Edinburgh Research Explorer

Emily Sena

Research Fellow

  1. 2020
  2. Insights into therapeutic products, preclinical research models and clinical trials in cardiac regenerative and reparative medicine: where are we now and the way ahead. Current opinion paper of the ESC working group on cardiovascular regenerative and reparative medicine

    Grigorian, S. L., Sanz-ruiz, R., Climent, A., Badimon, L., Barile, L., Bolli, R., Chamuleau, S., Grobbee, D. E., Janssens, S., Kastrup, J., Kragten-tabatabaie, L., Madonna, R., Mathur, A., Menasché, P., Pompilio, G., Prosper, F., Sena, E. S., Smart, N., Zimmermann, W. & Fernández-avilés, F., 1 Dec 2020, In: Cardiovascular Research.

    Research output: Contribution to journalArticlepeer-review

  3. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

    Percie Du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., Garner, P., Holgate, S. T., Howells, D. W., Karp, N. A., Lazic, S. E., Lidster, K., Maccallum, C. J., Macleod, M., Pearl, E. J. & 8 others, Petersen, O. H., Rawle, F., Reynolds, P., Rooney, K., Sena, E. S., Silberberg, S. D., Steckler, T. & Würbel, H., 1 Aug 2020, In: Experimental physiology.

    Research output: Contribution to journalEditorialpeer-review

  4. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research

    Percie Du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., Garner, P., Holgate, S. T., Howells, D. W., Karp, N. A., Lazic, S. E., Lidster, K., Maccallum, C. J., Macleod, M., Pearl, E. J. & 8 others, Petersen, O. H., Rawle, F., Reynolds, P., Rooney, K., Sena, E. S., Silberberg, S. D., Steckler, T. & Würbel, H., 15 Jul 2020, In: Journal of Physiology.

    Research output: Contribution to journalEditorialpeer-review

  5. Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

    Percie Du Sert, N., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., Garner, P., Holgate, S. T., Howells, D. W., Hurst, V., Karp, N. A., Lazic, S. E., Lidster, K., Maccallum, C. J., Macleod, M., Pearl, E. J. & 8 others, Petersen, O. H., Rawle, F., Reynolds, P., Rooney, K., Sena, E. S., Silberberg, S. D., Steckler, T. & Würbel, H., 14 Jul 2020, In: PLoS Biology. 18, 7, e3000411.

    Research output: Contribution to journalArticlepeer-review

  6. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

    Percie Du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., Garner, P., Holgate, S. T., Howells, D. W., Karp, N. A., Lazic, S. E., Lidster, K., Maccallum, C. J., Macleod, M., Pearl, E. J. & 9 others, Petersen, O. H., Rawle, F., Reynolds, P., Rooney, K., Sena, E. S., Silberberg, S. D., Steckler, T., Würbel, H. & Boutron, I., 14 Jul 2020, In: PLoS Biology. 18, 7, p. e3000410

    Research output: Contribution to journalArticlepeer-review

  7. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

    Percie Du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., Garner, P., Holgate, S. T., Howells, D. W., Karp, N. A., Lazic, S. E., Lidster, K., Maccallum, C. J., Macleod, M., Pearl, E. J. & 8 others, Petersen, O. H., Rawle, F., Reynolds, P., Rooney, K., Sena, E. S., Silberberg, S. D., Steckler, T. & Würbel, H., 14 Jul 2020, In: BMC Veterinary Research. 16, 1

    Research output: Contribution to journalArticlepeer-review

  8. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

    Percie Du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., Garner, P., Holgate, S. T., Howells, D. W., Karp, N. A., Lazic, S. E., Lidster, K., Maccallum, C. J., Macleod, M., Pearl, E. J. & 8 others, Petersen, O. H., Rawle, F., Reynolds, P., Rooney, K., Sena, E. S., Silberberg, S. D., Steckler, T. & Würbel, H., 14 Jul 2020, In: Journal of Cerebral Blood Flow and Metabolism. 40, 9, p. 1769-1777

    Research output: Contribution to journalArticlepeer-review

  9. Evidence Synthesis International (ESI): Position Statement

    Gough, D., Davies, P., Jamtvedt, G., Langlois, E., Littell, J., Lotfi, T., Masset, E., Merlin, T., Pullin, A. S., Ritskes-hoitinga, M., Røttingen, J., Sena, E., Stewart, R., Tovey, D., White, H., Yost, J., Lund, H. & Grimshaw, J., 10 Jul 2020, In: Systematic Reviews. 9, 1

    Research output: Contribution to journalArticlepeer-review

  10. Quality and validity of large animal experiments in stroke: A systematic review

    Kringe, L., Sena, E. S., Motschall, E., Bahor, Z., Wang, Q., Herrmann, A. M., Mülling, C., Meckel, S. & Boltze, J., 23 Jun 2020, In: Journal of Cerebral Blood Flow and Metabolism. p. 271678X20931062

