Edinburgh Research Explorer

Prof Donal O'Carroll

Chair of Stem Cell Biology

  1. 2019
  2. Targeting the RNA m6A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia

    Paris, J., Morgan, M., Monteiro De Campos, J., Spencer, G., Shmakova, A., Ivanova, I., Mapperley, C., Lawson, H., Wotherspoon, D., Pires Sepulveda, C., Vukovic, M., Allen, L., Sarapuu, A., Tavosanis, A., Guitart, A., Villacreces, A., Much, C., Junho, C., Anvari Azar, A., Van De Lagemaat, L. & 7 others, Vernimmen, D., Nehme, A., Mazurier, F., Somervaille, T., Gregory, R., O'Carroll, D. & Kranc, K., 3 Jul 2019, In : Cell Stem Cell. 25, 12 p.

    Research output: Contribution to journalArticle

  3. A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

    Morgan, M., Kabayama, Y., Much, C., Ivanova, I., Di Giacomo, M., Auchynnikava, T., Monahan, J. M., Vitsios, D. M., Vasiliauskaitė, L., Comazzetto, S., Rappsilber, J., Allshire, R. C., Porse, B. T., Enright, A. J. & O'Carroll, D., 7 Jan 2019, In : Cell Research . 12 p.

    Research output: Contribution to journalArticle

  4. 2018
  5. PIWI-interacting RNAs: small RNAs with big functions

    Ozata, D. M., Gainetdinov, I., Zoch, A., O’Carroll, D. & Zamore, P. D., 16 Nov 2018, In : Nature Reviews Genetics. 20 p.

    Research output: Contribution to journalReview article

  6. Deficiency in the nuclear long noncoding RNA causes myogenic defects and heart remodeling in mice

    Ballarino, M., Cipriano, A., Tita, R., Santini, T., Desideri, F., Morlando, M., Colantoni, A., Carrieri, C., Nicoletti, C., Musarò, A., Carroll, D. O. & Bozzoni, I., 14 Sep 2018, In : EMBO Journal. 37, 18

    Research output: Contribution to journalArticle

  7. Terminal uridylyltransferases target RNA viruses as part of the innate immune system

    Le Pen, J., Jiang, H., Di Domenico, T., Kneuss, E., Kosałka, J., Leung, C., Morgan, M., Much, C., Rudolph, K. L. M., Enright, A. J., O'Carroll, D., Wang, D. & Miska, E. A., 13 Aug 2018, In : Nature Structural & Molecular Biology. 25, 9, p. 778-786 9 p.

    Research output: Contribution to journalArticle

  8. Defective germline reprogramming rewires the spermatogonial transcriptome

    Vasiliauskaitė, L., Berrens, R. V., Ivanova, I., Carrieri, C., Reik, W., Enright, A. J. & O’carroll, D., 30 Apr 2018, In : Nature Structural & Molecular Biology. 25, 5, p. 394-404 16 p.

    Research output: Contribution to journalArticle

  9. MicroRNA degradation by a conserved target RNA regulates animal behavior

    Bitetti, A., Mallory, A. C., Golini, E., Carrieri, C., Carreño Gutiérrez, H., Perlas, E., Pérez-Rico, Y. A., Tocchini-Valentini, G. P., Enright, A. J., Norton, W. H. J., Mandillo, S., O'Carroll, D. & Shkumatava, A., 26 Feb 2018, In : Nature Structural & Molecular Biology. 25, 3, p. 244-251 8 p.

    Research output: Contribution to journalArticle

  10. 2017
  11. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells

    Wasserman, G. A., Szymaniak, A. D., Hinds, A. C., Yamamoto, K., Kamata, H., Smith, N. M. S., Hillard, K., Carrieri, C., Labadorf, A. T., Quinton, L. J., Ai, X., Varelas, X., Chen, F., Mizgerd, J. P., Fine, A., O'Carroll, D. & Jones, M. R., 2 Oct 2017, In : Journal of Clinical Investigation. 127, 10, p. 3866-3876 11 p.

    Research output: Contribution to journalArticle

  12. The RNA m6A reader YTHDF2 is essential for the post-transcriptional regulation of the maternal transcriptome and oocyte competence.

