Edinburgh Research Explorer

Prof Bill Earnshaw

Professor of Chromosome Dynamics

  1. 2020
  2. APC/CCdh1 is required for the termination of CPC activity upon mitotic exit

    Tsunematsu, T., Arakaki, R., Kawai, H., Ruppert, J., Tsuneyama, K., Earnshaw, W. C., Pagano, M. & Kudo, Y., 15 Sep 2020, In : Journal of Cell Science.

    Research output: Contribution to journalArticle

  3. CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly

    Otake, K., Ohzeki, J., Shono, N., Kugou, K., Okazaki, K., Nagase, T., Yamakawa, H., Kouprina, N., Larionov, V., Kimura, H., Earnshaw, W. C. & Masumoto, H., 11 Aug 2020, In : Journal of Cell Science. 133, jcs.243303.

    Research output: Contribution to journalArticle

  4. Chromokinesin KIF4A teams up with Stathmin 1 to regulate abscission in a SUMO-dependent manner

    Cuijpers, S., Willemstein, E., Ruppert, J., van Elsland, D. M., Earnshaw, B. & Vertegaal, A. C. O., 24 Jul 2020, In : Journal of Cell Science.

    Research output: Contribution to journalArticle

  5. H3K9me maintenance on a Human Artificial Chromosome is required for 3 segregation but not centromere epigenetic memory

    Martins, N. M. C., Cisneros Soberanis, F., Pesenti, E., Kochanova, N., Shang, W-H., Hori, T., Nagase, T., Kimura, H., Larionov, V., Masumoto, H., Fukagawa, T. & Earnshaw, B., 24 Jul 2020, In : Journal of Cell Science. 133, jcs242610.

    Research output: Contribution to journalArticle

  6. 2019
  7. Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1

    Papini, D., Fant, X., Ogawa, H., Desban, N., Samejima, K., Feizbakhsh, O., Askin, B., Ly, T., Earnshaw, W. C. & Ruchaud, S., 6 Nov 2019, In : Journal of Cell Science. jcs.234401.

    Research output: Contribution to journalArticle

  8. Borealin–nucleosome interaction secures chromosome association of the chromosomal passenger complex

    Abad, M. A., Ruppert, J., Buzuk, L., Wear, M., Zou, J., Webb, K., Kelly, D., Voigt, P., Rappsilber, J., Earnshaw, W. & Arulanandam, A., 15 Oct 2019, In : Journal of Cell Biology.

    Research output: Contribution to journalArticle

  9. A novel assay to screen siRNA libraries identifies protein kinases as required for chromosome transmission

    Liskovykh, M., Goncharov, N. V., Petrov, N., Aksenova, V., Pegoraro, G., Ozbun, L. L., Reinhold, W. C., Varma, S., Dasso, M., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 12 Sep 2019, In : Genome Research. 29, 9

    Research output: Contribution to journalArticle

  10. De novo formation and epigenetic maintenance of centromere chromatin

    Ohzeki, J., Larionov, V., Earnshaw, W. C. & Masumoto, H., 1 Jun 2019, In : Current opinion in cell biology. 58, p. 15-25 11 p.

    Research output: Contribution to journalReview article

  11. In vitro BioID: Mapping the CENP-A microenvironment with high temporal and spatial resolution

    Remnant, L., Booth, D. G., Vargiu, G., Spanos, C., Kerr, A. R. W. & Earnshaw, W. C., 20 Mar 2019, In : Molecular Biology of the Cell. 30, 11, p. 1314-1325 12 p.

    Research output: Contribution to journalArticle

  12. 2018
  13. Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies

    Kouprina, N., Petrov, N., Molina, O., Liskovykh, M., Pesenti, E., Ohzeki, J-I., Masumoto, H., Earnshaw, W. C. & Larionov, V., 21 Sep 2018, In : ACS Synthetic Biology. 7, 9, p. 1974-1989 16 p.

    Research output: Contribution to journalReview article

  14. Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy

    Lee, H-S., Carmena, M., Liskovykh, M., Peat, E., Kim, J-H., Oshimura, M., Masumoto, H., Teulade-Fichou, M-P., Pommier, Y., Earnshaw, W. C., Larionov, V. & Kouprina, N., 30 Aug 2018, In : Cancer Research.

