Edinburgh Research Explorer

Prof Brian Walker

(Former employee or visitor)

  1. 2019
  2. Heritability of cortisol production and metabolism throughout adolescence: a twin study

    van Keulen, B. J., Dolan, C. V., Andrew, R., Walker, B., Hulshoff Pol, H. E., Boomsma, D. I., Rotteveel, J. & finken, M. JJ., 14 Oct 2019, In : Journal of Clinical Endocrinology & Metabolism.

    Research output: Contribution to journalArticle

  3. Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study

    Wei, L., Kao-Yang, Y-H., Walker, B., MacDonald, T. M. & Andrew, R., 10 Apr 2019, In : BMJ. 365.

    Research output: Contribution to journalArticle

  4. Higher Insulin Resistance and Adiposity in Postmenopausal Women With Breast Cancer Treated With Aromatase Inhibitors

    Gibb, F., Dixon, M. J., Clarke, C., Homer, N., Faqehi, A., Andrew, R. & Walker, B., 28 Mar 2019, In : Journal of Clinical Endocrinology & Metabolism. 104, 9, p. 3670–3678

    Research output: Contribution to journalArticle

  5. 2018
  6. Species-specific regulation of angiogenesis by glucocorticoids reveals contrasting effects on inflammatory and angiogenic pathways

    Morgan, R., Keen, J., Halligan, D., O'Callaghan, A., Andrew, R., Livingstone, D., Livingstone, D., Abernethie, A., Maltese, G., Walker, B. & Hadoke, P., 15 Feb 2018, In : PLoS ONE. 13, 2, p. e0192746

    Research output: Contribution to journalArticle

  7. 2017
  8. Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia

    Alwashih, M. A., Watson, D. G., Andrew, R., Stimson, R. H., Alossaimi, M., Blackburn, G. & Walker, B. R., 6 Dec 2017, In : Scientific Reports. 7, 1, p. 17092

    Research output: Contribution to journalArticle

  9. Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis

    Homer, N., Kothiya, S., Rutter, A., Walker, B. & Andrew, R., Dec 2017, In : Analytical Biochemistry. 538

    Research output: Contribution to journalArticle

  10. Hair cortisol in twins: Heritability and genetic overlap with psychological variables and stress-system genes

    Rietschel, L., Streit, F., Zhu, G., McAloney, K., Frank, J., Couvy-Duchesne, B., Witt, S. H., Binz, T., McGrath, J. J., Hickie, I. B., Hansell, N. K., Wright, M. J., Gillespie, N., Forstner, A. J., Schulze, T. G., Wust, S., Nöthen, M. M., Baumgartner, M., Walker, B., Crawford, A. & 4 others, Colodro-Conde, L., Medland, S. E., Martin, N. G. & Rietschel, M., 10 Nov 2017, In : Scientific Reports.

    Research output: Contribution to journalArticle

  11. The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels

    Neumann, A., Direk, N., Crawford, A. A., Mirza, S., Adams, H., Bolton, J., Hayward, C., Strachan, D. P., Payne, E. K., Smith, J. A., Milaneschi, Y., Penninx, B., Hottenga, J. J., de Geus, E., Oldehinkel, A. J., van der Most, P. J., de Rijke, Y., Walker, B. R. & Tiemeier, H., Nov 2017, In : Psychoneuroendocrinology. 85, p. 88-95 8 p.

    Research output: Contribution to journalArticle

  12. Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans

    Alwashih, M. A., Stimson, R., Andrew, R., Walker, B. & Watson, D. G., 13 Sep 2017, In : Scientific Reports.

    Research output: Contribution to journalArticle

  13. Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity

    Morgan, R., Beck, K. R., Nixon, M., Homer, N. Z. M., Crawford, A. A., Melchers, D., Houtman, R., Meijer, O. C., Stomby, A., Anderson, A. J., Upreti, R., Stimson, R. H., Olsson, T., Michoel, T., Cohain, A., Ruusalepp, A., Schadt, E. E., Björkegren, J. L. M., Andrew, R., Kenyon, C. J. & 4 others, Hadoke, P. W. F., Odermatt, A., Keen, J. A. & Walker, B. R., 6 Sep 2017, In : Scientific Reports. 7, 1, p. 10633

    Research output: Contribution to journalArticle

  14. 11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI

    Mylonas, K. J., Turner, N. A., Bageghni, S. A., Kenyon, C. J., White, C. I., McGregor, K., Kimmitt, R. A., Sulston, R., Kelly, V., Walker, B. R., Porter, K. E., Chapman, K. E. & Gray, G. A., 1 Jun 2017, In : Journal of Endocrinology. 233, 3, p. 315-327 13 p.

    Research output: Contribution to journalArticle

  15. Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

    Tachmazidou, I., Süveges, D., Min, J. L., Ritchie, G. R. S., Steinberg, J., Walter, K., Iotchkova, V., Schwartzentruber, J., Huang, J., Memari, Y., Mccarthy, S., Crawford, A. A., Bombieri, C., Cocca, M., Farmaki, A., Gaunt, T. R., Jousilahti, P., Kooijman, M. N., Lehne, B., Malerba, G. & 83 others, Männistö, S., Matchan, A., Medina-gomez, C., Metrustry, S. J., Nag, A., Ntalla, I., Paternoster, L., Rayner, N. W., Sala, C., Scott, W. R., Shihab, H. A., Southam, L., St Pourcain, B., Traglia, M., Trajanoska, K., Zaza, G., Zhang, W., Artigas, M. S., Bansal, N., Benn, M., Chen, Z., Danecek, P., Lin, W., Locke, A., Luan, J., Manning, A. K., Mulas, A., Sidore, C., Tybjaerg-hansen, A., Varbo, A., Zoledziewska, M., Finan, C., Hatzikotoulas, K., Hendricks, A. E., Kemp, J. P., Moayyeri, A., Panoutsopoulou, K., Szpak, M., Wilson, S. G., Boehnke, M., Cucca, F., Di Angelantonio, E., Langenberg, C., Lindgren, C., Mccarthy, M. I., Morris, A. P., Nordestgaard, B. G., Scott, R. A., Tobin, M. D., Wareham, N. J., Burton, P., Chambers, J. C., Smith, G. D., Dedoussis, G., Felix, J. F., Franco, O. H., Gambaro, G., Gasparini, P., Hammond, C. J., Hofman, A., Jaddoe, V. W. V., Kleber, M., Kooner, J. S., Perola, M., Relton, C., Ring, S. M., Rivadeneira, F., Salomaa, V., Spector, T. D., Stegle, O., Toniolo, D., Uitterlinden, A. G., Barroso, I., Greenwood, C. M. T., Perry, J. R. B., Walker, B. R., Butterworth, A. S., Xue, Y., Durbin, R., Small, K. S., Soranzo, N., Timpson, N. J. & Zeggini, E., 1 Jun 2017, In : American Journal of Human Genetics. 100, 6, p. 865-884

    Research output: Contribution to journalArticle

  16. Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™)

    Webster, S. P., McBride, A., Binnie, M., Sooy, K., Seckl, J. R., Andrew, R., Pallin, T. D., Hunt, H. J., Perrior, T. R., Ruffles, V. S., Ketelbey, J. W., Boyd, A. & Walker, B. R., Mar 2017, In : British Journal of Pharmacology.

    Research output: Contribution to journalArticle

  17. Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct

    Stimson, R., Anderson, A. J., Lynne, R., Macfarlane, D. P., de Beaux, A. C., Mole, D., Andrew, R. & Walker, B., 8 Feb 2017, In : Diabetes Obesity & Metabolism.

    Research output: Contribution to journalArticle

  18. Safer topical treatment for inflammation using 5α-tetrahydrocorticosterone in mouse models

    Gastaldello, A., Livingstone, D. E. W., Abernethie, A. J., Tsang, N., Walker, B. R., Hadoke, P. W. F. & Andrew, R., 24 Jan 2017, In : Biochemical Pharmacology. 129, p. 73–84

    Research output: Contribution to journalArticle

  19. Inhibition or deletion of 11Β-HSD1 does not increase angiogenesis in ischemic retinopathy

    Davidson, C., Dover, A., McVicar, C., Megaw, R., Glenn, J., Hadoke, P., Stitt, A. W. & Walker, B., 11 Jan 2017, In : Diabetes and Metabolism.

    Research output: Contribution to journalArticle

  20. Metabolic dysfunction in female mice with disruption of 5α-reductase 1

    Livingstone, D., Di Rollo, E. M., Mak, T. C-S., Sooy, K., Walker, B. & Andrew, R., Jan 2017, In : Journal of Endocrinology. 232, 1, p. 29-36

    Research output: Contribution to journalArticle

  21. 2016
  22. Vascular Dysfunction in Horses with Endocrinopathic Laminitis

    Morgan, R. A., Keen, J. A., Walker, B. R. & Hadoke, P. W. F., 29 Sep 2016, In : PLoS ONE. 11, 9, e0163815.

    Research output: Contribution to journalArticle

  23. Genome-wide associations for birth weight and correlations with adult disease

    Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-tajes, J., Feenstra, B., Van Zuydam, N. R., Gaulton, K. J., Grarup, N., Bradfield, J. P., Strachan, D. P., Li-gao, R., Ahluwalia, T. S., Kreiner, E., Rueedi, R., Lyytikäinen, L., Cousminer, D. L., Wu, Y., Thiering, E. & 143 others, Wang, C. A., Have, C. T., Hottenga, J., Vilor-tejedor, N., Joshi, P. K., Boh, E. T. H., Ntalla, I., Pitkänen, N., Mahajan, A., Van Leeuwen, E. M., Joro, R., Lagou, V., Nodzenski, M., Diver, L. A., Zondervan, K. T., Bustamante, M., Marques-vidal, P., Mercader, J. M., Bennett, A. J., Rahmioglu, N., Nyholt, D. R., Ma, R. C. W., Tam, C. H. T., Tam, W. H., Ganesh, S. K., Van Rooij, F. J. A., Jones, S. E., Loh, P., Ruth, K. S., Tuke, M. A., Tyrrell, J., Wood, A. R., Yaghootkar, H., Scholtens, D. M., Paternoster, L., Prokopenko, I., Kovacs, P., Atalay, M., Willems, S. M., Panoutsopoulou, K., Wang, X., Carstensen, L., Geller, F., Schraut, K. E., Murcia, M., Van Beijsterveldt, C. E. M., Willemsen, G., Appel, E. V. R., Fonvig, C. E., Trier, C., Tiesler, C. M. T., Standl, M., Kutalik, Z., Bonàs-guarch, S., Hougaard, D. M., Sánchez, F., Torrents, D., Waage, J., Hollegaard, M. V., De Haan, H. G., Rosendaal, F. R., Medina-gomez, C., Ring, S. M., Hemani, G., Mcmahon, G., Robertson, N. R., Groves, C. J., Langenberg, C., Luan, J., Scott, R. A., Zhao, J. H., Mentch, F. D., Mackenzie, S. M., Reynolds, R. M., Lowe, W. L., Tönjes, A., Stumvoll, M., Lindi, V., Lakka, T. A., Van Duijn, C. M., Kiess, W., Körner, A., Sørensen, T. I. A., Niinikoski, H., Pahkala, K., Raitakari, O. T., Zeggini, E., Dedoussis, G. V., Teo, Y., Saw, S., Melbye, M., Campbell, H., Wilson, J. F., Vrijheid, M., De Geus, E. J. C. N., Boomsma, D. I., Kadarmideen, H. N., Holm, J., Hansen, T., Sebert, S., Hattersley, A. T., Beilin, L. J., Newnham, J. P., Pennell, C. E., Heinrich, J., Adair, L. S., Borja, J. B., Mohlke, K. L., Eriksson, J. G., Widén, E., Kähönen, M., Viikari, J. S., Lehtimäki, T., Vollenweider, P., Bønnelykke, K., Bisgaard, H., Mook-kanamori, D. O., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Pisinger, C., Pedersen, O., Power, C., Hyppönen, E., Wareham, N. J., Hakonarson, H., Davies, E., Walker, B. R., Jaddoe, V. W. V., Järvelin, M., Grant, S. F. A., Vaag, A. A., Lawlor, D. A., Frayling, T. M., Smith, G. D., Morris, A. P., Ong, K. K., Felix, J. F., Timpson, N. J., Perry, J. R. B., Evans, D. M., Mccarthy, M. I. & Freathy, R. M., 28 Sep 2016, In : Nature. 538, 7624, p. 248-252