    Research output: Contribution to journalArticlepeer-review

  11. UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings

    McFall, A., Hietamies, T. M., Bernard, A., Aimable, M., Allan, S. M., Bath, P. M., Brezzo, G., Carare, R. O., Carswell, H. V., Clarkson, A. N., Currie, G., Farr, T. D., Fowler, J., Good, M., Hainsworth, A. H., Hall, C., Horsburgh, K., Kalaria, R., Kehoe, P., Lawrence, C. & 17 others, MacLeod, M., McNeilly, A., Miller, A. A., Miners, S., Mok, V., O'Sullivan, M., Platt, B., Sena, E., Sharp, M., Strangeward, P., Szymkowiak, S., Touyz, R. M., Trueman, R. C., White, C., McCabe, C., Work, L. M. & Quinn, T. J., 9 Mar 2020, In: Journal of Cerebral Blood Flow and Metabolism.

    Research output: Contribution to journalArticlepeer-review

  12. Attitudes towards animal study registries and their characteristics: An online survey of three cohorts of animal researchers

    Wieschowski, S., Laser, H., Sena, E. S., Bleich, A., Tolba, R., Strech, D. & Lopes, L. C. (ed.), 6 Jan 2020, In: PLoS ONE. 15, 1, p. e0226443

    Research output: Contribution to journalArticlepeer-review

  13. 2019
  14. Design of Meta-Analysis Studies

    MacLeod, M., Tanriver Ayder, E., Hair, K. & Sena, E., 17 Oct 2019, Handbook of Experimental Pharmacology . Springer

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

  15. Outcome heterogeneity and bias in acute experimental Spinal Cord Injury – a meta-analysis

    Watzlawick, R., Antonic, A., Sena, E., Kopp, M. A., Rind, J., Dirnagl, U., MacLeod, M., Howells, D. W. & Schwab, J. M., 2 Jul 2019, In: Neurology.

    Research output: Contribution to journalArticlepeer-review

  16. A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

    Hair, K., Macleod, M. R. & Sena, E. S., 12 Jun 2019, In: Research integrity and peer review. 4, 1

    Research output: Contribution to journalArticlepeer-review

  17. Protocol for a systematic review and meta-analysis of data from preclinical studies employing forced swimming test: An update

    Ramos-Hryb, A. B., Bahor, Z., McCann, S., Sena, E., Macleod, M. R. & Lino De Oliveira, C., 31 May 2019, In: BMJ Case Reports. 3, 1, e000043.

    Research output: Contribution to journalArticlepeer-review

  18. Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis

    Currie, G. L., Angel-scott, H. N., Colvin, L., Cramond, F., Hair, K., Khandoker, L., Liao, J., Macleod, M., Mccann, S. K., Morland, R., Sherratt, N., Stewart, R., Tanriver-ayder, E., Thomas, J., Wang, Q., Wodarski, R., Xiong, R., Rice, A. S. C., Sena, E. S. & Lalu, M., 20 May 2019, In: PLoS Biology. 17, 5, p. e3000243

    Research output: Contribution to journalLetterpeer-review

  19. Did a change in Nature journals’ editorial policy for life sciences research improve reporting?

    MacLeod, M., Sena, E., Howells, D. W. & The NPQIP Collaborative group, 1 Feb 2019, In: BMJ Open Science. 3, 1, p. e000035

    Research output: Contribution to journalArticlepeer-review

  20. How our approaches to assessing benefits and harms can be improved

    Sena, E. & Currie, G., 1 Feb 2019, In: Animal Welfare. 28, 1, p. 107-115

    Research output: Contribution to journalArticlepeer-review

  21. Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis

    Lalu, M. M., Fergusson, D. A., Cheng, W., Avey, M. T., Corbett, D., Dowlatshahi, D., Macleod, M. R., Sena, E. S., Moher, D., Shorr, R., Mccann, S. K., Gray, L. J., Hill, M. D., O'connor, A., Thayer, K., Haggar, F., Dobriyal, A., Chung, H. S., Welton, N. J. & Hutton, B., 3 Jan 2019, In: F1000Research. 8, p. 11

    Research output: Contribution to journalArticlepeer-review

  22. 2018
  23. Neuropathic pain clinical trials: factors associated with decreases in estimated drug efficacy

    Finnerup, N. B., Haroutounian, S., Baron, R., Dworkin, R. H., Gilron, I., Haanpaa, M., Jensen, T. S., Kamerman, P. R., Mcnicol, E., Moore, A., Raja, S. N., Andersen, N. T., Sena, E. S., Smith, B. H., Rice, A. S. C. & Attal, N., 1 Nov 2018, In: Pain. 159, 11, p. 2339-2346

    Research output: Contribution to journalReview articlepeer-review

  24. The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials

    Yarborough, M., Bredenoord, A., D'Abramo, F., Joyce, N. C., Kimmelman, J., Ogbogu, U., Sena, E., Strech, D. & Dirnagl, U., Jun 2018, In: PLoS Biology. 16, 6, p. e2006343

    Research output: Contribution to journalArticlepeer-review

  25. Reproducibility of preclinical animal research improves with heterogeneity of study samples

    Voelkl, B., Vogt, L., Sena, E. S. & Würbel, H., 22 Feb 2018, In: PLoS Biology. 16, 2, p. e2003693

    Research output: Contribution to journalArticlepeer-review

  26. A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models

    Jue, T. R., Sena, E. S., Macleod, M. R., McDonald, K. L. & Hirst, T. C., 29 Jan 2018, In: Oncotarget. 9, 13, p. 11387-11401 15 p.

