Edinburgh Research Explorer

Brian Walker

(Former employee or visitor)

  1. Article › Research › Peer-reviewed
  2. 11 beta HSD1-/- mice have enhanced angiogenic response and improved myodardial function following coronary artery ligation

    Small, G. R., Hadoke, P. W. F., Gray, G. A., Sharif, I., Mullins, J. J., Seckl, J. R. & Walker, B. R., Oct 2004, In : Hypertension. 44, 4, p. 587-587 1 p.

    Research output: Contribution to journalArticle

  3. 11 beta-Hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

    Sandeep, T. C., Yau, J. L. W., MacLullich, A. M. J., Noble, J., Deary, I. J., Walker, B. R. & Seckl, J. R., 27 Apr 2004, In : Proceedings of the National Academy of Sciences (PNAS). 101, 17, p. 6734-6739 6 p.

    Research output: Contribution to journalArticle

  4. 11 beta-Hydroxysteroid dehydrogenase type 1 is a predominant 11 beta-reductase in the intact perfused rat liver

    Jamieson, P. M., Walker, B. R., Chapman, K. E., Andrew, R., Rossiter, S. & Seckl, J. R., Jun 2000, In : Journal of Endocrinology. 165, 3, p. 685-692 8 p.

    Research output: Contribution to journalArticle

  5. 11 beta-hydroxysteroid dehydrogenase type 2 in mouse aorta - Localization and influence on response to glucocorticoids

    Christy, C., Hadoke, P. W. F., Paterson, J. M., Mullins, J. J., Seckl, J. R. & Walker, B. R., Oct 2003, In : Hypertension. 42, 4, p. 580-587 8 p.

    Research output: Contribution to journalArticle

  6. 11β-HSD1 inhibitors for the treatment of type 2 diabetes and cardiovascular disease

    Anderson, A. & Walker, B. R., Sep 2013, In : Drugs. 73, 13, p. 1385-1393 9 p.

    Research output: Contribution to journalArticle

  7. 11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI

    Mylonas, K. J., Turner, N. A., Bageghni, S. A., Kenyon, C. J., White, C. I., McGregor, K., Kimmitt, R. A., Sulston, R., Kelly, V., Walker, B. R., Porter, K. E., Chapman, K. E. & Gray, G. A., 1 Jun 2017, In : Journal of Endocrinology. 233, 3, p. 315-327 13 p.

    Research output: Contribution to journalArticle

  8. 11β-Hydroxysteroid Dehydrogenase Activity in the Brain Does Not Contribute to Systemic Interconversion of Cortisol and Cortisone in Healthy Men

    Kilgour, A. H. M., Semple, S., Marshall, I., Andrews, P., Andrew, R. & Walker, B. R., Feb 2015, In : Journal of Clinical Endocrinology & Metabolism. 100, 2, p. 483-489 7 p.

    Research output: Contribution to journalArticle

  9. 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo

    Mitic, T., Shave, S., Semjonous, N., McNae, I., Cobice, D. F., Lavery, G. G., Webster, S. P., Hadoke, P. W. F., Walker, B. R. & Andrew, R., 1 Jul 2013, In : Biochemical Pharmacology. 86, 1, p. 146-153 8 p.

    Research output: Contribution to journalArticle

  10. 11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

    Kipari, T., Hadoke, P. W. F., Iqbal, J., Man, T-Y., Miller, E., Coutinho, A. E., Zhang, Z., Sullivan, K. M., Mitic, T., Livingstone, D. E. W., Schrecker, C., Samuel, K., White, C. I., Bouhlel, M. A., Chinetti-Gbaguidi, G., Staels, B., Andrew, R., Walker, B. R., Savill, J. S., Chapman, K. E. & 1 others, Seckl, J. R., Apr 2013, In : The FASEB Journal. 27, 4, p. 1519-1531 13 p.

    Research output: Contribution to journalArticle

  11. 11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline

    MacLullich, A. M. J., Ferguson, K. J., Reid, L. M., Deary, I. J., Starr, J., Wardlaw, J. M., Walker, B. R., Andrew, R. & Seckl, J. R., Jan 2012, In : Neurobiology of Aging. 33, 1, p. 207.e1–207.e8 8 p.

