Ruppert, J., van Elsland, D. M., Earnshaw, B. & Vertegaal, A. C. O., 24 Jul 2020, In: Journal of Cell Science.

    Research output: Contribution to journalArticlepeer-review

  32. Chromosomal passengers: conducting cell division

    Ruchaud, S., Carmena, M. & Earnshaw, W. C., Oct 2007, In: Nature reviews Molecular cell biology. 8, 10, p. 798-812 15 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  33. Chromosome Engineering Allows the Efficient Isolation of Vertebrate Neocentromeres

    Shang, W-H., Hori, T., Fukagawa, T., Toyoda, A., Fujiyama, A., Misu, S., Monma, N., Ikeo, K., Hiratani, I., Maeshima, K., Martins, N. M. C., Earnshaw, W. C. & Kimura, H., 25 Mar 2013, In: Developmental Cell. 24, 6, p. 635-648 14 p.

    Research output: Contribution to journalArticlepeer-review

  34. Chromosomes work better when they are tense

    Earnshaw, W. C., 1 Jan 2009, In: Nature reviews Molecular cell biology. 10, 8, p. 8 1 p.

    Research output: Contribution to journalReview articlepeer-review

  35. Condensin i associates with structural and gene regulatory regions in vertebrate chromosomes

    Kim, J. H., Zhang, T., Wong, N. C., Davidson, N., Maksimovic, J., Oshlack, A., Earnshaw, W. C., Kalitsis, P. & Hudson, D. F., 2013, In: Nature Communications. 4, 2537.

    Research output: Contribution to journalArticlepeer-review

  36. Condensin regulates the stiffness of vertebrate centromeres

    Ribeiro, S. A., Gatlin, J. C., Dong, Y., Cameron, L., Hudson, D. F., Farr, C. F., Joglekar, A., McEwen, B. F., Salmon, E. D., Earnshaw, W. C. & Vagnarelli, P., 1 May 2009, In: Molecular Biology of the Cell. 20, 9, p. 2371-2380 10 p.

    Research output: Contribution to journalArticlepeer-review

  37. Condensin: Architect of mitotic chromosomes

    Hudson, D. F., Marshall, K. M. & Earnshaw, W. C., Feb 2009, In: Chromosome Research. 17, 2, p. 131-144 14 p.

    Research output: Contribution to journalArticlepeer-review

  38. Contrasting roles of condensin I and condensin II in mitotic chromosome formation

    Green, L. C., Kalitsis, P., Chang, T. M., Cipetic, M., Kim, J. H., Marshall, O., Choo, K. H. A., Hudson, D. F., Turnbull, L., Whitchurch, C. B., Vagnarelli, P., Samejima, K. & Earnshaw, W. C., 15 Mar 2012, In: Journal of Cell Science. 125, 6, p. 1591-1604 14 p.

    Research output: Contribution to journalArticlepeer-review

  39. DNA content of a functioning chicken kinetochore

    Ribeiro, S. A., Vagnarelli, P. & Earnshaw, W. C., 15 Mar 2014, In: Chromosome Research.

    Research output: Contribution to journalArticlepeer-review

  40. Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line

    Yue, Z., Carvalho, A., Xu, Z., Yuan, X., Cardinale, S., Ribeiro, S., Lai, F., Ogawa, H., Gudmundsdottir, E., Gassmann, R., Morrison, C. G., Ruchaud, S. & Earnshaw, W. C., 20 Oct 2008, In: Journal of Cell Biology. 183, 2, p. 279-296 18 p.

    Research output: Contribution to journalArticlepeer-review

  41. Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells

    Kim, J. H., Lee, H. S., Lee, N. C. O., Goncharov, N. V., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Kouprina, N. & Larionov, V., 22 Mar 2016, In: Oncotarget. 7, 12, p. 14841-14856 16 p.

    Research output: Contribution to journalArticlepeer-review

  42. Discovering centromere proteins: from cold white hands to the A, B, C of CENPs

    Earnshaw, W. C., 23 Jun 2015, In: Nature reviews Molecular cell biology. 16, 7, p. 443-449 7 p.

