Edinburgh Research Explorer

Dr David Clarke

Chancellor's Fellow

Willingness to take Ph.D. students: Yes

Area of Expertise

Research expertiseProtein Chemistry, Mass Spectrometry

Current Research Interests

Biomolecular Mass Spectrometry, Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), Top-Down Mass Spectrometry, Protein Chemistry, Enzymology, Structural Biology.


The core research theme of our group is the application of modern techniques in mass spectrometry (MS) for the functional and structural characterisation of biological systems. The School of Chemistry houses an excellent array of MS instrumentation - including FT-ICR, an ion mobility equipped Q-Tof, an extended mass range ESI Q-tof, and a MALDI ToF-ToF.

Our research utilises a range of MS-based techniques including - top-down and middle down fragmentation, ion-mobility mass spectrometry, native mass spectrometry, and hydrogen/deuterium exchange. In addition, MS-based studies are supported by complementary biochemical analysis and structural biology approaches.




MChem, PhD

Research activities & awards

  1. Inspiring Science: Science Fest

    Activity: Participating in or organising an eventPublic Engagement – Festival/Exhibition

  2. Analytical Chemistry (Journal)

    Activity: Publication peer-review and editorial workPublication peer-review

  3. Irish Mass Spectrometry Society Annual Meeting

    Activity: Participating in or organising an eventParticipation in conference

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