Edinburgh Research Explorer

Prof Brian Walker

(Former employee or visitor)

  1. 2019
  2. Heritability of cortisol production and metabolism throughout adolescence: a twin study

    van Keulen, B. J., Dolan, C. V., Andrew, R., Walker, B., Hulshoff Pol, H. E., Boomsma, D. I., Rotteveel, J. & finken, M. JJ., 14 Oct 2019, In : Journal of Clinical Endocrinology & Metabolism.

    Research output: Contribution to journalArticle

  3. Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study

    Wei, L., Chia-Cheng Lai, E., Kao-Yang, Y-H., Walker, B., MacDonald, T. M. & Andrew, R., 10 Apr 2019, In : BMJ. 365.

    Research output: Contribution to journalArticle

  4. Higher Insulin Resistance and Adiposity in Postmenopausal Women With Breast Cancer Treated With Aromatase Inhibitors

    Gibb, F., Dixon, M. J., Clarke, C., Homer, N., Faqehi, A., Andrew, R. & Walker, B., 28 Mar 2019, In : Journal of Clinical Endocrinology & Metabolism. 104, 9, p. 3670–3678

    Research output: Contribution to journalArticle

  5. 2018
  6. Species-specific regulation of angiogenesis by glucocorticoids reveals contrasting effects on inflammatory and angiogenic pathways

    Morgan, R., Keen, J., Halligan, D., O'Callaghan, A., Andrew, R., Livingstone, D., Livingstone, D., Abernethie, A., Maltese, G., Walker, B. & Hadoke, P., 15 Feb 2018, In : PLoS ONE. 13, 2, p. e0192746

    Research output: Contribution to journalArticle

  7. 2017
  8. Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia

    Alwashih, M. A., Watson, D. G., Andrew, R., Stimson, R. H., Alossaimi, M., Blackburn, G. & Walker, B. R., 6 Dec 2017, In : Scientific Reports. 7, 1, p. 17092

    Research output: Contribution to journalArticle

  9. Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis

    Homer, N., Kothiya, S., Rutter, A., Walker, B. & Andrew, R., Dec 2017, In : Analytical Biochemistry. 538

    Research output: Contribution to journalArticle

  10. Hair cortisol in twins: Heritability and genetic overlap with psychological variables and stress-system genes

    Rietschel, L., Streit, F., Zhu, G., McAloney, K., Frank, J., Couvy-Duchesne, B., Witt, S. H., Binz, T., McGrath, J. J., Hickie, I. B., Hansell, N. K., Wright, M. J., Gillespie, N., Forstner, A. J., Schulze, T. G., Wust, S., Nöthen, M. M., Baumgartner, M., Walker, B., Crawford, A. & 4 others, Colodro-Conde, L., Medland, S. E., Martin, N. G. & Rietschel, M., 10 Nov 2017, In : Scientific Reports.

    Research output: Contribution to journalArticle

  11. The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels

    Neumann, A., Direk, N., Crawford, A. A., Mirza, S., Adams, H., Bolton, J., Hayward, C., Strachan, D. P., Payne, E. K., Smith, J. A., Milaneschi, Y., Penninx, B., Hottenga, J. J., de Geus, E., Oldehinkel, A. J., van der Most, P. J., de Rijke, Y., Walker, B. R. & Tiemeier, H., Nov 2017, In : Psychoneuroendocrinology. 85, p. 88-95 8 p.

    Research output: Contribution to journalArticle

  12. Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans

    Alwashih, M. A., Stimson, R., Andrew, R., Walker, B. & Watson, D. G., 13 Sep 2017, In : Scientific Reports.

    Research output: Contribution to journalArticle

  13. Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity

    Morgan, R., Beck, K. R., Nixon, M., Homer, N. Z. M., Crawford, A. A., Melchers, D., Houtman, R., Meijer, O. C., Stomby, A., Anderson, A. J., Upreti, R., Stimson, R. H., Olsson, T., Michoel, T., Cohain, A., Ruusalepp, A., Schadt, E. E., Björkegren, J. L. M., Andrew, R., Kenyon, C. J. & 4 others, Hadoke, P. W. F., Odermatt, A., Keen, J. A. & Walker, B. R., 6 Sep 2017, In : Scientific Reports. 7, 1, p. 10633

    Research output: Contribution to journalArticle

  14. 11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI

    Mylonas, K. J., Turner, N. A., Bageghni, S. A., Kenyon, C. J., White, C. I., McGregor, K., Kimmitt, R. A., Sulston, R., Kelly, V., Walker, B. R., Porter, K. E., Chapman, K. E. & Gray, G. A., 1 Jun 2017, In : Journal of Endocrinology. 233, 3, p. 315-327 13 p.