    Research output: Contribution to journalArticlepeer-review

  43. Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis

    Colombie, N., Cullen, F., Brittle, A., Jang, J., Earnshaw, B., Carmena, M., McKim, K. & Ohkura, H., Oct 2008, In: Development. 135, 19, p. 3239-3246

    Research output: Contribution to journalArticlepeer-review

  44. Effects of Full-Length Borealin on the Composition and Protein-Protein Interaction Activity of a Binary Chromosomal Passenger Complex

    Zhou, L., Li, J., George, R., Ruchaud, S., Zhou, H-G., Ladbury, J. E., Earnshaw, W. C. & Yuan, X., 17 Feb 2009, In: Biochemistry. 48, 6, p. 1156-1161 6 p.

    Research output: Contribution to journalArticlepeer-review

  45. Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance: H3K4me2 is necessary for kinetochore assembly and function

    Molina, O., Vargiu, G., Alba Abad, M., Zhiteneva, A., Arulanandam, J., Masumoto, H., Kouprina, N., Larionov, V. & Earnshaw, W., 14 Nov 2016, In: Nature Communications. 51 p.

    Research output: Contribution to journalArticlepeer-review

  46. Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

    Bergmann, J. H., Rodríguez, M. G., Martins, N. M. C., Kimura, H., Kelly, D. A., Masumoto, H., Larionov, V., Jansen, L. E. T. & Earnshaw, W. C., Jan 2011, In: EMBO Journal. 30, 2, p. 328-340 13 p.

    Research output: Contribution to journalArticlepeer-review

  47. Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3

    Martins, N. M. C., Bergmann, J. H., Shono, N., Kimura, H., Larionov, V., Masumoto, H. & Earnshaw, W. C., 1 Jan 2016, In: Molecular Biology of the Cell. 27, 1, p. 177-96 20 p.

    Research output: Contribution to journalArticlepeer-review

  48. Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function

    Bergmann, J. H., Jakubsche, J. N., Martins, N. M., Kagansky, A., Nakano, M., Kimura, H., Kelly, D. A., Turner, B. M., Masumoto, H., Larionov, V. & Earnshaw, W. C., 2012, In: Journal of Cell Science. 125, 2, p. 411-421

    Research output: Contribution to journalArticlepeer-review

  49. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

    Earnshaw, B., Allshire, R., Black, B. E., Bloom, K., Salmon, E. D., Brinkley, B. R., Brown, W., Cheesman, I. M., Choo, K. H. A., Copenhaver, G. P., DeLuca, J. G. & (47 other authors), E. A., Apr 2013, In: Chromosome Research. 21, 2, p. 101-106

    Research output: Contribution to journalArticlepeer-review

  50. Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis

    Samejima, K., Booth, D. G., Ogawa, H., Paulson, J. R., Xie, L., Watson, C. A., Platani, M., Kanemaki, M. T. & Earnshaw, W. C., 22 Feb 2018, In: Journal of Cell Science. 131, 4, 17 p.

    Research output: Contribution to journalArticlepeer-review

  51. Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies

    Pesenti, E., Kouprina, N., Liskovykh, M., Aurich-Costa, J., Larionov, V., Masumoto, H., Earnshaw, W. C. & Molina, O., 20 Apr 2018, In: ACS Synthetic Biology. 7, 4, p. 1116-1130 15 p.

    Research output: Contribution to journalArticlepeer-review

  52. Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette

    Kononenko, A. V., Lee, N. C. O., Liskovykh, M., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 20 May 2015, In: Nucleic Acids Research. 43, 9, e57.

    Research output: Contribution to journalArticlepeer-review

  53. Genetic and epigenetic regulation of centromeres: A look at HAC formation

    Ohzeki, J. I., Larionov, V., Earnshaw, W. C. & Masumoto, H., 1 Jan 2015, In: Chromosome Research . 23, 1, p. 87-103 17 p.

    Research output: Contribution to journalArticlepeer-review

  54. Gradient of Increasing Aurora B Kinase Activity Is Required for Cells to Execute Mitosis

    Xu, Z., Vagnarelli, P., Ogawa, H., Samejima, K. & Earnshaw, W. C., 17 Dec 2010, In: Journal of Biological Chemistry. 285, 51, p. 40163-40170 8 p.

