Edinburgh Research Explorer

Brian Walker

(Former employee or visitor)

  1. 2020
  2. Long-term stability of cortisol production and metabolism throughout adolescence: longitudinal twin study

    van Keulen, B. J., Dolan, C. V., Andrew, R., Walker, B., Hulshoff Pol, H. E., Boomsma, D. I., Rotteveel, J. & Finken, M. JJ., 25 Mar 2020, In : Twin Research and Human Genetics.

    Research output: Contribution to journalArticle

  3. 2019
  4. Heritability of cortisol production and metabolism throughout adolescence: a twin study

    van Keulen, B. J., Dolan, C. V., Andrew, R., Walker, B., Hulshoff Pol, H. E., Boomsma, D. I., Rotteveel, J. & finken, M. JJ., 14 Oct 2019, In : Journal of Clinical Endocrinology & Metabolism.

    Research output: Contribution to journalArticle

  5. Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study

    Wei, L., Chia-Cheng Lai, E., Kao-Yang, Y-H., Walker, B. R., MacDonald, T. M. & Andrew, R., 10 Apr 2019, In : British Medical Journal (BMJ). 365, 8196, 11 p., l1204.

    Research output: Contribution to journalArticle

  6. Higher Insulin Resistance and Adiposity in Postmenopausal Women With Breast Cancer Treated With Aromatase Inhibitors

    Gibb, F., Dixon, M. J., Clarke, C., Homer, N., Faqehi, A., Andrew, R. & Walker, B., 28 Mar 2019, In : Journal of Clinical Endocrinology & Metabolism. 104, 9, p. 3670–3678

    Research output: Contribution to journalArticle

  7. 2018
  8. Species-specific regulation of angiogenesis by glucocorticoids reveals contrasting effects on inflammatory and angiogenic pathways

    Morgan, R., Keen, J., Halligan, D., O'Callaghan, A., Andrew, R., Livingstone, D., Livingstone, D., Abernethie, A., Maltese, G., Walker, B. & Hadoke, P., 15 Feb 2018, In : PLoS ONE. 13, 2, e0192746.

    Research output: Contribution to journalArticle

  9. 2017
  10. Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia

    Alwashih, M. A., Watson, D. G., Andrew, R., Stimson, R. H., Alossaimi, M., Blackburn, G. & Walker, B. R., 6 Dec 2017, In : Scientific Reports. 7, 1, p. 17092

    Research output: Contribution to journalArticle

  11. Development of a Bayesian response-adaptive trial design for the Dexamethasone for Excessive Menstruation study

    Holm Hansen, C., Warner, P., Parker, R. A., Walker, B. R., Critchley, H. O. D. & Weir, C. J., 1 Dec 2017, In : Statistical Methods in Medical Research.

    Research output: Contribution to journalArticle

  12. Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis

    Homer, N., Kothiya, S., Rutter, A., Walker, B. & Andrew, R., Dec 2017, In : Analytical Biochemistry. 538

    Research output: Contribution to journalArticle

  13. Hair cortisol in twins: Heritability and genetic overlap with psychological variables and stress-system genes

    Rietschel, L., Streit, F., Zhu, G., McAloney, K., Frank, J., Couvy-Duchesne, B., Witt, S. H., Binz, T., McGrath, J. J., Hickie, I. B., Hansell, N. K., Wright, M. J., Gillespie, N., Forstner, A. J., Schulze, T. G., Wust, S., Nöthen, M. M., Baumgartner, M., Walker, B., Crawford, A. & 4 others, Colodro-Conde, L., Medland, S. E., Martin, N. G. & Rietschel, M., 10 Nov 2017, In : Scientific Reports.

    Research output: Contribution to journalArticle

  14. The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels

    Neumann, A., Direk, N., Crawford, A. A., Mirza, S., Adams, H., Bolton, J., Hayward, C., Strachan, D. P., Payne, E. K., Smith, J. A., Milaneschi, Y., Penninx, B., Hottenga, J. J., de Geus, E., Oldehinkel, A. J., van der Most, P. J., de Rijke, Y., Walker, B. R. & Tiemeier, H., Nov 2017, In : Psychoneuroendocrinology. 85, p. 88-95 8 p.

    Research output: Contribution to journalArticle

  15. Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans

    Alwashih, M. A., Stimson, R., Andrew, R., Walker, B. & Watson, D. G., 13 Sep 2017, In : Scientific Reports.

    Research output: Contribution to journalArticle

  16. Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity

    Morgan, R. A., Beck, K. R., Nixon, M., Homer, N. Z. M., Crawford, A. A., Melchers, D., Houtman, R., Meijer, O. C., Stomby, A., Anderson, A. J., Upreti, R., Stimson, R. H., Olsson, T., Michoel, T., Cohain, A., Ruusalepp, A., Schadt, E. E., Björkegren, J. L. M., Andrew, R., Kenyon, C. J. & 4 others, Hadoke, P. W. F., Odermatt, A., Keen, J. A. & Walker, B. R., 6 Sep 2017, In : Scientific Reports. 7, 1, 10633.

