Edinburgh Research Explorer

Dinesh Soares, PhD

(Former employee or visitor)

  1. 2004
  2. Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded

    Blein, S., Ginham, R., Uhrin, D., Smith, B. O., Soares, D. C., Veltel, S., McIlhinney, R. A. J., White, J. H. & Barlow, P. N., 2004, In: Journal of Biological Chemistry. 279, 46, p. 48292-306 15 p.

    Research output: Contribution to journalArticlepeer-review

  3. 2005
  4. ARABIDOPSIS CRINKLY4 function, internalization, and turnover are dependent on the extracellular crinkly repeat domain

    Gifford, M. L., Robertson, F. C., Soares, D. C. & Ingram, G. C., 2005, In: The Plant Cell. 17, 4, p. 1154-66 13 p.

    Research output: Contribution to journalArticlepeer-review

  5. Large-scale modelling as a route to multiple surface comparisons of the CCP module family

    Soares, D. C., Gerloff, D. L., Syme, N. R., Coulson, A. F. W., Parkinson, J. & Barlow, P. N., 2005, In: Protein engineering, design & selection : PEDS. 18, 8, p. 379-88 10 p.

    Research output: Contribution to journalArticlepeer-review

  6. Opportunities for new therapies based on the natural regulators of complement activation

    Brook, E., Herbert, A. P., Jenkins, H. T., Soares, D. C. & Barlow, P. N., 2005, In: Annals of the New York Academy of Sciences. 1056, p. 176-188 13 p.

    Research output: Contribution to journalArticlepeer-review

  7. Functional insights from the structure of the multifunctional C345C domain of C5 of complement

    Bramham, J., Thai, C-T., Soares, D. C., Uhrín, D., Ogata, R. T. & Barlow, P., 18 Mar 2005, In: Journal of Biological Chemistry. 280, 11, p. 10636-10645 10 p.

    Research output: Contribution to journalArticlepeer-review

  8. Structural Biology of the Complement System: Complement Control Protein Modules in the Regulators of Complement Activation

    Soares, D. & Barlow, P., 29 Mar 2005, CRC Press. Morikis, D. & Lambris, J. (eds.). Boca Raton, FL: CRC Press, p. 19-62 44 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  9. 2006
  10. Disease-associated sequence variations in factor H: A structural biology approach

    Herbert, A. P., Soares, D. C., Pangburn, M. K. & Barlow, P. N., 2006, Current Topics in Complement. Springer-Verlag GmbH, Vol. 586. p. 313-327 15 p. (Advances in Experimental Medicine and Biology ).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

  11. 2007
  12. Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

    Royer, B., Soares, D. C., Barlow, P. N., Bontrop, R. E., Roll, P., Robaglia-Schlupp, A., Blancher, A., Levasseur, A., Cau, P., Pontarotti, P. & Szepetowski, P., 2007, In: BMC Genetics. 8, 72, p. 1-9 9 p.

    Research output: Contribution to journalArticlepeer-review

  13. Structure-based mapping of DAF active site residues that accelerate the decay of C3 convertases

    Kuttner-Kondo, L., Hourcade, D. E., Anderson, V. E., Muqim, N., Mitchell, L., Soares, D. C., Barlow, P. N. & Medof, M. E., 2007, In: Journal of Biological Chemistry. 282, 25, p. 18552-62 11 p.

    Research output: Contribution to journalArticlepeer-review

  14. 2008
  15. The evolution of TEP1, an exceptionally polymorphic immunity gene in Anopheles gambiae

    Obbard, D. J., Callister, D. M., Jiggins, F. M., Soares, D. C., Yan, G. & Little, T. J., 2008, In: BMC Evolutionary Biology. 8, 274, p. 1-11 11 p.

    Research output: Contribution to journalArticlepeer-review

  16. The DISC locus in psychiatric illness

    Chubb, J. E., Bradshaw, N. J., Soares, D. C., Porteous, D. J. & Millar, J. K., Jan 2008, In: Molecular Psychiatry. 13, 1, p. 36-64 29 p.