    Research output: Contribution to journalArticlepeer-review

  55. H3K9me maintenance on a Human Artificial Chromosome is required for 3 segregation but not centromere epigenetic memory

    Martins, N. M. C., Cisneros Soberanis, F., Pesenti, E., Kochanova, N., Shang, W-H., Hori, T., Nagase, T., Kimura, H., Larionov, V., Masumoto, H., Fukagawa, T. & Earnshaw, B., 24 Jul 2020, In: Journal of Cell Science. 133, jcs242610.

    Research output: Contribution to journalArticlepeer-review

  56. HACking the centromere chromatin code: Insights from human artificial chromosomes

    Bergmann, J. H., Larionov, V., Masumoto, H., Martins, N. M. C. & Earnshaw, W. C., Jul 2012, In: Chromosome Research . 20, 5, p. 505-519 15 p.

    Research output: Contribution to journalArticlepeer-review

  57. HP1α targets the chromosomal passenger complex for activation at heterochromatin before mitotic entry

    Ruppert, J. G., Samejima, K., Platani, M., Molina, O., Kimura, H., Jeyaprakash, A. A., Ohta, S. & Earnshaw, W. C., 15 Mar 2018, In: EMBO Journal. 37, 6, 18 p.

    Research output: Contribution to journalArticlepeer-review

  58. Hierarchical inactivation of a synthetic human kinetochore by a chromatin modifier

    Cardinale, S., Bergmann, J. H., Kelly, D., Nakano, M., Valdivia, M. M., Kimura, H., Masumoto, H., Larionov, V. & Earnshaw, W. C., 2009, In: Molecular Biology of the Cell. 20, 19, p. 4194-204 11 p.

    Research output: Contribution to journalArticlepeer-review

  59. Histone H4 Lys 20 Monomethylation of the CENP-A Nucleosome Is Essential for Kinetochore Assembly

    Hori, T., Shang, W-H., Toyoda, A., Misu, S., Monma, N., Ikeo, K., Molina, O., Vargiu, G., Fujiyama, A., Kimura, H., Earnshaw, W. C. & Fukagawa, T., 23 Jun 2014, In: Developmental Cell. 29, 6, p. 740-9 10 p.

    Research output: Contribution to journalArticlepeer-review

  60. Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies

    Kouprina, N., Petrov, N., Molina, O., Liskovykh, M., Pesenti, E., Ohzeki, J-I., Masumoto, H., Earnshaw, W. C. & Larionov, V., 21 Sep 2018, In: ACS Synthetic Biology. 7, 9, p. 1974-1989 16 p.

    Research output: Contribution to journalReview articlepeer-review

  61. Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression

    Iida, Y., Kim, J-H., Kazuki, Y., Hoshiya, H., Takiguchi, M., Hayashi, M., Erliandri, I., Lee, H-S., Samoshkin, A., Masumoto, H., Earnshaw, W. C., Kouprina, N., Larionov, V. & Oshimura, M., Oct 2010, In: DNA Research. 17, 5, p. 293-301 9 p.

    Research output: Contribution to journalArticlepeer-review

  62. Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells

    Kim, J-H., Kononenko, A., Erliandri, I., Larionov, V., Kouprina, N., Kim, T-A., Nakano, M., Iida, Y., Masumoto, H., Oshimura, M., Barrett, J. C. & Earnshaw, W. C., 13 Dec 2011, In: Proceedings of the National Academy of Sciences. 108, 50, p. 20048-20053 6 p.

    Research output: Contribution to journalArticlepeer-review

  63. Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology

    Kouprina, N., Tomilin, A. N., Masumoto, H., Earnshaw, W. C. & Larionov, V., 1 Apr 2014, In: Expert Opinion on Drug Delivery. 11, 4, p. 517-535 19 p.