    Research output: Contribution to journalArticle

  15. Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

    Tachmazidou, I., Süveges, D., Min, J. L., Ritchie, G. R. S., Steinberg, J., Walter, K., Iotchkova, V., Schwartzentruber, J., Huang, J., Memari, Y., Mccarthy, S., Crawford, A. A., Bombieri, C., Cocca, M., Farmaki, A., Gaunt, T. R., Jousilahti, P., Kooijman, M. N., Lehne, B., Malerba, G. & 83 others, Männistö, S., Matchan, A., Medina-gomez, C., Metrustry, S. J., Nag, A., Ntalla, I., Paternoster, L., Rayner, N. W., Sala, C., Scott, W. R., Shihab, H. A., Southam, L., St Pourcain, B., Traglia, M., Trajanoska, K., Zaza, G., Zhang, W., Artigas, M. S., Bansal, N., Benn, M., Chen, Z., Danecek, P., Lin, W., Locke, A., Luan, J., Manning, A. K., Mulas, A., Sidore, C., Tybjaerg-hansen, A., Varbo, A., Zoledziewska, M., Finan, C., Hatzikotoulas, K., Hendricks, A. E., Kemp, J. P., Moayyeri, A., Panoutsopoulou, K., Szpak, M., Wilson, S. G., Boehnke, M., Cucca, F., Di Angelantonio, E., Langenberg, C., Lindgren, C., Mccarthy, M. I., Morris, A. P., Nordestgaard, B. G., Scott, R. A., Tobin, M. D., Wareham, N. J., Burton, P., Chambers, J. C., Smith, G. D., Dedoussis, G., Felix, J. F., Franco, O. H., Gambaro, G., Gasparini, P., Hammond, C. J., Hofman, A., Jaddoe, V. W. V., Kleber, M., Kooner, J. S., Perola, M., Relton, C., Ring, S. M., Rivadeneira, F., Salomaa, V., Spector, T. D., Stegle, O., Toniolo, D., Uitterlinden, A. G., Barroso, I., Greenwood, C. M. T., Perry, J. R. B., Walker, B. R., Butterworth, A. S., Xue, Y., Durbin, R., Small, K. S., Soranzo, N., Timpson, N. J. & Zeggini, E., 1 Jun 2017, In : American Journal of Human Genetics. 100, 6, p. 865-884

    Research output: Contribution to journalArticle

  16. Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™)

    Webster, S. P., McBride, A., Binnie, M., Sooy, K., Seckl, J. R., Andrew, R., Pallin, T. D., Hunt, H. J., Perrior, T. R., Ruffles, V. S., Ketelbey, J. W., Boyd, A. & Walker, B. R., Mar 2017, In : British Journal of Pharmacology.

    Research output: Contribution to journalArticle

  17. Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct

    Stimson, R., Anderson, A. J., Lynne, R., Macfarlane, D. P., de Beaux, A. C., Mole, D., Andrew, R. & Walker, B., 8 Feb 2017, In : Diabetes Obesity & Metabolism.

    Research output: Contribution to journalArticle

  18. Safer topical treatment for inflammation using 5α-tetrahydrocorticosterone in mouse models

    Gastaldello, A., Livingstone, D. E. W., Abernethie, A. J., Tsang, N., Walker, B. R., Hadoke, P. W. F. & Andrew, R., 24 Jan 2017, In : Biochemical Pharmacology. 129, p. 73–84

    Research output: Contribution to journalArticle

  19. Inhibition or deletion of 11Β-HSD1 does not increase angiogenesis in ischemic retinopathy

    Davidson, C., Dover, A., McVicar, C., Megaw, R., Glenn, J., Hadoke, P., Stitt, A. W. & Walker, B., 11 Jan 2017, In : Diabetes and Metabolism.

    Research output: Contribution to journalArticle

  20. Metabolic dysfunction in female mice with disruption of 5α-reductase 1

    Livingstone, D., Di Rollo, E. M., Mak, T. C-S., Sooy, K., Walker, B. & Andrew, R., Jan 2017, In : Journal of Endocrinology. 232, 1, p. 29-36

    Research output: Contribution to journalArticle

  21. 2016
  22. Vascular Dysfunction in Horses with Endocrinopathic Laminitis

    Morgan, R. A., Keen, J. A., Walker, B. R. & Hadoke, P. W. F., 29 Sep 2016, In : PLoS ONE. 11, 9, e0163815.

