Edinburgh Research Explorer

Emily Sena

Research Fellow

  1. 2007
  2. Comparison of treatment effects between animal experiments and clinical trials: systematic review

    Perel, P., Roberts, I., Sena, E., Wheble, P., Briscoe, C., Sandercock, P., Macleod, M., Mignini, L. E., Jayaram, P. & Khan, K. S., 27 Jan 2007, In: British Medical Journal (BMJ). 334, 7586, p. 197-197

    Research output: Contribution to journalArticlepeer-review

  3. Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke

    Sena, E., Wheble, P., Sandercock, P. & Macleod, M., Feb 2007, In: Stroke. 38, 2, p. 388-394 7 p.

    Research output: Contribution to journalReview articlepeer-review

  4. How can we improve the pre-clinical development of drugs for stroke?

    Sena, E., van der Worp, H. B., Howells, D. & Macleod, M., Sep 2007, In: Trends in Neurosciences. 30, 9, p. 433-439 7 p.

    Research output: Contribution to journalArticlepeer-review

  5. Hypothermia in animal models of acute ischaemic stroke: A systematic review and meta-analysis

    Van Der Worp, H. B., Sena, E. S., Donnan, G. A., Howells, D. W. & Macleod, M. R., Dec 2007, In: Brain. 130, 12, p. 3063-3074 12 p.

    Research output: Contribution to journalReview articlepeer-review

  6. 2008
  7. A systematic review and meta-analysis of the efficacy of piracetam and piracetam-like compounds in experimental stroke

    Wheble, P. C. R., Sena, E. S. & Macleod, M. R., 2008, In: Cerebrovascular diseases. 25, 1-2, p. 5-11 7 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  8. Empirical evidence of bias in the design of experimental stroke studies - A metaepidemiologic approach

    Crossley, N. A., Sena, E., Goehler, J., Horn, J., van der Worp, B., Bath, P. M. W., Macleod, M. & Dirnagl, U., Mar 2008, In: Stroke. 39, 3, p. 929-934 6 p.

    Research output: Contribution to journalArticlepeer-review

  9. Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality

    Macleod, M. R., van der Worp, H. B., Sena, E. S., Howells, D. W., Dirnagl, U. & Donnan, G. A., Oct 2008, In: Stroke. 39, 10, p. 2824-2829 6 p.

    Research output: Contribution to journalArticlepeer-review

  10. 2009
  11. Systematic Review and Stratified Meta-analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke

    Banwell, V., Sena, E. S. & Macleod, M. R., 2009, In: Journal of Stroke and Cerebrovascular Diseases. 18, 4, p. 269-276 8 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  12. Reprint: Good laboratory practice: preventing introduction of bias at the bench

    Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., van der Worp, H. B., Traystman, R. J., Minematsu, K., Donnan, G. A. & Howells, D. W., Feb 2009, In: Journal of Cerebral Blood Flow and Metabolism. 29, 2, p. 221-223 3 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  13. REPRINT: Good laboratory practice: Preventing introduction of bias at the bench

    Macleod, M. R., Fisher, M., O'collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., Van Der Worp, H. B., Traystman, R. J., Minematsu, K., Donnan, G. A. & Howells, D. W., 25 Feb 2009, In: International Journal of Stroke. 4, 1, p. 3-5 3 p.

    Research output: Contribution to journalArticlepeer-review

  14. Good Laboratory Practice Preventing Introduction of Bias at the Bench

    Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., van der Worp, H. B., Traystman, R., Minematsu, K., Donnan, G. A. & Howells, D. W., Mar 2009, In: Stroke. 40, 3, p. E50-E52 3 p.

    Research output: Contribution to journalArticlepeer-review

  15. A Systematic Review Of Erythropoietin In Experimental Stroke

    Forsberg, K. O., Jerndal, M. J., Sena, E. S., O'Collins, V. E., Macleod, M. R., Linden, T., Nilsson, M. & Howells, D. W., Apr 2009, In: Stroke. 40, 4, p. E215-E215 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  16. 2010
  17. An Enriched Environment Improves Sensorimotor Function Post-Ischemic Stroke

    Janssen, H., Bernhardt, J., Collier, J. M., Sena, E. S., McElduff, P., Attia, J., Pollack, M., Howells, D. W., Nilsson, M., Calford, M. B. & Spratt, N. J., 2010, In: Neurorehabilitation and Neural Repair. 24, 9, p. 802-813 12 p.