    Research output: Contribution to journalArticlepeer-review

  27. Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies

    Hooijmans, C. R., De Vries, R. B. M., Ritskes-hoitinga, M., Rovers, M. M., Leeflang, M. M., Inthout, J., Wever, K. E., Hooft, L., De Beer, H., Kuijpers, T., Macleod, M. R., Sena, E. S., Ter Riet, G., Morgan, R. L., Thayer, K. A., Rooney, A. A., Guyatt, G. H., Schünemann, H. J., Langendam, M. W. & Minnerup, J. (ed.), 11 Jan 2018, In: PLoS ONE. 13, 1, p. e0187271

    Research output: Contribution to journalArticlepeer-review

  28. 2017
  29. Letter to the editor - round table unites to tackle culture change in an effort to improve animal research reporting

    Osborne, N. J., Ritskes-Hoitinga, M., Ahluwahlia, A., Alam, S., Brown, M., Henderson, H., de Leeuw, W., Marsh, J., Moher, D., van Oort, E., Rawle, F., Riederer, B. M., Sanchez-Morgado, J., Sena, E. S., Struthers, C., Westmore, M., Avey, M. T., Kalman, R., O'Connor, A., Sargeant, J. & 2 others, Petrie, A. & Smith, A., 7 Nov 2017, In: BMC Veterinary Research. 13, 1, p. 314

    Research output: Contribution to journalEditorialpeer-review

  30. Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE

    Simonato, M., Iyengar, S., Brooks-Kayal, A., Collins, S., Depaulis, A., Howells, D. W., Jensen, F., Liao, J., Macleod, M. R., Patel, M., Potschka, H., Walker, M., Whittemore, V. & Sena, E. S., Nov 2017, In: Epilepsia. 58 Suppl 4, p. 68-77 10 p.

    Research output: Contribution to journalArticlepeer-review

  31. The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments

    Percie du Sert, N., Alfieri, A., Allan, S. M., Carswell, H. V. O., Deuchar, G. A., Farr, T. D., Flecknell, P., Gallagher, L., Gibson, C., Haley, M. J., MacLeod, M., McColl, B., McCabe, C., Morancho, A., Moon, L., O'Neill, M., Perez de Puig, I., Planas, A., Ragan, I., Rosell, A. & 10 others, Roy, L., Ryder, K., Simats, A., Sena, E., Sutherland, B., Tricklebank, M., Trueman, R., Whitfield, L., Wong, R. & Macrae, M., Nov 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 11, p. 3488-3517 30 p., 271678X17709185.

    Research output: Contribution to journalArticlepeer-review

  32. Optimization of large animal MI models; a systematic analysis of control groups from preclinical studies

    Zwetsloot, P. P., Kouwenberg, L. H. J. A., Sena, E. S., Eding, J. E., Den Ruijter, H. M., Sluijter, J. P. G., Pasterkamp, G., Doevendans, P. A., Hoefer, I. E., Chamuleau, S. A. J., Van Hout, G. P. J. & Jansen Of Lorkeers, S. J., 27 Oct 2017, In: Scientific Reports. 7, 1

    Research output: Contribution to journalArticlepeer-review

  33. Risk of bias reporting in the recent animal focal cerebral ischaemia literature

    Bahor, Z., Liao, J., MacLeod, M., Bannach-brown, A., Mccann, S., Wever, K., Thomas, J., Ottavi, T., Howells, D., Rice, A., Ananiadou, S. & Sena, E., 13 Oct 2017, In: Clinical science. 131, 20, p. 2525-2532 8 p.

    Research output: Contribution to journalArticlepeer-review

  34. Standardized mean differences cause funnel plot distortion in publication bias assessments

    Zwetsloot, P., Van Der Naald, M., Sena, E. S., Howells, D. W., Inthout, J., De Groot, J. A., Chamuleau, S. A., Macleod, M. R. & Wever, K. E., 8 Sep 2017, In: eLIFE. 6

    Research output: Contribution to journalArticlepeer-review

  35. Systematic Review and Meta-analysis: Important Tools in Understanding Drug Development for Stroke

    Mccann, S. K., Sena, E. S., Currie, G. L., Macleod, M. R. & Howells, D. W., 13 Jan 2017, Springer Series in Translational Stroke Research. p. 73-93 Chapter 2. (Neuroprotective Therapy for Stroke and Ischemic Disease).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  36. 2016
  37. Multicenter Evaluation of Geometric Accuracy of MRI Protocols Used in Experimental Stroke

    Milidonis, X., Lennen, R. J., Jansen, M., Mueller, S., Boehm-Sturm, P., Holmes, W. M., Sena, E., MacLeod, M. & Marshall, I., 7 Sep 2016, In: PLoS ONE.