    Research output: Contribution to journalArticle

  23. Genome-wide associations for birth weight and correlations with adult disease

    Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-tajes, J., Feenstra, B., Van Zuydam, N. R., Gaulton, K. J., Grarup, N., Bradfield, J. P., Strachan, D. P., Li-gao, R., Ahluwalia, T. S., Kreiner, E., Rueedi, R., Lyytikäinen, L., Cousminer, D. L., Wu, Y., Thiering, E. & 143 others, Wang, C. A., Have, C. T., Hottenga, J., Vilor-tejedor, N., Joshi, P. K., Boh, E. T. H., Ntalla, I., Pitkänen, N., Mahajan, A., Van Leeuwen, E. M., Joro, R., Lagou, V., Nodzenski, M., Diver, L. A., Zondervan, K. T., Bustamante, M., Marques-vidal, P., Mercader, J. M., Bennett, A. J., Rahmioglu, N., Nyholt, D. R., Ma, R. C. W., Tam, C. H. T., Tam, W. H., Ganesh, S. K., Van Rooij, F. J. A., Jones, S. E., Loh, P., Ruth, K. S., Tuke, M. A., Tyrrell, J., Wood, A. R., Yaghootkar, H., Scholtens, D. M., Paternoster, L., Prokopenko, I., Kovacs, P., Atalay, M., Willems, S. M., Panoutsopoulou, K., Wang, X., Carstensen, L., Geller, F., Schraut, K. E., Murcia, M., Van Beijsterveldt, C. E. M., Willemsen, G., Appel, E. V. R., Fonvig, C. E., Trier, C., Tiesler, C. M. T., Standl, M., Kutalik, Z., Bonàs-guarch, S., Hougaard, D. M., Sánchez, F., Torrents, D., Waage, J., Hollegaard, M. V., De Haan, H. G., Rosendaal, F. R., Medina-gomez, C., Ring, S. M., Hemani, G., Mcmahon, G., Robertson, N. R., Groves, C. J., Langenberg, C., Luan, J., Scott, R. A., Zhao, J. H., Mentch, F. D., Mackenzie, S. M., Reynolds, R. M., Lowe, W. L., Tönjes, A., Stumvoll, M., Lindi, V., Lakka, T. A., Van Duijn, C. M., Kiess, W., Körner, A., Sørensen, T. I. A., Niinikoski, H., Pahkala, K., Raitakari, O. T., Zeggini, E., Dedoussis, G. V., Teo, Y., Saw, S., Melbye, M., Campbell, H., Wilson, J. F., Vrijheid, M., De Geus, E. J. C. N., Boomsma, D. I., Kadarmideen, H. N., Holm, J., Hansen, T., Sebert, S., Hattersley, A. T., Beilin, L. J., Newnham, J. P., Pennell, C. E., Heinrich, J., Adair, L. S., Borja, J. B., Mohlke, K. L., Eriksson, J. G., Widén, E., Kähönen, M., Viikari, J. S., Lehtimäki, T., Vollenweider, P., Bønnelykke, K., Bisgaard, H., Mook-kanamori, D. O., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Pisinger, C., Pedersen, O., Power, C., Hyppönen, E., Wareham, N. J., Hakonarson, H., Davies, E., Walker, B. R., Jaddoe, V. W. V., Järvelin, M., Grant, S. F. A., Vaag, A. A., Lawlor, D. A., Frayling, T. M., Smith, G. D., Morris, A. P., Ong, K. K., Felix, J. F., Timpson, N. J., Perry, J. R. B., Evans, D. M., Mccarthy, M. I. & Freathy, R. M., 28 Sep 2016, In : Nature. 538, 7624, p. 248-252

    Research output: Contribution to journalArticle

  24. Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging

    Cobice, D. F., Livingstone, D. E. W., Mackay, C. L., Goodwin, R. J. A., Smith, L. B., Walker, B. R. & Andrew, R., 27 Sep 2016, In : Analytical Chemistry. 88, 21

    Research output: Contribution to journalArticle

  25. Does metformin reduce excess birthweight in offspring of obese pregnant women? A randomised controlled trial of efficacy, exploration of mechanisms and evaluation of other pregnancy complications

    Chiswick, C., Reynolds, R., Denison, F., Drake, A., Forbes, S., Newby, D., Walker, B., Quenby, S., Wray, S., Weeks, A., Lashen, H., Murray, G., Whyte, S., Andrew, R., Homer, N., Semple, S., Gray, C., Aldhous, M., Noble, K., Cunningham-Burley, S. & 1 others, Norman, J., 31 Aug 2016, In : Efficacy and Mechanism Evaluation. 3, 7

    Research output: Contribution to journalArticle

  26. ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone; a rationale for safer glucocorticoid replacement therapy

    Nixon, M., Mackenzie, S., Taylor, A. I., Homer, N., Livingstone, D., Mouras, R., Morgan, R., Mole, D., Stimson, R., Reynolds, R., Elfick, A., Andrew, R. & Walker, B., 17 Aug 2016, In : Science Translational Medicine. 8, 352, 352ra109.

    Research output: Contribution to journalArticle

  27. Metformin increases cortisol regeneration by 11βHSD1 in obese men with and without type 2 diabetes mellitus

    Anderson, A. J., Andrew, R., Homer, N. Z., Jones, G. C., Smith, K., Livingstone, D. E., Walker, B. R. & Stimson, R. H., 26 Jul 2016, In : Journal of Clinical Endocrinology & Metabolism. p. jc20162069

    Research output: Contribution to journalArticle

  28. Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation

    Ramage, L. E., Akyol, M., Fletcher, A. M., Forsythe, J., Nixon, M., Carter, R. N., van Beek, E. J. R., Morton, N. M., Walker, B. R. & Stimson, R. H., 12 Jul 2016, In : Cell Metabolism. 24, 1, p. 130-41 12 p.

