Edinburgh Research Explorer

Miss Emily Sena

Research Fellow

  1. 2020
  2. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

    Percie Du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., Garner, P., Holgate, S. T., Howells, D. W., Karp, N. A., Lazic, S. E., Lidster, K., Maccallum, C. J., Macleod, M., Pearl, E. J. & 9 others, Petersen, O. H., Rawle, F., Reynolds, P., Rooney, K., Sena, E. S., Silberberg, S. D., Steckler, T., Würbel, H. & Boutron, I., 14 Jul 2020, In : PLoS Biology. 18, 7, p. e3000410

    Research output: Contribution to journalArticle

  3. Evidence Synthesis International (ESI): Position Statement

    Gough, D., Davies, P., Jamtvedt, G., Langlois, E., Littell, J., Lotfi, T., Masset, E., Merlin, T., Pullin, A. S., Ritskes-hoitinga, M., Røttingen, J., Sena, E., Stewart, R., Tovey, D., White, H., Yost, J., Lund, H. & Grimshaw, J., 10 Jul 2020, In : Systematic Reviews. 9, 1

    Research output: Contribution to journalArticle

  4. Quality and validity of large animal experiments in stroke: A systematic review

    Kringe, L., Sena, E. S., Motschall, E., Bahor, Z., Wang, Q., Herrmann, A. M., Mülling, C., Meckel, S. & Boltze, J., 23 Jun 2020, In : Journal of Cerebral Blood Flow and Metabolism. p. 271678X20931062

    Research output: Contribution to journalArticle

  5. UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings

    McFall, A., Hietamies, T. M., Bernard, A., Aimable, M., Allan, S. M., Bath, P. M., Brezzo, G., Carare, R. O., Carswell, H. V., Clarkson, A. N., Currie, G., Farr, T. D., Fowler, J., Good, M., Hainsworth, A. H., Hall, C., Horsburgh, K., Kalaria, R., Kehoe, P., Lawrence, C. & 17 others, MacLeod, M., McNeilly, A., Miller, A. A., Miners, S., Mok, V., O'Sullivan, M., Platt, B., Sena, E., Sharp, M., Strangeward, P., Szymkowiak, S., Touyz, R. M., Trueman, R. C., White, C., McCabe, C., Work, L. M. & Quinn, T. J., 9 Mar 2020, In : Journal of Cerebral Blood Flow and Metabolism.

    Research output: Contribution to journalArticle

  6. Attitudes towards animal study registries and their characteristics: An online survey of three cohorts of animal researchers

    Wieschowski, S., Laser, H., Sena, E. S., Bleich, A., Tolba, R., Strech, D. & Lopes, L. C. (ed.), 6 Jan 2020, In : PLoS ONE. 15, 1, p. e0226443

    Research output: Contribution to journalArticle

  7. 2019
  8. Design of Meta-Analysis Studies

    MacLeod, M., Tanriver Ayder, E., Hair, K. & Sena, E., 17 Oct 2019, Handbook of Experimental Pharmacology . Springer

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  9. Outcome heterogeneity and bias in acute experimental Spinal Cord Injury – a meta-analysis

    Watzlawick, R., Antonic, A., Sena, E., Kopp, M. A., Rind, J., Dirnagl, U., MacLeod, M., Howells, D. W. & Schwab, J. M., 2 Jul 2019, In : Neurology.

    Research output: Contribution to journalArticle

  10. A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

    Hair, K., Macleod, M. R. & Sena, E. S., 12 Jun 2019, In : Research integrity and peer review. 4, 1

    Research output: Contribution to journalArticle

  11. Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis

    Currie, G. L., Angel-scott, H. N., Colvin, L., Cramond, F., Hair, K., Khandoker, L., Liao, J., Macleod, M., Mccann, S. K., Morland, R., Sherratt, N., Stewart, R., Tanriver-ayder, E., Thomas, J., Wang, Q., Wodarski, R., Xiong, R., Rice, A. S. C., Sena, E. S. & Lalu, M., 20 May 2019, In : PLoS Biology. 17, 5, p. e3000243

    Research output: Contribution to journalLetter

  12. Did a change in Nature journals’ editorial policy for life sciences research improve reporting?

    The NPQIP Collaborative group, MacLeod, M., Sena, E. & Howells, D. W., 1 Feb 2019, In : BMJ Open Science. 3, 1, p. e000035