    Research output: Contribution to journalArticlepeer-review

  64. INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization

    Xu, Z., Ogawa, H., Vagnarelli, P., Bergmann, J. H., Hudson, D. F., Ruchaud, S., Earnshaw, W. C., Samejima, K. & Fukagawa, T., 30 Nov 2009, In: Journal of Cell Biology. 187, 5, p. 637-653 17 p.

    Research output: Contribution to journalArticlepeer-review

  65. Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

    Nakano, M., Cardinale, S., Noskov, V. N., Gassmann, R., Vagnarelli, P., Kandels-Lewis, S., Larionov, V., Earnshaw, W. C. & Masumoto, H., 15 Apr 2008, In: Developmental Cell. 14, 4, p. 507-522 16 p.

    Research output: Contribution to journalArticlepeer-review

  66. Isolation of mitotic chromosomes from vertebrate cells and characterisation of their proteome by mass spectrometry

    Samejima, I. & Earnshaw, W., 12 Apr 2018, Methods in Cell Biology. Elsevier, Vol. 144. p. 329-348 20 p. (Methods in Cell Biology; vol. 144).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

  67. KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation

    Ohzeki, J-I., Shono, N., Otake, K., Martins, N. M. C., Kugou, K., Kimura, H., Nagase, T., Larionov, V., Earnshaw, W. C. & Masumoto, H., 6 Jun 2016, In: Developmental Cell. 37, 5, p. 413-27 15 p.

    Research output: Contribution to journalArticlepeer-review

  68. Ki-67 and the Chromosome Periphery Compartment in Mitosis

    Booth, D. G. & Earnshaw, W. C., 1 Dec 2017, In: Trends In Cell Biology. 27, 12, p. 906-916 11 p.

    Research output: Contribution to journalReview articlepeer-review

  69. Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery

    Booth, D. G., Takagi, M., Sanchez-Pulido, L., Petfalski, E., Vargiu, G., Samejima, K., Imamoto, N., Ponting, C. P., Tollervey, D., Earnshaw, W. C. & Vagnarelli, P., 27 May 2014, In: eLIFE. 3, 22 p., e01641.

    Research output: Contribution to journalArticlepeer-review

  70. Localizing kinetochores in condensin deficient DT40 cells using same cell correlative confocal light microscopy/electron tomography

    Dong, Y., Meng, X., McEwen, B. F., Vagnarelli, P., Ribeiro, S. & Earnshaw, W. C., 1 Aug 2008, In: Microscopy and Microanalysis. 14, SUPPL. 2, p. 1070-1071 2 p.

    Research output: Contribution to journalArticlepeer-review

  71. Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

    Carmena, M., Ruchaud, S. & Earnshaw, W. C., 1 Dec 2009, In: Current opinion in cell biology. 21, 6, p. 796-805 10 p.

    Research output: Contribution to journalArticlepeer-review

  72. Mapping the epigenetic landscape of the kinetochore

    Earnshaw, W. C., Nakano, M., Cardinale, S., Noskov, V. N., Gassmann, R., Vagnarelli, P., Kandels-Lewis, S., Larionov, V. & Masumoto, H., Jun 2008, In: Febs Journal. 275, p. 7-7 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  73. Method to Assemble Genomic DNA Fragments or Genes on Human Artificial Chromosome with Regulated Kinetochore Using a Multi-Integrase System

    Lee, N. C. O., Kim, J-H., Petrov, N. S., Lee, H-S., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 19 Jan 2018, In: ACS Synthetic Biology. 7, 1, p. 63-74 12 p.

    Research output: Contribution to journalArticlepeer-review

  74. Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes

    Platani, M., Trinkle-Mulcahy, L., Porter, M., Arulanandam, A. & Earnshaw, W. C., 6 Jul 2015, In: Journal of Cell Biology. 210, 1, p. 45-62 18 p.

    Research output: Contribution to journalArticlepeer-review

  75. Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα

    Samejima, K., Samejima, I., Vagnarelli, P., Ogawa, H., Vargiu, G., Kelly, D. A., Alves, F. L., Kerr, A., Ohta, S., Rappsilber, J., Earnshaw, W. C., Green, L. C., Hudson, D. F., Farr, C. J. & Cooke, C. A., 1 Nov 2012, In: Journal of Cell Biology. 199, 5, p. 755-770 16 p.