    Research output: Contribution to journalArticle

  29. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness

    Morton, N. M., Beltram, J., Carter, R. N., Michailidou, Z., Gorjanc, G., McFadden, C., Barrios-Llerena, M. E., Rodriguez-Cuenca, S., Gibbins, M. T. G., Aird, R. E., Moreno-Navarrete, J. M., Munger, S. C., Svenson, K. L., Gastaldello, A., Ramage, L., Naredo, G., Zeyda, M., Wang, Z. V., Howie, A. F., Saari, A. & 13 others, Sipilä, P., Stulnig, T. M., Gudnason, V., Kenyon, C. J., Seckl, J. R., Walker, B. R., Webster, S. P., Dunbar, D. R., Churchill, G. A., Vidal-Puig, A., Fernandez-Real, J. M., Emilsson, V. & Horvat, S., 6 Jun 2016, In : Nature Medicine.

    Research output: Contribution to journalArticle

  30. Adrenal insufficiency in patients on long-term opioid analgesia

    Gibb, F. W., Stewart, A., Walker, B. R. & Strachan, M. W. J., 4 Jun 2016, In : Clinical Endocrinology.

    Research output: Contribution to journalArticle

  31. 11β-Hydroxysteroid Dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice

    Coutinho, A., Kipari, T., Zhang, Z., Esteves, C., Lucas, C., Gilmour, J. S., Webster, S., Walker, B., Hughes, J., Savill, J., Seckl, J., Rossi, A. & Chapman, K., 4 May 2016, In : Endocrinology. 157, 7, p. 2928-2936 9 p.

    Research output: Contribution to journalArticle

  32. The prevalence of structural pituitary abnormalities by MRI scanning in men presenting with isolated hypogonadotrophic hypogonadism

    Dalvi, M., Walker, B. R., Strachan, M. W. J., Zammitt, N. N. & Gibb, F. W., May 2016, In : Clinical Endocrinology. 84, 6, p. 858–861

    Research output: Contribution to journalArticle

  33. Aromatase Inhibition Reduces Insulin Sensitivity in Healthy Men

    Gibb, F. W., Homer, N. Z. M., Faqehi, A. M. M., Upreti, R., Livingstone, D. E., Mcinnes, K. J., Andrew, R. & Walker, B. R., 11 Mar 2016, In : Journal of Clinical Endocrinology & Metabolism. p. jc.2015-4146

    Research output: Contribution to journalArticle

  34. Systematic review and meta-analysis reveals acutely elevated plasma cortisol following fasting but not less severe calorie restriction

    Nakamura, Y., Walker, B. R. & Ikuta, T., 7 Jan 2016, In : Stress. p. 1-7

    Research output: Contribution to journalArticle

  35. 2015
  36. Clinical research: developing an appropriate career structure

    Mellanby, R. J., Price, J., Wooldridge, L., Jonsson, N. N., Clegg, P. D., Emes, R. D., England, G., Corr, S. A., Piercy, R. J., Mulcahy, G., Wood, J. L., Walker, B. R. & Argyle, D. J., 28 Nov 2015, In : Veterinary Record. 177, 21, p. 544-7 4 p.

    Research output: Contribution to journalArticle

  37. Controlling cortisol's contribution to degenerative disease

    Walker, B. R., Nov 2015, In : Psychoneuroendocrinology. 61, p. 1

    Research output: Contribution to journalMeeting abstract

  38. When two glucocorticoids are better than one: 'Relative corticosterone deficiency' in human metabolic syndrome

    Mackenzie, S., Nixon, M., Taylor, A., Reynolds, R., Bolton, J., Hayward, C., Wilson, J., Philips, D., Homer, N., Andrew, R. & Walker, B., Nov 2015, In : Psychoneuroendocrinology. 61, p. 29-29 1 p.

    Research output: Contribution to journalMeeting abstract

  39. Health Behaviours during Pregnancy in Women with Very Severe Obesity

    Mohd-Shukri, N. A., Duncan, A., Denison, F. C., Forbes, S., Walker, B. R., Norman, J. E. & Reynolds, R. M., 7 Oct 2015, In : Nutrients. 7, 10, p. 8431-43 13 p.

    Research output: Contribution to journalArticle

  40. Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial

    Chiswick, C., Reynolds, R., Denison, F., Drake, A., Forbes, S., Newby, D., Walker, B., Quenby, S., Wray, S., Weeks, A., Lashen, H., Rodriguez Carbonell, A., Murray, G., Whyte, S. & Norman, J., Oct 2015, In : The Lancet Diabetes and Endocrinology.

    Research output: Contribution to journalArticle

  41. Development of a Bayesian response-adaptive trial design for the Dexamethasone for Excessive Menstruation study

    Holm Hansen, C., Warner, P., Parker, R. A., Walker, B. R., Critchley, H. O. & Weir, C. J., 30 Sep 2015, In : Statistical Methods in Medical Research.

    Research output: Contribution to journalArticle

  42. Decreased maternal hypothalamic-pituitary-adrenal axis activity in very severely obese pregnancy: Associations with birthweight and gestation at delivery

    Stirrat, L. I., O'Reilly, J. R., Barr, S. M., Andrew, R., Riley, S. C., Howie, A. F., Bowman, M., Smith, R., Lewis, J. G., Denison, F. C., Forbes, S., Seckl, J. R., Walker, B. R., Norman, J. E. & Reynolds, R. M., 25 Sep 2015, In : Psychoneuroendocrinology. 63, p. 135-143 9 p.