    Research output: Contribution to journalArticle

  13. How our approaches to assessing benefits and harms can be improved

    Sena, E. & Currie, G., 1 Feb 2019, In : Animal Welfare. 28, 1, p. 107-115

    Research output: Contribution to journalArticle

  14. Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis

    Lalu, M. M., Fergusson, D. A., Cheng, W., Avey, M. T., Corbett, D., Dowlatshahi, D., Macleod, M. R., Sena, E. S., Moher, D., Shorr, R., Mccann, S. K., Gray, L. J., Hill, M. D., O'connor, A., Thayer, K., Haggar, F., Dobriyal, A., Chung, H. S., Welton, N. J. & Hutton, B., 3 Jan 2019, In : F1000Research. 8, p. 11

    Research output: Contribution to journalArticle

  15. 2018
  16. Neuropathic pain clinical trials: factors associated with decreases in estimated drug efficacy

    Finnerup, N. B., Haroutounian, S., Baron, R., Dworkin, R. H., Gilron, I., Haanpaa, M., Jensen, T. S., Kamerman, P. R., Mcnicol, E., Moore, A., Raja, S. N., Andersen, N. T., Sena, E. S., Smith, B. H., Rice, A. S. C. & Attal, N., 1 Nov 2018, In : Pain. 159, 11, p. 2339-2346

    Research output: Contribution to journalReview article

  17. The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials

    Yarborough, M., Bredenoord, A., D'Abramo, F., Joyce, N. C., Kimmelman, J., Ogbogu, U., Sena, E., Strech, D. & Dirnagl, U., Jun 2018, In : PLoS Biology. 16, 6, p. e2006343

    Research output: Contribution to journalArticle

  18. Reproducibility of preclinical animal research improves with heterogeneity of study samples

    Voelkl, B., Vogt, L., Sena, E. S. & Würbel, H., 22 Feb 2018, In : PLoS Biology. 16, 2, p. e2003693

    Research output: Contribution to journalArticle

  19. A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models

    Jue, T. R., Sena, E. S., Macleod, M. R., McDonald, K. L. & Hirst, T. C., 29 Jan 2018, In : Oncotarget. 9, 13, p. 11387-11401 15 p.

    Research output: Contribution to journalArticle

  20. Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies

    Hooijmans, C. R., De Vries, R. B. M., Ritskes-hoitinga, M., Rovers, M. M., Leeflang, M. M., Inthout, J., Wever, K. E., Hooft, L., De Beer, H., Kuijpers, T., Macleod, M. R., Sena, E. S., Ter Riet, G., Morgan, R. L., Thayer, K. A., Rooney, A. A., Guyatt, G. H., Schünemann, H. J., Langendam, M. W. & Minnerup, J. (ed.), 11 Jan 2018, In : PLoS ONE. 13, 1, p. e0187271

    Research output: Contribution to journalArticle

  21. 2017
  22. Letter to the editor - round table unites to tackle culture change in an effort to improve animal research reporting

    Osborne, N. J., Ritskes-Hoitinga, M., Ahluwahlia, A., Alam, S., Brown, M., Henderson, H., de Leeuw, W., Marsh, J., Moher, D., van Oort, E., Rawle, F., Riederer, B. M., Sanchez-Morgado, J., Sena, E. S., Struthers, C., Westmore, M., Avey, M. T., Kalman, R., O'Connor, A., Sargeant, J. & 2 others, Petrie, A. & Smith, A., 7 Nov 2017, In : BMC Veterinary Research. 13, 1, p. 314

    Research output: Contribution to journalEditorial

  23. Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE

    Simonato, M., Iyengar, S., Brooks-Kayal, A., Collins, S., Depaulis, A., Howells, D. W., Jensen, F., Liao, J., Macleod, M. R., Patel, M., Potschka, H., Walker, M., Whittemore, V. & Sena, E. S., Nov 2017, In : Epilepsia. 58 Suppl 4, p. 68-77 10 p.

    Research output: Contribution to journalArticle

  24. The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments

    Percie du Sert, N., Alfieri, A., Allan, S. M., Carswell, H. V. O., Deuchar, G. A., Farr, T. D., Flecknell, P., Gallagher, L., Gibson, C., Haley, M. J., MacLeod, M., McColl, B., McCabe, C., Morancho, A., Moon, L., O'Neill, M., Perez de Puig, I., Planas, A., Ragan, I., Rosell, A. & 10 others, Roy, L., Ryder, K., Simats, A., Sena, E., Sutherland, B., Tricklebank, M., Trueman, R., Whitfield, L., Wong, R. & Macrae, M., Nov 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 11, p. 3488-3517 30 p., 271678X17709185.