    Research output: Contribution to journalArticlepeer-review

  18. Can Animal Models of Disease Reliably Inform Human Studies?

    van der Worp, H. B., Howells, D. W., Sena, E. S., Porritt, M. J., Rewell, S., O'Collins, V. & Macleod, M. R., Mar 2010, In: PLoS Medicine. 7, 3, p. - 8 p., e1000245.

    Research output: Contribution to journalArticlepeer-review

  19. Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

    Sena, E. S., van der Worp, H. B., Bath, P. M. W., Howells, D. W. & Macleod, M. R., Mar 2010, In: PLoS Biology. 8, 3, 8 p., e1000344.

    Research output: Contribution to journalArticlepeer-review

  20. A systematic review and meta-analysis of erythropoietin in experimental stroke

    Jerndal, M., Forsberg, K., Sena, E. S., Macleod, M. R., O'Collins, V. E., Linden, T., Nilsson, M. & Howells, D. W., May 2010, In: Journal of Cerebral Blood Flow and Metabolism. 30, 5, p. 961-968 8 p.

    Research output: Contribution to journalArticlepeer-review

  21. Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia

    Howells, D. W., Porritt, M. J., Rewell, S. S. J., O'Collins, V., Sena, E. S., van der Worp, H. B., Traystman, R. J. & Macleod, M. R., Aug 2010, In: Journal of Cerebral Blood Flow and Metabolism. 30, 8, p. 1412-1431 20 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  22. Improving the translational hit of experimental treatments in multiple sclerosis

    Vesterinen, H. M., Sena, E. S., Ffrench-Constant, C., Williams, A., Chandran, S. & Macleod, M. R., Sep 2010, In: Multiple Sclerosis Journal. 16, 9, p. 1044-1055 12 p.

    Research output: Contribution to journalArticlepeer-review

  23. Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis

    Sena, E. S., Briscoe, C. L., Howells, D. W., Donnan, G. A., Sandercock, P. A. G. & Macleod, M. R., Dec 2010, In: Journal of Cerebral Blood Flow and Metabolism. 30, 12, p. 1905-13 9 p.

    Research output: Contribution to journalArticlepeer-review

  24. 2011
  25. Making the most of animal data – improving the prospect of success in pragmatic trials in the neurosciences

    Egan, K. J., Sena, E. S., Vesterinen, H. M. & Macleod, M. R., 1 Jan 2011, In: Trials. 12, Suppl 1, p. A102

    Research output: Contribution to journalArticlepeer-review

  26. Treatment of intracerebral hemorrhage in animal models: Meta-analysis

    Frantzias, J., Sena, E. S., Macleod, M. R. & Salman, R. A-S., Feb 2011, In: Annals of Neurology. 69, 2, p. 389-399 11 p.

    Research output: Contribution to journalArticlepeer-review

  27. Dopamine agonists in animal models of Parkinson's disease: A systematic review and meta-analysis

    Rooke, E. D. M., Vesterinen, H. M., Sena, E. S., Egan, K. J. & Macleod, M. R., Jun 2011, In: Parkinsonism & Related Disorders. 17, 5, p. 313-320 8 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  28. 2012
  29. Exploring the Efficacy of Constraint in Animal Models of Stroke: Meta-analysis and Systematic Review of the Current Evidence

    Janssen, H., Speare, S., Spratt, N. J., Sena, E. S., Ada, L., Hannan, A. J., McElduff, P. & Bernhardt, J., 2012, In: Neurorehabilitation and Neural Repair.

    Research output: Contribution to journalArticlepeer-review

  30. Improving the efficiency of the development of drugs for stroke

    Howells, D. W., Sena, E. S., O'Collins, V. & Macleod, M. R., Jul 2012, In: International Journal of Stroke. 7, 5, p. 371-377 7 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  31. Developing our understanding of the pathogenesis of Alzheimer's disease using a systematically identified dataset of interventions tested in transgenic mouse models

    Egan, K. J., Sena, E. S., Vesterinen, H. M. & Macleod, M. R., Sep 2012, In: European Journal of Neurology. 19, p. 460-460 1 p.

    Research output: Contribution to journalMeeting abstract

  32. Stem cell-based therapy for experimental stroke: A systematic review and meta-analysis

    Lees, J. S., Sena, E. S., Egan, K. J., Antonic, A., Koblar, S. A., Howells, D. W. & Macleod, M. R., Oct 2012, In: International Journal of Stroke. 7, 7, p. 582-588 7 p.

