Edinburgh Research Explorer

Dr Christopher Mowat

Senior Lecturer

  1. 2017
  2. Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

    Hutchinson, J. P., Rowland, P., Taylor, M. R. D., Christodoulou, E. M., Haslam, C., Hobbs, C. M., Holmes, D., Liddle, J., Mole, D. J., Uings, I. J., Walker, A. L., Webster, S. P., Mowat, C. & Chung, C., 12 Jun 2017, In : Nature Communications.

    Research output: Contribution to journalArticle

  3. The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis

    Liddle, J., Beaufils, B., Binnie, M., Bouillot, A., Denis, A. A., Hann, M. M., Haslam, C. P., Holmes, D. S., Hutchinson, J. P., Kranz, M., McBride, A., Mirguet, O., Mole, D. J., Mowat, C. G., Pal, S., Rowland, P., Trottet, L., Uings, I. J., Walker, A. L. & Webster, S. P., May 2017, In : Bioorganic & Medicinal Chemistry Letters. 27, 9

    Research output: Contribution to journalArticle

  4. Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis

    Walker, A. L., Ancellin, N., Beaufils, B., Bergeal, M., Binnie, M., Clapham, D., Haslam, C. P., Holmes, D. S., Hutchinson, J. P., Liddle, J., McBride, A., Mirguet, O., Mowat, C. G., Rowland, P., Tiberghien, N., Trottet, L., Uings, I., Webster, S. P., Zheng, X. & Mole, D. J., 27 Apr 2017, In : Journal of Medicinal Chemistry.

    Research output: Contribution to journalArticle

  5. 2016
  6. Insights into the mechanism of inhibition of tryptophan 2,3-dioxygenase by isatin derivatives

    Pantouris, G., Loudon-Griffiths, J. & Mowat, C. G., 20 Apr 2016, In : Journal of enzyme inhibition and medicinal chemistry. 31, sup1, p. 70-78 9 p.

    Research output: Contribution to journalArticle

  7. Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

    Mole, D. J., Webster, S. P., Uings, I., Zheng, X., Binnie, M., Wilson, K., Hutchinson, J. P., Mirguet, O., Walker, A., Beaufils, B., Ancellin, N., Trottet, L., Bénéton, V., Mowat, C. G., Wilkinson, M., Rowland, P., Haslam, C., Mcbride, A., Homer, N. Z. M., Baily, J. E. & 7 others, Sharp, M. G. F., Garden, O. J., Hughes, J., Howie, S. E. M., Holmes, D. S., Liddle, J. & Iredale, J. P., Feb 2016, In : Nature Medicine.

    Research output: Contribution to journalArticle

  8. 2014
  9. Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1

    Pantouris, G., Serys, M., Yuasa, H. J., Ball, H. J. & Mowat, C. G., 1 Sep 2014, In : Amino Acids. 46, 9, p. 2155-2163 9 p.

    Research output: Contribution to journalArticle

  10. Antitumour agents as inhibitors of tryptophan 2,3-dioxygenase

    Pantouris, G. & Mowat, C. G., 3 Jan 2014, In : Biochemical and Biophysical Research Communications. 443, 1, p. 28-31 4 p.

    Research output: Contribution to journalArticle

  11. 2013
  12. Probing the location of displayed cytochrome b562 on amyloid by scanning tunnelling microscopy

    Forman, C. J., Wang, N., Yang, Z. Y., Mowat, C. G., Jarvis, S., Durkan, C. & Barker, P. D., 3 May 2013, In : Nanotechnology. 24, 17, 12 p., 175102.

    Research output: Contribution to journalArticle

  13. 2012
  14. How is the distal pocket of a heme protein optimized for binding of tryptophan?

    Chauhan, N., Basran, J., Rafice, S. A., Efimov, I., Millett, E. S., Mowat, C. G., Moody, P. C. E., Handa, S. & Raven, E. L., Dec 2012, In : Febs Journal. 279, 24, p. 4501-4509 9 p.

    Research output: Contribution to journalArticle

  15. Cytochromes

    Mowat, C. & Chapman, S., Sep 2012, Encyclopedia of Biophysics. Roberts, G. & Davidson, V. (eds.). Springer, p. 428-433

    Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

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