    Research output: Contribution to journalArticle

  25. Optimization of large animal MI models; a systematic analysis of control groups from preclinical studies

    Zwetsloot, P. P., Kouwenberg, L. H. J. A., Sena, E. S., Eding, J. E., Den Ruijter, H. M., Sluijter, J. P. G., Pasterkamp, G., Doevendans, P. A., Hoefer, I. E., Chamuleau, S. A. J., Van Hout, G. P. J. & Jansen Of Lorkeers, S. J., 27 Oct 2017, In : Scientific Reports. 7, 1

    Research output: Contribution to journalArticle

  26. Risk of bias reporting in the recent animal focal cerebral ischaemia literature

    Bahor, Z., Liao, J., MacLeod, M., Bannach-brown, A., Mccann, S., Wever, K., Thomas, J., Ottavi, T., Howells, D., Rice, A., Ananiadou, S. & Sena, E., 13 Oct 2017, In : Clinical science. 131, 20, p. 2525-2532 8 p.

    Research output: Contribution to journalArticle

  27. Standardized mean differences cause funnel plot distortion in publication bias assessments

    Zwetsloot, P., Van Der Naald, M., Sena, E. S., Howells, D. W., Inthout, J., De Groot, J. A., Chamuleau, S. A., Macleod, M. R. & Wever, K. E., 8 Sep 2017, In : eLIFE. 6

    Research output: Contribution to journalArticle

  28. Systematic Review and Meta-analysis: Important Tools in Understanding Drug Development for Stroke

    Mccann, S. K., Sena, E. S., Currie, G. L., Macleod, M. R. & Howells, D. W., 13 Jan 2017, Springer Series in Translational Stroke Research. p. 73-93 Chapter 2. (Neuroprotective Therapy for Stroke and Ischemic Disease).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  29. 2016
  30. Multicenter Evaluation of Geometric Accuracy of MRI Protocols Used in Experimental Stroke

    Milidonis, X., Lennen, R. J., Jansen, M., Mueller, S., Boehm-Sturm, P., Holmes, W. M., Sena, E., MacLeod, M. & Marshall, I., 7 Sep 2016, In : PLoS ONE.

    Research output: Contribution to journalArticle

  31. Systematic review and meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke: an update

    McCann, S. K., Cramond, F., MacLeod, M. & Sena, E., 15 Aug 2016, In : Translational Stroke Research.

    Research output: Contribution to journalArticle

  32. The Efficacy of Trastuzumab in Animal Models of Breast Cancer: A Systematic Review and Meta-Analysis

    Chen, J., Yang, C., Guo, B., Sena, E. S., Macleod, M. R., Yuan, Y. & Hirst, T. C., 27 Jul 2016, In : PLoS ONE. 11, 7, e0158240.

    Research output: Contribution to journalArticle

  33. Protocol for a retrospective, controlled cohort study of the impact of a change in Nature journals' editorial policy for life sciences research on the completeness of reporting study design and execution

    Cramond, F., Irvine, C., Liao, J., Howells, D., Sena, E., Currie, G. & Macleod, M., 9 Jul 2016, In : Scientometrics. 108, p. 315-328 14 p.

    Research output: Contribution to journalArticle

  34. Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis

    Watzlawick, R., Rind, J., Sena, E. S., Brommer, B., Zhang, T., Kopp, M. A., Dirnagl, U., Macleod, M. R., Howells, D. W. & Schwab, J. M., 31 May 2016, In : PLoS Biology. 14, 5, p. e1002468

    Research output: Contribution to journalArticle

  35. Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations

    Andrews, N. A., Latrémolière, A., Basbaum, A. I., Mogil, J. S., Porreca, F., Rice, A. S. C., Woolf, C. J., Currie, G. L., Dworkin, R. H., Eisenach, J. C., Evans, S., Gewandter, J. S., Gover, T. D., Handwerker, H., Huang, W., Iyengar, S., Jensen, M. P., Kennedy, J. D., Lee, N., Levine, J. & 14 others, Lidster, K., Machin, I., McDermott, M. P., McMahon, S. B., Price, T. J., Ross, S. E., Scherrer, G., Seal, R. P., Sena, E. S., Silva, E., Stone, L., Svensson, C. I., Turk, D. C. & Whiteside, G., Apr 2016, In : Pain. 157, 4, p. 901-9 9 p.

    Research output: Contribution to journalArticle

  36. Cardiac Stem Cell Treatment in Myocardial Infarction: A Systematic Review and Meta-Analysis of Preclinical Studies

    Zwetsloot, P. P., Végh, A. M., Jansen Of Lorkeers, S. J., van Hout, G. P., Currie, G. L., Sena, E. S., Gremmels, H., Buikema, J. W., Goumans, M-J., Macleod, M. R., Doevendans, P. A., Chamuleau, S. A. & Sluijter, J. P., 17 Feb 2016, In : Circulation Research. 118, 8, p. 1223-1232

    Research output: Contribution to journalArticle

  37. How to avoid bumping into the translational roadblock

    Macleod, M. R. & Sena, E., 1 Jan 2016, Neuromethods. HUMANA PRESS INC, p. 7-17 11 p. (Neuromethods; vol. 120).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  38. 2015
  39. The Missing Medians: Exclusion of Ordinal Data from Meta-Analyses

    Cumming, T. B., Churilov, L. & Sena, E. S., 23 Dec 2015, In : PLoS ONE. 10, 12, e0145580.

