Edinburgh Research Explorer

Prof Colin Smith

Personal Chair Neuropathology

Research Interests

My main areas of research are;

 1/ Traumatic Brain Injury. This involves animal and human studies both locally and in collaboration with researchers at the University of Pennsylvania.

 2/ Human Tissue banking. This involves the development of optimal storage of human tissues for DNA, RNA and protein studies.


I am principally involved in the study of traumatic brain injury using animal models and autopsy derived human tissue. The main areas of interest relate to the molecular mechanisms underlying white matter injury and the responses of brain tissue to brain injury including age related changes. I am also looking at factors that may influence the long-term outcome, particularly neuroinflammation.


 There are a number of brain and tissue bank facilities within Academic Neuropathology. I am involved in running the Sudden Death Brain and Tissue Bank. This bank has formed collaborative research with a number of local, national and international researchers. We are currently assessing epigenetic variation in the human population and proteomics of the synaptosome in psychiatric disorders.


Research activities & awards

  1. British Neuropathological Society (External organisation)

    Activity: MembershipMembership of peer review panel or committee

  2. MRC (External organisation)

    Activity: MembershipMembership of peer review panel or committee

  3. Public outreach interviews (Brain Banking)

    Activity: OtherTypes of Public engagement and outreach - Media article or participation

View all (4) »

ID: 14630