    Research output: Contribution to journalArticlepeer-review

  33. 2013
  34. Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure

    Batchelor, P. E., Wills, T. E., Skeers, P., Battistuzzo, C. R., Macleod, M. R., Howells, D. W. & Sena, E. S., 2013, In: PLoS ONE. 8, 8, p. e72659

    Research output: Contribution to journalArticlepeer-review

  35. Systematic review and meta-analysis of therapeutic hypothermia in animal models of spinal cord injury

    Batchelor, P. E., Skeers, P., Antonic, A., Wills, T. E., Howells, D. W., Macleod, M. R. & Sena, E. S., 2013, In: PLoS ONE. 8, 8, p. e71317

    Research output: Contribution to journalArticlepeer-review

  36. Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted?

    Hirst, T. C., Vesterinen, H. M., Sena, E. S., Egan, K. J., Macleod, M. R. & Whittle, I. R., 15 Jan 2013, In: British Journal of Cancer. 108, 1, p. 64-71 8 p.

    Research output: Contribution to journalArticlepeer-review

  37. Animal models of bone cancer pain: systematic review and meta-analyses: Systematic review and meta-analyses

    Currie, G. L., Delaney, A., Bennett, M. I., Dickenson, A. H., Egan, K. J., Vesterinen, H. M., Sena, E. S., Macleod, M. R., Colvin, L. A. & Fallon, M. T., 7 Mar 2013, In: Pain. 154, 6, p. 917-26 10 p.

    Research output: Contribution to journalArticlepeer-review

  38. The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine

    Sena, E. S., Jeffreys, A. L., Cox, S. F., Sastra, S. A., Churilov, L., Rewell, S., Batchelor, P. E., van der Worp, H. B., Macleod, M. R. & Howells, D. W., Apr 2013, In: International Journal of Stroke. 8, 3, p. 180-185 6 p.

    Research output: Contribution to journalArticlepeer-review

  39. Transparency in the reporting of in vivo pre-clinical pain research: The relevance and implications of the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines

    Rice, A. S. C., Morland, R., Huang, W., Currie, G. L., Sena, E. S. & Macleod, M. R., 1 Apr 2013, In: Scandinavian Journal of Pain. 4, 2, p. 58-62

    Research output: Contribution to journalArticlepeer-review

  40. Prevalence and natural history of pain in adults with multiple sclerosis: Systematic review and meta-analysis

    Foley, P. L., Vesterinen, H. M., Laird, B. J., Sena, E. S., Colvin, L. A., Chandran, S., Macleod, M. R. & Fallon, M. T., May 2013, In: Pain. 154, 5, p. 632-642 11 p.

    Research output: Contribution to journalArticlepeer-review

  41. Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke

    Vesterinen, H. M., Currie, G. L., Carter, S., Mee, S., Watzlawick, R., Egan, K. J., Macleod, M. R. & Sena, E. S., 20 May 2013, In: Systematic Reviews. 2, 1, p. 33

    Research output: Contribution to journalArticlepeer-review

  42. Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

    Tsilidis, K. K., Panagiotou, O. A., Sena, E. S., Aretouli, E., Evangelou, E., Howells, D. W., Al-Shahi Salman, R., Macleod, M. R. & Ioannidis, J. P. A., Jul 2013, In: PLoS Biology. 11, 7, p. e1001609

    Research output: Contribution to journalArticlepeer-review

  43. Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies

    Antonic, A., Sena, E. S., Lees, J. S., Wills, T. E., Skeers, P., Batchelor, P. E., Macleod, M. R. & Howells, D. W., Dec 2013, In: PLoS Biology. 11, 12, e1001738.

    Research output: Contribution to journalArticlepeer-review

  44. 2014
  45. Bringing rigour to translational medicine

    Howells, D. W., Sena, E. S. & Macleod, M. R., Jan 2014, In: Nature Reviews Neurology. 10, 1, p. 37-43 7 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  46. Edaravone improves functional and structural outcomes in animal models of focal cerebral ischemia: A systematic review

    Wu, S., Sena, E., Egan, K., Macleod, M. & Mead, G., Jan 2014, In: International Journal of Stroke. 9, 1, p. 101-106 6 p.

    Research output: Contribution to journalArticlepeer-review

  47. Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis

    Watzlawick, R., Sena, E. S., Dirnagl, U., Brommer, B., Kopp, M. A., Macleod, M. R., Howells, D. W. & Schwab, J. M., Jan 2014, In: JAMA Neurology. 71, 1, p. 91-9 9 p.