    Research output: Contribution to journalArticlepeer-review

  76. Mitotic post-translational modifications of histones promote chromatin compaction in vitro

    Zhiteneva, A., Bonfiglio, J. J., Makarov, A., Colby, T., Vagnarelli, P., Schirmer, E. C., Matic, I. & Earnshaw, W. C., 13 Sep 2017, In: Open Biology. 7, 9

    Research output: Contribution to journalArticlepeer-review

  77. Molecular Basis for Cdk1 Regulated Timing of Mis18 Complex Assembly and CENP-A Deposition

    Spiller, F., Medina-Pritchard, B., Alba Abad, M., Wear, M., Molina, O., Earnshaw, W. & Arulanandam, A., 4 Apr 2017, In: EMBO Reports. e201643564.

    Research output: Contribution to journalArticlepeer-review

  78. Molecular and Genetic Analysis of Condensin Function in Vertebrate Cells

    Hudson, D. F., Ohta, S., Freisinger, T., MacIsaac, F., Sennels, L., Alves, F., Lai, F., Kerr, A., Rappsilber, J. & Earnshaw, W. C., 2008, In: Molecular Biology of the Cell. 19, 7, p. 3070-3079 10 p.

    Research output: Contribution to journalArticlepeer-review

  79. Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint

    Combes, G., Barysz, H., Garand, C., Gama Braga, L., Alharbi, I., Thebault, P., Murakami, L., Bryne, D. P., Stankovic, S., Eyers, P. A., Bolanos-Garcia, V. M., Earnshaw, W. C., Maciejowski, J., Jallepalli, P. V. & Elowe, S., 19 Mar 2018, In: Current biology : CB. 28, 6, p. 872-883 17 p.

    Research output: Contribution to journalArticlepeer-review

  80. Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling

    Griffith, E., Walker, S., Martin, C-A., Vagnarelli, P., Stiff, T., Vernay, B., Al Sanna, N., Saggar, A., Hamel, B., Earnshaw, W. C., Jeggo, P. A., Jackson, A. P. & O'Driscoll, M., Feb 2008, In: Nature Genetics. 40, 2, p. 232-236 5 p.

    Research output: Contribution to journalArticlepeer-review

  81. Nano Random Forests to mine protein complexes and their relationships in quantitative proteomics data

    Montaño-gutierrez, L., Ohta, S., Kustatscher, G., Earnshaw, B. & Rappsilber, J., 5 Jan 2017, In: Molecular Biology of the Cell.

    Research output: Contribution to journalArticlepeer-review

  82. Nap1 regulates proper CENP-B binding to nucleosomes

    Tachiwana, H., Miya, Y., Shono, N., Ohzeki, J-I., Osakabe, A., Otake, K., Larionov, V., Earnshaw, W. C., Kimura, H., Masumoto, H. & Kurumizaka, H., 2013, In: Nucleic Acids Research. 41, 5, p. 2869-2880 12 p.

    Research output: Contribution to journalArticlepeer-review

  83. Neocentromeres

    Fukagawa, T. & Earnshaw, W. C., 6 Oct 2014, In: Current Biology. 24, 19, p. R946-R947

    Research output: Contribution to journalShort surveypeer-review

  84. Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere

    Kouprina, N., Samoshkin, A., Erliandri, I., Nakano, M., Lee, H-S., Fu, H., Iida, Y., Aladjem, M., Oshimura, M., Masumoto, H., Earnshaw, W. C. & Larionov, V., 21 Dec 2012, In: ACS Synthetic Biology. 1, 12, p. 590-601 12 p.

    Research output: Contribution to journalArticlepeer-review

  85. PREditOR: A synthetic biology approach to removing heterochromatin from cells

    Molina, O., Carmena, M., Maudlin, I. E. & Earnshaw, W. C., 6 Dec 2016, In: Chromosome Research. 24, 4, p. 495-509

    Research output: Contribution to journalArticlepeer-review

  86. Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing

    Castonguay, E., White, S. A., Kagansky, A., St-Cyr, D. J., Castillo, A. G., Brugger, C., White, R., Bonilla, C., Spitzer, M., Earnshaw, W. C., Schalch, T., Ekwall, K., Tyers, M. & Allshire, R. C., 1 Jan 2015, In: Molecular and Cellular Biology. 35, 4, p. 662-674 13 p.