    Research output: Contribution to journalArticlepeer-review

  38. Systematic review and meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke: an update

    McCann, S. K., Cramond, F., MacLeod, M. & Sena, E., 15 Aug 2016, In: Translational Stroke Research.

    Research output: Contribution to journalArticlepeer-review

  39. The Efficacy of Trastuzumab in Animal Models of Breast Cancer: A Systematic Review and Meta-Analysis

    Chen, J., Yang, C., Guo, B., Sena, E. S., Macleod, M. R., Yuan, Y. & Hirst, T. C., 27 Jul 2016, In: PLoS ONE. 11, 7, e0158240.

    Research output: Contribution to journalArticlepeer-review

  40. Protocol for a retrospective, controlled cohort study of the impact of a change in Nature journals' editorial policy for life sciences research on the completeness of reporting study design and execution

    Cramond, F., Irvine, C., Liao, J., Howells, D., Sena, E., Currie, G. & Macleod, M., 9 Jul 2016, In: Scientometrics. 108, p. 315-328 14 p.

    Research output: Contribution to journalArticlepeer-review

  41. Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis

    Watzlawick, R., Rind, J., Sena, E. S., Brommer, B., Zhang, T., Kopp, M. A., Dirnagl, U., Macleod, M. R., Howells, D. W. & Schwab, J. M., 31 May 2016, In: PLoS Biology. 14, 5, p. e1002468

    Research output: Contribution to journalArticlepeer-review

  42. Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations

    Andrews, N. A., Latrémolière, A., Basbaum, A. I., Mogil, J. S., Porreca, F., Rice, A. S. C., Woolf, C. J., Currie, G. L., Dworkin, R. H., Eisenach, J. C., Evans, S., Gewandter, J. S., Gover, T. D., Handwerker, H., Huang, W., Iyengar, S., Jensen, M. P., Kennedy, J. D., Lee, N., Levine, J. & 14 others, Lidster, K., Machin, I., McDermott, M. P., McMahon, S. B., Price, T. J., Ross, S. E., Scherrer, G., Seal, R. P., Sena, E. S., Silva, E., Stone, L., Svensson, C. I., Turk, D. C. & Whiteside, G., Apr 2016, In: Pain. 157, 4, p. 901-9 9 p.

    Research output: Contribution to journalArticlepeer-review

  43. Cardiac Stem Cell Treatment in Myocardial Infarction: A Systematic Review and Meta-Analysis of Preclinical Studies

    Zwetsloot, P. P., Végh, A. M., Jansen Of Lorkeers, S. J., van Hout, G. P., Currie, G. L., Sena, E. S., Gremmels, H., Buikema, J. W., Goumans, M-J., Macleod, M. R., Doevendans, P. A., Chamuleau, S. A. & Sluijter, J. P., 17 Feb 2016, In: Circulation Research. 118, 8, p. 1223-1232

    Research output: Contribution to journalArticlepeer-review

  44. How to avoid bumping into the translational roadblock

    Macleod, M. R. & Sena, E., 1 Jan 2016, Neuromethods. HUMANA PRESS INC, p. 7-17 11 p. (Neuromethods; vol. 120).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  45. 2015
  46. The Missing Medians: Exclusion of Ordinal Data from Meta-Analyses

    Cumming, T. B., Churilov, L. & Sena, E. S., 23 Dec 2015, In: PLoS ONE. 10, 12, e0145580.

    Research output: Contribution to journalArticlepeer-review

  47. Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review

    Kashangura, R., Sena, E. S., Young, T. & Garner, P., 1 Dec 2015, In: International Journal of Epidemiology. 44, 6, p. 1970–1981

    Research output: Contribution to journalArticlepeer-review

  48. Determinants of the Efficacy of Cardiac Ischemic Preconditioning: A Systematic Review and Meta-Analysis of Animal Studies

    Wever, K. E., Hooijmans, C. R., Riksen, N. P., Sterenborg, T. B., Sena, E. S., Ritskes-Hoitinga, M. & Warlé, M. C., 18 Nov 2015, In: PLoS ONE. 10, 11, p. e0142021

    Research output: Contribution to journalArticlepeer-review

  49. Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models

    van Hout, G. P. J., Jansen Of Lorkeers, S. J., Wever, K. E., Sena, E. S., Kouwenberg, L. H. J. A., van Solinge, W. W., Macleod, M. R., Doevendans, P. A., Pasterkamp, G., Chamuleau, S. A. J. & Hoefer, I. E., 20 Oct 2015, In: Cardiovascular Research.

