Edinburgh Research Explorer

Prof Donal O'Carroll

Chair of Stem Cell Biology

  1. 2019
  2. Targeting the RNA m6A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia

    Paris, J., Morgan, M., Monteiro De Campos, J., Spencer, G., Shmakova, A., Ivanova, I., Mapperley, C., Lawson, H., Wotherspoon, D., Pires Sepulveda, C., Vukovic, M., Allen, L., Sarapuu, A., Tavosanis, A., Guitart, A., Villacreces, A., Much, C., Junho, C., Anvari Azar, A., Van De Lagemaat, L. & 7 others, Vernimmen, D., Nehme, A., Mazurier, F., Somervaille, T., Gregory, R., O'Carroll, D. & Kranc, K., 3 Jul 2019, In : Cell Stem Cell. 25, 12 p.

    Research output: Contribution to journalArticle

  3. A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

    Morgan, M., Kabayama, Y., Much, C., Ivanova, I., Di Giacomo, M., Auchynnikava, T., Monahan, J. M., Vitsios, D. M., Vasiliauskaitė, L., Comazzetto, S., Rappsilber, J., Allshire, R. C., Porse, B. T., Enright, A. J. & O'Carroll, D., 7 Jan 2019, In : Cell Research . 12 p.

    Research output: Contribution to journalArticle

  4. 2018
  5. PIWI-interacting RNAs: small RNAs with big functions

    Ozata, D. M., Gainetdinov, I., Zoch, A., O’Carroll, D. & Zamore, P. D., 16 Nov 2018, In : Nature Reviews Genetics. 20 p.

    Research output: Contribution to journalReview article

  6. Deficiency in the nuclear long noncoding RNA causes myogenic defects and heart remodeling in mice

    Ballarino, M., Cipriano, A., Tita, R., Santini, T., Desideri, F., Morlando, M., Colantoni, A., Carrieri, C., Nicoletti, C., Musarò, A., Carroll, D. O. & Bozzoni, I., 14 Sep 2018, In : EMBO Journal. 37, 18

    Research output: Contribution to journalArticle

  7. Terminal uridylyltransferases target RNA viruses as part of the innate immune system

    Le Pen, J., Jiang, H., Di Domenico, T., Kneuss, E., Kosałka, J., Leung, C., Morgan, M., Much, C., Rudolph, K. L. M., Enright, A. J., O'Carroll, D., Wang, D. & Miska, E. A., 13 Aug 2018, In : Nature Structural & Molecular Biology. 25, 9, p. 778-786 9 p.

    Research output: Contribution to journalArticle

  8. Defective germline reprogramming rewires the spermatogonial transcriptome

    Vasiliauskaitė, L., Berrens, R. V., Ivanova, I., Carrieri, C., Reik, W., Enright, A. J. & O’carroll, D., 30 Apr 2018, In : Nature Structural & Molecular Biology. 25, 5, p. 394-404 16 p.

    Research output: Contribution to journalArticle

  9. MicroRNA degradation by a conserved target RNA regulates animal behavior

    Bitetti, A., Mallory, A. C., Golini, E., Carrieri, C., Carreño Gutiérrez, H., Perlas, E., Pérez-Rico, Y. A., Tocchini-Valentini, G. P., Enright, A. J., Norton, W. H. J., Mandillo, S., O'Carroll, D. & Shkumatava, A., 26 Feb 2018, In : Nature Structural & Molecular Biology. 25, 3, p. 244-251 8 p.

    Research output: Contribution to journalArticle

  10. 2017
  11. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells

    Wasserman, G. A., Szymaniak, A. D., Hinds, A. C., Yamamoto, K., Kamata, H., Smith, N. M. S., Hillard, K., Carrieri, C., Labadorf, A. T., Quinton, L. J., Ai, X., Varelas, X., Chen, F., Mizgerd, J. P., Fine, A., O'Carroll, D. & Jones, M. R., 2 Oct 2017, In : Journal of Clinical Investigation. 127, 10, p. 3866-3876 11 p.

    Research output: Contribution to journalArticle

  12. The RNA m6A reader YTHDF2 is essential for the post-transcriptional regulation of the maternal transcriptome and oocyte competence.

    Ivanova, I., Much, C., Di Giacomo, M., Azzi, C., Morgan, M., Morgan, M., Ventura De Oliveira Moreira, P., Monahan, J., Carrieri, C., Enright, A. J. & O'Carroll, D., 30 Aug 2017, In : Molecular Cell.

    Research output: Contribution to journalArticle

  13. mRNA 3ʹ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome

    Morgan, M., Much, C., DiGiacomo, M., Azzi, C., Ivanova, I., Vitsios, D., Pistolic, J., Collier, P., Ventura De Oliveira Moreira, P., Benes, V., Enright, A. J. & O'Carroll, D., 9 Aug 2017, In : Nature.

