Edinburgh Research Explorer

Brian Walker

(Former employee or visitor)

  1. Long-term stability of cortisol production and metabolism throughout adolescence: longitudinal twin study

    van Keulen, B. J., Dolan, C. V., Andrew, R., Walker, B., Hulshoff Pol, H. E., Boomsma, D. I., Rotteveel, J. & Finken, M. JJ., 25 Mar 2020, In : Twin Research and Human Genetics.

    Research output: Contribution to journalArticle

  2. Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans

    Alwashih, M. A., Stimson, R., Andrew, R., Walker, B. & Watson, D. G., 13 Sep 2017, In : Scientific Reports.

    Research output: Contribution to journalArticle

  3. Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia

    Alwashih, M. A., Watson, D. G., Andrew, R., Stimson, R. H., Alossaimi, M., Blackburn, G. & Walker, B. R., 6 Dec 2017, In : Scientific Reports. 7, 1, p. 17092

    Research output: Contribution to journalArticle

  4. 11β-HSD1 inhibitors for the treatment of type 2 diabetes and cardiovascular disease

    Anderson, A. & Walker, B. R., Sep 2013, In : Drugs. 73, 13, p. 1385-1393 9 p.

    Research output: Contribution to journalArticle

  5. Metformin increases cortisol regeneration by 11βHSD1 in obese men with and without type 2 diabetes mellitus

    Anderson, A. J., Andrew, R., Homer, N. Z., Jones, G. C., Smith, K., Livingstone, D. E., Walker, B. R. & Stimson, R. H., 26 Jul 2016, In : Journal of Clinical Endocrinology & Metabolism. p. jc20162069

    Research output: Contribution to journalArticle

  6. Tissue-Specific Increases in 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Normal Weight Postmenopausal Women

    Andersson, T., Simonyte, K., Andrew, R., Strand, M., Buren, J., Walker, B. R., Mattsson, C. & Olsson, T., 29 Dec 2009, In : PLoS ONE. 4, 12, p. - 8 p., e8475.

    Research output: Contribution to journalArticle

  7. Glucocorticoid metabolism and the Metabolic Syndrome: Associations in an elderly cohort

    Andrew, R., Gale, C., Walker, B. R., Seckl, J. R. & Martyn, C. N., Sep 2002, In : Experimental and clinical endocrinology & diabetes. 110, 6, p. 284-290 7 p.

    Research output: Contribution to journalArticle

  8. Obesity and gender influence cortisol secretion and metabolism in man

    Andrew, R., Phillips, D. I. & Walker, B. R., 1998, In : Journal of Clinical Endocrinology & Metabolism. 83, 5, p. 1806-9 4 p.

    Research output: Contribution to journalArticle

  9. Influence of gender and body composition on glucocorticoid metabolism in middle-aged humans

    Andrew, R., Phillips, D. I. & Walker, B. R., 2000, In : International Journal of Obesity. 24 Suppl 2, p. S144-5

    Research output: Contribution to journalArticle

  10. Distinguishing the activities of 11beta-hydroxysteroid dehydrogenases in vivo using isotopically labeled cortisol

    Andrew, R., Smith, K., Jones, G. C. & Walker, B. R., 2002, In : Journal of Clinical Endocrinology & Metabolism. 87, 1, p. 277-85 9 p.

    Research output: Contribution to journalArticle

  11. The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans

    Andrew, R., Westerbacka, J., Wahren, J., Yki-Järvinen, H. & Walker, B. R., 2005, In : Diabetes . 54, 5, p. 1364-70 7 p.

    Research output: Contribution to journalArticle

  12. 5α-Reductase type 1 inhibition or deficiency causes weight gain and insulin resistance in mice and men

    Andrew, R., Upreti, R., Livingstone, D. E. W., Barat, P., Hughes, K. A., MacFarlane, D. P., Gray, C. D., Minns, F. C., Marshall, I., Stewart, L. H. & Walker, B. R., 2013, Association of Physicians Annual Meeting.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  13. Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance

    Andrews, R. C., Herlihy, O., Livingstone, D. E. W., Andrew, R. & Walker, B. R., 2002, In : Journal of Clinical Endocrinology & Metabolism. 87, 12, p. 5587-93 7 p.