    Research output: Contribution to journalArticlepeer-review

  50. Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

    Macleod, M. R., Lawson Mclean, A., Kyriakopoulou, A., Serghiou, S., de Wilde, A., Sherratt, N., Hirst, T., Hemblade, R., Bahor, Z., Nunes-Fonseca, C., Potluru, A., Thomson, A., Baginskitae, J., Egan, K., Vesterinen, H., Currie, G. L., Churilov, L., Howells, D. W. & Sena, E. S., 13 Oct 2015, In: PLoS Biology. 13, 10, e1002273.

    Research output: Contribution to journalArticlepeer-review

  51. The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease: Database on interventions for Alzheimer's disease

    Egan, K. J., Vesterinen, H. M., Mccann, S. K., Sena, E. S. & Macleod, M. R., 1 Aug 2015, In: Evidence-based Preclinical Medicine. 2, 1, p. 20-26

    Research output: Contribution to journalArticlepeer-review

  52. Effect of endothelin receptor antagonists on clinically relevant outcomes after experimental subarachnoid hemorrhage: a systematic review and meta-analysis

    Laban, K. G., Vergouwen, M. D. I., Dijkhuizen, R. M., Sena, E. S., Macleod, M. R., Rinkel, G. J. E. & van der Worp, H. B., Jul 2015, In: Journal of Cerebral Blood Flow and Metabolism. 35, 7, p. 1085-1089 5 p.

    Research output: Contribution to journalArticlepeer-review

  53. Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis

    Vesterinen, H. M., Connick, P., Irvine, C. M. J., Sena, E. S., Egan, K. J., Carmichael, G. G., Tariq, A., Pavitt, S., Chataway, J., Macleod, M. R. & Chandran, S., 9 Apr 2015, In: PLoS ONE. 10, 4, e0117705.

    Research output: Contribution to journalArticlepeer-review

  54. Magnetic resonance imaging in experimental stroke and comparison with histology: systematic review and meta-analysis

    Milidonis, X., Marshall, I., Macleod, M. R. & Sena, E. S., Mar 2015, In: Stroke; a journal of cerebral circulation. 46, 3, p. 843-851 9 p.

    Research output: Contribution to journalArticlepeer-review

  55. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

    Finnerup, N. B., Attal, N., Haroutounian, S., McNicol, E., Baron, R., Dworkin, R. H., Gilron, I., Haanpää, M., Hansson, P., Jensen, T. S., Kamerman, P. R., Lund, K., Moore, A., Raja, S. N., Rice, A. S. C., Rowbotham, M., Sena, E., Siddall, P., Smith, B. H. & Wallace, M., 1 Feb 2015, In: Lancet Neurology. 14, 2, p. 162-173 12 p.

    Research output: Contribution to journalArticlepeer-review

  56. Similar effect of autologous and allogeneic cell therapy for ischemic heart disease: systematic review and meta-analysis of large animal studies

    Jansen Of Lorkeers, S. J., Eding, J. E. C., Vesterinen, H. M., van der Spoel, T. I. G., Sena, E. S., Duckers, H. J., Doevendans, P. A., Macleod, M. R. & Chamuleau, S. A. J., 2 Jan 2015, In: Circulation Research. 116, 1, p. 80-86 7 p.

    Research output: Contribution to journalArticlepeer-review

  57. 2014
  58. A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?

    Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., Lawson Mclean, A., Macleod, M. R., Grant, R., Brennan, P. M., Sena, E. S. & Whittle, I. R., 1 Dec 2014, In: Evidence-based Preclinical Medicine. 1, 1, p. 21-33

    Research output: Contribution to journalArticlepeer-review

  59. Incidence, Prevalence and Predictors of Chemotherapy Induced Peripheral Neuropathy: a Systematic Review and Meta-Analysis

    Seretny, M., Currie, G. L., Sena, E. S., Ramnarine, S., Grant, R., MacLeod, M. R., Colvin, L. & Fallon, M., Dec 2014, In: Pain. 155, 12, p. 2461-2470

    Research output: Contribution to journalArticlepeer-review

  60. Efficacy of antidepressants in animal models of ischemic stroke: a systematic review and meta-analysis

    McCann, S. K., Irvine, C., Mead, G. E., Sena, E. S., Currie, G. L., Egan, K. E., Macleod, M. R. & Howells, D. W., Oct 2014, In: Stroke. 45, 10, p. 3055-3063 9 p.

    Research output: Contribution to journalArticlepeer-review

  61. Exercise Reduces Infarct Volume and Facilitates Neurobehavioral Recovery: Results From a Systematic Review and Meta-analysis of Exercise in Experimental Models of Focal Ischemia

    Egan, K. J., Janssen, H., Sena, E. S., Longley, L., Speare, S., Howells, D. W., Spratt, N. J., Macleod, M. R., Mead, G. E. & Bernhardt, J., Oct 2014, In: Neurorehabilitation and Neural Repair. 28, 8, p. 800-812 13 p.