    Ivanova, I., Much, C., Di Giacomo, M., Azzi, C., Morgan, M., Morgan, M., Ventura De Oliveira Moreira, P., Monahan, J., Carrieri, C., Enright, A. J. & O'Carroll, D., 30 Aug 2017, In : Molecular Cell.

    Research output: Contribution to journalArticle

  13. mRNA 3ʹ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome

    Morgan, M., Much, C., DiGiacomo, M., Azzi, C., Ivanova, I., Vitsios, D., Pistolic, J., Collier, P., Ventura De Oliveira Moreira, P., Benes, V., Enright, A. J. & O'Carroll, D., 9 Aug 2017, In : Nature.

    Research output: Contribution to journalArticle

  14. A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming

    Vasilauskaite, L., Vitsios, D., Berrens, R., Carrieri, C., Reik, W., Enright, A. J. & O'Carroll, D., 1 Jul 2017, In : Nature Structural & Molecular Biology. 24, p. 604–606

    Research output: Contribution to journalArticle

  15. The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses

    Kozlowski, E., Wasserman, G. A., Morgan, M., O'Carroll, D., Ramirez, N-G. P., Gummuluru, S., Rah, J. Y., Gower, A. C., Ieong, M., Quinton, L. J., Mizgerd, J. P. & Jones, M. R., 30 Jun 2017, In : PLoS ONE. 12, 6, p. e0179797

    Research output: Contribution to journalArticle

  16. Transposon-driven transcription is a conserved feature of vertebrate spermatogenesis and transcript evolution

    Davis, M. P., Carrieri, C., Saini, H. K., van Dongen, S., Leonardi, T., Bussotti, G., Monahan, J. M., Auchynnikava, T., Bitetti, A., Rappsilber, J., Allshire, R. C., Shkumatava, A., O'Carroll, D. & Enright, A. J., 12 May 2017, In : EMBO Reports.

    Research output: Contribution to journalArticle

  17. A transit amplifying population underpins the efficient regenerative capacity of the testis

    Carrieri, C., Comazzetto, S., Grover, A., Morgan, M., Buness, A., Nerlov, C. & O'Carroll, D., 1 May 2017, In : Journal of Experimental Medicine.

    Research output: Contribution to journalArticle

  18. Fumarate hydratase is a critical metabolic regulator of haematopoietic stem cell functions

    Guitart, A., Panagopoulou, T., Villacreces, A., Vukovic, M., Sepulveda, C., Allen, L., Carter, R., van de Lagemaat, L., Morgan, M., Giles, P., Sas, Z., Vila Gonzalez, M., Lawson, H., Paris, J., Edward-Hicks, J., Schaak, K., Subramani, C., Gezer, D., Armesilla-Diaz, A., Bukowski-Wills, J. & 9 others, Easterbrook, A., Coman, D., O'Carroll, D., Vernimmen, D., Rodrigues, N. P., Pollard, P. J., Finch, A., Kranc, K. & Morton, N., 15 Feb 2017, In : Journal of Experimental Medicine. 214, 3, p. 719-735

    Research output: Contribution to journalArticle

  19. 2016
  20. Endogenous mouse Dicer is an exclusively cytoplasmic protein

    Much, C., Auchynnikava, T., Pavlinic, D., Buness, A., Rappsilber, J., Benes, V., Allshire, R. & O'Carroll, D., 2 Jun 2016, In : PLoS Genetics.

    Research output: Contribution to journalArticle

  21. 2015
  22. Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance

    Vukovic, M., Guitart, A. V., Sepulveda, C., Villacreces, A., O'Duibhir, E., Panagopoulou, T. I., Ivens, A., Menendez-Gonzalez, J., Iglesias, J. M., Allen, L., Glykofrydis, F., Subramani, C., Armesilla-Diaz, A., Post, A. E. M., Schaak, K., Gezer, D., So, C. W. E., Holyoake, T. L., Wood, A., O'Carroll, D. & 2 others, Ratcliffe, P. J. & Kranc, K. R., 14 Dec 2015, In : Journal of Experimental Medicine. 212, 13, p. 2223-2234 12 p.