    Research output: Contribution to journalArticle

  17. 11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI

    Mylonas, K. J., Turner, N. A., Bageghni, S. A., Kenyon, C. J., White, C. I., McGregor, K., Kimmitt, R. A., Sulston, R., Kelly, V., Walker, B. R., Porter, K. E., Chapman, K. E. & Gray, G. A., 1 Jun 2017, In : Journal of Endocrinology. 233, 3, p. 315-327 13 p.

    Research output: Contribution to journalArticle

  18. Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

    Tachmazidou, I., Süveges, D., Min, J. L., Ritchie, G. R. S., Steinberg, J., Walter, K., Iotchkova, V., Schwartzentruber, J., Huang, J., Memari, Y., Mccarthy, S., Crawford, A. A., Bombieri, C., Cocca, M., Farmaki, A., Gaunt, T. R., Jousilahti, P., Kooijman, M. N., Lehne, B., Malerba, G. & 83 others, Männistö, S., Matchan, A., Medina-gomez, C., Metrustry, S. J., Nag, A., Ntalla, I., Paternoster, L., Rayner, N. W., Sala, C., Scott, W. R., Shihab, H. A., Southam, L., St Pourcain, B., Traglia, M., Trajanoska, K., Zaza, G., Zhang, W., Artigas, M. S., Bansal, N., Benn, M., Chen, Z., Danecek, P., Lin, W., Locke, A., Luan, J., Manning, A. K., Mulas, A., Sidore, C., Tybjaerg-hansen, A., Varbo, A., Zoledziewska, M., Finan, C., Hatzikotoulas, K., Hendricks, A. E., Kemp, J. P., Moayyeri, A., Panoutsopoulou, K., Szpak, M., Wilson, S. G., Boehnke, M., Cucca, F., Di Angelantonio, E., Langenberg, C., Lindgren, C., Mccarthy, M. I., Morris, A. P., Nordestgaard, B. G., Scott, R. A., Tobin, M. D., Wareham, N. J., Burton, P., Chambers, J. C., Smith, G. D., Dedoussis, G., Felix, J. F., Franco, O. H., Gambaro, G., Gasparini, P., Hammond, C. J., Hofman, A., Jaddoe, V. W. V., Kleber, M., Kooner, J. S., Perola, M., Relton, C., Ring, S. M., Rivadeneira, F., Salomaa, V., Spector, T. D., Stegle, O., Toniolo, D., Uitterlinden, A. G., Barroso, I., Greenwood, C. M. T., Perry, J. R. B., Walker, B. R., Butterworth, A. S., Xue, Y., Durbin, R., Small, K. S., Soranzo, N., Timpson, N. J. & Zeggini, E., 1 Jun 2017, In : American Journal of Human Genetics. 100, 6, p. 865-884

    Research output: Contribution to journalArticle

  19. Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™)

    Webster, S. P., McBride, A., Binnie, M., Sooy, K., Seckl, J. R., Andrew, R., Pallin, T. D., Hunt, H. J., Perrior, T. R., Ruffles, V. S., Ketelbey, J. W., Boyd, A. & Walker, B. R., Mar 2017, In : British Journal of Pharmacology.

    Research output: Contribution to journalArticle

  20. Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct

    Stimson, R. H., Anderson, A. J., Lynne, R., Macfarlane, D. P., de Beaux, A. C., Mole, D. J., Andrew, R. & Walker, B. R., 8 Feb 2017, In : Diabetes Obesity & Metabolism.

    Research output: Contribution to journalArticle

  21. Safer topical treatment for inflammation using 5α-tetrahydrocorticosterone in mouse models

    Gastaldello, A., Livingstone, D. E. W., Abernethie, A. J., Tsang, N., Walker, B. R., Hadoke, P. W. F. & Andrew, R., 24 Jan 2017, In : Biochemical Pharmacology. 129, p. 73–84

    Research output: Contribution to journalArticle

  22. Inhibition or deletion of 11Β-HSD1 does not increase angiogenesis in ischemic retinopathy

    Davidson, C. T., Dover, A. R., McVicar, C. M., Megaw, R., Glenn, J. V., Hadoke, P. W. F., Stitt, A. W. & Walker, B. R., 11 Jan 2017, In : Diabetes and Metabolism.

