Edinburgh Research Explorer

Prof Bruce Whitelaw

Genus Personal Chair of Animal Biotechnology

Profile photo
Phone: +44 (0)131 651 9100

Willingness to take PhD students: Yes

Education/Academic qualification

Doctor of Philosophy (PhD), University of Edinburgh
Analysis of the transcriptional control domains of thehuman c-myc proto-oncogene
Bachelor of Science, University of Edinburgh

Current Research Interests

Development of genetically engineered livestock for biomedical and agricultural applications.

Research Interests

My group investigates the molecular events that accompany changes in the expression status of genes in mammals. We aim to develop and exploit gene transfer technology to investigate differentiation in mammals and exemplify the use of this technology through the generation of animal models of human disease, novel in vivo screening resources, and animals more able to combat infectious disease.

This work will advance our understanding of how cellular signals integrate to allow tissues to work normally in the whole animal, while identifying routes to intervene when normal development is perturbed through disease. We aim to exploit this knowledge to develop innovative biotechnological solutions to combat infectious disease in animals, evaluate new treatments of human disease through transgenic animal models, and establish efficient protein production systems in animals.

Biography

Bruce Whitelaw was awarded a BSc degree in Medical Microbiology (Virology elective) from the University of Edinburgh in 1982 and his PhD in 1987 from the University of Glasgow.

His thesis title “The regulation of the myc proto-oncogene” focussed on the molecular biology of gene activation; a theme he has maintained throughout his career through the development and application of gene expression systems in transgenic animals.

His first appointment was to the AFRC’s Animal Breeding Research Organisation working on the then novel idea of producing human pharmaceutical proteins in animal bioreactors. He subsequently held research position at the BBRSC’s Institute of Animal Physiology and Genetics Research, and then Roslin Institute. Currently Bruce is Deputy Director and Director of Partnerships at The Roslin Institute and Professor of Animal Biotechnology at the Royal (Dick) School of Veterinary Studies. Having pioneered the use of lentivirus vectors for transgene delivery, he is currently establishing robust methodology for genome editing in livestock.

Bruce actively seeks to apply this technology in the field of animal biotechnology. Specifically, he aims to exploit this knowledge to develop innovative biotechnological solutions to combat infectious disease in animals, evaluate new treatments of human disease through transgenic animal models, and establish efficient protein production systems in animals.

Teaching

Post-graduate, Honours projects and summer students.

PhD students:

1999 - Simon A. Boa "Nucleosome organisation over the ovine beta-lactoblobulin gene" (Edinburgh)

2002 - Margaret L. Opsahl "Variegated transgene expression in mice" (Edinburgh)

2004 - Chris Palgrave "African Swine Fever Virus pathogenesis: comparative analysis of immunoregulatory genes in domestic and wild pigs" (Edinburgh)

2005 - Gillian H. Little "Stat5 binding to chromatin" (Edinburgh)

2006 - Douglas B. Vasey "p21 expression in the mouse" (Dundee)

2006 - Ravikumar Manikam "Myostatin expression in the mouse mammary gland" (Edinburgh)

2007 - Rachel Young "Oxidative stress reporter genes" (Dundee)

2010 - Neil Mackenzie "Viral vector delivery of RNAi" (Edinburgh)

2012 - Chiara Sartori "Generation of iPS cells" (Edinburgh)

2012 - Reinhard Huber "Animal welfare and ethics of (transgenic and cloned) pigs used as biomedical research models" (Porto)

2013 - James Glover "The Role of the Prdm Proteins in Primordial Germ Cell Development" (Edinburgh)

Current - Rachel Huddard "Strategies to rescue null-phenotypes in chimeric mice"

Current - Thomas Tzelos "RNA interference (RNAi) - from genome to control" (Moredun/Edinburgh)

Current - Maeve Ballantyne "Functional consequence of genetic polymorphism in porcine RELA"

Current - Alex Brown "Interfering strategies against PRRSV"

Current - Luise Seeker "Telomere length and survival in farmed livestock" (SRUS/Edinburgh)

Administrative Roles

External Committees:

BBSRC Pool of Experts (Strategy) (Bruce Whitelaw)

Scientific Advisory Board Immunogenes Ag (Bruce Whitelaw)

Scientific Advisory Board Recombinetics Inc (Bruce Whitelaw)

Jury Member of BBVA Foundation Frontier of Knowledge Awards (Bruce Whitelaw)
 

Internal Committees:

Executive (Bruce Whitelaw)