    Research output: Contribution to journalArticle

  24. Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging

    Cobice, D. F., Livingstone, D. E. W., Mackay, C. L., Goodwin, R. J. A., Smith, L. B., Walker, B. R. & Andrew, R., 27 Sep 2016, In : Analytical Chemistry. 88, 21

    Research output: Contribution to journalArticle

  25. Does metformin reduce excess birthweight in offspring of obese pregnant women? A randomised controlled trial of efficacy, exploration of mechanisms and evaluation of other pregnancy complications

    Chiswick, C., Reynolds, R., Denison, F., Drake, A., Forbes, S., Newby, D., Walker, B., Quenby, S., Wray, S., Weeks, A., Lashen, H., Murray, G., Whyte, S., Andrew, R., Homer, N., Semple, S., Gray, C., Aldhous, M., Noble, K., Cunningham-Burley, S. & 1 others, Norman, J., 31 Aug 2016, In : Efficacy and Mechanism Evaluation. 3, 7

    Research output: Contribution to journalArticle

  26. ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone; a rationale for safer glucocorticoid replacement therapy

    Nixon, M., Mackenzie, S., Taylor, A. I., Homer, N., Livingstone, D., Mouras, R., Morgan, R., Mole, D., Stimson, R., Reynolds, R., Elfick, A., Andrew, R. & Walker, B., 17 Aug 2016, In : Science translational medicine. 8, 352, 352ra109.

    Research output: Contribution to journalArticle

  27. Metformin increases cortisol regeneration by 11βHSD1 in obese men with and without type 2 diabetes mellitus

    Anderson, A. J., Andrew, R., Homer, N. Z., Jones, G. C., Smith, K., Livingstone, D. E., Walker, B. R. & Stimson, R. H., 26 Jul 2016, In : Journal of Clinical Endocrinology & Metabolism. p. jc20162069

    Research output: Contribution to journalArticle

  28. Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation

    Ramage, L. E., Akyol, M., Fletcher, A. M., Forsythe, J., Nixon, M., Carter, R. N., van Beek, E. J. R., Morton, N. M., Walker, B. R. & Stimson, R. H., 12 Jul 2016, In : Cell Metabolism. 24, 1, p. 130-41 12 p.

    Research output: Contribution to journalArticle

  29. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness

    Morton, N. M., Beltram, J., Carter, R. N., Michailidou, Z., Gorjanc, G., McFadden, C., Barrios-Llerena, M. E., Rodriguez-Cuenca, S., Gibbins, M. T. G., Aird, R. E., Moreno-Navarrete, J. M., Munger, S. C., Svenson, K. L., Gastaldello, A., Ramage, L., Naredo, G., Zeyda, M., Wang, Z. V., Howie, A. F., Saari, A. & 13 others, Sipilä, P., Stulnig, T. M., Gudnason, V., Kenyon, C. J., Seckl, J. R., Walker, B. R., Webster, S. P., Dunbar, D. R., Churchill, G. A., Vidal-Puig, A., Fernandez-Real, J. M., Emilsson, V. & Horvat, S., 6 Jun 2016, In : Nature Medicine.

    Research output: Contribution to journalArticle

  30. Adrenal insufficiency in patients on long-term opioid analgesia

    Gibb, F. W., Stewart, A., Walker, B. R. & Strachan, M. W. J., 4 Jun 2016, In : Clinical Endocrinology.

    Research output: Contribution to journalArticle

  31. 11β-Hydroxysteroid Dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice

    Coutinho, A., Kipari, T., Zhang, Z., Esteves, C., Lucas, C., Gilmour, J. S., Webster, S., Walker, B., Hughes, J., Savill, J., Seckl, J., Rossi, A. & Chapman, K., 4 May 2016, In : Endocrinology. 157, 7, p. 2928-2936 9 p.

    Research output: Contribution to journalArticle

  32. The prevalence of structural pituitary abnormalities by MRI scanning in men presenting with isolated hypogonadotrophic hypogonadism

    Dalvi, M., Walker, B. R., Strachan, M. W. J., Zammitt, N. N. & Gibb, F. W., May 2016, In : Clinical Endocrinology. 84, 6, p. 858–861

    Research output: Contribution to journalArticle

  33. Aromatase Inhibition Reduces Insulin Sensitivity in Healthy Men

    Gibb, F. W., Homer, N. Z. M., Faqehi, A. M. M., Upreti, R., Livingstone, D. E., Mcinnes, K. J., Andrew, R. & Walker, B. R., 11 Mar 2016, In : Journal of Clinical Endocrinology & Metabolism. p. jc.2015-4146

    Research output: Contribution to journalArticle

  34. Systematic review and meta-analysis reveals acutely elevated plasma cortisol following fasting but not less severe calorie restriction

    Nakamura, Y., Walker, B. R. & Ikuta, T., 7 Jan 2016, In : Stress. p. 1-7

    Research output: Contribution to journalArticle

  35. 2015
  36. Clinical research: developing an appropriate career structure

    Mellanby, R. J., Price, J., Wooldridge, L., Jonsson, N. N., Clegg, P. D., Emes, R. D., England, G., Corr, S. A., Piercy, R. J., Mulcahy, G., Wood, J. L., Walker, B. R. & Argyle, D. J., 28 Nov 2015, In : Veterinary Record. 177, 21, p. 544-7 4 p.

    Research output: Contribution to journalArticle

  37. Controlling cortisol's contribution to degenerative disease

    Walker, B. R., Nov 2015, In : Psychoneuroendocrinology. 61, p. 1

    Research output: Contribution to journalMeeting abstract

  38. When two glucocorticoids are better than one: 'Relative corticosterone deficiency' in human metabolic syndrome

    Mackenzie, S., Nixon, M., Taylor, A., Reynolds, R., Bolton, J., Hayward, C., Wilson, J., Philips, D., Homer, N., Andrew, R. & Walker, B., Nov 2015, In : Psychoneuroendocrinology. 61, p. 29-29 1 p.

    Research output: Contribution to journalMeeting abstract

  39. Health Behaviours during Pregnancy in Women with Very Severe Obesity

    Mohd-Shukri, N. A., Duncan, A., Denison, F. C., Forbes, S., Walker, B. R., Norman, J. E. & Reynolds, R. M., 7 Oct 2015, In : Nutrients. 7, 10, p. 8431-43 13 p.

    Research output: Contribution to journalArticle

  40. Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial

    Chiswick, C., Reynolds, R., Denison, F., Drake, A., Forbes, S., Newby, D., Walker, B., Quenby, S., Wray, S., Weeks, A., Lashen, H., Rodriguez Carbonell, A., Murray, G., Whyte, S. & Norman, J., Oct 2015, In : The Lancet Diabetes and Endocrinology.

    Research output: Contribution to journalArticle

  41. Development of a Bayesian response-adaptive trial design for the Dexamethasone for Excessive Menstruation study

    Holm Hansen, C., Warner, P., Parker, R. A., Walker, B. R., Critchley, H. O. & Weir, C. J., 30 Sep 2015, In : Statistical Methods in Medical Research.

    Research output: Contribution to journalArticle

  42. Decreased maternal hypothalamic-pituitary-adrenal axis activity in very severely obese pregnancy: Associations with birthweight and gestation at delivery

    Stirrat, L. I., O'Reilly, J. R., Barr, S. M., Andrew, R., Riley, S. C., Howie, A. F., Bowman, M., Smith, R., Lewis, J. G., Denison, F. C., Forbes, S., Seckl, J. R., Walker, B. R., Norman, J. E. & Reynolds, R. M., 25 Sep 2015, In : Psychoneuroendocrinology. 63, p. 135-143 9 p.

    Research output: Contribution to journalArticle

  43. Estrogens protect male mice from obesity complications and influence glucocorticoid metabolism

    Dakin, R. S., Walker, B., Seckl, J. R., Hadoke, P. W. F. & Drake, A. J., 30 Jun 2015, In : International Journal of Obesity.

    Research output: Contribution to journalArticle

  44. Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography

    Kirkby, N. S., Low, L., Wu, J., Miller, E., Seckl, J. R., Walker, B. R., Webb, D. J. & Hadoke, P. W. F., 26 May 2015, In : Journal of Visualized Experiments (JoVE). 99, p. e50627

    Research output: Contribution to journalArticle

  45. Diet-induced weight loss has chronic tissue-specific effects on glucocorticoid metabolism in overweight postmenopausal women

    Stomby, A., Simonyte, K., Mellberg, C., Ryberg, M., Stimson, R. H., Larsson, C., Lindahl, B., Andrew, R., Walker, B. R. & Olsson, T., May 2015, In : International Journal of Obesity. 39, 5, p. 814-9 6 p.

    Research output: Contribution to journalArticle

  46. Hypothalamic Pituitary Adrenal Axis Hormones Are Reduced in Obese Pregnancy

    Stirrat, L., O'Reilly, J., Riley, S., Howie, A., Bowman, M., Smith, R., Lewis, J., Walker, B., Norman, J. & Reynolds, R., Mar 2015, In : Reproductive Sciences. 22, p. 58A-58A 1 p.

    Research output: Contribution to journalMeeting abstract

  47. 11β-Hydroxysteroid Dehydrogenase Activity in the Brain Does Not Contribute to Systemic Interconversion of Cortisol and Cortisone in Healthy Men

    Kilgour, A. H. M., Semple, S., Marshall, I., Andrews, P., Andrew, R. & Walker, B. R., Feb 2015, In : Journal of Clinical Endocrinology & Metabolism. 100, 2, p. 483-489 7 p.

    Research output: Contribution to journalArticle

  48. 5 alpha-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents

    Livingstone, D. E. W., Barat, P., Di Rollo, E. M., Rees, G. A., Weldin, B. A., Rog-Zielinska, E. A., MacFarlane, D. P., Walker, B. R. & Andrew, R., Feb 2015, In : Diabetes . 64, 2, p. 447-458 12 p.