    Research output: Contribution to journalArticlepeer-review

  48. Meta-analysis of data from animal studies: A practical guide

    Vesterinen, H. M., Sena, E. S., Egan, K. J., Hirst, T., Churolov, L., Currie, G., Antonic, A., Howells, D. W. & Macleod, M. R., 15 Jan 2014, In: Journal of Neuroscience Methods. 221, p. 92-102 11 p.

    Research output: Contribution to journalArticlepeer-review

  49. Similar effect of autologous and allogeneic cell therapy for ischaemic heart disease: systematic review and meta-analysis of large animal studies

    Lorkeers, S. J. J. O., Eding, J. E. C., van der Spoel, T. I. G., Vesterinen, H. M., Sena, E. S., Duckers, H. J., Doevendans, P. A., Macleod, M. R. & Chamuleau, S. A. J., May 2014, In: European journal of clinical investigation. 44, p. 5-6 2 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  50. Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically

    Sena, E. S., Currie, G. L., McCann, S. K., Macleod, M. R. & Howells, D. W., May 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, 5, p. 737-42 6 p.

    Research output: Contribution to journalArticlepeer-review

  51. Using animal models to understand cancer pain in humans

    Currie, G. L., Sena, E. S., Fallon, M. T., Macleod, M. R. & Colvin, L. A., Jun 2014, In: Current pain and headache reports. 18, 6, 8 p., 423.

    Research output: Contribution to journalLiterature reviewpeer-review

  52. Efficacy of antidepressants in animal models of ischemic stroke: a systematic review and meta-analysis

    McCann, S. K., Irvine, C., Mead, G. E., Sena, E. S., Currie, G. L., Egan, K. E., Macleod, M. R. & Howells, D. W., Oct 2014, In: Stroke. 45, 10, p. 3055-3063 9 p.

    Research output: Contribution to journalArticlepeer-review

  53. Exercise Reduces Infarct Volume and Facilitates Neurobehavioral Recovery: Results From a Systematic Review and Meta-analysis of Exercise in Experimental Models of Focal Ischemia

    Egan, K. J., Janssen, H., Sena, E. S., Longley, L., Speare, S., Howells, D. W., Spratt, N. J., Macleod, M. R., Mead, G. E. & Bernhardt, J., Oct 2014, In: Neurorehabilitation and Neural Repair. 28, 8, p. 800-812 13 p.

    Research output: Contribution to journalArticlepeer-review

  54. WHY ANIMAL MODELS OF GENE THERAPY HAVE LET GLIOMA PATIENTS DOWN

    Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., McLean, A. L., Macleod, M. R., Whittle, I. R., Grant, R., Brennan, P. M. & Sena, E. S., Oct 2014, In: Neuro-oncology. 16, 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  55. Incidence, Prevalence and Predictors of Chemotherapy Induced Peripheral Neuropathy: a Systematic Review and Meta-Analysis

    Seretny, M., Currie, G. L., Sena, E. S., Ramnarine, S., Grant, R., MacLeod, M. R., Colvin, L. & Fallon, M., Dec 2014, In: Pain. 155, 12, p. 2461-2470

    Research output: Contribution to journalArticlepeer-review

  56. A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?

    Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., Lawson Mclean, A., Macleod, M. R., Grant, R., Brennan, P. M., Sena, E. S. & Whittle, I. R., 1 Dec 2014, In: Evidence-based Preclinical Medicine. 1, 1, p. 21-33

    Research output: Contribution to journalArticlepeer-review

  57. 2015
  58. Similar effect of autologous and allogeneic cell therapy for ischemic heart disease: systematic review and meta-analysis of large animal studies

    Jansen Of Lorkeers, S. J., Eding, J. E. C., Vesterinen, H. M., van der Spoel, T. I. G., Sena, E. S., Duckers, H. J., Doevendans, P. A., Macleod, M. R. & Chamuleau, S. A. J., 2 Jan 2015, In: Circulation Research. 116, 1, p. 80-86 7 p.

    Research output: Contribution to journalArticlepeer-review

  59. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

    Finnerup, N. B., Attal, N., Haroutounian, S., McNicol, E., Baron, R., Dworkin, R. H., Gilron, I., Haanpää, M., Hansson, P., Jensen, T. S., Kamerman, P. R., Lund, K., Moore, A., Raja, S. N., Rice, A. S. C., Rowbotham, M., Sena, E., Siddall, P., Smith, B. H. & Wallace, M., 1 Feb 2015, In: Lancet Neurology. 14, 2, p. 162-173 12 p.

    Research output: Contribution to journalArticlepeer-review

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