Science Management Group (Bruce Whitelaw)

Search Committee (Bruce Whitelaw)

Animal Ethics Committee (Bruce Whitelaw)

Postgraduate Student Committee (Bruce Whitelaw)

Genetic Modification Safety Committee (Simon Lillico)

Store User Group (Claire Neil)

Websites

Highlighted research outputs

  1. Live pigs produced from genome edited zygotes

    Research output: Contribution to journalArticle

  2. Efficient TALEN-mediated gene knockout in livestock

    Research output: Contribution to journalArticle

  3. Milk Lacking α-Casein Leads to Permanent Reduction in Body Size in Mice

    Research output: Contribution to journalArticle

  4. Ovine-Induced Pluripotent Stem Cells Can Contribute to Chimeric Lambs

    Research output: Contribution to journalArticle

  5. Transgenic sheep designed for transplantation studies

    Research output: Contribution to journalArticle

  6. A strategy to exploit surrogate sire technology in livestock breeding programs

    Research output: Contribution to journalArticle

  7. Unexpected mutations were expected and unrelated to CRISPR-Cas9 activity

    Research output: Contribution to journalLetter

  8. CRISPR-Based Gene Drives for Pest Control

    Research output: Contribution to journalArticle

  9. A high resolution atlas of gene expression in the domestic sheep (Ovis aries)

    Research output: Contribution to journalArticle

  10. Introduction to Mammalian Genome Special Issue: Genome editing

    Research output: Contribution to journalEditorial

  11. Genome Editing and the Future of Farming meeting report

    Research output: Contribution to journalArticle

  12. Functional Annotation of the Sheep (Ovis aries) Genome

    Research output: Contribution to conferenceAbstract

  13. GENETICALLY-EDITED SWINE

    Research output: Patent

  14. A Csf1r-EGFP transgene provides a novel marker for monocyte subsets in sheep

    Research output: Contribution to journalArticle

  15. New insights and current tools for genetically engineered (GE) sheep and goats

    Research output: Contribution to journalLiterature review

  16. Gene targeting, genome editing: from Dolly to editors

    Research output: Contribution to journalLiterature review

  17. Promotion of alleles by genome editing in livestock breeding programmes

    Research output: Contribution to journalEditorial

  18. CD13/aminopeptidase N is a negative regulator of mast cell activation

    Research output: Contribution to journalArticle

  19. Large animal models of cardiovascular disease

    Research output: Contribution to journalArticle

  20. Genetically engineering milk

    Research output: Contribution to journalArticle

  21. The sheep gene expression atlas project

    Research output: Contribution to conferenceAbstract

  22. Animal and cellular models of human disease

    Research output: Contribution to journalArticle

  23. Engineering resilience to African swine fever

    Research output: Contribution to journalMeeting abstract

  24. Gene targeting, genome editing: from Dolly to editors

    Research output: Contribution to journalMeeting abstract

  25. Introducing genetic resistance for trypanosomiasis into sheep and cattle

    Research output: Contribution to journalMeeting abstract

  26. Production of germline ablated male pigs via Crispr/Cas editing of the NANOS2 gene

    Research output: Contribution to journalMeeting abstract

  27. The Genome Editing Revolution in Livestock Marches on

    Research output: Contribution to journalComment/debate

  28. Genome edited sheep and cattle

    Research output: Contribution to journalArticle

  29. Highly efficient targeted chromosome deletions using CRISPR/Cas9

    Research output: Contribution to journalArticle

  30. Editing myostatin in livestock animals

    Research output: Contribution to journalMeeting abstract

  31. After three decades of GE animals: what will the 4th bring?

    Research output: Contribution to journalMeeting abstract

  32. TALEN-mediated engineering of the porcine genome

    Research output: Contribution to journalMeeting abstract

  33. Use of Genome Editing in Animal Breeding P rograms

    Research output: Contribution to conferencePaper

  34. Toward Ovine iPSCs

    Research output: Contribution to journalArticle

  35. Novel GM Animal Technologies and their Governance

    Research output: Contribution to journalArticle

  36. TT2013 meeting report: the Transgenic Technology meeting visits Asia for the first time

    Research output: Contribution to journalComment/debate

  37. Gene inactivation and nonmeiotic allele introgression in livestock species using talens

    Research output: Contribution to journalMeeting abstract

  38. Genetics and Biosynthesis of Milk Proteins

    Research output: Chapter in Book/Report/Conference proceedingChapter

  39. Viral and nonviral vectors

    Research output: Contribution to journalMeeting abstract