    Research output: Contribution to journalArticle

  15. An intrinsic S/G checkpoint enforced by ATR

    Saldivar, J. C., Hamperl, S., Bocek, M. J., Chung, M., Bass, T. E., Cisneros-Soberanis, F., Samejima, K., Xie, L., Paulson, J. R., Earnshaw, W. C., Cortez, D., Meyer, T. & Cimprich, K. A., 24 Aug 2018, In : Science. 361, 6404, p. 806-810 5 p.

    Research output: Contribution to journalArticle

  16. Seh1 targets GATOR2 and Nup153 to mitotic chromosomes

    Platani, M., Samejima, I., Samejima, K., Kanemaki, M. T. & Earnshaw, W. C., 1 May 2018, In : Journal of Cell Science. 131, 9, 16 p., jcs213140.

    Research output: Contribution to journalArticle

  17. Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies

    Pesenti, E., Kouprina, N., Liskovykh, M., Aurich-Costa, J., Larionov, V., Masumoto, H., Earnshaw, W. C. & Molina, O., 20 Apr 2018, In : ACS Synthetic Biology. 7, 4, p. 1116-1130 15 p.

    Research output: Contribution to journalArticle

  18. Isolation of mitotic chromosomes from vertebrate cells and characterisation of their proteome by mass spectrometry

    Samejima, I. & Earnshaw, W., 12 Apr 2018, Methods in Cell Biology. Elsevier, Vol. 144. p. 329-348 20 p. (Methods in Cell Biology; vol. 144).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  19. Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint

    Combes, G., Barysz, H., Garand, C., Gama Braga, L., Alharbi, I., Thebault, P., Murakami, L., Bryne, D. P., Stankovic, S., Eyers, P. A., Bolanos-Garcia, V. M., Earnshaw, W. C., Maciejowski, J., Jallepalli, P. V. & Elowe, S., 19 Mar 2018, In : Current biology : CB. 28, 6, p. 872-883 17 p.

    Research output: Contribution to journalArticle

  20. A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

    Ladds, M. J. G. W., van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A-L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 16 Mar 2018, In : Nature Communications. 9, 1, 14 p., 1107 (2018).

    Research output: Contribution to journalArticle

  21. HP1α targets the chromosomal passenger complex for activation at heterochromatin before mitotic entry

    Ruppert, J. G., Samejima, K., Platani, M., Molina, O., Kimura, H., Jeyaprakash, A. A., Ohta, S. & Earnshaw, W. C., 15 Mar 2018, In : EMBO Journal. 37, 6, 18 p.

    Research output: Contribution to journalArticle

  22. Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis

    Samejima, K., Booth, D. G., Ogawa, H., Paulson, J. R., Xie, L., Watson, C. A., Platani, M., Kanemaki, M. T. & Earnshaw, W. C., 22 Feb 2018, In : Journal of Cell Science. 131, 4, 17 p.

    Research output: Contribution to journalArticle

  23. A pathway for mitotic chromosome formation

    Gibcus, J. H., Samejima, K., Goloborodko, A., Samejima, I., Naumova, N., Nuebler, J., Kanemaki, M. T., Xie, L., Paulson, J. R., Earnshaw, W. C., Mirny, L. A. & Dekker, J., 9 Feb 2018, In : Science. 359, 6376, 14 p., eaao6135.

    Research output: Contribution to journalArticle

  24. Method to Assemble Genomic DNA Fragments or Genes on Human Artificial Chromosome with Regulated Kinetochore Using a Multi-Integrase System

    Lee, N. C. O., Kim, J-H., Petrov, N. S., Lee, H-S., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 19 Jan 2018, In : ACS Synthetic Biology. 7, 1, p. 63-74 12 p.

    Research output: Contribution to journalArticle

  25. 2017
  26. Ki-67 and the Chromosome Periphery Compartment in Mitosis

    Booth, D. G. & Earnshaw, W. C., 1 Dec 2017, In : Trends In Cell Biology. 27, 12, p. 906-916 11 p.

    Research output: Contribution to journalReview article

  27. Using human artificial chromosomes to study centromere assembly and function

    Molina, O., Kouprina, N., Masumoto, H., Larionov, V. & Earnshaw, W., 1 Oct 2017, In : Chromosoma. p. 559-575 17 p.

    Research output: Contribution to journalArticle

  28. Mitotic post-translational modifications of histones promote chromatin compaction in vitro

    Zhiteneva, A., Bonfiglio, J. J., Makarov, A., Colby, T., Vagnarelli, P., Schirmer, E. C., Matic, I. & Earnshaw, W. C., 13 Sep 2017, In : Open Biology. 7, 9

    Research output: Contribution to journalArticle

  29. Molecular Basis for Cdk1 Regulated Timing of Mis18 Complex Assembly and CENP-A Deposition

    Spiller, F., Medina-Pritchard, B., Alba Abad, M., Wear, M., Molina, O., Earnshaw, W. & Arulanandam, A., 4 Apr 2017, In : EMBO Reports. e201643564.