    Research output: Contribution to journalArticle

  23. Metabolic dysfunction in female mice with disruption of 5α-reductase 1

    Livingstone, D. E. W., Di Rollo, E. M., Mak, T. C-S., Sooy, K., Walker, B. R. & Andrew, R., Jan 2017, In : Journal of Endocrinology. 232, 1, p. 29-36

    Research output: Contribution to journalArticle

  24. 2016
  25. Genome-wide associations for birth weight and correlations with adult disease

    Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-tajes, J., Feenstra, B., Van Zuydam, N. R., Gaulton, K. J., Grarup, N., Bradfield, J. P., Strachan, D. P., Li-gao, R., Ahluwalia, T. S., Kreiner, E., Rueedi, R., Lyytikäinen, L., Cousminer, D. L., Wu, Y., Thiering, E. & 32 others, Wang, C. A., Have, C. T., Hottenga, J-J., Vilor-Tejedor, N., Joshi, P. K., Boh, E. T. H., Ntalla, I., Pitkänen, N., Mahajan, A., van Leeuwen, E. M., Joro, R., Lagou, V., Nodzenski, M., Diver, L. A., Zondervan, K. T., Bustamante, M., Marques-Vidal, P., Mercader, J. M., Bennett, A. J., Rahmioglu, N., Nyholt, D. R., Ma, R. C. W., Tam, C. H. T., Tam, W. H., CHARGE Consortium Hematology Working Group, Ganesh, S. K., Van Rooij, F. J. A., Reynolds, R. M., Early Growth Genetics (EGG) consortium, Campbell, H., Wilson, J. F. & Walker, B. R., 13 Oct 2016, In : Nature. 538, 7624, p. 248-252 5 p.

    Research output: Contribution to journalArticle

  26. Vascular Dysfunction in Horses with Endocrinopathic Laminitis

    Morgan, R. A., Keen, J. A., Walker, B. R. & Hadoke, P. W. F., 29 Sep 2016, In : PLoS ONE. 11, 9, e0163815.

    Research output: Contribution to journalArticle

  27. Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging

    Cobice, D. F., Livingstone, D. E. W., Mackay, C. L., Goodwin, R. J. A., Smith, L. B., Walker, B. R. & Andrew, R., 27 Sep 2016, In : Analytical Chemistry. 88, 21

    Research output: Contribution to journalArticle

  28. Metformin increases cortisol regeneration by 11βHSD1 in obese men with and without type 2 diabetes mellitus

    Anderson, A. J., Andrew, R., Homer, N. Z., Jones, G. C., Smith, K., Livingstone, D. E., Walker, B. R. & Stimson, R. H., 26 Jul 2016, In : Journal of Clinical Endocrinology & Metabolism. p. jc20162069

    Research output: Contribution to journalArticle

  29. Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation

    Ramage, L. E., Akyol, M., Fletcher, A. M., Forsythe, J., Nixon, M., Carter, R. N., van Beek, E. J. R., Morton, N. M., Walker, B. R. & Stimson, R. H., 12 Jul 2016, In : Cell Metabolism. 24, 1, p. 130-41 12 p.

    Research output: Contribution to journalArticle

  30. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness

    Morton, N. M., Beltram, J., Carter, R. N., Michailidou, Z., Gorjanc, G., McFadden, C., Barrios-Llerena, M. E., Rodriguez-Cuenca, S., Gibbins, M. T. G., Aird, R. E., Moreno-Navarrete, J. M., Munger, S. C., Svenson, K. L., Gastaldello, A., Ramage, L., Naredo, G., Zeyda, M., Wang, Z. V., Howie, A. F., Saari, A. & 13 others, Sipilä, P., Stulnig, T. M., Gudnason, V., Kenyon, C. J., Seckl, J. R., Walker, B. R., Webster, S. P., Dunbar, D. R., Churchill, G. A., Vidal-Puig, A., Fernandez-Real, J. M., Emilsson, V. & Horvat, S., Jul 2016, In : Nature Medicine. 22, 7, p. 771-779 9 p.

    Research output: Contribution to journalArticle

  31. Adrenal insufficiency in patients on long-term opioid analgesia

    Gibb, F. W., Stewart, A., Walker, B. R. & Strachan, M. W. J., 4 Jun 2016, In : Clinical Endocrinology.

    Research output: Contribution to journalArticle

  32. The prevalence of structural pituitary abnormalities by MRI scanning in men presenting with isolated hypogonadotrophic hypogonadism

    Dalvi, M., Walker, B. R., Strachan, M. W. J., Zammitt, N. N. & Gibb, F. W., May 2016, In : Clinical Endocrinology. 84, 6, p. 858–861

    Research output: Contribution to journalArticle

  33. Aromatase Inhibition Reduces Insulin Sensitivity in Healthy Men

    Gibb, F. W., Homer, N. Z. M., Faqehi, A. M. M., Upreti, R., Livingstone, D. E., Mcinnes, K. J., Andrew, R. & Walker, B. R., 11 Mar 2016, In : Journal of Clinical Endocrinology & Metabolism. p. jc.2015-4146