    Research output: Contribution to journalArticlepeer-review

  87. Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster

    Carmena, M., Lombardia, M. O., Ogawa, H. & Earnshaw, W. C., 1 Jan 2014, In: Open Biology. 4, 11, 140162.

    Research output: Contribution to journalArticlepeer-review

  88. Protecting a transgene expression from the HAC-based vector by different chromatin insulators

    Lee, N. C., Kononenko, A. V., Lee, H-S., Larionov, V., Kouprina, N., Tolkunova, E. N., Liskovykh, M. A., Tomilin, A. N., Masumoto, H. & Earnshaw, W. C., 16 May 2013, In: Cellular and Molecular Life Sciences. 15 p.

    Research output: Contribution to journalArticlepeer-review

  89. Proteomics analysis with a nano Random Forest approach reveals novel functional interactions regulated by SMC complexes on mitotic chromosomes

    Ohta, S., Montaňo-Gutierrez, L. F., Alves, F. D. L., Ogawa, H., Toramoto, I., Sato, N., Morrison, C. G., Takeda, S., Hudson, D. F., Rappsilber, J. & Earnshaw, W. C., 1 Aug 2016, In: Molecular and Cellular Proteomics. 15, 8, p. 2802-2818 56 p.

    Research output: Contribution to journalArticlepeer-review

  90. Proteomics of isolated mitotic chromosomes identifies the kinetochore protein Ska3/Rama1

    Ohta, S., Bukowski-Wills, J-C., Wood, L., de Lima Alves, F., Chen, Z., Rappsilber, J. & Earnshaw, W. C., 1 Jan 2010, In: Cold Spring Harbor Symposia on Quantitative Biology. 75, p. 433-438 6 p.

    Research output: Contribution to journalArticlepeer-review

  91. Re-engineering an alphoid-HAC-based vector to enable high-throughput analyses of gene function

    Kononenko, A. V., Lee, N. C. O., Kouprina, N., Larionov, V. & Earnshaw, W. C., 1 May 2013, In: Nucleic Acids Research. 41, 10, e107.

    Research output: Contribution to journalArticlepeer-review

  92. Reed-sternberg cells form by abscission failure in the presence of functional aurora B kinase

    Xavier de Carvalho, A., Maiato, H., Maia, A. F., Ribeiro, S. A., Pontes, P., Bickmore, W., Earnshaw, W. C. & Sambade, C., 1 May 2015, In: PLoS ONE. 10, 5, p. e0124629

    Research output: Contribution to journalArticlepeer-review

  93. Regulation of both apoptosis and cell survival by the v-Src oncoprotein

    Johnson, D., Agochiya, M., Samejima, K., Earnshaw, W., Frame, M. & Wyke, J., Aug 2000, In: Cell Death and Differentiation. 7, 8, p. 685-96 12 p.

    Research output: Contribution to journalArticlepeer-review

  94. Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome

    Erliandri, I., Fu, H., Nakano, M., Kim, J. H., Miga, K. H., Liskovykh, M., Earnshaw, W. C., Masumoto, H., Kouprina, N., Aladjem, M. I. & Larionov, V., 1 Jan 2014, In: Nucleic Acids Research. 42, 18, p. 11502-11516 15 p.

    Research output: Contribution to journalArticlepeer-review

  95. Repo-Man Coordinates Chromosomal Reorganization with Nuclear Envelope Reassembly during Mitotic Exit

    Vagnarelli, P., Ribeiro, S., Sennels, L., Sanchez-Pulido, L., Alves, F. D. L., Verheyen, T., Kelly, D. A., Ponting, C. P., Rappsilber, J. & Earnshaw, W. C., 16 Aug 2011, In: Developmental Cell. 21, 2, p. 328-342 15 p.

