Edinburgh Research Explorer
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Research Interests

Despite significant improvements in the care of patients with acute respiratory distress syndrome mortality remains high and there are no effective drug therapies to target the rampant inflammatory processes that are occurring within the lung.  In this context my main research interest is in neutrophil recruitment and function in response to host tissue injury and cell death. Current research focusses on the effects of mitochondrial-synthesised formylated peptides and their binding to the G-protein coupled receptor formyl peptide receptor 1 present on the surface of a variety of inflammatory cell types including neutrophils.  This involves biomarker analysis of a wide variety of clinical samples, the study of in vivo models of acute lung inflammation and investigation of function of primary human neutrophils in vitro.


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