    Research output: Contribution to journalArticle

  12. 19F-magnetic resonance spectroscopy as a tool to quantify 11[beta]-hydroxysteroid dehydrogenase activity in vivo

    Naredo-Gonzalez, G., Jansen, M., Upreti, R., Semple, S., Merrifield, G., Sutcliffe, O., Hansen, M., Marshall, I., Andrew, R. & Walker, B., 2013, In : Endocrine Abstracts. p. 1-1

    Research output: Contribution to journalArticle

  13. 5 alpha-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents

    Livingstone, D. E. W., Barat, P., Di Rollo, E. M., Rees, G. A., Weldin, B. A., Rog-Zielinska, E. A., MacFarlane, D. P., Walker, B. R. & Andrew, R., 22 Jan 2015, In : Diabetes . 64, 2, p. 447-458 12 p.

    Research output: Contribution to journalArticle

  14. 5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor

    McInnes, K. J., Kenyon, C. J., Chapman, K. E., Livingstone, D. E. W., Macdonald, L. J., Walker, B. R. & Andrew, R., 2004, In : Journal of Biological Chemistry. 279, 22, p. 22908-12 5 p.

    Research output: Contribution to journalArticle

  15. 5α-Reductase type 1 modulates insulin sensitivity in men

    Upreti, R., Hughes, K. A., Livingstone, D. E. W., Gray, C. D., Minns, F. C., Macfarlane, D. P., Marshall, I., Stewart, L. H., Walker, B. R. & Andrew, R., Aug 2014, In : Journal of Clinical Endocrinology & Metabolism. 99, 8, p. E1397-E1406 10 p.

    Research output: Contribution to journalArticle

  16. 5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects

    Yang, CHENYING., Nixon, M., Kenyon, C. J., Livingstone, D. E. W., Duffin, R., Rossi, A. G., Walker, B. R. & Andrew, R., 2011, In : British Journal of Pharmacology. 164, 6, p. 1661-71 11 p.

    Research output: Contribution to journalArticle

  17. A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet

    Raubenheimer, P. J., Nyirenda, M. J. & Walker, B. R., 2006, In : Diabetes . 55, 7, p. 2015-20 6 p.

    Research output: Contribution to journalArticle

  18. A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome

    Gambineri, A., Tomassoni, F., Munarini, A., Stimson, R. H., Mioni, R., Pagotto, U., Chapman, K. E., Andrew, R., Mantovani, V., Pasquali, R. & Walker, B. R., 2011, In : European Journal of Endocrinology. 165, 2, p. 283-92 10 p.

    Research output: Contribution to journalArticle

  19. A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid

    Forbes, S., Godsland, I. F., Taylor-Robinson, S. D., Bell, J. D., Thomas, E. L., Patel, N., Hamilton, G., Parker, K. H., Marshall, I., Gray, C. D., Bedford, D., Caslake, M., Walker, B. R. & Johnston, D. G., Sep 2013, In : Diabetologia. 56, 9, p. 2021-2033 13 p.

    Research output: Contribution to journalArticle

  20. ATHEROPROTECTION BY 11B-HSD1 INHIBITION IN APOLIPOPROTEIN E KNOCKOUT MICE IS ASSOCIATED WITH LOWERING OF BLOOD PRESSURE

    Iqbal, J., Sullivan, K., Livingstone, D. E., Andrew, R., Walker, B. R. & Hadoke, P. W. F., Jun 2009, In : Heart. 95, p. A61-A61 1 p.

    Research output: Contribution to journalArticle

  21. Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance

    Andrews, R. C., Herlihy, O., Livingstone, D. E. W., Andrew, R. & Walker, B. R., 2002, In : Journal of Clinical Endocrinology & Metabolism. 87, 12, p. 5587-93 7 p.

    Research output: Contribution to journalArticle

  22. Accounting for fluctuations in a lattice model of microemulsions

    Dawson, K. A., Walker, B. L. & Berera, A., 1 Jun 1990, In : Physica a-Statistical mechanics and its applications. 165, 3, p. 320-351 32 p.