    Research output: Contribution to journalArticlepeer-review

  17. Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations

    Hocking, H. G., Herbert, A. P., Kavanagh, D., Soares, D. C., Ferreira, V. P., Pangburn, M. K., Uhrín, D. & Barlow, P. N., 4 Apr 2008, In: Journal of Biological Chemistry. 283, 14, p. 9475-9487 13 p.

    Research output: Contribution to journalArticlepeer-review

  18. A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder

    Pickard, B. S., Knight, H. M., Hamilton, R. S., Soares, D. C., Walker, R., Boyd, J. K. F., Machell, J., Maclean, A., McGhee, K. A., Condie, A., Porteous, D. J., Clair, D. S., Davis, I., Blackwood, D. H. R. & Muir, W. J., 30 Sep 2008, In: Proceedings of the National Academy of Sciences (PNAS). 105, 39, p. 14940-14945 6 p.

    Research output: Contribution to journalArticlepeer-review

  19. 2009
  20. NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction

    Bradshaw, N. J., Christie, S., Soares, D. C., Carlyle, B. C., Porteous, D. J. & Millar, J. K., Jan 2009, In: Neuroscience Letters. 449, 3, p. 228-233 6 p.

    Research output: Contribution to journalArticlepeer-review

  21. An interrupted beta-propeller and protein disorder: structural bioinformatics insights into the N-terminus of alsin

    Soares, D. C., Barlow, P. N., Porteous, D. J. & Devon, R. S., Feb 2009, In: Journal of Molecular Modeling. 15, 2, p. 113-122 10 p.

    Research output: Contribution to journalArticlepeer-review

  22. Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement

    Phelan, M. M., Thai, C-T., Soares, D. C., Ogata, R. T., Barlow, P. N. & Bramham, J., Jul 2009, In: Journal of Biological Chemistry. 284, 29, p. 19637-19649 13 p.

    Research output: Contribution to journalArticlepeer-review

  23. A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression

    Knight, H. M., Pickard, B. S., Maclean, A., Malloy, M. P., Soares, D. C., McRae, A. F., Condie, A., White, A., Hawkins, W., McGhee, K., van Beck, M., MacIntyre, D. J., Starr, J., Deary, I. J., Visscher, P. M., Porteous, D. J., Cannon, R. E., St Clair, D., Muir, W. J. & Blackwood, D. H., Dec 2009, In: American Journal of Human Genetics. 85, 6, p. 833-846 14 p.

    Research output: Contribution to journalArticlepeer-review

  24. eEF1A2 and neuronal degeneration

    Abbott, C. M., Newbery, H. J., Squires, C. E., Brownstein, D., Griffiths, L. A. & Soares, D. C., Dec 2009, In: Biochemical Society Transactions. 37, Pt 6, p. 1293-7 5 p.

    Research output: Contribution to journalArticlepeer-review

  25. 2010
  26. The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module

    Schmidt, C. Q., Herbert, A. P., Mertens, H. D. T., Guariento, M., Soares, D. C., Uhrin, D., Rowe, A. J., Svergun, D. I. & Barlow, P. N., 2010, In: Journal of Molecular Biology. 395, 1, p. 105-22 18 p.

    Research output: Contribution to journalArticlepeer-review

  27. Oxovanadium(IV) Cyclam and Bicyclam Complexes: Potential CXCR4 Receptor Antagonists

    Ross, A., Soares, D. C., Covelli, D., Pannecouque, C., Budd, L., Collins, A., Robertson, N., Parsons, S., De Clercq, E., Kennepohl, P. & Sadler, P. J., 1 Feb 2010, In: Inorganic Chemistry. 49, 3, p. 1122-1132 11 p.

    Research output: Contribution to journalArticlepeer-review

  28. The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro

    Serfiotis-Mitsa, D., Herbert, A. P., Roberts, G. A., Soares, D. C., White, J. H., Blakely, G. W., Uhrin, D. & Dryden, D. T. F., Mar 2010, In: Nucleic Acids Research. 38, 5, p. 1723-1737 15 p.

