Edinburgh Research Explorer

Bill Earnshaw

Professor of Chromosome Dynamics

  1. 2020
  2. APC/CCdh1 is required for the termination of CPC activity upon mitotic exit

    Tsunematsu, T., Arakaki, R., Kawai, H., Ruppert, J., Tsuneyama, K., Earnshaw, W. C., Pagano, M. & Kudo, Y., 15 Sep 2020, In : Journal of Cell Science.

    Research output: Contribution to journalArticle

  3. CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly

    Otake, K., Ohzeki, J., Shono, N., Kugou, K., Okazaki, K., Nagase, T., Yamakawa, H., Kouprina, N., Larionov, V., Kimura, H., Earnshaw, W. C. & Masumoto, H., 11 Aug 2020, In : Journal of Cell Science. 133, jcs.243303.

    Research output: Contribution to journalArticle

  4. Chromokinesin KIF4A teams up with Stathmin 1 to regulate abscission in a SUMO-dependent manner

    Cuijpers, S., Willemstein, E., Ruppert, J., van Elsland, D. M., Earnshaw, B. & Vertegaal, A. C. O., 24 Jul 2020, In : Journal of Cell Science.

    Research output: Contribution to journalArticle

  5. H3K9me maintenance on a Human Artificial Chromosome is required for 3 segregation but not centromere epigenetic memory

    Martins, N. M. C., Cisneros Soberanis, F., Pesenti, E., Kochanova, N., Shang, W-H., Hori, T., Nagase, T., Kimura, H., Larionov, V., Masumoto, H., Fukagawa, T. & Earnshaw, B., 24 Jul 2020, In : Journal of Cell Science. 133, jcs242610.

    Research output: Contribution to journalArticle

  6. 2019
  7. Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1

    Papini, D., Fant, X., Ogawa, H., Desban, N., Samejima, K., Feizbakhsh, O., Askin, B., Ly, T., Earnshaw, W. C. & Ruchaud, S., 6 Nov 2019, In : Journal of Cell Science. jcs.234401.

    Research output: Contribution to journalArticle

  8. Borealin–nucleosome interaction secures chromosome association of the chromosomal passenger complex

    Abad, M. A., Ruppert, J., Buzuk, L., Wear, M., Zou, J., Webb, K., Kelly, D., Voigt, P., Rappsilber, J., Earnshaw, W. & Arulanandam, A., 30 Sep 2019, In : Journal of Cell Biology. 218, 12, p. 3912–3925 13 p.

    Research output: Contribution to journalArticle

  9. A novel assay to screen siRNA libraries identifies protein kinases as required for chromosome transmission

    Liskovykh, M., Goncharov, N. V., Petrov, N., Aksenova, V., Pegoraro, G., Ozbun, L. L., Reinhold, W. C., Varma, S., Dasso, M., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 12 Sep 2019, In : Genome Research. 29, 9

    Research output: Contribution to journalArticle

  10. De novo formation and epigenetic maintenance of centromere chromatin

    Ohzeki, J., Larionov, V., Earnshaw, W. C. & Masumoto, H., 1 Jun 2019, In : Current opinion in cell biology. 58, p. 15-25 11 p.

    Research output: Contribution to journalReview article

  11. In vitro BioID: Mapping the CENP-A microenvironment with high temporal and spatial resolution

    Remnant, L., Booth, D. G., Vargiu, G., Spanos, C., Kerr, A. R. W. & Earnshaw, W. C., 20 Mar 2019, In : Molecular Biology of the Cell. 30, 11, p. 1314-1325 12 p.

    Research output: Contribution to journalArticle

  12. 2018
  13. Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies

    Kouprina, N., Petrov, N., Molina, O., Liskovykh, M., Pesenti, E., Ohzeki, J-I., Masumoto, H., Earnshaw, W. C. & Larionov, V., 21 Sep 2018, In : ACS Synthetic Biology. 7, 9, p. 1974-1989 16 p.

    Research output: Contribution to journalReview article

  14. Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy

    Lee, H-S., Carmena, M., Liskovykh, M., Peat, E., Kim, J-H., Oshimura, M., Masumoto, H., Teulade-Fichou, M-P., Pommier, Y., Earnshaw, W. C., Larionov, V. & Kouprina, N., 30 Aug 2018, In : Cancer Research.

    Research output: Contribution to journalArticle

  15. An intrinsic S/G checkpoint enforced by ATR

    Saldivar, J. C., Hamperl, S., Bocek, M. J., Chung, M., Bass, T. E., Cisneros-Soberanis, F., Samejima, K., Xie, L., Paulson, J. R., Earnshaw, W. C., Cortez, D., Meyer, T. & Cimprich, K. A., 24 Aug 2018, In : Science. 361, 6404, p. 806-810 5 p.

    Research output: Contribution to journalArticle

  16. Seh1 targets GATOR2 and Nup153 to mitotic chromosomes

    Platani, M., Samejima, I., Samejima, K., Kanemaki, M. T. & Earnshaw, W. C., 1 May 2018, In : Journal of Cell Science. 131, 9, 16 p., jcs213140.

    Research output: Contribution to journalArticle

  17. Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies

    Pesenti, E., Kouprina, N., Liskovykh, M., Aurich-Costa, J., Larionov, V., Masumoto, H., Earnshaw, W. C. & Molina, O., 20 Apr 2018, In : ACS Synthetic Biology. 7, 4, p. 1116-1130 15 p.

    Research output: Contribution to journalArticle

  18. Isolation of mitotic chromosomes from vertebrate cells and characterisation of their proteome by mass spectrometry

    Samejima, I. & Earnshaw, W., 12 Apr 2018, Methods in Cell Biology. Elsevier, Vol. 144. p. 329-348 20 p. (Methods in Cell Biology; vol. 144).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  19. Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint

    Combes, G., Barysz, H., Garand, C., Gama Braga, L., Alharbi, I., Thebault, P., Murakami, L., Bryne, D. P., Stankovic, S., Eyers, P. A., Bolanos-Garcia, V. M., Earnshaw, W. C., Maciejowski, J., Jallepalli, P. V. & Elowe, S., 19 Mar 2018, In : Current biology : CB. 28, 6, p. 872-883 17 p.

    Research output: Contribution to journalArticle

  20. A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

    Ladds, M. J. G. W., van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A-L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 16 Mar 2018, In : Nature Communications. 9, 1, 14 p., 1107 (2018).

    Research output: Contribution to journalArticle

  21. HP1α targets the chromosomal passenger complex for activation at heterochromatin before mitotic entry

    Ruppert, J. G., Samejima, K., Platani, M., Molina, O., Kimura, H., Jeyaprakash, A. A., Ohta, S. & Earnshaw, W. C., 15 Mar 2018, In : EMBO Journal. 37, 6, 18 p.

    Research output: Contribution to journalArticle

  22. Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis

    Samejima, K., Booth, D. G., Ogawa, H., Paulson, J. R., Xie, L., Watson, C. A., Platani, M., Kanemaki, M. T. & Earnshaw, W. C., 22 Feb 2018, In : Journal of Cell Science. 131, 4, 17 p.

    Research output: Contribution to journalArticle

  23. A pathway for mitotic chromosome formation

    Gibcus, J. H., Samejima, K., Goloborodko, A., Samejima, I., Naumova, N., Nuebler, J., Kanemaki, M. T., Xie, L., Paulson, J. R., Earnshaw, W. C., Mirny, L. A. & Dekker, J., 9 Feb 2018, In : Science. 359, 6376, 14 p., eaao6135.

    Research output: Contribution to journalArticle

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