  40. Analysis Of Photoreceptor Abnormality In Gucy2d E837D/R838S Transgenic Pigs

    Research output: Contribution to conferenceAbstract

  41. Genotype Selection and Modification and the Future of Livestock Production

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

  42. Mammary gland development is delayed in mice deficient for aminopeptidase N

    Research output: Contribution to journalArticle

  43. Reprogramming Pig Fetal Fibroblasts Reveals a Functional LIF Signaling Pathway

    Research output: Contribution to journalArticle

  44. Transgenic Livestock for Food Production, An Introduction to.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  45. Dynein light chain 1 (LC8) sequence is highly conserved between pig species

    Research output: Contribution to journalEditorial

  46. Spatial p21 expression profile in the mid-term mouse embryo

    Research output: Contribution to journalArticle

  47. An introduction to non-mouse models

    Research output: Contribution to conferenceAbstract

  48. Gene targeting of the rat Csf1r locus using homologous recombination in ES cells

    Research output: Contribution to conferenceAbstract

  49. Lentiviral transgenesis in livestock

    Research output: Contribution to journalArticle

  50. Mice Transgenic For Human Dominant Mutations Of The GUCY2D Gene

    Research output: Contribution to conferenceAbstract

  51. Pigs Transgenic For Human Dominant Mutations Of The GUCY2D Gene

    Research output: Contribution to conferenceAbstract

  52. The future of animal production: improving productivity and sustainability

    Research output: Contribution to journalArticle

  53. Spatial monitoring of toxicity in HMOX-LacZ transgenic mice

    Research output: Contribution to journalArticle

  54. Peroxiredoxin Gene Expression Signatures in Liver Reflect Toxic Insult

    Research output: Contribution to journalArticle

  55. Precision genetics for complex objectives in animal agriculture

    Research output: Contribution to journalArticle

  56. Zinc finger nuclease technology heralds a new era in mammalian transgenesis

    Research output: Contribution to journalLiterature review

  57. Developing welfare protocols for transgenic large animals

    Research output: Contribution to journalMeeting abstract

  58. Characterisation and cardiac directed differentiation of canine adult stem cells

    Research output: Contribution to conferenceAbstract

  59. The minipig as a platform for new technologies in toxicology

    Research output: Contribution to journalArticle

  60. p21(Waf1/Cip1) as a molecular sensor for BoHV-4 replication

    Research output: Contribution to journalArticle

  61. CMV enhancer-promoter is preferentially active in exocrine cells in vivo

    Research output: Contribution to journalArticle

  62. Mammary gland differentiation inversely correlates with GDF-8 expression

    Research output: Contribution to journalArticle

  63. Illuminating Role of CYP1A1 in Skin Function

    Research output: Contribution to journalArticle

  64. Production of transgenic farm animals by viral vector mediated gene transfer

    Research output: Contribution to journalArticle

  65. p21-LacZ reporter mice reflect p53-dependent toxic insult

    Research output: Contribution to journalArticle

  66. Producing recombinant human milk proteins in the milk of livestock species

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

  67. RNA-based biotechnologies: potential future impact on animal health.

    Research output: Contribution to journalArticle

  68. Transgenic embryos and mice produced from low titre lentiviral vectors

    Research output: Contribution to journalArticle

  69. A virus-neutralising antibody is not cytotoxic in vitro

    Research output: Contribution to journalArticle

  70. Disease-resistant genetically modified animals

    Research output: Contribution to journalArticle

  71. Development of Germline Manipulation Technologies in Livestock

    Research output: Chapter in Book/Report/Conference proceedingChapter

  72. Live lambs born from zona-pellucida denuded embryos

    Research output: Contribution to journalArticle

  73. Transgenic livestock made easy

    Research output: Contribution to journalArticle

  74. Transgene methylation in mice reflects copy number but not expression level

    Research output: Contribution to journalArticle

  75. On the use of post-transcriptional processing elements in transgenes

    Research output: Contribution to journalArticle

  76. Mono-allelic expression of variegating transgene locus in the mouse

    Research output: Contribution to journalArticle

  77. A future for transgenic livestock

    Research output: Contribution to journalArticle

  78. Biosynthesis of Milk Proteins

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  79. Does genetic modification violate intrinsic value?