    Research output: Contribution to journalArticlepeer-review

  29. In silico structure-function analysis of pathological variation in the HSD11B2 gene sequence

    Manning, J., Bailey, M. A., Soares, D. C., Dunbar, D. R. & Mullins, J. J., Aug 2010, In: Physiological Genomics. 42, 3, p. 319-330 12 p.

    Research output: Contribution to journalArticlepeer-review

  30. 2011
  31. DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness

    Soares, D. C., Carlyle, B. C., Bradshaw, N. J. & Porteous, D. J., 2011, In: ACS Chemical Neuroscience. 2, 11, p. 609-632 24 p.

    Research output: Contribution to journalArticlepeer-review

  32. PKA Phosphorylation of NDE1 Is DISC1/PDE4 Dependent and Modulates Its Interaction with LIS1 and NDEL1

    Bradshaw, N. J., Soares, D. C., Carlyle, B. C., Ogawa, F., Davidson-Smith, H., Christie, S., Mackie, S., Thomson, P. A., Porteous, D. J. & Millar, J. K., Jun 2011, In: Journal of Neuroscience. 31, 24, p. 9043-9054 12 p.

    Research output: Contribution to journalArticlepeer-review

  33. 2012
  34. Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H

    Makou, E., Mertens, H. D. T., Maciejewski, M., Soares, D. C., Matis, I., Schmidt, C. Q., Herbert, A. P., Svergun, D. I. & Barlow, P. N., 2012, In: Journal of Molecular Biology. 424, 5, p. 295-312

    Research output: Contribution to journalArticlepeer-review

  35. Structural Analysis of the C-Terminal Region (Modules 18-20) of Complement Regulator Factor H (FH)

    Morgan, H. P., Mertens, H. D. T., Guariento, M., Schmidt, C. Q., Soares, D. C., Svergun, D. I., Herbert, A. P., Barlow, P. N. & Hannan, J. P., 28 Feb 2012, In: PLoS ONE. 7, 2, p. 1-10 10 p., e32187.

    Research output: Contribution to journalArticlepeer-review

  36. 2013
  37. DISC1 genetics, biology and psychiatric illness

    Thomson, P. A., Malavasi, E. L. V., Grünewald, E., Soares, D. C., Borkowska, M. & Millar, J. K., 1 Feb 2013, In: Frontiers in Biology. 8, 1, p. 1-31

    Research output: Contribution to journalLiterature reviewpeer-review

  38. The intermediate filament protein, vimentin, is a regulator of NOD2 activity

    Stevens, C., Henderson, P., Nimmo, E. R., Soares, D. C., Dogan, B., Simpson, K. W., Barrett, J. C., International Inflammatory Bowel Disease Genetics Consortium, Wilson, D. C. & Satsangi, J., May 2013, In: Gut. 62, 5, p. 695-707 13 p.

    Research output: Contribution to journalArticlepeer-review

  39. NDE1 and NDEL1: twin neurodevelopmental proteins with similar ‘nature’ but different ‘nurture’

    Bradshaw, N., Hennah, W. & Soares, D., Sep 2013, In: BioMolecular Concepts. 4, 5, p. 447-464 18 p.

    Research output: Contribution to journalArticlepeer-review

  40. DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking

    Ogawa, F., Malavasi, E. L. V., Crummie, D. K., Eykelenboom, J. E., Soares, D. C., Mackie, S., Porteous, D. J. & Millar, J. K., 2 Oct 2013, In: Human Molecular Genetics.

    Research output: Contribution to journalArticlepeer-review

  41. 2014
  42. DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan: response to Sullivan

    Porteous, D. J., Thomson, P. A., Millar, J. K., Evans, K. L., Hennah, W., Soares, D. C., McCarthy, S., McCombie, W. R., Clapcote, S. J., Korth, C., Brandon, N. J., Sawa, A., Kamiya, A., Roder, J. C., Lawrie, S. M., McIntosh, A. M., St Clair, D. & Blackwood, D. H., Feb 2014, In: Molecular Psychiatry. 19, 2, p. 141-143 3 p.