    Research output: Contribution to journalArticle

  43. Estrogens protect male mice from obesity complications and influence glucocorticoid metabolism

    Dakin, R. S., Walker, B., Seckl, J. R., Hadoke, P. W. F. & Drake, A. J., 30 Jun 2015, In : International Journal of Obesity.

    Research output: Contribution to journalArticle

  44. Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography

    Kirkby, N. S., Low, L., Wu, J., Miller, E., Seckl, J. R., Walker, B. R., Webb, D. J. & Hadoke, P. W. F., 26 May 2015, In : Journal of Visualized Experiments (JoVE). 99, p. e50627

    Research output: Contribution to journalArticle

  45. Diet-induced weight loss has chronic tissue-specific effects on glucocorticoid metabolism in overweight postmenopausal women

    Stomby, A., Simonyte, K., Mellberg, C., Ryberg, M., Stimson, R. H., Larsson, C., Lindahl, B., Andrew, R., Walker, B. R. & Olsson, T., May 2015, In : International Journal of Obesity. 39, 5, p. 814-9 6 p.

    Research output: Contribution to journalArticle

  46. Hypothalamic Pituitary Adrenal Axis Hormones Are Reduced in Obese Pregnancy

    Stirrat, L., O'Reilly, J., Riley, S., Howie, A., Bowman, M., Smith, R., Lewis, J., Walker, B., Norman, J. & Reynolds, R., Mar 2015, In : Reproductive Sciences. 22, p. 58A-58A 1 p.

    Research output: Contribution to journalMeeting abstract

  47. 11β-Hydroxysteroid Dehydrogenase Activity in the Brain Does Not Contribute to Systemic Interconversion of Cortisol and Cortisone in Healthy Men

    Kilgour, A. H. M., Semple, S., Marshall, I., Andrews, P., Andrew, R. & Walker, B. R., Feb 2015, In : Journal of Clinical Endocrinology & Metabolism. 100, 2, p. 483-489 7 p.

    Research output: Contribution to journalArticle

  48. 5 alpha-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents

    Livingstone, D. E. W., Barat, P., Di Rollo, E. M., Rees, G. A., Weldin, B. A., Rog-Zielinska, E. A., MacFarlane, D. P., Walker, B. R. & Andrew, R., Feb 2015, In : Diabetes . 64, 2, p. 447-458 12 p.

    Research output: Contribution to journalArticle

  49. Efficacy of metformin in pregnant obese women: a randomised controlled trial

    Chiswick, C. A., Reynolds, R. M., Denison, F. C., Whyte, S. A., Drake, A. J., Newby, D. E., Walker, B. R., Forbes, S., Murray, G. D., Quenby, S., Wray, S. & Norman, J. E., 14 Jan 2015, In : BMJ Open. 5, 1, p. e006854

    Research output: Contribution to journalArticle

  50. Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice

    Yau, J. L. W., Wheelan, N., Noble, J., Walker, B. R., Webster, S. P., Kenyon, C. J., Ludwig, M. & Seckl, J. R., Jan 2015, In : Neurobiology of Aging. 36, 1, p. 334-343 10 p.

    Research output: Contribution to journalArticle

  51. 2014
  52. β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction

    Liu, X., Turban, S., Carter, R. N., Ahmad, S., Ramage, L., Webster, S. P., Walker, B. R., Seckl, J. R. & Morton, N. M., 14 Oct 2014, In : Frontiers in Endocrinology. 5, p. 165

    Research output: Contribution to journalArticle

  53. Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with type 2 diabetes with and without fatty liver

    Macfarlane, D. P., Raubenheimer, P. J., Preston, T., Gray, C. D., Bastin, M. E., Marshall, I., Iredale, J. P., Andrew, R. & Walker, B. R., 1 Oct 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 307, 7, p. G760-768 9 p.

    Research output: Contribution to journalArticle

  54. Relative adrenal insufficiency in mice deficient in 5α-reductase 1

    Livingstone, D. E. W., Di Rollo, E. M., Yang, C., Codrington, L. E., Mathews, J. A., Kara, M., Hughes, K. A., Kenyon, C. J., Walker, B. R. & Andrew, R., 1 Aug 2014, In : Journal of Endocrinology. 222, 2, p. 257-266 10 p.

    Research output: Contribution to journalArticle

  55. 5α-Reductase type 1 modulates insulin sensitivity in men

    Upreti, R., Hughes, K. A., Livingstone, D. E., Gray, C. D., Minns, F. C., Macfarlane, D. P., Marshall, I., Stewart, L. H., Walker, B. R. & Andrew, R., Aug 2014, In : Journal of Clinical Endocrinology & Metabolism. 99, 8, p. E1397-E1406 10 p.