    Research output: Contribution to journalArticle

  49. Efficacy of metformin in pregnant obese women: a randomised controlled trial

    Chiswick, C. A., Reynolds, R. M., Denison, F. C., Whyte, S. A., Drake, A. J., Newby, D. E., Walker, B. R., Forbes, S., Murray, G. D., Quenby, S., Wray, S. & Norman, J. E., 14 Jan 2015, In : BMJ Open. 5, 1, p. e006854

    Research output: Contribution to journalArticle

  50. Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice

    Yau, J. L. W., Wheelan, N., Noble, J., Walker, B. R., Webster, S. P., Kenyon, C. J., Ludwig, M. & Seckl, J. R., Jan 2015, In : Neurobiology of Aging. 36, 1, p. 334-343 10 p.

    Research output: Contribution to journalArticle

  51. 2014
  52. β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction

    Liu, X., Turban, S., Carter, R. N., Ahmad, S., Ramage, L., Webster, S. P., Walker, B. R., Seckl, J. R. & Morton, N. M., 14 Oct 2014, In : Frontiers in Endocrinology. 5, p. 165

    Research output: Contribution to journalArticle

  53. Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with type 2 diabetes with and without fatty liver

    Macfarlane, D. P., Raubenheimer, P. J., Preston, T., Gray, C. D., Bastin, M. E., Marshall, I., Iredale, J. P., Andrew, R. & Walker, B. R., 1 Oct 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 307, 7, p. G760-768 9 p.

    Research output: Contribution to journalArticle

  54. Relative adrenal insufficiency in mice deficient in 5α-reductase 1

    Livingstone, D. E. W., Di Rollo, E. M., Yang, C., Codrington, L. E., Mathews, J. A., Kara, M., Hughes, K. A., Kenyon, C. J., Walker, B. R. & Andrew, R., 1 Aug 2014, In : Journal of Endocrinology. 222, 2, p. 257-266 10 p.

    Research output: Contribution to journalArticle

  55. 5α-Reductase type 1 modulates insulin sensitivity in men

    Upreti, R., Hughes, K. A., Livingstone, D. E., Gray, C. D., Minns, F. C., Macfarlane, D. P., Marshall, I., Stewart, L. H., Walker, B. R. & Andrew, R., Aug 2014, In : Journal of Clinical Endocrinology & Metabolism. 99, 8, p. E1397-E1406 10 p.

    Research output: Contribution to journalArticle

  56. Activation of the Hypothalamic-Pituitary-Adrenal Axis in Adults With Mineralocorticoid Receptor Haploinsufficiency

    Walker, B. R., Andrew, R., Escoubet, B. & Zennaro, M-C., Aug 2014, In : Journal of Clinical Endocrinology & Metabolism. 99, 8, p. E1586-E1591 6 p.

    Research output: Contribution to journalArticle

  57. Relationship between final height and health outcomes in adults with congenital adrenal hyperplasia: United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE)

    Han, T. S., Conway, G. S., Willis, D. S., Krone, N., Rees, D. A., Stimson, R. H., Arlt, W., Walker, B. R., Ross, R. J. & United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE), Aug 2014, In : Journal of Clinical Endocrinology & Metabolism. 99, 8, p. E1547-55

    Research output: Contribution to journalArticle

  58. Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

    on behalf of the CORtisol NETwork (CORNET) Consortium, 10 Jul 2014, In : PLoS Genetics. 10, 7, e1004474.

    Research output: Contribution to journalArticle

  59. Tissue-specific dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in overweight/obese women with polycystic ovary syndrome compared with weight-matched controls

    Gambineri, A., Fanelli, F., Tomassoni, F., Munarini, A., Pagotto, U., Andrew, R., Walker, B. R. & Pasquali, R., Jul 2014, In : European Journal of Endocrinology. 171, 1, p. 47-57 11 p.

    Research output: Contribution to journalArticle

  60. Inhibiting 11β-hydroxysteroid dehydrogenase type 1 prevents stress effects on hippocampal synaptic plasticity and impairs contextual fear conditioning

    Sarabdjitsingh, R. A., Zhou, M., Yau, J. L. W., Webster, S. P., Walker, B. R., Seckl, J. R., Joëls, M. & Krugers, H. J., Jun 2014, In : Neuropharmacology. 81, p. 231-236 6 p.

    Research output: Contribution to journalArticle

  61. Tissue-specific dysregulation of cortisol regeneration by 11 beta HSD1 in obesity: has it promised too much?

    Stomby, A., Andrew, R., Walker, B. R. & Olsson, T., Jun 2014, In : Diabetologia. 57, 6, p. 1100-1110 11 p.

    Research output: Contribution to journalLiterature review

  62. INHIBITION OF 5A-REDUCTASE TYPE 1 WITH DUTASTERIDE IN MEN INCREASES BODY FAT AND IMPAIRS INSULIN SENSITIVITY

    Upreti, R., Hughes, K. A., Gray, C. D., Minns, F. C., Marshall, A. R., Stewart, L. H., Walker, B. R. & Andrew, R., May 2014, In : Internal Medicine Journal. 44, p. 20-20 1 p.

    Research output: Contribution to journalMeeting abstract

  63. Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

    Chau, Y-Y., Bandiera, R., Serrels, A., Martínez-Estrada, O. M., Qing, W., Lee, M., Slight, J., Thornburn, A., Berry, R., McHaffie, S., Stimson, R. H., Walker, B. R., Chapuli, R. M., Schedl, A. & Hastie, N., Apr 2014, In : Nature Cell Biology. 16, 4, p. 367-75 9 p.

    Research output: Contribution to journalArticle

  64. Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia

    Chapagain, A., Caton, P. W., Kieswich, J., Andrikopoulos, P., Nayuni, N., Long, J. H., Harwood, S. M., Webster, S. P., Raftery, M. J., Thiemermann, C., Walker, B. R., Seckl, J. R., Corder, R. & Yaqoob, M. M., 11 Mar 2014, In : Proceedings of the National Academy of Sciences. 111, 10, p. 3817-22 6 p.

    Research output: Contribution to journalArticle

  65. Displacement of Cortisol From Human Heart by Acute Administration of a Mineralocorticoid Receptor Antagonist

    Iqbal, J., Andrew, R., Cruden, N. L., Kenyon, C. J., Hughes, K. A., Newby, D. E., Hadoke, P. W. F. & Walker, B. R., Mar 2014, In : Journal of Clinical Endocrinology & Metabolism. 99, 3, p. 915-922 8 p.

    Research output: Contribution to journalArticle

  66. Treatment and health outcomes in adults with congenital adrenal hyperplasia

    Han, T. S., Walker, B. R., Arlt, W. & Ross, R. J., Feb 2014, In : Nature reviews endocrinology. 10, 2, p. 115-124 10 p.

    Research output: Contribution to journalLiterature review

  67. 2013
  68. Mass Spectrometry Imaging for Dissecting Steroid Intracrinology within Target Tissues

    Cobice, D. F., Mackay, C. L., Goodwin, R. J. A., McBride, A., Langridge-Smith, P. R., Webster, S. P., Walker, B. R. & Andrew, R., 3 Dec 2013, In : Analytical Chemistry. 85, 23, p. 11576-11584 9 p.

    Research output: Contribution to journalArticle

  69. ECAT-V: where clinical and research training meet

    Argyle, D. J., Iredale, J. P., Jackson, A. P. & Walker, B. R., 19 Oct 2013, In : Veterinary Record. 173, 15, p. 364-5 2 p.

    Research output: Contribution to journalArticle

  70. 11β-HSD1 inhibitors for the treatment of type 2 diabetes and cardiovascular disease

    Anderson, A. & Walker, B. R., Sep 2013, In : Drugs. 73, 13, p. 1385-1393 9 p.

    Research output: Contribution to journalArticle

  71. A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid

    Forbes, S., Godsland, I. F., Taylor-Robinson, S. D., Bell, J. D., Thomas, E. L., Patel, N., Hamilton, G., Parker, K. H., Marshall, I., Gray, C. D., Bedford, D., Caslake, M., Walker, B. R. & Johnston, D. G., Sep 2013, In : Diabetologia. 56, 9, p. 2021-2033 13 p.

    Research output: Contribution to journalArticle

  72. Reduced Cortisol Metabolism during Critical Illness Reply

    Van den Berghe, G., Boonen, E. & Walker, B. R., 1 Aug 2013, In : The New England Journal of Medicine. 369, 5, p. 481-481 1 p.

    Research output: Contribution to journalLetter

  73. Evaluation of an FFQ to assess total energy and nutrient intakes in severely obese pregnant women

    Mohd-Shukri, N. A., Bolton, J. L., Norman, J. E., Walker, B. R. & Reynolds, R. M., Aug 2013, In : Public Health Nutrition. 16, 8, p. 1427-1435 9 p.

    Research output: Contribution to journalArticle

  74. 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo

    Mitic, T., Shave, S., Semjonous, N., McNae, I., Cobice, D. F., Lavery, G. G., Webster, S. P., Hadoke, P. W. F., Walker, B. R. & Andrew, R., 1 Jul 2013, In : Biochemical Pharmacology. 86, 1, p. 146-153 8 p.

    Research output: Contribution to journalArticle

  75. Measurement of tamsulosin in human serum by liquid chromatography-tandem mass spectrometry

    Upreti, R., Homer, N. Z. M., Naredo, G., Cobice, D. F., Hughes, K. A., Stewart, L. H., Walker, B. R. & Andrew, R., 1 Jul 2013, In : Journal of Chromatography B. 930, p. 121-8 8 p.

    Research output: Contribution to journalArticle

  76. Individual multi-locus heterozygosity is associated with lower morning plasma cortisol concentrations

    Zgaga, L., Vitart, V., Hayward, C., Kastelan, D., Polasek, O., Jakovljevic, M., Kolcic, I., Biloglav, Z., Wright, A. F., Campbell, H., Walker, B. R. & Rudan, I., Jul 2013, In : European Journal of Endocrinology. 169, 1, p. 59-64 6 p.

    Research output: Contribution to journalArticle

  77. Maternal Obesity Has Little Effect on the Immediate Offspring but Impacts on the Next Generation

    King, V., Dakin, R. S., Liu, L., Hadoke, P. W. F., Walker, B. R., Seckl, J. R., Norman, J. E. & Drake, A. J., Jul 2013, In : Endocrinology . 154, 7, p. 2514-2524

    Research output: Contribution to journalArticle

  78. Quality of life in adults with congenital adrenal hyperplasia relates to glucocorticoid treatment, adiposity and insulin resistance: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE)

    Han, T. S., Krone, N., Willis, D. S., Conway, G. S., Hahner, S., Rees, D. A., Stimson, R. H., Walker, B. R., Arlt, W., Ross, R. J. & United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE), Jun 2013, In : European Journal of Endocrinology. 168, 6, p. 887-93 7 p.

    Research output: Contribution to journalArticle

  79. Reduced Cortisol Metabolism during Critical Illness

    Boonen, E., Vervenne, H., Meersseman, P., Andrew, R., Mortier, L., Declercq, P. E., Vanwijngaerden, Y-M., Spriet, I., Wouters, P. J., Vander Perre, S., Langouche, L., Vanhorebeek, I., Walker, B. R. & Van den Berghe, G., 18 Apr 2013, In : The New England Journal of Medicine. 368, 16, p. 1477-1488 12 p.

    Research output: Contribution to journalArticle

  80. 11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

    Kipari, T., Hadoke, P. W. F., Iqbal, J., Man, T-Y., Miller, E., Coutinho, A. E., Zhang, Z., Sullivan, K. M., Mitic, T., Livingstone, D. E. W., Schrecker, C., Samuel, K., White, C. I., Bouhlel, M. A., Chinetti-Gbaguidi, G., Staels, B., Andrew, R., Walker, B. R., Savill, J. S., Chapman, K. E. & 1 others, Seckl, J. R., Apr 2013, In : The FASEB Journal. 27, 4, p. 1519-1531 13 p.