    Research output: Contribution to journalEditorialpeer-review

  43. 708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits

    Thomson, P. A., Parla, J. S., McRae, A. F., Kramer, M., Ramakrishnan, K., Yao, J., Soares, D. C., McCarthy, S., Morris, S. W., Cardone, L., Cass, S., Ghiban, E., Hennah, W., Evans, K. L., Rebolini, D., Millar, J. K., Harris, S. E., Starr, J. M., MacIntyre, D. J., Generation Scotland & 7 others, McIntosh, A. M., Watson, J. D., Deary, I. J., Visscher, P. M., Blackwood, D. H., McCombie, W. R. & Porteous, D. J., 1 Jun 2014, In: Molecular Psychiatry. 19, 6, p. 668-675 8 p.

    Research output: Contribution to journalArticlepeer-review

  44. Monoallelic and Biallelic Mutations in MAB21L2 Cause a Spectrum of Major Eye Malformations

    Rainger, J., Pehlivan, D., Johansson, S., Bengani, H., Sanchez-Pulido, L., Williamson, K. A., Ture, M., Barker, H., Rosendahl, K., Spranger, J., Horn, D., Meynert, A., Floyd, J. A. B., Prescott, T., Anderson, C. A., Rainger, J. K., Karaca, E., Gonzaga-Jauregui, C., Jhangiani, S., Muzny, D. M. & 16 others, Seawright, A., Soares, D. C., Kharbanda, M., Murday, V., Finch, A., Gibbs, R. A., van Heyningen, V., Taylor, M. S., Yakut, T., Knappskog, P. M., Hurles, M. E., Ponting, C., Lupski, J. R., Houge, G., FitzPatrick, D. R. & UK10K, 5 Jun 2014, In: American Journal of Human Genetics. 94, 6, p. 915-923 9 p.

    Research output: Contribution to journalArticlepeer-review

  45. 2015
  46. Atypical Femoral Fracture in Osteoporosis Pseudoglioma Syndrome Associated With Two Novel Compound Heterozygous Mutations in LRP5

    Alonso, N., Soares, D. C., McCloskey, E., Summers, G. D., Ralston, S. H. & Gregson, C. L., Apr 2015, In: Journal of Bone and Mineral Research. 30, 4, p. 615-620

    Research output: Contribution to journalArticlepeer-review

  47. RPGR: its role in photoreceptor physiology, human disease, and future therapies

    Megaw, R., Soares, D. & Wright, A., Sep 2015, In: Experimental Eye Research. 138, p. 32-41 10 p.

    Research output: Contribution to journalArticlepeer-review

  48. Evolutionary Characterization of the Retinitis Pigmentosa GTPase Regulator Gene

    Raghupathy, R. K., Gautier, P., Soares, D. C., Wright, A. F. & Shu, X., 1 Oct 2015, In: Investigative Ophthalmology & Visual Science. 56, 11, p. 6255-64 10 p.

    Research output: Contribution to journalArticlepeer-review

  49. Specific Interaction between eEF1A and HIV RT Is Critical for HIV-1 Reverse Transcription and a Potential Anti-HIV Target

    Li, D., Wei, T., Rawle, D. J., Qin, F., Wang, R., Soares, D. C., Jin, H., Sivakumaran, H., Lin, M-H., Spann, K., Abbott, C. M. & Harrich, D., 1 Dec 2015, In: Plos Pathogens. 11, 12, e1005289.

    Research output: Contribution to journalArticlepeer-review

  50. 2016
  51. Condensin II mutation causes T cell lymphoma through tissue-specific genome instability

    Woodward, J., Taylor, G. C., Soares, D. C., Boyle, S., Sie, D., Read, D., Chathoth, K., Vukovic, M., Tarrats, N., Jamieson, D., Campbell, K. J., Blyth, K., Acosta, J. C., Ylstra, B., Arends, M. J., Kranc, K. R., Jackson, A. P., Bickmore, W. A. & Wood, A. J., 2016, In: Genes and Development. 30, 19, p. 2173-2186 14 p.