    Research output: Contribution to journalArticle

  14. ECAT-V: where clinical and research training meet

    Argyle, D. J., Iredale, J. P., Jackson, A. P. & Walker, B. R., 19 Oct 2013, In : Veterinary Record. 173, 15, p. 364-5 2 p.

    Research output: Contribution to journalArticle

  15. Health Status of Adults with Congenital Adrenal Hyperplasia: A Cohort Study of 203 Patients

    Arlt, W., Willis, D. S., Wild, S. H., Krone, N., Doherty, E. J., Hahner, S., Han, T. S., Carroll, P. V., Conway, G. S., Rees, D. A., Stimson, R. H., Walker, B. R., Connell, J. M. C., Ross, R. J. & United Kingdom Congenital Adrenal, Nov 2010, In : Journal of Clinical Endocrinology & Metabolism. 95, 11, p. 5110-5121 12 p.

    Research output: Contribution to journalArticle

  16. Truncal distribution of fat mass, metabolic profile and hypothalamic-pituitary adrenal axis activity in prepubertal obese children

    Barat, P., Gayard-Cros, M., Andrew, R., Corcuff, J-B., Jouret, B., Barthe, N., Perez, P., Germain, C., Tauber, M., Walker, B. R., Mormede, P. & Duclos, M., 2007, In : The Journal of pediatrics. 150, 5, p. 535-9, 539.e1

    Research output: Contribution to journalArticle

  17. Effects of gonadectomy on glucocorticoid metabolism in obese Zucker rats

    Barat, P., Livingstone, D. E. W., Elferink, C. M. C., McDonnell, C. R., Walker, B. R. & Andrew, R., 2007, In : Endocrinology . 148, 10, p. 4836-43 8 p.

    Research output: Contribution to journalArticle

  18. Using 3T Magnetic Resonance Imaging to Assess Fat Distribution and Ectopic Lipid Deposition in Morbidly Obese Pregnant Women in the Third Trimester

    Barr, S. M., Chiswick, C., Cooper, A., Gray, C. D., Semple, S. I. K., Morton, N. M., Walker, B. R. & Norman, J. E., 2012, 59th Annual Scientific Meeting of the Society for Gynecologic Investigation.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  19. Pro-inflammatory gene mRNA levels are elevated in subcutaneous but not visceral adipose tissue in obese pregnant women

    Barr, S. M., Walker, B. R., Morton, N. M. & Norman, J. E., Jul 2011, In : BJOG: An International Journal of Obstetrics and Gynaecology. 118, 8, p. 1008-1009 2 p.

    Research output: Contribution to journalMeeting abstract

  20. Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

    on behalf of the CORtisol NETwork (CORNET) Consortium, 10 Jul 2014, In : PLoS Genetics. 10, 7, e1004474.

    Research output: Contribution to journalArticle

  21. Reduced Cortisol Metabolism during Critical Illness

    Boonen, E., Vervenne, H., Meersseman, P., Andrew, R., Mortier, L., Declercq, P. E., Vanwijngaerden, Y-M., Spriet, I., Wouters, P. J., Vander Perre, S., Langouche, L., Vanhorebeek, I., Walker, B. R. & Van den Berghe, G., 18 Apr 2013, In : New England Journal of Medicine. 368, 16, p. 1477-1488 12 p.

    Research output: Contribution to journalArticle

  22. Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome - Nested case-control study

    Brunner, E. J., Hemingway, H., Walker, B. R., Page, M., Clarke, P., Juneja, M., Shipley, M. J., Kumari, M., Andrew, R., Seckl, J. R., Papadopoulos, A., Checkley, S., Rumley, A., Lowe, G. D. O., Stansfeld, S. A. & Marmot, M. G., 19 Nov 2002, In : Circulation. 106, 21, p. 2659-2665 7 p.