    Research output: Contribution to journalArticle

  81. Genotype-Phenotype Correlation in 153 Adult Patients With Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency: Analysis of the United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE) Cohort

    Krone, N., Rose, I. T., Willis, D. S., Hodson, J., Wild, S. H., Doherty, E. J., Hahner, S., Parajes, S., Stimson, R. H., Han, T. S., Carroll, P. V., Conway, G. S., Walker, B. R., MacDonald, F., Ross, R. J., Arlt, W. & United Kingdom Congenital Adrenal, Feb 2013, In : Journal of Clinical Endocrinology & Metabolism. 98, 2, p. E346-E354 9 p.

    Research output: Contribution to journalArticle

  82. Glucocorticoid treatment regimen and health outcomes in adults with congenital adrenal hyperplasia

    Han, T. S., Stimson, R. H., Rees, D. A., Krone, N., Willis, D. S., Conway, G. S., Arlt, W., Walker, B. R., Ross, R. J. & United Kingdom Congenital Adrenal, Feb 2013, In : Clinical Endocrinology. 78, 2, p. 197-203 7 p.

    Research output: Contribution to journalArticle

  83. 19F-magnetic resonance spectroscopy as a tool to quantify 11[beta]-hydroxysteroid dehydrogenase activity in vivo

    Naredo-Gonzalez, G., Jansen, M., Upreti, R., Semple, S., Merrifield, G., Sutcliffe, O., Hansen, M., Marshall, I., Andrew, R. & Walker, B., 2013, In : Endocrine Abstracts. p. 1-1

    Research output: Contribution to journalArticle

  84. 5α-Reductase type 1 inhibition or deficiency causes weight gain and insulin resistance in mice and men

    Andrew, R., Upreti, R., Livingstone, D. E. W., Barat, P., Hughes, K. A., MacFarlane, D. P., Gray, C. D., Minns, F. C., Marshall, I., Stewart, L. H. & Walker, B. R., 2013, Association of Physicians Annual Meeting.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  85. Inhibition of 5α-reductase type 1 with dutasteride impairs insulin sensitivity

    Upreti, R., Hughes, K. A., Gray, C. D., Minns, F. C., Marshall, I., Stewart, L. H., Walker, B. R. & Andrew, R., 2013, Society for Endocrinology BES.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  86. The post-prandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol production

    Stimson, R. H., Mohd-Shukri, N. A., Bolton, J. L., Andrew, R., Reynolds, R. M. & Walker, B. R., 2013, In : Journal of Clinical Endocrinology & Metabolism. 99, 1, p. 160-168 9 p.

    Research output: Contribution to journalArticle

  87. 2012
  88. Contribution of Endogenous Glucocorticoids and Their Intravascular Metabolism by 11β-HSDs to Postangioplasty Neointimal Proliferation in Mice

    Iqbal, J., Macdonald, L. J., Low, L., Seckl, J. R., Yau, C. W., Walker, B. R. & Hadoke, P. W. F., Dec 2012, In : Endocrinology . 153, 12, p. 5896-5905 10 p.

    Research output: Contribution to journalArticle

  89. Mineralocorticoid Receptor Antagonists Displace Cortisol, not Aldosterone, from the Human Heart

    Iqbal, J., Andrew, R., Cruden, N., Kenyon, C., Hughes, K., Hadoke, P., Newby, D. & Walker, B., 20 Nov 2012, In : Circulation. 126, 21, 2 p.

    Research output: Contribution to journalMeeting abstract

  90. Recycling Between Cortisol and Cortisone in Human Splanchnic, Subcutaneous Adipose, and Skeletal Muscle Tissues In Vivo

    Hughes, K. A., Manolopoulos, K. N., Iqbal, J., Cruden, N. L., Stimson, R. H., Reynolds, R. M., Newby, D. E., Andrew, R., Karpe, F. & Walker, B. R., Jun 2012, In : Diabetes . 61, 6, p. 1357-1364

    Research output: Contribution to journalArticle

  91. Glucocorticoid treatment and impaired mood, memory and metabolism in people with diabetes: the Edinburgh Type 2 Diabetes Study

    Reynolds, R. M., Labad, J., Sears, A. V., Williamson, R. M., Strachan, M. W. J., Deary, I. J., Lowe, G. D. O., Price, J. F., Walker, B. R. & the Edinburgh Type 2 Diabetes study investigators, May 2012, In : European Journal of Endocrinology. 166, 5, p. 861-868 8 p.

    Research output: Contribution to journalArticle

  92. The overexpression of 11 type 1 beta-hydroxysteroid dehydrogenase in pancreatic beta cells prevents beta cell failure induced by a fatty regime

    Turban, S., Liu, X., Ramage, L., Webster, S., Walker, B., Dunbar, D., Mullins, J., Seckl, J. & Morton, N., Mar 2012, In : Diabetes and Metabolism. 38, p. A20-A20 1 p.

    Research output: Contribution to journalMeeting abstract

  93. Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice

    Michailidou, Z., Turban, S., Miller, E., Zou, X., Schrader, J., Ratcliffe, P. J., Hadoke, P. W. F., Walker, B. R., Iredale, J. P., Morton, N. M. & Seckl, J. R., 3 Feb 2012, In : Journal of Biological Chemistry. 287, 6, p. 4188-4197 10 p.

    Research output: Contribution to journalArticle

  94. 11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline

    MacLullich, A. M. J., Ferguson, K. J., Reid, L. M., Deary, I. J., Starr, J., Wardlaw, J. M., Walker, B. R., Andrew, R. & Seckl, J. R., Jan 2012, In : Neurobiology of Aging. 33, 1, p. 207.e1–207.e8 8 p.

    Research output: Contribution to journalArticle

  95. Leptin Levels and Depressive Symptoms in People With Type 2 Diabetes: The Edinburgh Type 2 Diabetes Study

    Labad, J., Price, J. F., Strachan, M. W. J., Fowkes, F. G. R., Deary, I. J., Seckl, J. R., Walker, B. R., Sattar, N., Reynolds, R. M. & Edinburgh Type 2 Diabet Study, Jan 2012, In : Psychosomatic Medicine. 74, 1, p. 39-45 7 p.

    Research output: Contribution to journalArticle

  96. Using 3T Magnetic Resonance Imaging to Assess Fat Distribution and Ectopic Lipid Deposition in Morbidly Obese Pregnant Women in the Third Trimester

    Barr, S. M., Chiswick, C., Cooper, A., Gray, C. D., Semple, S. I. K., Morton, N. M., Walker, B. R. & Norman, J. E., 2012, 59th Annual Scientific Meeting of the Society for Gynecologic Investigation.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  97. 2011
  98. Reduced Gluteal Expression of Adipogenic and Lipogenic Genes in Black South African Women Is Associated with Obesity-Related Insulin Resistance

    Goedecke, J. H., Evans, J., Keswell, D., Stimson, R. H., Livingstone, D. E. W., Hayes, P., Adams, K., Dave, J. A., Victor, H., Levitt, N. S., Lambert, E. V., Walker, B. R., Seckl, J. R., Olsson, T. & Kahn, S. E., Dec 2011, In : Journal of Clinical Endocrinology & Metabolism. 96, 12, p. E2029-E2033 5 p.

    Research output: Contribution to journalArticle

  99. EFFECT OF INTRACELLULAR GLUCOCORTICOID METABOLISM ON NEOINTIMAL PROLIFERATION IN A MOUSE MODEL OF WIRE ANGIOPLASTY

    Iqbal, J., Macdonald, L. J., Yau, C. W., Walker, B. R. & Hadoke, P. W. F., Oct 2011, In : Heart. 97, 20, p. 1-1 1 p.

    Research output: Contribution to journalMeeting abstract

  100. A poorer metabolic profile in subjects with early psychosis is associated with a distinct diurnal pattern in salivary cortisol

    Ortega, L., Monseny, R., Lopez, X., Duch, M., Valero, J., Franch, J., Walker, B. R., Reynolds, R. M. & Labad, J., Sep 2011, In : European Neuropsychopharmacology. 21, p. S461-S462 2 p.

    Research output: Contribution to journalMeeting abstract

  101. Diet and Physical Activity in Severely Obese Pregnancy: Associations with Gestational Weight Gain and Birthweight

    Mohd-Shukri, N. A., Bolton, J., Forbes, S., Denison, F. C., Norman, J. E., Walker, B. R. & Reynolds, R. M., Sep 2011, In : Journal of the Developmental Origins of Health and Disease. 2, p. S93-S93 1 p.

    Research output: Contribution to journalMeeting abstract

  102. Maternal Diet-Induced Obesity in C57BL/6 Mice Alters Vascular Function in Their Offspring but Not Metabolism or Vascular Remodelling after Intravascular Injury

    Dakin, R. S., Hadoke, P. W. F., Walker, B. R., Seckl, J. R. & Drake, A. J., Sep 2011, In : Journal of the Developmental Origins of Health and Disease. 2, p. S39-S40 2 p.

    Research output: Contribution to journalMeeting abstract

  103. Overeating is associated with obesity measures in subjects with early psychosis

    Monseny, R., Ortega, L., Sole, M., Magrinya, G., Feliu, T., Franch, J., Gutierrez-Zotes, A., Walker, B. R., Reynolds, R. M. & Labad, J., Sep 2011, In : European Neuropsychopharmacology. 21, p. S518-S519 2 p.

    Research output: Contribution to journalMeeting abstract

  104. Genetics of cortisol secretion and depressive symptoms: A candidate gene and genome wide association approach

    Velders, F. P., Kuningas, M., Kumari, M., Dekker, M. J., Uitterlinden, A. G., Kirschbaum, C., Hek, K., Hofman, A., Verhulst, F. C., Kivimaki, M., Van Duijn, C. M., Walker, B. R. & Tiemeier, H., Aug 2011, In : Psychoneuroendocrinology. 36, 7, p. 1053-1061 9 p.

    Research output: Contribution to journalArticle

  105. Pro-inflammatory gene mRNA levels are elevated in subcutaneous but not visceral adipose tissue in obese pregnant women

    Barr, S. M., Walker, B. R., Morton, N. M. & Norman, J. E., Jul 2011, In : BJOG: An International Journal of Obstetrics and Gynaecology. 118, 8, p. 1008-1009 2 p.

    Research output: Contribution to journalMeeting abstract

  106. Role of both glucocorticoids and 7-oxysterols in atheroprotection of ApoE-/- mice deficient in 11 beta-HSD1 enzyme

    Mitic, T., Hadoke, P. W. F., Chuaiphichai, S., Man, T. Y., Miller, E., Andrew, R., Walker, B. R., Chapman, K. E. & Seckl, J. R., Jun 2011, In : Febs Journal. 278, p. 468-468 1 p.

    Research output: Contribution to journalMeeting abstract

  107. Increased prevalence of non-alcoholic fatty liver disease in European women with a history of gestational diabetes

    Forbes, S., Taylor-Robinson, S. D., Patel, N., Allan, P., Walker, B. R. & Johnston, D. G., Mar 2011, In : Diabetologia. 54, 3, p. 641-647 7 p.

