Edinburgh Research Explorer

Dr Douglas Houston

Senior Lecturer

  1. 2019
  2. Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP Binding Sites of NMD Master Regulator: UPF1

    Kalathiya, U., Padariya, M., Pawlicka, K., Verma, C. S., Houston, D., Hupp, T. & Alfaro, J. A., 11 Nov 2019, In : International Journal of Molecular Sciences.

    Research output: Contribution to journalArticle

  3. Design of drug-like Hepsin inhibitors against prostate cancer and kidney stones

    Blay, V., Houston, D., Li, M. C., P. Ho, S., Stoller, M. L., Hsieh, H-P. & Houston, D., 23 Sep 2019, (Accepted/In press) In : Acta Pharmaceutica Sinica B.

    Research output: Contribution to journalArticle

  4. Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity

    Makarov, A. A., Zou, J., Houston, D. R., Spanos, C., Solovyova, A. S., Cardenal-Peralta, C., Rappsilber, J. & Schirmer, E. C., 11 Jul 2019, In : Nature Communications. 10, 1, 3056.

    Research output: Contribution to journalArticle

  5. An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin

    Coufalova, D., Remnant, L., Hernychova, L., Muller, P., Healy, A., Kannan, S., Vojtesek, B., Westwood, N., Verma, C. S., Vojtesek, B., Hupp, T. R. & Houston, D. R., 15 May 2019, In : Journal of proteomics. 199, p. 89-101 13 p.

    Research output: Contribution to journalArticle

  6. Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy

    Dudley, L., Gonzalez Cabodevilla, A., Makar, A., Sztacho, M., Michelberger, T., Marsh, J., Houston, D., Martens, S., Jiang, X. & Gammoh, N., 2 May 2019, In : EMBO Journal. 38, 9

    Research output: Contribution to journalArticle

  7. Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing

    Rojas, F., Silvester, E., Young, J., Milne, R., Tettey, M., Houston, D. R., Walkinshaw, M. D., Pérez-Pi, I., Auer, M., Denton, H., Smith, T. K., Thompson, J. & Matthews, K. R., 10 Jan 2019, In : Cell. 176, 1-2, p. 306-317.e16 28 p.

    Research output: Contribution to journalArticle

  8. 2018
  9. ALDH1 bio-activates nifuroxazide to eradicate ALDH(High) melanoma-initiating cells

    Sarvi, S., Crispin, R., Lu, Y., Zeng, L., Hurley, T. D., Houston, D., Von Kriegsheim, A., Chen, C-H., Mochly-Rosen, D., Ranzani, M., Mathers, M. E., Xu, X., Xu, W., Adams, D. J., Carragher, N., Fujita, M., Schuchter, L., Unciti-Broceta, A., Brunton, V. & Patton, E., 20 Dec 2018, In : Cell Chemical Biology. 25, 12, p. 1456-1469 21 p.

    Research output: Contribution to journalArticle

  10. Demonstration of the Anthelmintic Potency of Marimastat in the Heligmosomoides Polygyrus Rodent Model

    Robertson, E., Harcus, Y., Johnston, C. J. C., Page, A. P., Walkinshaw, M. D., Maizels, R. M. & Houston, D., 1 Dec 2018, In : Journal of parasitology. 104, 6, p. 705-709 5 p.

    Research output: Contribution to journalArticle

  11. Fatty-acylation target sequence in the ligand-binding domain of vertebrate steroid receptors demarcates evolution from estrogen-related receptors

    Lathe, R. & Houston, D., Nov 2018, In : The Journal of Steroid Biochemistry and Molecular Biology. 184, p. 20-28 9 p.

    Research output: Contribution to journalArticle

  12. Development of potent inhibitors of receptor tyrosine kinases by ligand-based drug design and target-biased phenotypic screening

    Myers, S., Temps, C., Houston, D., Brunton, V. & Unciti-Broceta, A., 21 Feb 2018, In : Journal of Medicinal Chemistry. 61, 5, p. 2104-2110 7 p.

    Research output: Contribution to journalArticle

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