    Research output: Contribution to journalArticle

  80. Recombinant protein production in milk.

    Research output: Contribution to journalArticle

  81. Transgenic animal welfare

    Research output: Contribution to journalArticle

  82. Pharmaceutical proteins in milk from transgenic animals.

    Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

  83. Potential to exploit RNA processing elements in transgenic mice.

    Research output: Contribution to journalArticle

  84. Multiple copies of beta-lactoglobulin promoter do not function as LCR

    Research output: Contribution to journalArticle

  85. Frontiers in transgenic research

    Research output: Contribution to journalArticle

  86. Genetic engineering: Animal cell technology

    Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

  87. The changing role of cell culture in the generation of transgenic livestock

    Research output: Contribution to journalArticle

  88. Toward designer milk

    Research output: Contribution to journalArticle

  89. Optimisation of transgene expresssion in the mammary gland.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  90. Chromatin structures of goat and sheep beta-lactoglobulin gene differ

    Research output: Contribution to journalArticle

  91. Transgenic mice secreting coronavirus neutralizing antibodies into the milk

    Research output: Contribution to journalArticle

  92. Chromatin heterogeneity within multicopy transgene arrays

    Research output: Contribution to journalArticle

  93. Truncated beta-lactoglobulin transgenes are expressed in the kidney

    Research output: Contribution to journalArticle

  94. Stat5 as a target for regulation by extracellular matrix

    Research output: Contribution to journalArticle

  95. Ectopic expression of beta-lactoglobulin transgenes

    Research output: Contribution to journalArticle

  96. Pharmaceuticals from transgenic sheep

    Research output: Contribution to journalArticle

  97. Chromosomal position effects and the modulation of transgene expression

    Research output: Contribution to journalArticle

  98. Strategies for production of pharmaceutical proteins in milk

    Research output: Contribution to journalArticle

  99. Enhancing the efficiency of transgene expression

    Research output: Contribution to journalArticle

  100. The majority of G0 transgenic mice are derived from mosaic embryos

    Research output: Contribution to journalArticle

  101. Chromatin structure of ß-lactoglobulin transgenes

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  102. Comment on mosaic nature of G0 transgenic mice.

    Research output: Contribution to journalArticle

  103. Transgenic animals as bioreactors

    Research output: Contribution to journalArticle

  104. Regulatory domains within the P0 promoter of human c-myc

    Research output: Contribution to journalArticle

  105. Production of pharmaceutical proteins in milk

    Research output: Contribution to journalArticle

  106. Advances in animal biotechnology: Embryo micromanipulation and gene transfer

    Research output: Contribution to conferencePaper

  107. Targeting gene expression to the mammary gland

    Research output: Contribution to conferencePaper

  108. Methods of gene transfer and their potential use to modify milk composition

    Research output: Contribution to journalArticle

  109. Expression of b-lactoglobulin and hybrid transgenes in the mammary gland.

    Research output: Contribution to conferencePaper

  110. Expression of ß-lactoglobulin and hybrid transgenes in the mammary gland.

    Research output: Contribution to journalArticle

  111. Frequency of germline mosaicism in founder transgenic mice

    Research output: Contribution to journalArticle

  112. Modification of milk composition by gene transfer

    Research output: Contribution to conferencePaper

  113. The germline manipulation of livestock: progress during the past five years.

    Research output: Contribution to journalArticle

  114. The molecular manipulation of milk

    Research output: Contribution to conferencePaper

  115. EXPRESSION OF HUMAN ANTI-HEMOPHILIC FACTOR-IX IN THE MILK OF TRANSGENIC SHEEP

    Research output: Contribution to journalArticle

  116. Animal bioreactors.

    Research output: Contribution to journalArticle

  117. The molecular manipulation of milk composition

    Research output: Contribution to journalArticle

  118. Transcriptional regulation of the human c-myc gene

    Research output: Contribution to journalArticle

View all (202) »

Highlighted research activities & awards

  1. PET event, Revolutionising Reproduction: The Future of Fertility Treatment'

    Activity: Academic talk or presentation typesInvited talk

  2. Science Talk to Midlothian Farmers

    Activity: Academic talk or presentation typesInvited talk

  3. Nuffield Council on Bioethics (Event)

    Activity: Membership typesMembership of council

  4. Cheese and Wine Lecture to Students

    Activity: Academic talk or presentation typesInvited talk

  5. Coming of Age: The Legacy of Dolly at 20 Public Lecture

    Activity: Participating in or organising an event typesPublic Engagement – Public lecture/debate/seminar

View all (9) »

Highlighted research press coverage

View all (39) »

ID: 3782