    Research output: Contribution to journalArticlepeer-review

  62. WHY ANIMAL MODELS OF GENE THERAPY HAVE LET GLIOMA PATIENTS DOWN

    Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., McLean, A. L., Macleod, M. R., Whittle, I. R., Grant, R., Brennan, P. M. & Sena, E. S., Oct 2014, In: Neuro-oncology. 16, 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  63. Using animal models to understand cancer pain in humans

    Currie, G. L., Sena, E. S., Fallon, M. T., Macleod, M. R. & Colvin, L. A., Jun 2014, In: Current pain and headache reports. 18, 6, 8 p., 423.

    Research output: Contribution to journalLiterature reviewpeer-review

  64. Similar effect of autologous and allogeneic cell therapy for ischaemic heart disease: systematic review and meta-analysis of large animal studies

    Lorkeers, S. J. J. O., Eding, J. E. C., van der Spoel, T. I. G., Vesterinen, H. M., Sena, E. S., Duckers, H. J., Doevendans, P. A., Macleod, M. R. & Chamuleau, S. A. J., May 2014, In: European journal of clinical investigation. 44, p. 5-6 2 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  65. Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically

    Sena, E. S., Currie, G. L., McCann, S. K., Macleod, M. R. & Howells, D. W., May 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, 5, p. 737-42 6 p.

    Research output: Contribution to journalArticlepeer-review

  66. Meta-analysis of data from animal studies: A practical guide

    Vesterinen, H. M., Sena, E. S., Egan, K. J., Hirst, T., Churolov, L., Currie, G., Antonic, A., Howells, D. W. & Macleod, M. R., 15 Jan 2014, In: Journal of Neuroscience Methods. 221, p. 92-102 11 p.

    Research output: Contribution to journalArticlepeer-review

  67. Bringing rigour to translational medicine

    Howells, D. W., Sena, E. S. & Macleod, M. R., Jan 2014, In: Nature Reviews Neurology. 10, 1, p. 37-43 7 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  68. Edaravone improves functional and structural outcomes in animal models of focal cerebral ischemia: A systematic review

    Wu, S., Sena, E., Egan, K., Macleod, M. & Mead, G., Jan 2014, In: International Journal of Stroke. 9, 1, p. 101-106 6 p.

    Research output: Contribution to journalArticlepeer-review

  69. Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis

    Watzlawick, R., Sena, E. S., Dirnagl, U., Brommer, B., Kopp, M. A., Macleod, M. R., Howells, D. W. & Schwab, J. M., Jan 2014, In: JAMA Neurology. 71, 1, p. 91-9 9 p.

    Research output: Contribution to journalArticlepeer-review

  70. 2013
  71. Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies

    Antonic, A., Sena, E. S., Lees, J. S., Wills, T. E., Skeers, P., Batchelor, P. E., Macleod, M. R. & Howells, D. W., Dec 2013, In: PLoS Biology. 11, 12, e1001738.

    Research output: Contribution to journalArticlepeer-review

  72. Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

    Tsilidis, K. K., Panagiotou, O. A., Sena, E. S., Aretouli, E., Evangelou, E., Howells, D. W., Al-Shahi Salman, R., Macleod, M. R. & Ioannidis, J. P. A., Jul 2013, In: PLoS Biology. 11, 7, p. e1001609

    Research output: Contribution to journalArticlepeer-review

  73. Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke

    Vesterinen, H. M., Currie, G. L., Carter, S., Mee, S., Watzlawick, R., Egan, K. J., Macleod, M. R. & Sena, E. S., 20 May 2013, In: Systematic Reviews. 2, 1, p. 33

    Research output: Contribution to journalArticlepeer-review

  74. Prevalence and natural history of pain in adults with multiple sclerosis: Systematic review and meta-analysis

    Foley, P. L., Vesterinen, H. M., Laird, B. J., Sena, E. S., Colvin, L. A., Chandran, S., Macleod, M. R. & Fallon, M. T., May 2013, In: Pain. 154, 5, p. 632-642 11 p.

    Research output: Contribution to journalArticlepeer-review

  75. Transparency in the reporting of in vivo pre-clinical pain research: The relevance and implications of the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines

    Rice, A. S. C., Morland, R., Huang, W., Currie, G. L., Sena, E. S. & Macleod, M. R., 1 Apr 2013, In: Scandinavian Journal of Pain. 4, 2, p. 58-62

    Research output: Contribution to journalArticlepeer-review

  76. The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine

    Sena, E. S., Jeffreys, A. L., Cox, S. F., Sastra, S. A., Churilov, L., Rewell, S., Batchelor, P. E., van der Worp, H. B., Macleod, M. R. & Howells, D. W., Apr 2013, In: International Journal of Stroke. 8, 3, p. 180-185 6 p.

    Research output: Contribution to journalArticlepeer-review

  77. Animal models of bone cancer pain: systematic review and meta-analyses: Systematic review and meta-analyses

    Currie, G. L., Delaney, A., Bennett, M. I., Dickenson, A. H., Egan, K. J., Vesterinen, H. M., Sena, E. S., Macleod, M. R., Colvin, L. A. & Fallon, M. T., 7 Mar 2013, In: Pain. 154, 6, p. 917-26 10 p.