    Research output: Contribution to journalArticlepeer-review

  96. Repo-Man-PP1: A link between chromatin remodelling and nuclear envelope reassembly

    Vagnarelli, P. & Earnshaw, W. C., 1 Mar 2012, In: Nucleus (Austin, Tex.). 3, 2, p. 138 - 142

    Research output: Contribution to journalArticlepeer-review

  97. SUMOylation modulates the function of Aurora-B kinase

    Fernandez-Miranda, G., Perez de Castro, I., Carmena, M., Aguirre-Portoles, C., Ruchaud, S., Fant, X., Montoya, G., Earnshaw, W. C. & Malumbres, M., 15 Aug 2010, In: Journal of Cell Science. 123, 16, p. 2823-2833 11 p.

    Research output: Contribution to journalArticlepeer-review

  98. Seh1 targets GATOR2 and Nup153 to mitotic chromosomes

    Platani, M., Samejima, I., Samejima, K., Kanemaki, M. T. & Earnshaw, W. C., 1 May 2018, In: Journal of Cell Science. 131, 9, 16 p., jcs213140.

    Research output: Contribution to journalArticlepeer-review

  99. Stepwise unfolding supports a subunit model for vertebrate kinetochores

    Vargiu, G., Makarov, A., Allan, J., Fukagawa, T. & Earnshaw, W., 21 Mar 2017, In: Proceedings of the National Academy of Sciences. 114, 12, p. 3133-3138 6 p.

    Research output: Contribution to journalArticlepeer-review

  100. Super-resolution fluorescence microscopy as a tool to study the nanoscale organization of chromosomes.

    Flors, C. & Earnshaw, W. C., 1 Dec 2011, In: Current opinion in chemical biology. 15, 6, p. 838-844 7 p.

    Research output: Contribution to journalArticlepeer-review

  101. Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy

    Lee, H-S., Carmena, M., Liskovykh, M., Peat, E., Kim, J-H., Oshimura, M., Masumoto, H., Teulade-Fichou, M-P., Pommier, Y., Earnshaw, W. C., Larionov, V. & Kouprina, N., 30 Aug 2018, In: Cancer Research.

    Research output: Contribution to journalArticlepeer-review

  102. TD-60 links RalA GTPase function to the CPC in mitosis

    Papini, D., Langemeyer, L., Abad, M. A., Kerr, A., Samejima, I., Eyers, P. A., Arulanandam, A., Higgins, J. M. G., Barr, F. A. & Earnshaw, W. C., 9 Jul 2015, In: Nature Communications. 6, 7678.

    Research output: Contribution to journalArticlepeer-review

  103. Targeting the INCENP in-box-Aurora B interaction to inhibit CPC activity in vivo

    Gohard, F. H., St-Cyr, D. J., Tyers, M. & Earnshaw, W. C., 1 Jan 2014, In: Open Biology. 4, 11, 140163.

    Research output: Contribution to journalArticlepeer-review

  104. The Centromere: Chromatin Foundation for the Kinetochore Machinery

    Fukagawa, T. & Earnshaw, W. C., 8 Sep 2014, In: Developmental Cell. 30, 5, p. 496-508 13 p.

    Research output: Contribution to journalArticlepeer-review

  105. The Protein Composition of Mitotic Chromosomes Determined Using Multiclassifier Combinatorial Proteomics

    Ohta, S., Bukowski-Wills, J-C., Sanchez-Pulido, L., Alves, F. D. L., Wood, L., Chen, Z. A., Platani, M., Fischer, L., Hudson, D. F., Ponting, C., Fukagawa, T., Earnshaw, W. C. & Rappsilber, J., 3 Sep 2010, In: Cell. 142, 5, p. 810-821 12 p.

    Research output: Contribution to journalArticlepeer-review

  106. The chromosomal passenger complex (CPC): From easy rider to the godfather of mitosis

    Carmena, M., Earnshaw, W. C., Wheelock, M. & Funabiki, H., Dec 2012, In: Nature reviews Molecular cell biology. 13, 12, p. 789-803 15 p.