    Research output: Contribution to journalArticle

  23. Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia

    Chapagain, A., Caton, P. W., Kieswich, J., Andrikopoulos, P., Nayuni, N., Long, J. H., Harwood, S. M., Webster, S. P., Raftery, M. J., Thiemermann, C., Walker, B. R., Seckl, J. R., Corder, R. & Yaqoob, M. M., 11 Mar 2014, In : Proceedings of the National Academy of Sciences (PNAS). 111, 10, p. 3817-22 6 p.

    Research output: Contribution to journalArticle

  24. Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

    Chau, Y-Y., Bandiera, R., Serrels, A., Martínez-Estrada, O. M., Qing, W., Lee, M., Slight, J., Thornburn, A., Berry, R., McHaffie, S., Stimson, R. H., Walker, B. R., Chapuli, R. M., Schedl, A. & Hastie, N., Apr 2014, In : Nature Cell Biology. 16, 4, p. 367-375 9 p.

    Research output: Contribution to journalArticle

  25. Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial

    Chiswick, C., Reynolds, R. M., Denison, F., Drake, A. J., Forbes, S., Newby, D. E., Walker, B. R., Quenby, S., Wray, S., Weeks, A., Lashen, H., Rodriguez, A., Murray, G., Whyte, S. & Norman, J. E., Oct 2015, In : The Lancet Diabetes and Endocrinology.

    Research output: Contribution to journalArticle

  26. Efficacy of metformin in pregnant obese women: a randomised controlled trial

    Chiswick, C. A., Reynolds, R. M., Denison, F. C., Whyte, S. A., Drake, A. J., Newby, D. E., Walker, B. R., Forbes, S., Murray, G. D., Quenby, S., Wray, S. & Norman, J. E., 14 Jan 2015, In : BMJ Open. 5, 1, p. e006854

    Research output: Contribution to journalArticle

  27. 11 beta-hydroxysteroid dehydrogenase type 2 in mouse aorta - Localization and influence on response to glucocorticoids

    Christy, C., Hadoke, P. W. F., Paterson, J. M., Mullins, J. J., Seckl, J. R. & Walker, B. R., Oct 2003, In : Hypertension. 42, 4, p. 580-587 8 p.

    Research output: Contribution to journalArticle

  28. Is programming of glucocorticoid receptor expression by prenatal dexamethasone in the rat secondary to metabolic derangement in adulthood?

    Cleasby, M. E., Livingstone, D. E. W., Nyirenda, M. J., Seckl, J. R. & Walker, B. R., Jan 2003, In : European Journal of Endocrinology. 148, 1, p. 129-138 10 p.

    Research output: Contribution to journalArticle

  29. Programming of rat muscle and fat metabolism by in utero overexposure to glucocorticoids

    Cleasby, M. E., Kelly, P. A. T., Walker, B. R. & Seckl, J. R., Mar 2003, In : Endocrinology . 144, 3, p. 999-1007 9 p.

    Research output: Contribution to journalArticle

  30. Mass Spectrometry Imaging for Dissecting Steroid Intracrinology within Target Tissues

    Cobice, D. F., Mackay, C. L., Goodwin, R. J. A., McBride, A., Langridge-Smith, P. R., Webster, S. P., Walker, B. R. & Andrew, R., 3 Dec 2013, In : Analytical Chemistry. 85, 23, p. 11576-11584 9 p.

    Research output: Contribution to journalArticle

  31. Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging

    Cobice, D. F., Livingstone, D. E. W., Mackay, C. L., Goodwin, R. J. A., Smith, L. B., Walker, B. R. & Andrew, R., 27 Sep 2016, In : Analytical Chemistry. 88, 21

    Research output: Contribution to journalArticle

  32. Estrogens protect male mice from obesity complications and influence glucocorticoid metabolism

    Dakin, R. S., Walker, B., Seckl, J. R., Hadoke, P. W. F. & Drake, A. J., 30 Jun 2015, In : International Journal of Obesity.