    Research output: Contribution to journalArticle

  56. Activation of the Hypothalamic-Pituitary-Adrenal Axis in Adults With Mineralocorticoid Receptor Haploinsufficiency

    Walker, B. R., Andrew, R., Escoubet, B. & Zennaro, M-C., Aug 2014, In : Journal of Clinical Endocrinology & Metabolism. 99, 8, p. E1586-E1591 6 p.

    Research output: Contribution to journalArticle

  57. Relationship between final height and health outcomes in adults with congenital adrenal hyperplasia: United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE)

    Han, T. S., Conway, G. S., Willis, D. S., Krone, N., Rees, D. A., Stimson, R. H., Arlt, W., Walker, B. R., Ross, R. J. & United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE), Aug 2014, In : Journal of Clinical Endocrinology & Metabolism. 99, 8, p. E1547-55

    Research output: Contribution to journalArticle

  58. Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

    on behalf of the CORtisol NETwork (CORNET) Consortium, 10 Jul 2014, In : PLoS Genetics. 10, 7, e1004474.

    Research output: Contribution to journalArticle

  59. Tissue-specific dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in overweight/obese women with polycystic ovary syndrome compared with weight-matched controls

    Gambineri, A., Fanelli, F., Tomassoni, F., Munarini, A., Pagotto, U., Andrew, R., Walker, B. R. & Pasquali, R., Jul 2014, In : European Journal of Endocrinology. 171, 1, p. 47-57 11 p.

    Research output: Contribution to journalArticle

  60. Inhibiting 11β-hydroxysteroid dehydrogenase type 1 prevents stress effects on hippocampal synaptic plasticity and impairs contextual fear conditioning

    Sarabdjitsingh, R. A., Zhou, M., Yau, J. L. W., Webster, S. P., Walker, B. R., Seckl, J. R., Joëls, M. & Krugers, H. J., Jun 2014, In : Neuropharmacology. 81, p. 231-236 6 p.

    Research output: Contribution to journalArticle

  61. Tissue-specific dysregulation of cortisol regeneration by 11 beta HSD1 in obesity: has it promised too much?

    Stomby, A., Andrew, R., Walker, B. R. & Olsson, T., Jun 2014, In : Diabetologia. 57, 6, p. 1100-1110 11 p.

    Research output: Contribution to journalLiterature review

  62. INHIBITION OF 5A-REDUCTASE TYPE 1 WITH DUTASTERIDE IN MEN INCREASES BODY FAT AND IMPAIRS INSULIN SENSITIVITY

    Upreti, R., Hughes, K. A., Gray, C. D., Minns, F. C., Marshall, A. R., Stewart, L. H., Walker, B. R. & Andrew, R., May 2014, In : Internal Medicine Journal. 44, p. 20-20 1 p.

    Research output: Contribution to journalMeeting abstract

  63. Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

    Chau, Y-Y., Bandiera, R., Serrels, A., Martínez-Estrada, O. M., Qing, W., Lee, M., Slight, J., Thornburn, A., Berry, R., McHaffie, S., Stimson, R. H., Walker, B. R., Chapuli, R. M., Schedl, A. & Hastie, N., Apr 2014, In : Nature Cell Biology. 16, 4, p. 367-75 9 p.

    Research output: Contribution to journalArticle

  64. Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia

    Chapagain, A., Caton, P. W., Kieswich, J., Andrikopoulos, P., Nayuni, N., Long, J. H., Harwood, S. M., Webster, S. P., Raftery, M. J., Thiemermann, C., Walker, B. R., Seckl, J. R., Corder, R. & Yaqoob, M. M., 11 Mar 2014, In : Proceedings of the National Academy of Sciences. 111, 10, p. 3817-22 6 p.

    Research output: Contribution to journalArticle

  65. Displacement of Cortisol From Human Heart by Acute Administration of a Mineralocorticoid Receptor Antagonist

    Iqbal, J., Andrew, R., Cruden, N. L., Kenyon, C. J., Hughes, K. A., Newby, D. E., Hadoke, P. W. F. & Walker, B. R., Mar 2014, In : Journal of Clinical Endocrinology & Metabolism. 99, 3, p. 915-922 8 p.

    Research output: Contribution to journalArticle

  66. Treatment and health outcomes in adults with congenital adrenal hyperplasia

    Han, T. S., Walker, B. R., Arlt, W. & Ross, R. J., Feb 2014, In : Nature reviews endocrinology. 10, 2, p. 115-124 10 p.

    Research output: Contribution to journalLiterature review

  67. 2013
  68. Mass Spectrometry Imaging for Dissecting Steroid Intracrinology within Target Tissues

    Cobice, D. F., Mackay, C. L., Goodwin, R. J. A., McBride, A., Langridge-Smith, P. R., Webster, S. P., Walker, B. R. & Andrew, R., 3 Dec 2013, In : Analytical Chemistry. 85, 23, p. 11576-11584 9 p.

    Research output: Contribution to journalArticle

  69. ECAT-V: where clinical and research training meet

    Argyle, D. J., Iredale, J. P., Jackson, A. P. & Walker, B. R., 19 Oct 2013, In : Veterinary Record. 173, 15, p. 364-5 2 p.