    Research output: Contribution to journalArticlepeer-review

  78. Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted?

    Hirst, T. C., Vesterinen, H. M., Sena, E. S., Egan, K. J., Macleod, M. R. & Whittle, I. R., 15 Jan 2013, In: British Journal of Cancer. 108, 1, p. 64-71 8 p.

    Research output: Contribution to journalArticlepeer-review

  79. Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure

    Batchelor, P. E., Wills, T. E., Skeers, P., Battistuzzo, C. R., Macleod, M. R., Howells, D. W. & Sena, E. S., 2013, In: PLoS ONE. 8, 8, p. e72659

    Research output: Contribution to journalArticlepeer-review

  80. Systematic review and meta-analysis of therapeutic hypothermia in animal models of spinal cord injury

    Batchelor, P. E., Skeers, P., Antonic, A., Wills, T. E., Howells, D. W., Macleod, M. R. & Sena, E. S., 2013, In: PLoS ONE. 8, 8, p. e71317

    Research output: Contribution to journalArticlepeer-review

  81. 2012
  82. Stem cell-based therapy for experimental stroke: A systematic review and meta-analysis

    Lees, J. S., Sena, E. S., Egan, K. J., Antonic, A., Koblar, S. A., Howells, D. W. & Macleod, M. R., Oct 2012, In: International Journal of Stroke. 7, 7, p. 582-588 7 p.

    Research output: Contribution to journalArticlepeer-review

  83. Developing our understanding of the pathogenesis of Alzheimer's disease using a systematically identified dataset of interventions tested in transgenic mouse models

    Egan, K. J., Sena, E. S., Vesterinen, H. M. & Macleod, M. R., Sep 2012, In: European Journal of Neurology. 19, p. 460-460 1 p.

    Research output: Contribution to journalMeeting abstract

  84. Improving the efficiency of the development of drugs for stroke

    Howells, D. W., Sena, E. S., O'Collins, V. & Macleod, M. R., Jul 2012, In: International Journal of Stroke. 7, 5, p. 371-377 7 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  85. Exploring the Efficacy of Constraint in Animal Models of Stroke: Meta-analysis and Systematic Review of the Current Evidence

    Janssen, H., Speare, S., Spratt, N. J., Sena, E. S., Ada, L., Hannan, A. J., McElduff, P. & Bernhardt, J., 2012, In: Neurorehabilitation and Neural Repair.

    Research output: Contribution to journalArticlepeer-review

  86. 2011
  87. Dopamine agonists in animal models of Parkinson's disease: A systematic review and meta-analysis

    Rooke, E. D. M., Vesterinen, H. M., Sena, E. S., Egan, K. J. & Macleod, M. R., Jun 2011, In: Parkinsonism & Related Disorders. 17, 5, p. 313-320 8 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  88. Treatment of intracerebral hemorrhage in animal models: Meta-analysis

    Frantzias, J., Sena, E. S., Macleod, M. R. & Salman, R. A-S., Feb 2011, In: Annals of Neurology. 69, 2, p. 389-399 11 p.

    Research output: Contribution to journalArticlepeer-review

  89. Making the most of animal data – improving the prospect of success in pragmatic trials in the neurosciences

    Egan, K. J., Sena, E. S., Vesterinen, H. M. & Macleod, M. R., 1 Jan 2011, In: Trials. 12, Suppl 1, p. A102

    Research output: Contribution to journalArticlepeer-review

  90. 2010
  91. Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis

    Sena, E. S., Briscoe, C. L., Howells, D. W., Donnan, G. A., Sandercock, P. A. G. & Macleod, M. R., Dec 2010, In: Journal of Cerebral Blood Flow and Metabolism. 30, 12, p. 1905-13 9 p.

    Research output: Contribution to journalArticlepeer-review

  92. Improving the translational hit of experimental treatments in multiple sclerosis

    Vesterinen, H. M., Sena, E. S., Ffrench-Constant, C., Williams, A., Chandran, S. & Macleod, M. R., Sep 2010, In: Multiple Sclerosis Journal. 16, 9, p. 1044-1055 12 p.

    Research output: Contribution to journalArticlepeer-review

  93. Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia

    Howells, D. W., Porritt, M. J., Rewell, S. S. J., O'Collins, V., Sena, E. S., van der Worp, H. B., Traystman, R. J. & Macleod, M. R., Aug 2010, In: Journal of Cerebral Blood Flow and Metabolism. 30, 8, p. 1412-1431 20 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  94. A systematic review and meta-analysis of erythropoietin in experimental stroke

    Jerndal, M., Forsberg, K., Sena, E. S., Macleod, M. R., O'Collins, V. E., Linden, T., Nilsson, M. & Howells, D. W., May 2010, In: Journal of Cerebral Blood Flow and Metabolism. 30, 5, p. 961-968 8 p.