    Research output: Contribution to journalArticlepeer-review

  107. The chromosomal passenger complex activates Polo kinase at centromeres

    Carmena, M., Pinson, X., Platani, M., Salloum, Z., Xu, Z., Clark, A., Macisaac, F., Ogawa, H., Eggert, U., Glover, D. M., Archambault, V. & Earnshaw, B., 2012, In: PLoS Biology. 10, 1, 15 p., e1001250.

    Research output: Contribution to journalArticlepeer-review

  108. The inner centromere protein (INCENP) coil is a single α-helix (SAH) domain that binds directly to microtubules and is important for chromosome passenger complex (CPC) localization and function in mitosis

    Samejima, K., Platani, M., Wolny, M., Ogawa, H., Vargiu, G., Knight, P. J., Peckham, M. & Earnshaw, W. C., 28 Aug 2015, In: Journal of Biological Chemistry. 290, 35, p. 21460-21472 13 p.

    Research output: Contribution to journalArticlepeer-review

  109. The protein composition of mitotic chromosomes determined using multi-classifier combinatorial proteomics

    Ohta, S., Bukowski-Wills, J-C., Sanchez-Pulido, L., Alves, F. D. L., Wood, L., Chen, Z., Platani, M., Fischer, L., Hudson, D. F., Ponting, C., Fukagawa, T., Earnshaw, W. C. & Rappsilber, J., Nov 2010, In: Mutagenesis. 25, 6, p. 635-635 1 p.

    Research output: Contribution to journalArticlepeer-review

  110. Towards the Extension of Life-Span of a Human Somatic Stem Cells Using a Human Artificial Chromosome Carrying a Conditional Centromere

    Iida, Y., Ohzeki, J., Kazuki, Y., Hoshiya, H., Takiguchi, M., Hayashi, M., Nakano, M., Masumoto, H., Earnshaw, W. C., Larionov, V. & Oshimura, M., May 2009, In: Molecular Therapy. 17, p. S274-S274 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  111. Two interlinked bistable switches govern mitotic control in mammalian cells

    Rata, S., Suarez Peredo Rodriguez, M. F., Joseph, S., Peter, N., Echegaray Iturra, F., Yang, F., Madzvamuse, A., Ruppert, J. G., Samejima, K., Platani, M., Alvarez-Fernandez, M., Malumbres, M., Earnshaw, W. C., Novak, B. & Hochegger, H., 3 Dec 2018, In: Current Biology. 28, 23, p. 3824-3832.e6

    Research output: Contribution to journalArticlepeer-review

  112. Use of D140 conditional-knockout cell lines to study chromosomal passenger protein function

    Fant, X., Samejima, K., Carvalho, A., Ogawa, H., Xu, Z., Yue, Z., Earnshaw, W. C. & Ruchaud, S., Dec 2010, In: Biochemical Society Transactions. 38, p. 1655-1659 5 p.

    Research output: Contribution to journalArticlepeer-review

  113. Using human artificial chromosomes to study centromere assembly and function

    Molina, O., Kouprina, N., Masumoto, H., Larionov, V. & Earnshaw, W., 1 Oct 2017, In: Chromosoma. p. 559-575 17 p.

    Research output: Contribution to journalArticlepeer-review

  114. Using multi-dimensional proteomics to define the complete protein composition of mitotic chromosomes

    Earnshaw, W., Ohta, S., Bukowski-Wills, J., Alves, F., Sennels, L. & Rappsilber, J., Jul 2009, In: Febs Journal. 276, p. 33-33 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  115. Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair

    Mocciaro, A., Berdougo, E., Zeng, K., Black, E., Vagnarelli, P., Earnshaw, W., Gillespie, D., Jallepalli, P. & Schiebel, E., 17 May 2010, In: Journal of Cell Biology. 189, 4, p. 631-639 9 p.

    Research output: Contribution to journalArticlepeer-review

  116. Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore

    Samejima, I., Spanos, C., De Lima Alves, F., Hori, T., Perpelescu, M., Zou, J., Rappsilber, J., Fukagawa, T. & Earnshaw, W. C., 14 Dec 2015, In: Journal of Cell Biology. 211, 6, p. 1141-1156 16 p.

    Research output: Contribution to journalArticlepeer-review