    Research output: Contribution to journalArticle

  108. Quantitative 3-Dimensional Imaging of Murine Neointimal and Atherosclerotic Lesions by Optical Projection Tomography

    Kirkby, N. S., Low, L., Seckl, J. R., Walker, B. R., Webb, D. J. & Hadoke, P. W. F., 17 Feb 2011, In : PLoS ONE. 6, 2, p. - 8 p., e16906.

    Research output: Contribution to journalArticle

  109. Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis

    Macfarlane, D. P., Zou, X., Andrew, R., Morton, N. M., Livingstone, D. E. W., Aucott, R. L., Nyirenda, M. J., Iredale, J. P. & Walker, B. R., Feb 2011, In : American Journal of Physiology - Endocrinology And Metabolism. 300, 2, p. E402-E409 8 p.

    Research output: Contribution to journalArticle

  110. 5α-reduced glucocorticoids exhibit dissociated anti-inflammatory and metabolic effects

    Yang, CHENYING., Nixon, M., Kenyon, C. J., Livingstone, D. E. W., Duffin, R., Rossi, A. G., Walker, B. R. & Andrew, R., 2011, In : British Journal of Pharmacology. 164, 6, p. 1661-71 11 p.

    Research output: Contribution to journalArticle

  111. A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome

    Gambineri, A., Tomassoni, F., Munarini, A., Stimson, R. H., Mioni, R., Pagotto, U., Chapman, K. E., Andrew, R., Mantovani, V., Pasquali, R. & Walker, B. R., 2011, In : European Journal of Endocrinology. 165, 2, p. 283-92 10 p.

    Research output: Contribution to journalArticle

  112. 2010
  113. Glucocorticoid-Mediated Inhibition of Angiogenic Changes in Human Endothelial Cells Is Not Caused by Reductions in Cell Proliferation or Migration

    Logie, J. J., Ali, S., Marshall, K. M., Heck, M. M. S., Walker, B. R. & Hadoke, P. W. F., Dec 2010, In : PLoS ONE. 5, 12, 10 p., e14476.

    Research output: Contribution to journalArticle

  114. Kisspeptin-10 Inhibits Angiogenesis in Human Placental Vessels ex Vivo and Endothelial Cells in Vitro

    Ramaesh, T., Logie, J. J., Roseweir, A. K., Millar, R. P., Walker, B. R., Hadoke, P. W. F. & Reynolds, R. M., Dec 2010, In : Endocrinology. 151, 12, p. 5927-5934 8 p.

    Research output: Contribution to journalArticle

  115. Exogenous Glucocorticoids Inhibit Neointimal Proliferation but Increase Local Thrombosis in Mice

    Low, L., Seckl, J. R., Walker, B. R. & Hadoke, P. W., Nov 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 11, p. E260-E260 1 p.

    Research output: Contribution to journalMeeting abstract

  116. Exogenous, but Not Endogenous, Glucocorticoids Augment Atherosclerosis in Mice

    Low, L., Kirkby, N. S., Seckl, J. R., Walker, B. R. & Hadoke, P. W., Nov 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 11, p. E291-E291 1 p.

    Research output: Contribution to journalMeeting abstract

  117. Health Status of Adults with Congenital Adrenal Hyperplasia: A Cohort Study of 203 Patients

    Arlt, W., Willis, D. S., Wild, S. H., Krone, N., Doherty, E. J., Hahner, S., Han, T. S., Carroll, P. V., Conway, G. S., Rees, D. A., Stimson, R. H., Walker, B. R., Connell, J. M. C., Ross, R. J. & United Kingdom Congenital Adrenal, Nov 2010, In : Journal of Clinical Endocrinology & Metabolism. 95, 11, p. 5110-5121 12 p.

    Research output: Contribution to journalArticle

  118. Glucocorticoids Turn Over Slowly in Human Adipose Tissue in Vivo

    Hughes, K. A., Reynolds, R. M., Andrew, R., Critchley, H. O. D. & Walker, B. R., Oct 2010, In : Journal of Clinical Endocrinology & Metabolism. 95, 10, p. 4696-4702 7 p.

    Research output: Contribution to journalArticle

  119. Improved heart function follows enhanced inflammatory cell recruitment and angiogenesis in 11 beta HSD1-deficient mice post-MI

    McSweeney, S. J., Hadoke, P. W. F., Kozak, A. M., Small, G. R., Khaled, H., Walker, B. R. & Gray, G. A., Oct 2010, In : Cardiovascular Research. 88, 1, p. 159-167 9 p.

    Research output: Contribution to journalArticle

  120. Partial Deficiency or Short-Term Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Improves Cognitive Function in Aging Mice

    Sooy, K., Webster, S. P., Noble, J., Binnie, M., Walker, B. R., Seckl, J. R. & Yau, J. L. W., Oct 2010, In : The Journal of Neuroscience. 30, 41, p. 13867-13872 6 p.

    Research output: Contribution to journalArticle

  121. Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles

    Webster, S. P., Binnie, M., McConnell, K. M. M., Sooy, K., Ward, P., Greaney, M. F., Vinter, A., Pallin, T. D., Dyke, H. J., Gill, M. I. A., Warner, I., Seckl, J. R. & Walker, B. R., 1 Jun 2010, In : Bioorganic & Medicinal Chemistry Letters. 20, 11, p. 3265-3271 7 p.

    Research output: Contribution to journalArticle

  122. Extra-Adrenal Cortisol Production in Obese Men with Type Two Diabetes Mellitus - How Big Is the Therapeutic Target for 11 beta HSD1 Inhibitors?

    Stimson, R. H., Andrew, R., McAvoy, N. C., Tripathi, D., Hayes, P. C. & Walker, B. R., Jun 2010, In : Endocrine Reviews. 31, 3, p. S11-S11 1 p.

    Research output: Contribution to journalMeeting abstract

  123. Glucocorticoids Turn over Slowly in Human Adipose Tissue In Vivo.

    Hughes, K. A., Reynolds, R. M., Critchley, H. O. D., Andrew, R. & Walker, B. R., Jun 2010, In : Endocrine Reviews. 31, 3, p. - 1 p.

    Research output: Contribution to journalMeeting abstract

  124. Non-Invasive In-Vivo Monitoring of 11 beta-HSD1 Activity Using F-19-Magnetic Resonance Spectroscopy.

    Naredo-Gonzalez, G., Jansen, M., Merrifield, G. D., Sutcliffe, O. B., Hansen, M. K., Andrew, R. & Walker, B. R., Jun 2010, In : Endocrine Reviews. 31, 3, p. - 1 p.

    Research output: Contribution to journalMeeting abstract

  125. Reversible Interconversion of Cortisol and Cortisone in Human Subcutaneous Adipose Tissue and Skeletal Muscle In Vivo

    Hughes, K., Manolopoulos, K., Andrew, R., Karpe, F. & Walker, B. R., Jun 2010, In : Endocrine Reviews. 31, 3, p. S2497-S2497 1 p.

    Research output: Contribution to journalMeeting abstract

  126. Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice

    McNeilly, A. D., Macfarlane, D. P., O'Flaherty, E., Livingstone, D. E., Mitić, T., McConnell, K. M., McKenzie, S. M., Davies, E., Reynolds, R. M., Thiesson, H. C., Skøtt, O., Walker, B. R. & Andrew, R., May 2010, In : Journal of Hepatology. 52, 5, p. 705-711 7 p.

    Research output: Contribution to journalArticle

  127. Elevated Fasting Plasma Cortisol Is Associated with Ischemic Heart Disease and Its Risk Factors in People with Type 2 Diabetes: The Edinburgh Type 2 Diabetes Study

    Reynolds, R. M., Labad, J., Strachan, M. W. J., Braun, A., Fowkes, F. G. R., Lee, A. J., Frier, B. M., Seckl, J. R., Walker, B. R., Price, J. F. & ET2DS Investigators, Apr 2010, In : Journal of Clinical Endocrinology & Metabolism. 95, 4, p. 1602-1608 7 p.

    Research output: Contribution to journalArticle

  128. Morning Cortisol Levels and Cognitive Abilities in People With Type 2 Diabetes The Edinburgh Type 2 Diabetes Study

    Reynolds, R. M., Strachan, M. W. J., Labad, J., Lee, A. J., Frier, B. M., Fowkes, F. G., Mitchell, R., Seckl, J. R., Deary, I. J., Walker, B. R., Price, J. F. & Edinburgh Type 2 Diabet Study, Apr 2010, In : Diabetes Care. 33, 4, p. 714-720 7 p.

    Research output: Contribution to journalArticle

  129. Prenatal Dexamethasone Programs Expression of Genes in Liver and Adipose Tissue and Increased Hepatic Lipid Accumulation But Not Obesity on a High-Fat Diet

    Drake, A. J., Raubenheimer, P. J., Kerrigan, D., McInnes, K. J., Seckl, J. R. & Walker, B. R., Apr 2010, In : Endocrinology. 151, 4, p. 1581-1587 7 p.

    Research output: Contribution to journalArticle

  130. Low serum cortisol predicts early death after acute myocardial infarction

    Reynolds, R. M., Walker, B. R., Haw, S., Newby, D. E., Mackay, D. F., Cobbe, S. M., Pell, A. C. H., Fischbacher, C., Pringle, S., Murdoch, D., Dunn, F., Oldroyd, K., MacIntyre, P., O'Rourke, B. & Pell, J. P., Mar 2010, In : Critical Care Medicine. 38, 3, p. 973-975 3 p.

    Research output: Contribution to journalArticle

  131. Symptoms of depression but not anxiety are associated with central obesity and cardiovascular disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study

    Labad, J., Price, J. F., Strachan, M. W. J., Fowkes, F. G. R., Ding, J., Deary, I. J., Lee, A. J., Frier, B. M., Seckl, J. R., Walker, B. R. & Reynolds, R. M., Mar 2010, In : Diabetologia. 53, 3, p. 467-471 5 p.

    Research output: Contribution to journalArticle

  132. Effects of Proportions of Dietary Macronutrients on Glucocorticoid Metabolism in Diet-Induced Obesity in Rats

    Stimson, R. H., Lobley, G. E., Maraki, I., Morton, N. M., Andrew, R. & Walker, B. R., 19 Jan 2010, In : PLoS ONE. 5, 1, p. - 7 p., e8779.

    Research output: Contribution to journalArticle

  133. Functional Effects of Polymorphisms in the Human Gene Encoding 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1): A Sequence Variant at the Translation Start of 11 beta-HSD1 Alters Enzyme Levels

    Malavasi, E. L. V., Kelly, V., Nath, N., Gambineri, A., Dakin, R. S., Pagotto, U., Pasquali, R., Walker, B. R. & Chapman, K. E., Jan 2010, In : Endocrinology . 151, 1, p. 195-202 8 p.

    Research output: Contribution to journalArticle

  134. 2009
  135. Tissue-Specific Increases in 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Normal Weight Postmenopausal Women

    Andersson, T., Simonyte, K., Andrew, R., Strand, M., Buren, J., Walker, B. R., Mattsson, C. & Olsson, T., 29 Dec 2009, In : PLoS ONE. 4, 12, p. - 8 p., e8475.