    Research output: Contribution to journalArticle

  30. Stepwise unfolding supports a subunit model for vertebrate kinetochores

    Vargiu, G., Makarov, A., Allan, J., Fukagawa, T. & Earnshaw, W., 21 Mar 2017, In : Proceedings of the National Academy of Sciences. 114, 12, p. 3133-3138 6 p.

    Research output: Contribution to journalArticle

  31. Nano Random Forests to mine protein complexes and their relationships in quantitative proteomics data

    Montaño-gutierrez, L., Ohta, S., Kustatscher, G., Earnshaw, B. & Rappsilber, J., 5 Jan 2017, In : Molecular Biology of the Cell.

    Research output: Contribution to journalArticle

  32. 2016
  33. PREditOR: A synthetic biology approach to removing heterochromatin from cells

    Molina, O., Carmena, M., Maudlin, I. E. & Earnshaw, W. C., 6 Dec 2016, In : Chromosome Research. 24, 4, p. 495-509

    Research output: Contribution to journalArticle

  34. 3D-CLEM reveals that a major portion of mitotic chromosomes is not Chromatin

    Booth, D., Beckett, A. J., Molina, O., Samejima, I., Masumoto, H., Kouprina, N., Larionov, V., Prior, I. A. & Earnshaw, W., 17 Nov 2016, In : Molecular Cell.

    Research output: Contribution to journalArticle

  35. Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance: H3K4me2 is necessary for kinetochore assembly and function

    Molina, O., Vargiu, G., Alba Abad, M., Zhiteneva, A., Arulanandam, J., Masumoto, H., Kouprina, N., Larionov, V. & Earnshaw, W., 14 Nov 2016, In : Nature Communications. 51 p.

    Research output: Contribution to journalArticle

  36. Proteomics analysis with a nano Random Forest approach reveals novel functional interactions regulated by SMC complexes on mitotic chromosomes

    Ohta, S., Montaňo-Gutierrez, L. F., Alves, F. D. L., Ogawa, H., Toramoto, I., Sato, N., Morrison, C. G., Takeda, S., Hudson, D. F., Rappsilber, J. & Earnshaw, W. C., 1 Aug 2016, In : Molecular and Cellular Proteomics. 15, 8, p. 2802-2818 56 p.

    Research output: Contribution to journalArticle

  37. KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation

    Ohzeki, J-I., Shono, N., Otake, K., Martins, N. M. C., Kugou, K., Kimura, H., Nagase, T., Larionov, V., Earnshaw, W. C. & Masumoto, H., 6 Jun 2016, In : Developmental Cell. 37, 5, p. 413-27 15 p.

    Research output: Contribution to journalArticle

  38. Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells

    Kim, J. H., Lee, H. S., Lee, N. C. O., Goncharov, N. V., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Kouprina, N. & Larionov, V., 22 Mar 2016, In : Oncotarget. 7, 12, p. 14841-14856 16 p.

    Research output: Contribution to journalArticle

  39. Auxin/AID versus conventional knockouts: Distinguishing the roles of CENP-T/W in mitotic kinetochore assembly and stability

    Wood, L., Booth, D. G., Vargiu, G., Ohta, S., deLima Alves, F., Samejima, K., Fukagawa, T., Rappsilber, J. & Earnshaw, W. C., 20 Jan 2016, In : Open Biology. 6, 1, 150230.

    Research output: Contribution to journalArticle

  40. Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3

    Martins, N. M. C., Bergmann, J. H., Shono, N., Kimura, H., Larionov, V., Masumoto, H. & Earnshaw, W. C., 1 Jan 2016, In : Molecular Biology of the Cell. 27, 1, p. 177-96 20 p.

    Research output: Contribution to journalArticle

  41. 2015
  42. Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore

    Samejima, I., Spanos, C., De Lima Alves, F., Hori, T., Perpelescu, M., Zou, J., Rappsilber, J., Fukagawa, T. & Earnshaw, W. C., 14 Dec 2015, In : Journal of Cell Biology. 211, 6, p. 1141-1156 16 p.