    Research output: Contribution to journalArticle

  70. 11β-HSD1 inhibitors for the treatment of type 2 diabetes and cardiovascular disease

    Anderson, A. & Walker, B. R., Sep 2013, In : Drugs. 73, 13, p. 1385-1393 9 p.

    Research output: Contribution to journalArticle

  71. A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid

    Forbes, S., Godsland, I. F., Taylor-Robinson, S. D., Bell, J. D., Thomas, E. L., Patel, N., Hamilton, G., Parker, K. H., Marshall, I., Gray, C. D., Bedford, D., Caslake, M., Walker, B. R. & Johnston, D. G., Sep 2013, In : Diabetologia. 56, 9, p. 2021-2033 13 p.

    Research output: Contribution to journalArticle

  72. Reduced Cortisol Metabolism during Critical Illness Reply

    Van den Berghe, G., Boonen, E. & Walker, B. R., 1 Aug 2013, In : New England Journal of Medicine. 369, 5, p. 481-481 1 p.

    Research output: Contribution to journalLetter

  73. Evaluation of an FFQ to assess total energy and nutrient intakes in severely obese pregnant women

    Mohd-Shukri, N. A., Bolton, J. L., Norman, J. E., Walker, B. R. & Reynolds, R. M., Aug 2013, In : Public Health Nutrition. 16, 8, p. 1427-1435 9 p.

    Research output: Contribution to journalArticle

  74. 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo

    Mitic, T., Shave, S., Semjonous, N., McNae, I., Cobice, D. F., Lavery, G. G., Webster, S. P., Hadoke, P. W. F., Walker, B. R. & Andrew, R., 1 Jul 2013, In : Biochemical Pharmacology. 86, 1, p. 146-153 8 p.

    Research output: Contribution to journalArticle

  75. Measurement of tamsulosin in human serum by liquid chromatography-tandem mass spectrometry

    Upreti, R., Homer, N. Z. M., Naredo, G., Cobice, D. F., Hughes, K. A., Stewart, L. H., Walker, B. R. & Andrew, R., 1 Jul 2013, In : Journal of Chromatography B. 930, p. 121-8 8 p.

    Research output: Contribution to journalArticle

  76. Individual multi-locus heterozygosity is associated with lower morning plasma cortisol concentrations

    Zgaga, L., Vitart, V., Hayward, C., Kastelan, D., Polasek, O., Jakovljevic, M., Kolcic, I., Biloglav, Z., Wright, A. F., Campbell, H., Walker, B. R. & Rudan, I., Jul 2013, In : European Journal of Endocrinology. 169, 1, p. 59-64 6 p.

    Research output: Contribution to journalArticle

  77. Maternal Obesity Has Little Effect on the Immediate Offspring but Impacts on the Next Generation

    King, V., Dakin, R. S., Liu, L., Hadoke, P. W. F., Walker, B. R., Seckl, J. R., Norman, J. E. & Drake, A. J., Jul 2013, In : Endocrinology . 154, 7, p. 2514-2524

    Research output: Contribution to journalArticle

  78. Quality of life in adults with congenital adrenal hyperplasia relates to glucocorticoid treatment, adiposity and insulin resistance: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE)

    Han, T. S., Krone, N., Willis, D. S., Conway, G. S., Hahner, S., Rees, D. A., Stimson, R. H., Walker, B. R., Arlt, W., Ross, R. J. & United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE), Jun 2013, In : European Journal of Endocrinology. 168, 6, p. 887-93 7 p.

    Research output: Contribution to journalArticle

  79. Reduced Cortisol Metabolism during Critical Illness

    Boonen, E., Vervenne, H., Meersseman, P., Andrew, R., Mortier, L., Declercq, P. E., Vanwijngaerden, Y-M., Spriet, I., Wouters, P. J., Vander Perre, S., Langouche, L., Vanhorebeek, I., Walker, B. R. & Van den Berghe, G., 18 Apr 2013, In : New England Journal of Medicine. 368, 16, p. 1477-1488 12 p.

    Research output: Contribution to journalArticle

  80. 11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

    Kipari, T., Hadoke, P. W. F., Iqbal, J., Man, T-Y., Miller, E., Coutinho, A. E., Zhang, Z., Sullivan, K. M., Mitic, T., Livingstone, D. E. W., Schrecker, C., Samuel, K., White, C. I., Bouhlel, M. A., Chinetti-Gbaguidi, G., Staels, B., Andrew, R., Walker, B. R., Savill, J. S., Chapman, K. E. & 1 others, Seckl, J. R., Apr 2013, In : The FASEB Journal. 27, 4, p. 1519-1531 13 p.

