Edinburgh Research Explorer

Dr Douglas Houston

Senior Lecturer

  1. 2019
  2. Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity

    Makarov, A. A., Zou, J., Houston, D. R., Spanos, C., Solovyova, A. S., Cardenal-Peralta, C., Rappsilber, J. & Schirmer, E. C., 11 Jul 2019, In : Nature Communications. 10, 1, 3056.

    Research output: Contribution to journalArticle

  3. An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin

    Coufalova, D., Remnant, L., Hernychova, L., Muller, P., Healy, A., Kannan, S., Vojtesek, B., Westwood, N., Verma, C. S., Vojtesek, B., Hupp, T. R. & Houston, D. R., 15 May 2019, In : Journal of proteomics. 199, p. 89-101 13 p.

    Research output: Contribution to journalArticle

  4. Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy

    Dudley, L., Gonzalez Cabodevilla, A., Makar, A., Sztacho, M., Michelberger, T., Marsh, J., Houston, D., Martens, S., Jiang, X. & Gammoh, N., 2 May 2019, In : EMBO Journal. 38, 9

    Research output: Contribution to journalArticle

  5. Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing

    Rojas, F., Silvester, E., Young, J., Milne, R., Tettey, M., Houston, D. R., Walkinshaw, M. D., Pérez-Pi, I., Auer, M., Denton, H., Smith, T. K., Thompson, J. & Matthews, K. R., 10 Jan 2019, In : Cell. 176, 1-2, p. 306-317.e16 28 p.

    Research output: Contribution to journalArticle

  6. 2018
  7. ALDH1 bio-activates nifuroxazide to eradicate ALDH(High) melanoma-initiating cells

    Sarvi, S., Crispin, R., Lu, Y., Zeng, L., Hurley, T. D., Houston, D., Von Kriegsheim, A., Chen, C-H., Mochly-Rosen, D., Ranzani, M., Mathers, M. E., Xu, X., Xu, W., Adams, D. J., Carragher, N., Fujita, M., Schuchter, L., Unciti-Broceta, A., Brunton, V. & Patton, E., 20 Dec 2018, In : Cell Chemical Biology. 25, 12, p. 1456-1469 21 p.

    Research output: Contribution to journalArticle

  8. Demonstration of the Anthelmintic Potency of Marimastat in the Heligmosomoides Polygyrus Rodent Model

    Robertson, E., Harcus, Y., Johnston, C. J. C., Page, A. P., Walkinshaw, M. D., Maizels, R. M. & Houston, D., 1 Dec 2018, In : Journal of parasitology. 104, 6, p. 705-709 5 p.

    Research output: Contribution to journalArticle

  9. Fatty-acylation target sequence in the ligand-binding domain of vertebrate steroid receptors demarcates evolution from estrogen-related receptors

    Lathe, R. & Houston, D., Nov 2018, In : The Journal of Steroid Biochemistry and Molecular Biology. 184, p. 20-28 9 p.

    Research output: Contribution to journalArticle

  10. Development of potent inhibitors of receptor tyrosine kinases by ligand-based drug design and target-biased phenotypic screening

    Myers, S., Temps, C., Houston, D., Brunton, V. & Unciti-Broceta, A., 21 Feb 2018, In : Journal of Medicinal Chemistry. 61, 5, p. 2104-2110 7 p.

    Research output: Contribution to journalArticle

  11. 2017
  12. Mono-substituted Hydrocarbon Diastereomer Combinations Reveal Stapled Peptides with High Structural Fidelity

    Mcwhinnie, F. S., Sepp, K., Wilson, C., Kunath, T., Hupp, T. R., Baker, T. S., Houston, D. R. & Hulme, A. N., 21 Dec 2017, In : Chemistry - A European Journal.

    Research output: Contribution to journalArticle

  13. 2016
  14. Inhibitors of leishmania mexicana phosphoglycerate mutase identified by virtual screening and verified by inhibition studies

    Fuad, F. A. A., Houston, D. R., Michels, P. A. M., Fothergill-Gilmore, L. A. & Walkinshaw, M. D., 1 Jul 2016, In : Journal Sains Malaysiana. 45, 7, p. 1113-1120 8 p.

    Research output: Contribution to journalArticle

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