    Research output: Contribution to journalArticle

  33. Maternal Diet-Induced Obesity in C57BL/6 Mice Alters Vascular Function in Their Offspring but Not Metabolism or Vascular Remodelling after Intravascular Injury

    Dakin, R. S., Hadoke, P. W. F., Walker, B. R., Seckl, J. R. & Drake, A. J., Sep 2011, In : Journal of Developmental Origins of Health and Disease. 2, p. S39-S40 2 p.

    Research output: Contribution to journalMeeting abstract

  34. The prevalence of structural pituitary abnormalities by MRI scanning in men presenting with isolated hypogonadotrophic hypogonadism

    Dalvi, M., Walker, B. R., Strachan, M. W. J., Zammitt, N. N. & Gibb, F. W., May 2016, In : Clinical Endocrinology. 84, 6, p. 858–861

    Research output: Contribution to journalArticle

  35. Inhibition or deletion of 11Β-HSD1 does not increase angiogenesis in ischemic retinopathy

    Davidson, C. T., Dover, A. R., McVicar, C. M., Megaw, R., Glenn, J. V., Hadoke, P. W. F., Stitt, A. W. & Walker, B. R., 11 Jan 2017, In : Diabetes and Metabolism.

    Research output: Contribution to journalArticle

  36. Accounting for fluctuations in a lattice model of microemulsions

    Dawson, K. A., Walker, B. L. & Berera, A., 1 Jun 1990, In : Physica a-Statistical mechanics and its applications. 165, 3, p. 320-351 32 p.

    Research output: Contribution to journalArticle

  37. Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD 11B1) and lifetime cognitive change

    Deary, I. J., Hayward, C., Permana, P. A., Nair, S., Whalley, L. J., Starr, J., Chapman, K. E., Walker, B. R. & Seckl, J. R., 23 Jan 2006, In : Neuroscience Letters. 393, 1, p. 74-77 4 p.

    Research output: Contribution to journalArticle

  38. Acute effects of glucocorticoids on endothelial fibrinolytic and vasodilator function in humans

    Dover, A. R., Hadoke, P. W. F., Walker, B. R. & Newby, D. E., 2007, In : Journal of cardiovascular pharmacology. 50, 3, p. 321-6 6 p.

    Research output: Contribution to journalArticle

  39. Intravascular glucocorticoid metabolism during inflammation and injury in mice

    Dover, A. R., Hadoke, P. W. F., Macdonald, L. J., Miller, E., Newby, D. E. & Walker, B. R., 2007, In : Endocrinology . 148, 1, p. 166-72 7 p.

    Research output: Contribution to journalArticle

  40. Prenatal Dexamethasone Programs Expression of Genes in Liver and Adipose Tissue and Increased Hepatic Lipid Accumulation But Not Obesity on a High-Fat Diet

    Drake, A. J., Raubenheimer, P. J., Kerrigan, D., McInnes, K. J., Seckl, J. R. & Walker, B. R., Apr 2010, In : Endocrinology. 151, 4, p. 1581-1587 7 p.

    Research output: Contribution to journalArticle

  41. The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk

    Drake, A. J. & Walker, B. R., Jan 2004, In : Journal of Endocrinology. 180, 1, p. 1-16 16 p.

    Research output: Contribution to journalArticle

  42. Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats

    Drake, A. J., Walker, B. R. & Seckl, J. R., Jan 2005, In : American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 288, 1, p. R34-R38 5 p.

    Research output: Contribution to journalArticle

  43. Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases

    Finken, M. J., Andrews, R. C., Andrew, R. & Walker, B. R., 1999, In : Journal of Clinical Endocrinology & Metabolism. 84, 9, p. 3316-21 6 p.

    Research output: Contribution to journalArticle

  44. A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid

    Forbes, S., Godsland, I. F., Taylor-Robinson, S. D., Bell, J. D., Thomas, E. L., Patel, N., Hamilton, G., Parker, K. H., Marshall, I., Gray, C. D., Bedford, D., Caslake, M., Walker, B. R. & Johnston, D. G., Sep 2013, In : Diabetologia. 56, 9, p. 2021-2033 13 p.

    Research output: Contribution to journalArticle

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