Edinburgh Research Explorer

Dinesh Soares, PhD

(Former employee or visitor)

Profile photo

Willingness to take PhD students: Yes

Education/Academic qualification

Doctor of Philosophy (PhD), University of Edinburgh
Master of Research, University of York
Bachelor of Science, St. Xavier's College, University of Mumbai

Area of Expertise

Research expertiseBioinformatics, Structural Biology, Biochemistry, Biophysics, Evolutionary Biology


I am a Research Fellow at the MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh and also an affiliate of the Centre for Genomic & Experimental Medicine. I received my BSc in Biochemistry and Zoology from St. Xavier’s College, University of Mumbai, an M.Res. in Bioinformatics from the University of York, UK and subsequently a PhD in Structural Bioinformatics from the School of Chemistry at the University of Edinburgh, UK in 2007. I have since worked both as an experimental biochemist/biophysicist and computational structural biology specialist at the University of Edinburgh on a range of projects, but chiefly applied to the broad areas of immunology, neuroscience and psychiatry.

Current Research Interests

Understanding how missense mutations and post-translational modification affects protein structure and protein-protein interaction.

Research Interests

I am a computational structural biology specialist with a complementary experimental biochemistry and biophysics background. I work as an independent research fellow to provide research support, training, and consultation services to the MRC Institute of Genetics and Molecular Medicine (IGMM) research community in the areas of protein bioinformatics and have entered into several long-term scientific collaborations to analyse, predict, simulate, and illustrate protein sequence and structural biology data using computational techniques. The main focus of my research is in the application of protein structure prediction and molecular modelling methodologies to inform on protein function. These methods require extensive expert user intervention with integrated biology, chemistry, physics and computational knowledge, to fully exploit their potential. I collaborate widely with experimental laboratories where many of the hypotheses generated are tested. A number of my projects revolve around assessing the impact of missense mutations on the structure and function of the proteins discovered from next generation whole exome/genome sequencing projects for common and rare diseases. I also have a strong interest in comparative genomics and evolution of protein families and in understanding how post-translational modification underlies functional divergence among highly homologous proteins.

Highlighted research outputs

  1. Large-scale modelling as a route to multiple surface comparisons of the CCP module family

    Research output: Contribution to journalArticlepeer-review

  2. PKA Phosphorylation of NDE1 Is DISC1/PDE4 Dependent and Modulates Its Interaction with LIS1 and NDEL1

    Research output: Contribution to journalArticlepeer-review

  3. NDE1 and NDEL1: twin neurodevelopmental proteins with similar ‘nature’ but different ‘nurture’

    Research output: Contribution to journalArticlepeer-review

  4. DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness

    Research output: Contribution to journalArticlepeer-review

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