    Research output: Contribution to journalArticlepeer-review

  52. Novel de novo EEF1A2 missense mutations causing epilepsy and intellectual disability

    DDD study & Abbott, C. M., Jul 2016, In: Molecular Genetics & Genomic Medicine.

    Research output: Contribution to journalArticlepeer-review

  53. 2017
  54. Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy

    Lu, Z., Hu, X., Liu, F., Soares, D. C., Liu, X., Yu, S., Gao, M., Han, S., Qin, Y., Li, C., Jiang, T., Luo, D., Guo, A-Y., Tang, Z. & Liu, M., 5 Apr 2017, In: Scientific Reports. 7, p. 46098

    Research output: Contribution to journalArticlepeer-review

  55. Pathogenic Mutations in Retinitis Pigmentosa 2 Predominantly Result in Loss of RP2 Protein Stability in Human and Zebrafish

    Liu, F., Qin, Y., Yu, S., Soares, D. C., Yang, L., Weng, J., Li, C., Gao, M., Lu, Z., Hu, X., Liu, X., Jiang, T., Liu, J. Y., Shu, X., Tang, Z. & Liu, M., 14 Apr 2017, In: Journal of Biological Chemistry.

    Research output: Contribution to journalArticlepeer-review

  56. A Structural Organization for Disrupted in Schizophrenia 1, Identified by High-Throughput Screening, Reveals Distinctly Folded Regions Which Are Bisected by Mental Illness-Related Mutations

    Yerabham, A. S. K., Mas, P. J., Decker, C., Soares, D. C., Weiergräber, O. H., Nagel-Steger, L., Willbold, D., Hart, D. J., Bradshaw, N. J. & Korth, C., 21 Apr 2017, In: Journal of Biological Chemistry.

    Research output: Contribution to journalArticlepeer-review

  57. PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins

    Hall, E. A., Nahorski, M. S., Murray, L. M., Shaheen, R., Perkins, E., Dissanayake, K. N., Kristaryanto, Y., Jones, R., Vogt, J., Rivagorda, M., Handley, M. T., Mali, G. R., Quidwai, T., Soares, D. C., Keighren, M. A., Mckie, L., Mort, R. L., Gammoh, N., Garcia-munoz, A., Davey, T. & 15 others, Vermeren, M., Walsh, D., Budd, P., Aligianis, I. A., Faqeih, E., Quigley, A. J., Jackson, I. J., Kulathu, Y., Jackson, M., Ribchester, R. R., Von Kriegsheim, A., Alkuraya, F. S., Woods, C. G., Maher, E. R. & Mill, P., 4 May 2017, In: American Journal of Human Genetics.

    Research output: Contribution to journalArticlepeer-review

  58. SAF-A Regulates Interphase Chromosome Structure through Oligomerization with Chromatin-Associated RNAs

    Nozawa, R-S., Boteva, L., Soares, D. C., Naughton, C., Dun, A. R., Buckle, A., Ramsahoye, B., Bruton, P. C., Saleeb, R. S., Arnedo, M., Hill, B., Duncan, R. R., Maciver, S. K. & Gilbert, N., 15 Jun 2017, In: Cell. 169, 7, p. 1214-1227.e18 22 p.

    Research output: Contribution to journalArticlepeer-review

  59. Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia

    Teng, S., Thomson, P. A., Mccarthy, S., Kramer, M., Muller, S., Lihm, J., Morris, S., Soares, D. C., Hennah, W., Harris, S., Camargo, L. M., Malkov, V., Mcintosh, A. M., Millar, J. K., Blackwood, D. H., Evans, K. L., Deary, I. J., Porteous, D. J. & Mccombie, W. R., 20 Jun 2017, In: Molecular Psychiatry.

    Research output: Contribution to journalArticlepeer-review

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