    Research output: Contribution to journalArticle

  23. Activation of the Hypothalamic-Pituitary-Adrenal Axis in Adults With Mineralocorticoid Receptor Haploinsufficiency

    Walker, B. R., Andrew, R., Escoubet, B. & Zennaro, M-C., Aug 2014, In : Journal of Clinical Endocrinology & Metabolism. 99, 8, p. E1586-E1591 6 p.

    Research output: Contribution to journalArticle

  24. Acute effects of glucocorticoids on endothelial fibrinolytic and vasodilator function in humans

    Dover, A. R., Hadoke, P. W. F., Walker, B. R. & Newby, D. E., 2007, In : Journal of cardiovascular pharmacology. 50, 3, p. 321-6 6 p.

    Research output: Contribution to journalArticle

  25. Acute in vivo regulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by insulin and intralipid infusions in humans

    Wake, D. J., Homer, N. Z. M., Andrew, R. & Walker, B. R., 2006, In : Journal of Clinical Endocrinology & Metabolism. 91, 11, p. 4682-8 7 p.

    Research output: Contribution to journalArticle

  26. Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans

    Alwashih, M. A., Stimson, R., Andrew, R., Walker, B. & Watson, D. G., 13 Sep 2017, In : Scientific Reports.

    Research output: Contribution to journalArticle

  27. Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct

    Stimson, R. H., Anderson, A. J., Lynne, R., Macfarlane, D. P., de Beaux, A. C., Mole, D. J., Andrew, R. & Walker, B. R., 8 Feb 2017, In : Diabetes Obesity & Metabolism.

    Research output: Contribution to journalArticle

  28. Adrenal insufficiency in patients on long-term opioid analgesia

    Gibb, F. W., Stewart, A., Walker, B. R. & Strachan, M. W. J., 4 Jun 2016, In : Clinical Endocrinology.

    Research output: Contribution to journalArticle

  29. Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome - Nested case-control study

    Brunner, E. J., Hemingway, H., Walker, B. R., Page, M., Clarke, P., Juneja, M., Shipley, M. J., Kumari, M., Andrew, R., Seckl, J. R., Papadopoulos, A., Checkley, S., Rumley, A., Lowe, G. D. O., Stansfeld, S. A. & Marmot, M. G., 19 Nov 2002, In : Circulation. 106, 21, p. 2659-2665 7 p.

    Research output: Contribution to journalArticle

  30. Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors

    Reynolds, R. M., Walker, B. R., Syddall, H. E., Andrew, R., Wood, P. J., Whorwood, C. B. & Phillips, D. I., 2001, In : Journal of Clinical Endocrinology & Metabolism. 86, 1, p. 245-50 6 p.

    Research output: Contribution to journalArticle

  31. Altered peripheral sensitivity to glucocorticoids in primary open-angle glaucoma

    Stokes, J., Walker, B. R., Campbell, J. C., Seckl, J. R., O'Brien, C. & Andrew, R., Dec 2003, In : Investigative Ophthalmology & Visual Science. 44, 12, p. 5163-5167 5 p.

    Research output: Contribution to journalArticle

  32. Altered vascular contractility in adult female rats with hypertension programmed by prenatal glucocorticoid exposure

    Hadoke, P. W. F., Lindsay, R. S., Seckl, J. R., Walker, B. R. & Kenyon, C. J., Mar 2006, In : Journal of Endocrinology. 188, 3, p. 435-442 8 p.

    Research output: Contribution to journalArticle

  33. Apparent cortisone reductase deficiency: a functional defect in 11beta-hydroxysteroid dehydrogenase type 1

    Jamieson, A., Wallace, A. M., Andrew, R., Nunez, B. S., Walker, B. R., Fraser, R., White, P. C. & Connell, J. M., 1999, In : Journal of Clinical Endocrinology & Metabolism. 84, 10, p. 3570-4 5 p.