    Research output: Contribution to journalArticle

  136. 3-DIMENSIONAL EX VIVO ANALYSIS BY OPTICAL PROJECTION TOMOGRAPHY DEMONSTRATES THAT EXOGENOUS GLUCOCORTICOIDS AUGMENT ATHEROGENESIS IN APOE-/- MICE

    Low, L., Kirkby, N. S., Seckl, J. R., Walker, B. R. & Hadoke, P. W. F., 15 Nov 2009, In : Heart. 95, 22, p. - 2 p.

    Research output: Contribution to journalMeeting abstract

  137. Sustained Enhancement of Cardiac Function Follows Increased Recruitment of Pro-angiogenic Macrophages to Healing Infarcts of 11 Beta Hydroxysteroid Dehydrogenase Type 1 Deficient Mice

    McSweeney, S. J., Kozak, A. M., Khaled, H., Hadoke, P. W., Walker, B. R. & Gray, G. A., 3 Nov 2009, In : Circulation. 120, 18, p. S792-S792 1 p.

    Research output: Contribution to journalMeeting abstract

  138. Lack of regulation of 11 beta-hydroxysteroid dehydrogenase type 1 during short-term manipulation of GH in patients with hypopituitarism

    Sigurjonsdottir, H. A., Andrew, R., Stimson, R. H., Johannsson, G. & Walker, B. R., Sep 2009, In : European Journal of Endocrinology. 161, 3, p. 375-80 6 p.

    Research output: Contribution to journalArticle

  139. Selective 11-HSD1 inhibition reduces atherosclerosis and improves markers of plaque stability

    Iqbal, J., Sullivan, K., Kirkby, N. S., Livingstone, D. E., Andrew, R., Walker, B. R. & Hadoke, P. W., Sep 2009, In : European Heart Journal. 30, p. 757-757 1 p.

    Research output: Contribution to journalMeeting abstract

  140. Differential Effects of Abdominal Adipose Tissue Distribution on Insulin Sensitivity in Black and White South African Women

    Goedecke, J. H., Levitt, N. S., Lambert, E. V., Utzschneider, K. M., Faulenbach, M. V., Dave, J. A., West, S., Victor, H., Evans, J., Olsson, T., Walker, B. R., Seckl, J. R. & Kahn, S. E., Aug 2009, In : Obesity. 17, 8, p. 1506-1512 7 p.

    Research output: Contribution to journalArticle

  141. Circulating plasma cortisol concentrations are not associated with coronary artery disease or peripheral vascular disease

    Reynolds, R. M., Ilyas, B., Price, J. F., Fowkes, F. G. R., Newby, D. E., Webb, D. J. & Walker, B. R., Jul 2009, In : QJM: An International Journal of Medicine. 102, 7, p. 469-475 7 p.

    Research output: Contribution to journalArticle

  142. ATHEROPROTECTION BY 11B-HSD1 INHIBITION IN APOLIPOPROTEIN E KNOCKOUT MICE IS ASSOCIATED WITH LOWERING OF BLOOD PRESSURE

    Iqbal, J., Sullivan, K., Livingstone, D. E., Andrew, R., Walker, B. R. & Hadoke, P. W. F., Jun 2009, In : Heart. 95, p. A61-A61 1 p.

    Research output: Contribution to journalArticle

  143. Programming of Hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol and blood pressure

    Reynolds, R. M., Walker, B. R., Phillips, D. I. W., Dennison, E. M., Fraser, R., MacKenzie, S. M., Davies, E. & Connell, J. M., Jun 2009, In : Hypertension. 53, 6, p. 932-936 5 p.

    Research output: Contribution to journalArticle

  144. Dysregulation of glucocorticoid metabolism in murine obesity: comparable effects of leptin resistance and deficiency

    Livingstone, D. E. W., Grassick, S. L., Currie, G. L., Walker, B. R. & Andrew, R., May 2009, In : Journal of Endocrinology. 201, 2, p. 211-8 8 p.

    Research output: Contribution to journalArticle

  145. Insulin Response in Relation to Insulin Sensitivity An appropriate beta-cell response in black South African women

    Goedecke, J. H., Dave, J. A., Faulenbach, M. V., Utzschneider, K. M., Lambert, E. V., West, S., Collins, M., Olsson, T., Walker, B. R., Seckl, J. R., Kahn, S. E. & Levitt, N. S., May 2009, In : Diabetes Care. 32, 5, p. 860-865 6 p.

    Research output: Contribution to journalArticle

  146. Combined Receptor Antagonist Stimulation of the Hypothalamic-Pituitary-Adrenal Axis Test Identifies Impaired Negative Feedback Sensitivity to Cortisol in Obese Men

    Mattsson, C., Reynolds, R. M., Simonyte, K., Olsson, T. & Walker, B. R., Apr 2009, In : Journal of Clinical Endocrinology & Metabolism. 94, 4, p. 1347-1352 6 p.

    Research output: Contribution to journalArticle

  147. Cortisol Inactivation by 11 beta-Hydroxysteroid dehydrogenase-2 May Enhance Endometrial Angiogenesis via Reduced Thrombospondin-1 in Heavy Menstruation

    Rae, M., Mohamad, A., Price, D., Hadoke, P. W. F., Walker, B. R., Mason, J. I., Hillier, S. G., Critchley, H. O. D. & Mason, J. I., Apr 2009, In : Journal of Clinical Endocrinology & Metabolism. 94, 4, p. 1443-1450 8 p.

    Research output: Contribution to journalArticle

  148. Increased clearance of cortisol by 5 beta-reductase in a subgroup of women with adrenal hyperandrogenism in polycystic ovary syndrome

    Gambineri, A., Forlani, G., Munarini, A., Tomassoni, F., Cognigni, G. E., Ciampaglia, W., Pagotto, U., Walker, B. R. & Pasquali, R., Mar 2009, In : Journal of Endocrinological Investigation . 32, 3, p. 210-218 9 p.

    Research output: Contribution to journalArticle

  149. Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease

    Hadoke, P. W. F., Iqbal, J. & Walker, B. R., Mar 2009, In : British Journal of Pharmacology. 156, 5, p. 689-712 24 p.

    Research output: Contribution to journalLiterature review

  150. Development of a derivatisation method for the analysis of aldehyde modified amino acid residues in proteins by Fourier transform mass spectrometry

    Pournamdari, M., Saadi, A., Ellis, E., Andrew, R., Walker, B. & Watson, D. G., 9 Feb 2009, In : Analytica Chimica Acta. 633, 2, p. 216-222 7 p.

    Research output: Contribution to journalArticle

  151. Quantitative analysis of RU38486 (mifepristone) by HPLC triple quadrupole mass spectrometry

    Homer, N. Z., Reynolds, R. M., Mattson, C., Bailey, M. A., Walker, B. R. & Andrew, R., Feb 2009, In : Journal of Chromatography B. 877, 5-6, p. 497-501 5 p.

    Research output: Contribution to journalArticle

  152. Cortisol Release From Adipose Tissue by 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Humans

    Stimson, R. H., Andersson, J., Andrew, R., Redhead, D. N., Karpe, F., Hayes, P. C., Olsson, T. & Walker, B. R., Jan 2009, In : Diabetes . 58, 1, p. 46-53 8 p.

    Research output: Contribution to journalArticle

  153. Current management, morbidity and genotype-phenotype correlation in adults with congenital adrenal hyperplasia - analysis of the United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE) cohort

    Krone, N., Willis, D. S., Rose, I. T., Crosby, C., Wild, S. H., Doherty, E. J., Hahner, S., Han, T. S., Stimson, R. H., Carroll, P. V., Conway, G. S., Rees, D. A., Walker, B. R., MacDonald, F., Ross, R. J., Arlt, W. & United Kingdom Congenital Adrenal, 2009, In : Hormone Research. 72, p. 41-41 1 p.

    Research output: Contribution to journalMeeting abstract

  154. Increased clearance of cortisol by 5beta-reductase in a subgroup of women with adrenal hyperandrogenism in polycystic ovary syndrome

    Gambineri, A., Forlani, G., Munarini, A., Tomassoni, F., Cognigni, G. E., Ciampaglia, W., Pagotto, U., Walker, B. R. & Pasquali, R., 2009, In : Journal of Endocrinological Investigation . 32, 3, p. 210-8 9 p.

    Research output: Contribution to journalArticle

  155. 2008
  156. Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome

    Macfarlane, D. P., Forbes, S. & Walker, B. R., May 2008, In : Journal of Endocrinology. 197, 2, p. 189-204 16 p.

    Research output: Contribution to journalLiterature review

  157. 11-Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors in type 2 diabetes mellitus and obesity

    Hughes, K. A., Webster, S. P. & Walker, B. R., Apr 2008, In : Expert opinion on investigational drugs. 17, 4, p. 481-96 16 p.

    Research output: Contribution to journalLiterature review

  158. Idiopathic intracranial hypertension: Can studies of obesity provide the key to understanding pathogenesis?

    Ooi, L. -Y., Walker, B. R., Bodkin, P. A. & Whittle, I. R., Apr 2008, In : British Journal of Neurosurgery. 22, 2, p. 187-194 8 p.

    Research output: Contribution to journalLiterature review

  159. Regulation of the human AKR1D1 (5 beta-reductase) gene; a novel role for bile acids in modulating cortisol metabolism in chronic liver disease

    O'Flaherty, E., Walker, B. & Andrew, R., Feb 2008, In : Scottish Medical Journal. 53, 1, p. 52-52 1 p.

    Research output: Contribution to journalMeeting abstract

  160. 2007
  161. Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors

    Webster, S. P., Ward, P., Binnie, M., Craigie, E., McConnell, K. M. M., Sooy, K., Vinter, A., Seckl, J. R. & Walker, B. R., 15 May 2007, In : Bioorganic & Medicinal Chemistry Letters. 17, 10, p. 2838-2843 6 p.

    Research output: Contribution to journalArticle

  162. Omentall 11 beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity

    Michailidou, Z., Jensen, M. D., Dumesic, D. A., Chapman, K. E., Seckl, J. R., Walker, B. R. & Morton, N. M., May 2007, In : Obesity. 15, 5, p. 1155-1163 9 p.

    Research output: Contribution to journalArticle

  163. Acute effects of glucocorticoids on endothelial fibrinolytic and vasodilator function in humans

    Dover, A. R., Hadoke, P. W. F., Walker, B. R. & Newby, D. E., 2007, In : Journal of cardiovascular pharmacology. 50, 3, p. 321-6 6 p.

    Research output: Contribution to journalArticle

  164. Can cortisol predict the future in obesity?

    Reynolds, R. M. & Walker, B. R., 2007, In : Clinical Endocrinology. 67, 1, p. 1-2 2 p.

    Research output: Contribution to journalArticle

  165. Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men

    Stimson, R. H., Johnstone, A. M., Homer, N. Z. M., Wake, D. J., Morton, N. M., Andrew, R., Lobley, G. E. & Walker, B. R., 2007, In : Journal of Clinical Endocrinology & Metabolism. 92, 11, p. 4480-4 5 p.

    Research output: Contribution to journalArticle

  166. Effects of gonadectomy on glucocorticoid metabolism in obese Zucker rats

    Barat, P., Livingstone, D. E. W., Elferink, C. M. C., McDonnell, C. R., Walker, B. R. & Andrew, R., 2007, In : Endocrinology . 148, 10, p. 4836-43 8 p.