    Research output: Contribution to journalArticle

  23. 2014
  24. Oligoasthenoteratozoospermia and infertility in mice deficient for miR-34b/c and miR-449 Loci

    Comazzetto, S., Di Giacomo, M., Rasmussen, K. D., Much, C., Azzi, C., Perlas, E., Morgan, M. & O'Carroll, D., 16 Oct 2014, In : PLoS Genetics. 10, 10, 11 p., 1004597.

    Research output: Contribution to journalArticle

  25. G9a co-suppresses LINE1 elements in spermatogonia

    Di Giacomo, M., Comazzetto, S., Sampath, S. C., Sampath, S. C. & O'Carroll, D., 11 Sep 2014, In : Epigenetics & chromatin. 7, 7 p., 24.

    Research output: Contribution to journalArticle

  26. Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

    Grover, A., Mancini, E., Moore, S., Mead, A. J., Atkinson, D., Rasmussen, K. D., O'Carroll, D., Jacobsen, S. E. W. & Nerlov, C., 10 Feb 2014, In : Journal of Experimental Medicine. 211, 2, p. 181-188 8 p.

    Research output: Contribution to journalArticle

  27. Argonaute2 mediates compensatory expansion of the pancreatic beta Cell

    Tattikota, S. G., Rathjen, T., McAnulty, S. J., Wessels, H-H., Akerman, I., van de Bunt, M., Hausser, J., Esguerra, J. L. S., Musahl, A., Pandey, A. K., You, X., Chen, W., Herrera, P. L., Johnson, P. R., O'Carroll, D., Eliasson, L., Zavolan, M., Gloyn, A. L., Ferrer, J., Shalom-Feuerstein, R. & 2 others, Aberdam, D. & Poy, M. N., 7 Jan 2014, In : Cell Metabolism. 19, 1, p. 122-134 13 p.

    Research output: Contribution to journalArticle

  28. 2013
  29. MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice

    Tan, C. L., Plotkin, J. L., Veno, M. T., von Schimmelmann, M., Feinberg, P., Mann, S., Handler, A., Kjems, J., Surmeier, D. J., O'Carroll, D., Greengard, P. & Schaefer, A., 6 Dec 2013, In : Science. 342, 6163, p. 1254-1258 5 p.

    Research output: Contribution to journalArticle

  30. Multiple Epigenetic Mechanisms and the piRNA Pathway Enforce LINE1 Silencing during Adult Spermatogenesis

    Di Giacomo, M., Comazzetto, S., Saini, H., De Fazio, S., Carrieri, C., Morgan, M., Vasiliauskaite, L., Benes, V., Enright, A. J. & O'Carroll, D., 23 May 2013, In : Molecular Cell. 50, 4, p. 601-608 8 p.

    Research output: Contribution to journalArticle

  31. 2012
  32. Dicer is selectively important for the earliest stages of erythroid development

    Buza-Vidas, N., Cismasiu, V. B., Moore, S., Mead, A. J., Woll, P. S., Lutteropp, M., Melchiori, L., Luc, S., Bouriez-Jones, T., Atkinson, D., O'Carroll, D., Jacobsen, S. E. W. & Nerlov, C., 20 Sep 2012, In : Blood. 120, 12, p. 2412-2416 5 p.

    Research output: Contribution to journalArticle

  33. General principals of miRNA biogenesis and regulation in the brain

    O'Carroll, D. & Schaefer, A., 6 Jun 2012, In : Neuropsychopharmacology. 38, 1, p. 39-54 16 p.

    Research output: Contribution to journalLiterature review

  34. Quantitative functions of Argonaute proteins in mammalian development

    Wang, D., Zhang, Z., O'Loughlin, E., Lee, T., Houel, S., O'Carroll, D., Tarakhovsky, A., Ahn, N. G. & Yi, R., 1 Apr 2012, In : Genes & Development. 26, 7, p. 693-704 12 p.

    Research output: Contribution to journalArticle

  35. FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors

    Mancini, E., Sanjuan-Pla, A., Luciani, L., Moore, S., Grover, A., Zay, A., Rasmussen, K. D., Luc, S., Bilbao, D., O'Carroll, D., Jacobsen, S. E. & Nerlov, C., 2012, In : EMBO Journal. 31, 2, p. 351-65 15 p.