    Research output: Contribution to journalArticle

  81. Genotype-Phenotype Correlation in 153 Adult Patients With Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency: Analysis of the United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE) Cohort

    Krone, N., Rose, I. T., Willis, D. S., Hodson, J., Wild, S. H., Doherty, E. J., Hahner, S., Parajes, S., Stimson, R. H., Han, T. S., Carroll, P. V., Conway, G. S., Walker, B. R., MacDonald, F., Ross, R. J., Arlt, W. & United Kingdom Congenital Adrenal, Feb 2013, In : Journal of Clinical Endocrinology & Metabolism. 98, 2, p. E346-E354 9 p.

    Research output: Contribution to journalArticle

  82. Glucocorticoid treatment regimen and health outcomes in adults with congenital adrenal hyperplasia

    Han, T. S., Stimson, R. H., Rees, D. A., Krone, N., Willis, D. S., Conway, G. S., Arlt, W., Walker, B. R., Ross, R. J. & United Kingdom Congenital Adrenal, Feb 2013, In : Clinical Endocrinology. 78, 2, p. 197-203 7 p.

    Research output: Contribution to journalArticle

  83. 19F-magnetic resonance spectroscopy as a tool to quantify 11[beta]-hydroxysteroid dehydrogenase activity in vivo

    Naredo-Gonzalez, G., Jansen, M., Upreti, R., Semple, S., Merrifield, G., Sutcliffe, O., Hansen, M., Marshall, I., Andrew, R. & Walker, B., 2013, In : Endocrine Abstracts. p. 1-1

    Research output: Contribution to journalArticle

  84. 5α-Reductase type 1 inhibition or deficiency causes weight gain and insulin resistance in mice and men

    Andrew, R., Upreti, R., Livingstone, D. E. W., Barat, P., Hughes, K. A., MacFarlane, D. P., Gray, C. D., Minns, F. C., Marshall, I., Stewart, L. H. & Walker, B. R., 2013, Association of Physicians Annual Meeting.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  85. Inhibition of 5α-reductase type 1 with dutasteride impairs insulin sensitivity

    Upreti, R., Hughes, K. A., Gray, C. D., Minns, F. C., Marshall, I., Stewart, L. H., Walker, B. R. & Andrew, R., 2013, Society for Endocrinology BES.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  86. The post-prandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol production

    Stimson, R. H., Mohd-Shukri, N. A., Bolton, J. L., Andrew, R., Reynolds, R. M. & Walker, B. R., 2013, In : Journal of Clinical Endocrinology & Metabolism. 99, 1, p. 160-168 9 p.

    Research output: Contribution to journalArticle

  87. 2012
  88. Contribution of Endogenous Glucocorticoids and Their Intravascular Metabolism by 11β-HSDs to Postangioplasty Neointimal Proliferation in Mice

    Iqbal, J., Macdonald, L. J., Low, L., Seckl, J. R., Yau, C. W., Walker, B. R. & Hadoke, P. W. F., Dec 2012, In : Endocrinology . 153, 12, p. 5896-5905 10 p.

    Research output: Contribution to journalArticle

  89. Mineralocorticoid Receptor Antagonists Displace Cortisol, not Aldosterone, from the Human Heart

    Iqbal, J., Andrew, R., Cruden, N., Kenyon, C., Hughes, K., Hadoke, P., Newby, D. & Walker, B., 20 Nov 2012, In : Circulation. 126, 21, 2 p.

    Research output: Contribution to journalMeeting abstract

  90. Recycling Between Cortisol and Cortisone in Human Splanchnic, Subcutaneous Adipose, and Skeletal Muscle Tissues In Vivo

    Hughes, K. A., Manolopoulos, K. N., Iqbal, J., Cruden, N. L., Stimson, R. H., Reynolds, R. M., Newby, D. E., Andrew, R., Karpe, F. & Walker, B. R., Jun 2012, In : Diabetes . 61, 6, p. 1357-1364

    Research output: Contribution to journalArticle

  91. Glucocorticoid treatment and impaired mood, memory and metabolism in people with diabetes: the Edinburgh Type 2 Diabetes Study

    Reynolds, R. M., Labad, J., Sears, A. V., Williamson, R. M., Strachan, M. W. J., Deary, I. J., Lowe, G. D. O., Price, J. F., Walker, B. R. & the Edinburgh Type 2 Diabetes study investigators, May 2012, In : European Journal of Endocrinology. 166, 5, p. 861-868 8 p.

    Research output: Contribution to journalArticle

  92. The overexpression of 11 type 1 beta-hydroxysteroid dehydrogenase in pancreatic beta cells prevents beta cell failure induced by a fatty regime

    Turban, S., Liu, X., Ramage, L., Webster, S., Walker, B., Dunbar, D., Mullins, J., Seckl, J. & Morton, N., Mar 2012, In : Diabetes and Metabolism. 38, p. A20-A20 1 p.

    Research output: Contribution to journalMeeting abstract

  93. Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice

    Michailidou, Z., Turban, S., Miller, E., Zou, X., Schrader, J., Ratcliffe, P. J., Hadoke, P. W. F., Walker, B. R., Iredale, J. P., Morton, N. M. & Seckl, J. R., 3 Feb 2012, In : Journal of Biological Chemistry. 287, 6, p. 4188-4197 10 p.

    Research output: Contribution to journalArticle

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