    Research output: Contribution to journalArticle

  167. Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men

    Wake, D. J., Stimson, R. H., Tan, G. D., Homer, N. Z. M., Andrew, R., Karpe, F. & Walker, B. R., 2007, In : Journal of Clinical Endocrinology & Metabolism. 92, 5, p. 1848-56 9 p.

    Research output: Contribution to journalArticle

  168. Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning

    Walker, B. R., 2007, In : Proceedings of the Nutrition Society. 66, 1, p. 1-8 8 p.

    Research output: Contribution to journalArticle

  169. Glucocorticoids and 11beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome

    Stimson, R. H. & Walker, B. R., 2007, In : Minerva endocrinologica. 32, 3, p. 141-59 19 p.

    Research output: Contribution to journalArticle

  170. Glucocorticoids and cardiovascular disease

    Walker, B. R., 2007, In : European Journal of Endocrinology. 157, 5, p. 545-59 15 p.

    Research output: Contribution to journalArticle

  171. Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity

    Wake, D. J., Strand, M., Rask, E., Westerbacka, J., Livingstone, D. E. W., Soderberg, S., Andrew, R., Yki-Jarvinen, H., Olsson, T. & Walker, B. R., 2007, In : Clinical Endocrinology. 66, 3, p. 440-6 7 p.

    Research output: Contribution to journalArticle

  172. Intravascular glucocorticoid metabolism during inflammation and injury in mice

    Dover, A. R., Hadoke, P. W. F., Macdonald, L. J., Miller, E., Newby, D. E. & Walker, B. R., 2007, In : Endocrinology . 148, 1, p. 166-72 7 p.

    Research output: Contribution to journalArticle

  173. Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity

    Michailidou, Z., Jensen, M. D., Dumesic, D. A., Chapman, K. E., Seckl, J. R., Walker, B. R. & Morton, N. M., 2007, In : Obesity. 15, 5, p. 1155-63 9 p.

    Research output: Contribution to journalArticle

  174. Truncal distribution of fat mass, metabolic profile and hypothalamic-pituitary adrenal axis activity in prepubertal obese children

    Barat, P., Gayard-Cros, M., Andrew, R., Corcuff, J-B., Jouret, B., Barthe, N., Perez, P., Germain, C., Tauber, M., Walker, B. R., Mormede, P. & Duclos, M., 2007, In : The Journal of pediatrics. 150, 5, p. 535-9, 539.e1

    Research output: Contribution to journalArticle

  175. 2006
  176. Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women

    Goedecke, J. H., Wake, D. J., Levitt, N. S., Lambert, E. V., Collins, M. R., Morton, N. M., Andrew, R., Seckl, J. R. & Walker, B. R., Jul 2006, In : Clinical Endocrinology. 65, 1, p. 81-87 7 p.

    Research output: Contribution to journalArticle

  177. 11 beta-Hydroxysteroid dehydrogenase type 1 as a therapeutic target in metabolic syndrome and beyond

    Walker, B. R. & Seckl, J. R., 26 Mar 2006, In : Abstracts of Papers - American Chemical Society, National Meeting. 231, 1 p.

    Research output: Contribution to journalMeeting abstract

  178. Altered vascular contractility in adult female rats with hypertension programmed by prenatal glucocorticoid exposure

    Hadoke, P. W. F., Lindsay, R. S., Seckl, J. R., Walker, B. R. & Kenyon, C. J., Mar 2006, In : Journal of Endocrinology. 188, 3, p. 435-442 8 p.

    Research output: Contribution to journalArticle

  179. Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD 11B1) and lifetime cognitive change

    Deary, I. J., Hayward, C., Permana, P. A., Nair, S., Whalley, L. J., Starr, J., Chapman, K. E., Walker, B. R. & Seckl, J. R., 23 Jan 2006, In : Neuroscience Letters. 393, 1, p. 74-77 4 p.

    Research output: Contribution to journalArticle

  180. A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet

    Raubenheimer, P. J., Nyirenda, M. J. & Walker, B. R., 2006, In : Diabetes . 55, 7, p. 2015-20 6 p.

    Research output: Contribution to journalArticle

  181. Acute in vivo regulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by insulin and intralipid infusions in humans

    Wake, D. J., Homer, N. Z. M., Andrew, R. & Walker, B. R., 2006, In : Journal of Clinical Endocrinology & Metabolism. 91, 11, p. 4682-8 7 p.

    Research output: Contribution to journalArticle

  182. Cortisol--cause and cure for metabolic syndrome?

    Walker, B. R., 2006, In : Diabetic Medicine. 23, 12, p. 1281-8 8 p.

    Research output: Contribution to journalArticle

  183. Differences in cortisol concentrations in South Asian and European men living in the United Kingdom

    Reynolds, R. M., Fischbacher, C., Bhopal, R., Byrne, C. D., White, M., Unwin, N. & Walker, B. R., 2006, In : Clinical Endocrinology. 64, 5, p. 530-4 5 p.

    Research output: Contribution to journalArticle

  184. Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 in obesity

    Wake, D. J. & Walker, B. R., 2006, In : Endocrine Reviews. 29, 1, p. 101-8 8 p.

    Research output: Contribution to journalArticle

  185. Intra-vascular glucocorticoid metabolism as a modulator of vascular structure and function

    Hadoke, P. W. F., Macdonald, L., Logie, J. J., Small, G. R., Dover, A. R. & Walker, B. R., 2006, In : Cellular and Molecular Life Sciences. 63, 5, p. 565-78 14 p.

    Research output: Contribution to journalArticle

  186. Tissue production of cortisol by 11 beta-hydroxysteroid dehydrogenase type 1 and metabolic disease

    Walker, B. R. & Andrew, R., 2006, STRESS, OBESITY, AND METABOLIC SYNDROME. Chrousos, GP. & Tsigos, C. (eds.). OXFORD: BLACKWELL SCIENCE PUBL, p. 165-184 20 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  187. 2005
  188. Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats

    Drake, A. J., Walker, B. R. & Seckl, J. R., Jan 2005, In : American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 288, 1, p. R34-R38 5 p.

    Research output: Contribution to journalArticle

  189. Cortisol secretion and rate of bone loss in a population-based cohort of elderly men and women

    Reynolds, R. M., Dennison, E. M., Walker, B. R., Syddall, H. E., Wood, P. J., Andrew, R., Phillips, D. I. & Cooper, C., 2005, In : Calcified Tissue International. 77, 3, p. 134-8 5 p.

    Research output: Contribution to journalArticle

  190. Increased A-ring reduction of glucocorticoids in obese Zucker rats: effects of insulin sensitization

    Livingstone, D. E. W., McInnes, K. J., Walker, B. R. & Andrew, R., 2005, In : Obesity Research &Clinical Practice. 13, 9, p. 1523-6 4 p.

    Research output: Contribution to journalArticle

  191. Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone

    Sandeep, T. C., Andrew, R., Homer, N. Z. M., Andrews, R. C., Smith, K. & Walker, B. R., 2005, In : Diabetes . 54, 3, p. 872-9 8 p.

    Research output: Contribution to journalArticle

  192. Is there a gender difference in the associations of birthweight and adult hypothalamic-pituitary-adrenal axis activity?

    Reynolds, R. M., Walker, B. R., Syddall, H. E., Andrew, R., Wood, P. J. & Phillips, D. I. W., 2005, In : European Journal of Endocrinology. 152, 2, p. 249-53 5 p.

    Research output: Contribution to journalArticle

  193. Preventing local regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 enhances angiogenesis

    Small, G. R., Hadoke, P. W. F., Sharif, I., Dover, A. R., Armour, D., Kenyon, C. J., Gray, G. A. & Walker, B. R., 2005, In : Proceedings of the National Academy of Sciences. 102, 34, p. 12165-70 6 p.

    Research output: Contribution to journalArticle

  194. The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans

    Andrew, R., Westerbacka, J., Wahren, J., Yki-Järvinen, H. & Walker, B. R., 2005, In : Diabetes . 54, 5, p. 1364-70 7 p.

    Research output: Contribution to journalArticle

  195. 2004
  196. 11 beta HSD1-/- mice have enhanced angiogenic response and improved myodardial function following coronary artery ligation

    Small, G. R., Hadoke, P. W. F., Gray, G. A., Sharif, I., Mullins, J. J., Seckl, J. R. & Walker, B. R., Oct 2004, In : Hypertension. 44, 4, p. 587-587 1 p.

    Research output: Contribution to journalArticle

  197. Use of oral glucocorticoids and risk of cardiovascular and cerebrovascular disease in a population based case-control study

    Souverein, P. C., Van Staa, T. P., Egberts, A. C. G., Leufkens, H. G. M., Berard, A., Cooper, C. & Walker, B. R., 1 Aug 2004, In : Heart. 90, 8, p. 859-865 7 p.

    Research output: Contribution to journalArticle

  198. Glycosylated hemoglobin levels in healthy elderly nondiabetic men are negatively associated with verbal memory

    MacLullich, A. M. J., Deary, I. J., Starr, J., Walker, B. R. & Seckl, J. R., May 2004, In : Journal of the American Geriatrics Society. 52, 5, p. 848-849 2 p.

    Research output: Contribution to journalLetter

  199. 11 beta-Hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics

    Sandeep, T. C., Yau, J. L. W., MacLullich, A. M. J., Noble, J., Deary, I. J., Walker, B. R. & Seckl, J. R., 27 Apr 2004, In : Proceedings of the National Academy of Sciences. 101, 17, p. 6734-6739 6 p.

    Research output: Contribution to journalArticle

  200. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice

    Morton, N. M., Paterson, J. M., Masuzaki, H., Holmes, M. C., Staels, B., Fievet, C., Walker, B. R., Flier, J. S., Mullins, J. J. & Seckl, J. R., Apr 2004, In : Diabetes . 53, 4, p. 931-938 8 p.

    Research output: Contribution to journalArticle

  201. The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk

    Drake, A. J. & Walker, B. R., Jan 2004, In : Journal of Endocrinology. 180, 1, p. 1-16 16 p.

    Research output: Contribution to journalArticle

  202. 5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor

    McInnes, K. J., Kenyon, C. J., Chapman, K. E., Livingstone, D. E. W., Macdonald, L. J., Walker, B. R. & Andrew, R., 2004, In : Journal of Biological Chemistry. 279, 22, p. 22908-12 5 p.

    Research output: Contribution to journalArticle

  203. In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue

    Sutinen, J., Kannisto, K., Korsheninnikova, E., Nyman, T., Ehrenborg, E., Andrew, R., Wake, D. J., Hamsten, A., Walker, B. R. & Yki-Järvinen, H., 2004, In : Diabetologia. 47, 10, p. 1668-71 4 p.

    Research output: Contribution to journalArticle

  204. Influence of short-term dietary weight loss on cortisol secretion and metabolism in obese men

    Johnstone, A. M., Faber, P., Andrew, R., Gibney, E. R., Elia, M., Lobley, G., Stubbs, R. J. & Walker, B. R., 2004, In : European Journal of Endocrinology. 150, 2, p. 185-94 10 p.

    Research output: Contribution to journalArticle

  205. 2003
  206. Altered peripheral sensitivity to glucocorticoids in primary open-angle glaucoma

    Stokes, J., Walker, B. R., Campbell, J. C., Seckl, J. R., O'Brien, C. & Andrew, R., Dec 2003, In : Investigative Ophthalmology & Visual Science. 44, 12, p. 5163-5167 5 p.