    Research output: Contribution to journalArticle

  14. A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming

    Vasilauskaite, L., Vitsios, D., Berrens, R., Carrieri, C., Reik, W., Enright, A. J. & O'Carroll, D., 1 Jul 2017, In : Nature Structural & Molecular Biology. 24, p. 604–606

    Research output: Contribution to journalArticle

  15. The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses

    Kozlowski, E., Wasserman, G. A., Morgan, M., O'Carroll, D., Ramirez, N-G. P., Gummuluru, S., Rah, J. Y., Gower, A. C., Ieong, M., Quinton, L. J., Mizgerd, J. P. & Jones, M. R., 30 Jun 2017, In : PLoS ONE. 12, 6, p. e0179797

    Research output: Contribution to journalArticle

  16. Transposon-driven transcription is a conserved feature of vertebrate spermatogenesis and transcript evolution

    Davis, M. P., Carrieri, C., Saini, H. K., van Dongen, S., Leonardi, T., Bussotti, G., Monahan, J. M., Auchynnikava, T., Bitetti, A., Rappsilber, J., Allshire, R. C., Shkumatava, A., O'Carroll, D. & Enright, A. J., 12 May 2017, In : EMBO Reports.

    Research output: Contribution to journalArticle

  17. A transit amplifying population underpins the efficient regenerative capacity of the testis

    Carrieri, C., Comazzetto, S., Grover, A., Morgan, M., Buness, A., Nerlov, C. & O'Carroll, D., 1 May 2017, In : Journal of Experimental Medicine.

    Research output: Contribution to journalArticle

  18. Fumarate hydratase is a critical metabolic regulator of haematopoietic stem cell functions

    Guitart, A., Panagopoulou, T., Villacreces, A., Vukovic, M., Sepulveda, C., Allen, L., Carter, R., van de Lagemaat, L., Morgan, M., Giles, P., Sas, Z., Vila Gonzalez, M., Lawson, H., Paris, J., Edward-Hicks, J., Schaak, K., Subramani, C., Gezer, D., Armesilla-Diaz, A., Bukowski-Wills, J. & 9 others, Easterbrook, A., Coman, D., O'Carroll, D., Vernimmen, D., Rodrigues, N. P., Pollard, P. J., Finch, A., Kranc, K. & Morton, N., 15 Feb 2017, In : Journal of Experimental Medicine. 214, 3, p. 719-735

    Research output: Contribution to journalArticle

  19. 2016
  20. Endogenous mouse Dicer is an exclusively cytoplasmic protein

    Much, C., Auchynnikava, T., Pavlinic, D., Buness, A., Rappsilber, J., Benes, V., Allshire, R. & O'Carroll, D., 2 Jun 2016, In : PLoS Genetics.

    Research output: Contribution to journalArticle

  21. 2015
  22. Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance

    Vukovic, M., Guitart, A. V., Sepulveda, C., Villacreces, A., O'Duibhir, E., Panagopoulou, T. I., Ivens, A., Menendez-Gonzalez, J., Iglesias, J. M., Allen, L., Glykofrydis, F., Subramani, C., Armesilla-Diaz, A., Post, A. E. M., Schaak, K., Gezer, D., So, C. W. E., Holyoake, T. L., Wood, A., O'Carroll, D. & 2 others, Ratcliffe, P. J. & Kranc, K. R., 14 Dec 2015, In : Journal of Experimental Medicine. 212, 13, p. 2223-2234 12 p.

    Research output: Contribution to journalArticle

  23. 2014
  24. Oligoasthenoteratozoospermia and infertility in mice deficient for miR-34b/c and miR-449 Loci

    Comazzetto, S., Di Giacomo, M., Rasmussen, K. D., Much, C., Azzi, C., Perlas, E., Morgan, M. & O'Carroll, D., 16 Oct 2014, In : PLoS Genetics. 10, 10, 11 p., 1004597.

    Research output: Contribution to journalArticle

  25. G9a co-suppresses LINE1 elements in spermatogonia

    Di Giacomo, M., Comazzetto, S., Sampath, S. C., Sampath, S. C. & O'Carroll, D., 11 Sep 2014, In : Epigenetics & chromatin. 7, 7 p., 24.

    Research output: Contribution to journalArticle

  26. Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

    Grover, A., Mancini, E., Moore, S., Mead, A. J., Atkinson, D., Rasmussen, K. D., O'Carroll, D., Jacobsen, S. E. W. & Nerlov, C., 10 Feb 2014, In : Journal of Experimental Medicine. 211, 2, p. 181-188 8 p.

    Research output: Contribution to journalArticle

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