    Research output: Contribution to journalArticle

  34. Systematic review and meta-analysis reveals acutely elevated plasma cortisol following fasting but not less severe calorie restriction

    Nakamura, Y., Walker, B. R. & Ikuta, T., 7 Jan 2016, In : Stress. p. 1-7

    Research output: Contribution to journalArticle

  35. 2015
  36. Clinical research: developing an appropriate career structure

    Mellanby, R. J., Price, J., Wooldridge, L., Jonsson, N. N., Clegg, P. D., Emes, R. D., England, G., Corr, S. A., Piercy, R. J., Mulcahy, G., Wood, J. L., Walker, B. R. & Argyle, D. J., 28 Nov 2015, In : Veterinary Record. 177, 21, p. 544-7 4 p.

    Research output: Contribution to journalArticle

  37. Controlling cortisol's contribution to degenerative disease

    Walker, B. R., Nov 2015, In : Psychoneuroendocrinology. 61, p. 1

    Research output: Contribution to journalMeeting abstract

  38. When two glucocorticoids are better than one: 'Relative corticosterone deficiency' in human metabolic syndrome

    Mackenzie, S., Nixon, M., Taylor, A., Reynolds, R., Bolton, J., Hayward, C., Wilson, J., Philips, D., Homer, N., Andrew, R. & Walker, B., Nov 2015, In : Psychoneuroendocrinology. 61, p. 29-29 1 p.

    Research output: Contribution to journalMeeting abstract

  39. Health Behaviours during Pregnancy in Women with Very Severe Obesity

    Mohd-Shukri, N. A., Duncan, A., Denison, F. C., Forbes, S., Walker, B. R., Norman, J. E. & Reynolds, R. M., 7 Oct 2015, In : Nutrients. 7, 10, p. 8431-43 13 p.

    Research output: Contribution to journalArticle

  40. Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial

    Chiswick, C., Reynolds, R. M., Denison, F., Drake, A. J., Forbes, S., Newby, D. E., Walker, B. R., Quenby, S., Wray, S., Weeks, A., Lashen, H., Rodriguez, A., Murray, G., Whyte, S. & Norman, J. E., Oct 2015, In : The Lancet Diabetes and Endocrinology.

    Research output: Contribution to journalArticle

  41. Decreased maternal hypothalamic-pituitary-adrenal axis activity in very severely obese pregnancy: Associations with birthweight and gestation at delivery

    Stirrat, L. I., O'Reilly, J. R., Barr, S. M., Andrew, R., Riley, S. C., Howie, A. F., Bowman, M., Smith, R., Lewis, J. G., Denison, F. C., Forbes, S., Seckl, J. R., Walker, B. R., Norman, J. E. & Reynolds, R. M., 25 Sep 2015, In : Psychoneuroendocrinology. 63, p. 135-143 9 p.

    Research output: Contribution to journalArticle

  42. Estrogens protect male mice from obesity complications and influence glucocorticoid metabolism

    Dakin, R. S., Walker, B., Seckl, J. R., Hadoke, P. W. F. & Drake, A. J., 30 Jun 2015, In : International Journal of Obesity.

    Research output: Contribution to journalArticle

  43. Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography

    Kirkby, N. S., Low, L., Wu, J., Miller, E., Seckl, J. R., Walker, B. R., Webb, D. J. & Hadoke, P. W. F., 26 May 2015, In : Journal of Visualized Experiments (JoVE). 99, p. e50627

    Research output: Contribution to journalArticle

  44. Diet-induced weight loss has chronic tissue-specific effects on glucocorticoid metabolism in overweight postmenopausal women

    Stomby, A., Simonyte, K., Mellberg, C., Ryberg, M., Stimson, R. H., Larsson, C., Lindahl, B., Andrew, R., Walker, B. R. & Olsson, T., May 2015, In : International Journal of Obesity. 39, 5, p. 814-9 6 p.

    Research output: Contribution to journalArticle

  45. Hypothalamic Pituitary Adrenal Axis Hormones Are Reduced in Obese Pregnancy

    Stirrat, L., O'Reilly, J., Riley, S., Howie, A., Bowman, M., Smith, R., Lewis, J., Walker, B., Norman, J. & Reynolds, R., Mar 2015, In : Reproductive Sciences. 22, p. 58A-58A 1 p.

    Research output: Contribution to journalMeeting abstract

  46. 11β-Hydroxysteroid Dehydrogenase Activity in the Brain Does Not Contribute to Systemic Interconversion of Cortisol and Cortisone in Healthy Men

    Kilgour, A. H. M., Semple, S., Marshall, I., Andrews, P., Andrew, R. & Walker, B. R., Feb 2015, In : Journal of Clinical Endocrinology & Metabolism. 100, 2, p. 483-489 7 p.

    Research output: Contribution to journalArticle

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