    Research output: Contribution to journalArticle

  207. Body fat distribution and cortisol metabolism in healthy men: Enhanced 5 beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver

    Westerbacka, J., Yki-Jarvinen, H., Vehkavaara, S., Hakkinen, A. M., Andrew, R., Wake, D. J., Seckl, J. R. & Walker, B. R., 1 Oct 2003, In : Journal of Clinical Endocrinology & Metabolism. 88, 10, p. 4924-4931 8 p.

    Research output: Contribution to journalArticle

  208. 11 beta-hydroxysteroid dehydrogenase type 2 in mouse aorta - Localization and influence on response to glucocorticoids

    Christy, C., Hadoke, P. W. F., Paterson, J. M., Mullins, J. J., Seckl, J. R. & Walker, B. R., Oct 2003, In : Hypertension. 42, 4, p. 580-587 8 p.

    Research output: Contribution to journalArticle

  209. Cortisol metabolism in type 2 diabetes

    Walker, B. R. & Andrew, R., Jun 2003, In : Journal of Clinical Endocrinology & Metabolism. 88, 6, p. 2951-2952 2 p.

    Research output: Contribution to journalLetter

  210. Ten years on: Safety of short synacthen tests in assessing adrenocorticotropin deficiency in clinical practice

    Gleeson, H. K., Walker, B. R., Seckl, J. R. & Padfield, P. L., 1 May 2003, In : Journal of Clinical Endocrinology & Metabolism. 88, 5, p. 2106-2111 6 p.

    Research output: Contribution to journalEditorial

  211. Programming of rat muscle and fat metabolism by in utero overexposure to glucocorticoids

    Cleasby, M. E., Kelly, P. A. T., Walker, B. R. & Seckl, J. R., Mar 2003, In : Endocrinology . 144, 3, p. 999-1007 9 p.

    Research output: Contribution to journalArticle

  212. Is programming of glucocorticoid receptor expression by prenatal dexamethasone in the rat secondary to metabolic derangement in adulthood?

    Cleasby, M. E., Livingstone, D. E. W., Nyirenda, M. J., Seckl, J. R. & Walker, B. R., Jan 2003, In : European Journal of Endocrinology. 148, 1, p. 129-138 10 p.

    Research output: Contribution to journalArticle

  213. 2002
  214. Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome - Nested case-control study

    Brunner, E. J., Hemingway, H., Walker, B. R., Page, M., Clarke, P., Juneja, M., Shipley, M. J., Kumari, M., Andrew, R., Seckl, J. R., Papadopoulos, A., Checkley, S., Rumley, A., Lowe, G. D. O., Stansfeld, S. A. & Marmot, M. G., 19 Nov 2002, In : Circulation. 106, 21, p. 2659-2665 7 p.

    Research output: Contribution to journalArticle

  215. Glucocorticoid metabolism and the Metabolic Syndrome: Associations in an elderly cohort

    Andrew, R., Gale, C., Walker, B. R., Seckl, J. R. & Martyn, C. N., Sep 2002, In : Experimental and clinical endocrinology & diabetes. 110, 6, p. 284-290 7 p.

    Research output: Contribution to journalArticle

  216. Peripheral vascular structure and function in men with contrasting growth hormone levels

    Irving, R. J., Carson, M., Webb, D. & Walker, B., 1 Jul 2002, In : Journal of Clinical Endocrinology and Metabolism. 87, 1, p. 3309-3314 6 p.

    Research output: Contribution to journalArticle

  217. Skeletal muscle glucocorticoid receptor density and insulin resistance

    Reynolds, R. M., Chapman, K. E., Seckl, J. R., Walker, B. R., McKeigue, P. M. & Lithell, H. O., 15 May 2002, In : JAMA: the Journal of the American Medical Association. 287, 19, p. 2505-2506 2 p.

    Research output: Contribution to journalLetter

  218. Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance

    Andrews, R. C., Herlihy, O., Livingstone, D. E. W., Andrew, R. & Walker, B. R., 2002, In : Journal of Clinical Endocrinology & Metabolism. 87, 12, p. 5587-93 7 p.

    Research output: Contribution to journalArticle

  219. Contrasting effects of intrauterine growth retardation and premature delivery on adult cortisol secretion and metabolism in man

    Walker, B. R., Irving, R. J., Andrew, R. & Belton, N. R., 2002, In : Clinical Endocrinology. 57, 3, p. 351-5 5 p.

    Research output: Contribution to journalArticle

  220. Distinguishing the activities of 11beta-hydroxysteroid dehydrogenases in vivo using isotopically labeled cortisol

    Andrew, R., Smith, K., Jones, G. C. & Walker, B. R., 2002, In : Journal of Clinical Endocrinology & Metabolism. 87, 1, p. 277-85 9 p.

    Research output: Contribution to journalArticle

  221. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity

    Rask, E., Walker, B. R., Söderberg, S., Livingstone, D. E. W., Eliasson, M., Johnson, O., Andrew, R. & Olsson, T., 2002, In : Journal of Clinical Endocrinology & Metabolism. 87, 7, p. 3330-6 7 p.

    Research output: Contribution to journalArticle

  222. 2001
  223. Endothelial cell dysfunction in mice after transgenic knockout of type 2, but not type 1, 11 beta-hydromysteroid dehydrogenase

    Hadoke, P. W. F., Christy, C., Kotelevtsev, Y. V., Williams, B. C., Kenyon, C. J., Seckl, J. R., Mullins, J. J. & Walker, B. R., 4 Dec 2001, In : Circulation. 104, 23, p. 2832-2837 6 p.

    Research output: Contribution to journalArticle

  224. Increased glucocorticoid production and altered cortisol metabolism in women with mild to moderate Alzheimer's disease

    Rasmuson, S., Andrew, R., Nasman, B., Seckl, J. R., Walker, B. R. & Olsson, T., 15 Mar 2001, In : Biological Psychiatry. 49, 6, p. 547-552 6 p.

    Research output: Contribution to journalArticle

  225. Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors

    Reynolds, R. M., Walker, B. R., Syddall, H. E., Andrew, R., Wood, P. J., Whorwood, C. B. & Phillips, D. I., 2001, In : Journal of Clinical Endocrinology & Metabolism. 86, 1, p. 245-50 6 p.

    Research output: Contribution to journalArticle

  226. Endothelium-derived hyperpolarizing factor and potassium use different mechanisms to induce relaxation of human subcutaneous resistance arteries

    McIntyre, C. A., Buckley, C. H., Jones, G. C., Sandeep, T. C., Andrews, R. C., Elliott, A. I., Gray, G. A., Williams, B. C., McKnight, J. A., Walker, B. R. & Hadoke, P. W., 2001, In : British Journal of Pharmacology. 133, 6, p. 902-8 7 p.

    Research output: Contribution to journalArticle

  227. Glucocorticoid metabolism and adrenocortical reactivity to ACTH in myotonic dystrophy

    Johansson, A., Andrew, R., Forsberg, H., Cederquist, K., Walker, B. R. & Olsson, T., 2001, In : Journal of Clinical Endocrinology & Metabolism. 86, 9, p. 4276-83 8 p.

    Research output: Contribution to journalArticle

  228. Tissue-specific dysregulation of cortisol metabolism in human obesity

    Rask, E., Olsson, T., Söderberg, S., Andrew, R., Livingstone, D. E., Johnson, O. & Walker, B. R., 2001, In : Journal of Clinical Endocrinology & Metabolism. 86, 3, p. 1418-21 4 p.

    Research output: Contribution to journalArticle

  229. 2000
  230. 11 beta-Hydroxysteroid dehydrogenase type 1 is a predominant 11 beta-reductase in the intact perfused rat liver

    Jamieson, P. M., Walker, B. R., Chapman, K. E., Andrew, R., Rossiter, S. & Seckl, J. R., Jun 2000, In : Journal of Endocrinology. 165, 3, p. 685-692 8 p.

    Research output: Contribution to journalArticle

  231. Development-related increase in cortisol biosynthesis by human granulosa cells

    Yong, P. Y., Thong, K. J., Andrew, R., Walker, B. R. & Hillier, S. G., 2000, In : Journal of Clinical Endocrinology & Metabolism. 85, 12, p. 4728-33 6 p.

    Research output: Contribution to journalArticle

  232. Influence of gender and body composition on glucocorticoid metabolism in middle-aged humans

    Andrew, R., Phillips, D. I. & Walker, B. R., 2000, In : International Journal of Obesity. 24 Suppl 2, p. S144-5

    Research output: Contribution to journalArticle

  233. 1999
  234. Apparent cortisone reductase deficiency: a functional defect in 11beta-hydroxysteroid dehydrogenase type 1

    Jamieson, A., Wallace, A. M., Andrew, R., Nunez, B. S., Walker, B. R., Fraser, R., White, P. C. & Connell, J. M., 1999, In : Journal of Clinical Endocrinology & Metabolism. 84, 10, p. 3570-4 5 p.

    Research output: Contribution to journalArticle

  235. Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases

    Finken, M. J., Andrews, R. C., Andrew, R. & Walker, B. R., 1999, In : Journal of Clinical Endocrinology & Metabolism. 84, 9, p. 3316-21 6 p.

    Research output: Contribution to journalArticle

  236. 1998
  237. Selective attenuation of adrenoceptor-mediated contraction by endothelium-derived nitric oxide in isolated mouse aortae

    Hadoke, P. W. F., Kotelevtsev, Y., Williams, B. C., Mullins, J. J. & Walker, B. R., Dec 1998, In : British Journal of Pharmacology. 125, p. U55-U55 1 p.

    Research output: Contribution to journalArticle

  238. Increased glucocorticoid activity in men with cardiovascular risk factors

    Walker, B. R., Phillips, D. I. W., Noon, J. P., Panarelli, M., Andrew, R., Edwards, H. V., Holton, D. W., Seckl, J. R., Webb, D. J. & Watt, G. C. M., Apr 1998, In : Hypertension. 31, 4, p. 891-895 5 p.

    Research output: Contribution to journalArticle

  239. Elevated plasma cortisol concentrations: A link between low birth weight and the insulin resistance syndrome?

    Phillips, D. I. W., Barker, D. J. P., Fall, C. H. D., Seckl, J. R., Whorwood, C. B., Wood, P. J. & Walker, B. R., Mar 1998, In : Journal of Clinical Endocrinology & Metabolism. 83, 3, p. 757-760 4 p.

    Research output: Contribution to journalArticle

  240. Growth hormone replacement inhibits renal and hepatic 11 beta-hydroxysteroid dehydrogenases in ACTH-deficient patients

    Walker, B. R., Andrew, R., MacLeod, K. M. & Padfield, P. L., 1998, In : Clinical Endocrinology. 49, 2, p. 257-63 7 p.

    Research output: Contribution to journalArticle

  241. Obesity and gender influence cortisol secretion and metabolism in man

    Andrew, R., Phillips, D. I. & Walker, B. R., 1998, In : Journal of Clinical Endocrinology & Metabolism. 83, 5, p. 1806-9 4 p.

    Research output: Contribution to journalArticle

  242. 1990
  243. Accounting for fluctuations in a lattice model of microemulsions

    Dawson, K. A., Walker, B. L. & Berera, A., 1 Jun 1990, In : Physica a-Statistical mechanics and its applications. 165, 3, p. 320-351 32 p.

    Research output: Contribution to journalArticle