    Research output: Contribution to journalArticle

  36. 2011
  37. The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements

    De Fazio, S., Bartonicek, N., Di Giacomo, M., Abreu-Goodger, C., Sankar, A., Funaya, C., Antony, C., Moreira, P. N., Enright, A. J. & O'Carroll, D., 8 Dec 2011, In : Nature. 480, 7376, p. 259-U148 7 p.

    Research output: Contribution to journalArticle

  38. The miR-144/451(eGFP) allele, a novel tool for resolving the erythroid potential of hematopoietic precursors

    Rasmussen, K. D. & O'Carroll, D., 15 Sep 2011, In : Blood. 118, 11, p. 2988-2992 5 p.

    Research output: Contribution to journalArticle

  39. Blimp1 regulates the transition of neonatal to adult intestinal epithelium

    Muncan, V., Heijmans, J., Krasinski, S. D., Buller, N. V., Wildenberg, M. E., Meisner, S., Radonjic, M., Stapleton, K. A., Lamers, W. H., Biemond, I., Weerman, M. A. V. D. B., O'Carroll, D., Hardwick, J. C., Hommes, D. W. & van den Brink, G. R., Aug 2011, In : Nature Communications. 2, 9 p., 452.

    Research output: Contribution to journalArticle

  40. 2010
  41. Reversible Block of Mouse Neural Stem Cell Differentiation in the Absence of Dicer and MicroRNAs

    Andersson, T., Rahman, S., Sansom, S. N., Alsioe, J. M., Kaneda, M., Smith, J., O'Carroll, D., Tarakhovsky, A. & Livesey, F. J., 18 Oct 2010, In : PLoS ONE. 5, 10, 12 p., 13453.

    Research output: Contribution to journalArticle

  42. Genome-Wide Identification of Targets and Function of Individual MicroRNAs in Mouse Embryonic Stem Cells

    Hanina, S. A., Mifsud, W., Down, T. A., Hayashi, K., O'Carroll, D., Lao, K., Miska, E. A. & Surani, M. A., Oct 2010, In : PLoS Genetics. 6, 10, 13 p., 1001163.

    Research output: Contribution to journalArticle

  43. Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction

    Schaefer, A., Im, H-I., Veno, M. T., Fowler, C. D., Min, A., Intrator, A., Kjems, J., Kenny, P. J., O'Carroll, D. & Greengard, P., 30 Aug 2010, In : Journal of Experimental Medicine. 207, 9, p. 1843-1851 9 p.

    Research output: Contribution to journalArticle

  44. Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis

    Yang, J-S., Maurin, T., Robine, N., Rasmussen, K. D., Jeffrey, K. L., Chandwani, R., Papapetrou, E. P., Sadelain, M., O'Carroll, D. & Lai, E. C., 24 Aug 2010, In : Proceedings of the National Academy of Sciences. 107, 34, p. 15163-15168 6 p.

    Research output: Contribution to journalArticle

  45. The miR-144/451 locus is required for erythroid homeostasis

    Rasmussen, K. D., Simmini, S., Abreu-Goodger, C., Bartonicek, N., Di Giacomo, M., Bilbao-Cortes, D., Horos, R., Von Lindern, M., Enright, A. J. & O'Carroll, D., 5 Jul 2010, In : Journal of Experimental Medicine. 207, 7, p. 1351-1358 8 p.

    Research output: Contribution to journalArticle

  46. 2009
  47. Essential role for Argonaute2 protein in mouse oogenesis

    Kaneda, M., Tang, F., O'Carroll, D., Lao, K. & Surani, M. A., 10 Aug 2009, In : Epigenetics & chromatin. 2, 8 p., 9.

    Research output: Contribution to journalArticle

  48. DGCR8-dependent microRNA biogenesis is essential for skin development

    Yi, R., Pasolli, H. A., Landthaler, M., Hafner, M., Ojo, T., Sheridan, R., Sander, C., O'Carroll, D., Stoffel, M., Tuschl, T. & Fuchs, E., 13 Jan 2009, In : Proceedings of the National Academy of Sciences. 106, 2, p. 498-502 5 p.

    Research output: Contribution to journalArticle

  49. 2000
  50. Regulation of chromatin structure by site-specific histone H3 methyltransferases

    Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z. W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D. & Jenuwein, T., 10 Aug 2000, In : Nature. 406, 6796, p. 593-9 7 p.

    Research output: Contribution to journalArticle