    Research output: Contribution to journalArticle

  34. Aromatase Inhibition Reduces Insulin Sensitivity in Healthy Men

    Gibb, F. W., Homer, N. Z. M., Faqehi, A. M. M., Upreti, R., Livingstone, D. E., Mcinnes, K. J., Andrew, R. & Walker, B. R., 11 Mar 2016, In : Journal of Clinical Endocrinology & Metabolism. p. jc.2015-4146

    Research output: Contribution to journalArticle

  35. Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice

    McNeilly, A. D., Macfarlane, D. P., O'Flaherty, E., Livingstone, D. E., Mitić, T., McConnell, K. M., McKenzie, S. M., Davies, E., Reynolds, R. M., Thiesson, H. C., Skøtt, O., Walker, B. R. & Andrew, R., May 2010, In : Journal of Hepatology. 52, 5, p. 705-711 7 p.

    Research output: Contribution to journalArticle

  36. Body fat distribution and cortisol metabolism in healthy men: Enhanced 5 beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver

    Westerbacka, J., Yki-Jarvinen, H., Vehkavaara, S., Hakkinen, A. M., Andrew, R., Wake, D. J., Seckl, J. R. & Walker, B. R., 1 Oct 2003, In : Journal of Clinical Endocrinology & Metabolism. 88, 10, p. 4924-4931 8 p.

    Research output: Contribution to journalArticle

  37. Can cortisol predict the future in obesity?

    Reynolds, R. M. & Walker, B. R., 2007, In : Clinical Endocrinology. 67, 1, p. 1-2 2 p.

    Research output: Contribution to journalArticle

  38. Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity

    Morgan, R. A., Beck, K. R., Nixon, M., Homer, N. Z. M., Crawford, A. A., Melchers, D., Houtman, R., Meijer, O. C., Stomby, A., Anderson, A. J., Upreti, R., Stimson, R. H., Olsson, T., Michoel, T., Cohain, A., Ruusalepp, A., Schadt, E. E., Björkegren, J. L. M., Andrew, R., Kenyon, C. J. & 4 others, Hadoke, P. W. F., Odermatt, A., Keen, J. A. & Walker, B. R., 6 Sep 2017, In : Scientific Reports. 7, 1, 10633.

    Research output: Contribution to journalArticle

  39. Circulating plasma cortisol concentrations are not associated with coronary artery disease or peripheral vascular disease

    Reynolds, R. M., Ilyas, B., Price, J. F., Fowkes, F. G. R., Newby, D. E., Webb, D. J. & Walker, B. R., Jul 2009, In : QJM: An International Journal of Medicine. 102, 7, p. 469-475 7 p.

    Research output: Contribution to journalArticle

  40. Clinical research: developing an appropriate career structure

    Mellanby, R. J., Price, J., Wooldridge, L., Jonsson, N. N., Clegg, P. D., Emes, R. D., England, G., Corr, S. A., Piercy, R. J., Mulcahy, G., Wood, J. L., Walker, B. R. & Argyle, D. J., 28 Nov 2015, In : Veterinary Record. 177, 21, p. 544-7 4 p.

    Research output: Contribution to journalArticle

  41. Combined Receptor Antagonist Stimulation of the Hypothalamic-Pituitary-Adrenal Axis Test Identifies Impaired Negative Feedback Sensitivity to Cortisol in Obese Men

    Mattsson, C., Reynolds, R. M., Simonyte, K., Olsson, T. & Walker, B. R., Apr 2009, In : Journal of Clinical Endocrinology & Metabolism. 94, 4, p. 1347-1352 6 p.

    Research output: Contribution to journalArticle

  42. Contrasting effects of intrauterine growth retardation and premature delivery on adult cortisol secretion and metabolism in man

    Walker, B. R., Irving, R. J., Andrew, R. & Belton, N. R., 2002, In : Clinical Endocrinology. 57, 3, p. 351-5 5 p.

    Research output: Contribution to journalArticle

  43. Contribution of Endogenous Glucocorticoids and Their Intravascular Metabolism by 11β-HSDs to Postangioplasty Neointimal Proliferation in Mice

    Iqbal, J., Macdonald, L. J., Low, L., Seckl, J. R., Yau, C. W., Walker, B. R. & Hadoke, P. W. F., Dec 2012, In : Endocrinology . 153, 12, p. 5896-5905 10 p.

    Research output: Contribution to journalArticle

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