    Research output: Contribution to journalArticle

  43. The inner centromere protein (INCENP) coil is a single α-helix (SAH) domain that binds directly to microtubules and is important for chromosome passenger complex (CPC) localization and function in mitosis

    Samejima, K., Platani, M., Wolny, M., Ogawa, H., Vargiu, G., Knight, P. J., Peckham, M. & Earnshaw, W. C., 28 Aug 2015, In : Journal of Biological Chemistry. 290, 35, p. 21460-21472 13 p.

    Research output: Contribution to journalArticle

  44. Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development

    González-Loyola, A., Fernández-Miranda, G., Trakala, M., Partida, D., Samejima, K., Ogawa, H., Cañamero, M., de Martino, A., Martínez-Ramírez, Á., de Cárcer, G., de Castro., I. P., Earnshaw, W. C. & Malumbres, M., 3 Aug 2015, In : Molecular and Cellular Biology. 35, 20, p. 3566-3578 13 p.

    Research output: Contribution to journalArticle

  45. TD-60 links RalA GTPase function to the CPC in mitosis

    Papini, D., Langemeyer, L., Abad, M. A., Kerr, A., Samejima, I., Eyers, P. A., Arulanandam, A., Higgins, J. M. G., Barr, F. A. & Earnshaw, W. C., 9 Jul 2015, In : Nature Communications. 6, 7678.

    Research output: Contribution to journalArticle

  46. Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes

    Platani, M., Trinkle-Mulcahy, L., Porter, M., Arulanandam, A. & Earnshaw, W. C., 6 Jul 2015, In : Journal of Cell Biology. 210, 1, p. 45-62 18 p.

    Research output: Contribution to journalArticle

  47. Discovering centromere proteins: from cold white hands to the A, B, C of CENPs

    Earnshaw, W. C., 23 Jun 2015, In : Nature reviews Molecular cell biology. 16, 7, p. 443-449 7 p.

    Research output: Contribution to journalArticle

  48. Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette

    Kononenko, A. V., Lee, N. C. O., Liskovykh, M., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 20 May 2015, In : Nucleic Acids Research. 43, 9, e57.

    Research output: Contribution to journalArticle

  49. Reed-sternberg cells form by abscission failure in the presence of functional aurora B kinase

    Xavier de Carvalho, A., Maiato, H., Maia, A. F., Ribeiro, S. A., Pontes, P., Bickmore, W., Earnshaw, W. C. & Sambade, C., 1 May 2015, In : PLoS ONE. 10, 5, p. e0124629

    Research output: Contribution to journalArticle

  50. CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly

    Ohta, S., Wood, L., Toramoto, I., Yagyu, K. I., Fukagawa, T. & Earnshaw, W. C., 15 Apr 2015, In : Molecular Biology of the Cell. 26, 7, p. 1225-1237 13 p.

    Research output: Contribution to journalArticle

  51. Genetic and epigenetic regulation of centromeres: A look at HAC formation

    Ohzeki, J. I., Larionov, V., Earnshaw, W. C. & Masumoto, H., 1 Jan 2015, In : Chromosome Research . 23, 1, p. 87-103 17 p.

    Research output: Contribution to journalArticle

  52. Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing

    Castonguay, E., White, S. A., Kagansky, A., St-Cyr, D. J., Castillo, A. G., Brugger, C., White, R., Bonilla, C., Spitzer, M., Earnshaw, W. C., Schalch, T., Ekwall, K., Tyers, M. & Allshire, R. C., 1 Jan 2015, In : Molecular and Cellular Biology. 35, 4, p. 662-674 13 p.

    Research output: Contribution to journalArticle

  53. CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly

    Shono, N., Ohzeki, J. I., Otake, K., Martins, N. M. C., Nagase, T., Kimura, H., Larionov, V., Earnshaw, W. C. & Masumoto, H., 2015, In : Journal of Cell Science. 128, 24, p. 4572-4587 16 p.

    Research output: Contribution to journalArticle

  54. 2014
  55. A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function

    Kononenko, A. V., Bansal, R., Lee, N. C. O., Grimes, B. R., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 1 Dec 2014, In : Nucleic Acids Research. 42, 21, e164.

    Research output: Contribution to journalArticle

  56. Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide module

    Samejima, K., Ogawa, H., Ageichik, A. V., Peterson, K. L., Kaufmann, S. H., Kanemaki, M. T. & Earnshaw, W. C., 7 Nov 2014, In : Journal of Biological Chemistry. 289, 45, p. 31617-31623 7 p.

    Research output: Contribution to journalArticle

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