    Research output: Contribution to journalArticlepeer-review

  95. Can Animal Models of Disease Reliably Inform Human Studies?

    van der Worp, H. B., Howells, D. W., Sena, E. S., Porritt, M. J., Rewell, S., O'Collins, V. & Macleod, M. R., Mar 2010, In: PLoS Medicine. 7, 3, p. - 8 p., e1000245.

    Research output: Contribution to journalArticlepeer-review

  96. Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

    Sena, E. S., van der Worp, H. B., Bath, P. M. W., Howells, D. W. & Macleod, M. R., Mar 2010, In: PLoS Biology. 8, 3, 8 p., e1000344.

    Research output: Contribution to journalArticlepeer-review

  97. An Enriched Environment Improves Sensorimotor Function Post-Ischemic Stroke

    Janssen, H., Bernhardt, J., Collier, J. M., Sena, E. S., McElduff, P., Attia, J., Pollack, M., Howells, D. W., Nilsson, M., Calford, M. B. & Spratt, N. J., 2010, In: Neurorehabilitation and Neural Repair. 24, 9, p. 802-813 12 p.

    Research output: Contribution to journalArticlepeer-review

  98. 2009
  99. A Systematic Review Of Erythropoietin In Experimental Stroke

    Forsberg, K. O., Jerndal, M. J., Sena, E. S., O'Collins, V. E., Macleod, M. R., Linden, T., Nilsson, M. & Howells, D. W., Apr 2009, In: Stroke. 40, 4, p. E215-E215 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  100. Good Laboratory Practice Preventing Introduction of Bias at the Bench

    Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., van der Worp, H. B., Traystman, R., Minematsu, K., Donnan, G. A. & Howells, D. W., Mar 2009, In: Stroke. 40, 3, p. E50-E52 3 p.

    Research output: Contribution to journalArticlepeer-review

  101. REPRINT: Good laboratory practice: Preventing introduction of bias at the bench

    Macleod, M. R., Fisher, M., O'collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., Van Der Worp, H. B., Traystman, R. J., Minematsu, K., Donnan, G. A. & Howells, D. W., 25 Feb 2009, In: International Journal of Stroke. 4, 1, p. 3-5 3 p.

    Research output: Contribution to journalArticlepeer-review

  102. Reprint: Good laboratory practice: preventing introduction of bias at the bench

    Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., van der Worp, H. B., Traystman, R. J., Minematsu, K., Donnan, G. A. & Howells, D. W., Feb 2009, In: Journal of Cerebral Blood Flow and Metabolism. 29, 2, p. 221-223 3 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  103. Systematic Review and Stratified Meta-analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke

    Banwell, V., Sena, E. S. & Macleod, M. R., 2009, In: Journal of Stroke and Cerebrovascular Diseases. 18, 4, p. 269-276 8 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  104. 2008
  105. Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality

    Macleod, M. R., van der Worp, H. B., Sena, E. S., Howells, D. W., Dirnagl, U. & Donnan, G. A., Oct 2008, In: Stroke. 39, 10, p. 2824-2829 6 p.

    Research output: Contribution to journalArticlepeer-review

  106. Empirical evidence of bias in the design of experimental stroke studies - A metaepidemiologic approach

    Crossley, N. A., Sena, E., Goehler, J., Horn, J., van der Worp, B., Bath, P. M. W., Macleod, M. & Dirnagl, U., Mar 2008, In: Stroke. 39, 3, p. 929-934 6 p.

    Research output: Contribution to journalArticlepeer-review

  107. A systematic review and meta-analysis of the efficacy of piracetam and piracetam-like compounds in experimental stroke

    Wheble, P. C. R., Sena, E. S. & Macleod, M. R., 2008, In: Cerebrovascular diseases. 25, 1-2, p. 5-11 7 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  108. 2007
  109. Hypothermia in animal models of acute ischaemic stroke: A systematic review and meta-analysis

    Van Der Worp, H. B., Sena, E. S., Donnan, G. A., Howells, D. W. & Macleod, M. R., Dec 2007, In: Brain. 130, 12, p. 3063-3074 12 p.

    Research output: Contribution to journalReview articlepeer-review

  110. How can we improve the pre-clinical development of drugs for stroke?

    Sena, E., van der Worp, H. B., Howells, D. & Macleod, M., Sep 2007, In: Trends in Neurosciences. 30, 9, p. 433-439 7 p.

    Research output: Contribution to journalArticlepeer-review

  111. Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke

    Sena, E., Wheble, P., Sandercock, P. & Macleod, M., Feb 2007, In: Stroke. 38, 2, p. 388-394 7 p.

    Research output: Contribution to journalReview articlepeer-review

  112. Comparison of treatment effects between animal experiments and clinical trials: systematic review

    Perel, P., Roberts, I., Sena, E., Wheble, P., Briscoe, C., Sandercock, P., Macleod, M., Mignini, L. E., Jayaram, P. & Khan, K. S., 27 Jan 2007, In: British Medical Journal (BMJ). 334, 7586, p. 197-197

    Research output: Contribution to journalArticlepeer-review