Edinburgh Research Explorer

Prof David Melton

Personal Chair of Somatic Cell Genetics

  1. 2017
  2. Disruption of DNA repair in cancer cells by ubiquitination of a destabilising dimerization domain of nucleotide excision repair protein ERCC1

    Yang, L., Ritchie, A-M. & Melton, D., 21 Jul 2017, In : Oncotarget.

    Research output: Contribution to journalArticle

  3. 2015
  4. Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1- XPF

    Chapman, T. M., Gillen, K. J., Wallace, C., Lee, M. T., Bakrania, P., Khurana, P., Coombs, P. J., Stennett, L., Fox, S., Bureau, E. A., Brownlees, J., Melton, D. & Saxty, B., 1 Oct 2015, In : Bioorganic & Medicinal Chemistry Letters.

    Research output: Contribution to journalArticle

  5. N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF

    Chapman, T. M., Wallace, C., Gillen, K. J., Bakrania, P., Khurana, P., Coombs, P. J., Fox, S., Bureau, E. A., Brownlees, J., Melton, D. & Saxty, B., 1 Oct 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 19

    Research output: Contribution to journalArticle

  6. Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance

    McNeil, E. M., Astell, K. R., Ritchie, A-M., Shave, S., Houston, D. R., Bakrania, P., Jones, H. M., Khurana, P., Wallace, C., Chapman, T., Wear, M. A., Walkinshaw, M. D., Saxty, B. & Melton, D. W., Jul 2015, In : DNA Repair. 31, p. 19-28 10 p.

    Research output: Contribution to journalArticle

  7. Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma

    Ma, Y., Faller, W. J., Sansom, O. J., Brown, E. R., Doig, T. N., Melton, D. W. & Machesky, L. M., Apr 2015, In : Melanoma research. 25, 2, p. 169-172 4 p.

    Research output: Contribution to journalArticle

  8. 2014
  9. Mismatch repair deficiency in ovarian cancer -- molecular characteristics and clinical implications

    Xiao, X., Melton, D. W. & Gourley, C., Feb 2014, In : Gynecologic Oncology. 132, 2, p. 506-12 7 p.

    Research output: Contribution to journalArticle

  10. 2013
  11. The toxicity of nitrofuran compounds on melanoma and neuroblastoma cells is enhanced by Olaparib and ameliorated by melanin pigment

    McNeil, E. M., Ritchie, A-M. & Melton, D. W., Nov 2013, In : DNA Repair. 12, 11, p. 1000-1006 7 p.

    Research output: Contribution to journalArticle

  12. Evaluation of macroporous and microporous carriers for CHO-K1 cell growth and monoclonal antibody production

    Rodrigues, M. E., Costa, A. R., Fernandes, P., Henriques, M., Cunnah, P., Melton, D. W., Azeredo, J. & Oliveira, R., 28 Sep 2013, In : Journal of microbiology and biotechnology. 23, 9, p. 1308-21 14 p.

    Research output: Contribution to journalArticle

  13. Advances and Drawbacks of the Adaptation to Serum-Free Culture of CHO-K1 Cells for Monoclonal Antibody Production

    Rodrigues, M. E., Costa, A. R., Henriques, M., Cunnah, P., Melton, D. W., Azeredo, J. & Oliveira, R., Feb 2013, In : Applied biochemistry and biotechnology. 169, 4, p. 1279-1291 13 p.

    Research output: Contribution to journalArticle

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