    Research output: Contribution to journalArticle

  40. Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review

    Kashangura, R., Sena, E. S., Young, T. & Garner, P., 1 Dec 2015, In : International Journal of Epidemiology. 44, 6, p. 1970–1981

    Research output: Contribution to journalArticle

  41. Determinants of the Efficacy of Cardiac Ischemic Preconditioning: A Systematic Review and Meta-Analysis of Animal Studies

    Wever, K. E., Hooijmans, C. R., Riksen, N. P., Sterenborg, T. B., Sena, E. S., Ritskes-Hoitinga, M. & Warlé, M. C., 18 Nov 2015, In : PLoS ONE. 10, 11, p. e0142021

    Research output: Contribution to journalArticle

  42. Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models

    van Hout, G. P. J., Jansen Of Lorkeers, S. J., Wever, K. E., Sena, E. S., Kouwenberg, L. H. J. A., van Solinge, W. W., Macleod, M. R., Doevendans, P. A., Pasterkamp, G., Chamuleau, S. A. J. & Hoefer, I. E., 20 Oct 2015, In : Cardiovascular Research.

    Research output: Contribution to journalArticle

  43. Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

    Macleod, M. R., Lawson Mclean, A., Kyriakopoulou, A., Serghiou, S., De Wilde, A., Sherratt, N., Hirst, T., Hemblade, R., Bahor, Z., Nunes-fonseca, C., Potluru, A., Thomson, A., Baginskitae, J., Egan, K., Vesterinen, H., Currie, G. L., Churilov, L., Howells, D. W. & Sena, E. S., 13 Oct 2015, In : PLoS Biology. 13, 10, p. e1002273

    Research output: Contribution to journalArticle

  44. The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease: Database on interventions for Alzheimer's disease

    Egan, K. J., Vesterinen, H. M., Mccann, S. K., Sena, E. S. & Macleod, M. R., 1 Aug 2015, In : Evidence-based Preclinical Medicine. 2, 1, p. 20-26

    Research output: Contribution to journalArticle

  45. Effect of endothelin receptor antagonists on clinically relevant outcomes after experimental subarachnoid hemorrhage: a systematic review and meta-analysis

    Laban, K. G., Vergouwen, M. D. I., Dijkhuizen, R. M., Sena, E. S., Macleod, M. R., Rinkel, G. J. E. & van der Worp, H. B., Jul 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, 7, p. 1085-1089 5 p.

    Research output: Contribution to journalArticle

  46. Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis

    Vesterinen, H. M., Connick, P., Irvine, C. M. J., Sena, E. S., Egan, K. J., Carmichael, G. G., Tariq, A., Pavitt, S., Chataway, J., Macleod, M. R. & Chandran, S., 9 Apr 2015, In : PLoS ONE. 10, 4, e0117705.

    Research output: Contribution to journalArticle

  47. Magnetic resonance imaging in experimental stroke and comparison with histology: systematic review and meta-analysis

    Milidonis, X., Marshall, I., Macleod, M. R. & Sena, E. S., Mar 2015, In : Stroke; a journal of cerebral circulation. 46, 3, p. 843-851 9 p.

    Research output: Contribution to journalArticle

  48. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

    Finnerup, N. B., Attal, N., Haroutounian, S., McNicol, E., Baron, R., Dworkin, R. H., Gilron, I., Haanpää, M., Hansson, P., Jensen, T. S., Kamerman, P. R., Lund, K., Moore, A., Raja, S. N., Rice, A. S. C., Rowbotham, M., Sena, E., Siddall, P., Smith, B. H. & Wallace, M., Feb 2015, In : Lancet Neurology. 14, 2, p. 162-73 12 p.

    Research output: Contribution to journalArticle

  49. Similar effect of autologous and allogeneic cell therapy for ischemic heart disease: systematic review and meta-analysis of large animal studies

    Jansen Of Lorkeers, S. J., Eding, J. E. C., Vesterinen, H. M., van der Spoel, T. I. G., Sena, E. S., Duckers, H. J., Doevendans, P. A., Macleod, M. R. & Chamuleau, S. A. J., 2 Jan 2015, In : Circulation Research. 116, 1, p. 80-6 7 p.

    Research output: Contribution to journalArticle

  50. 2014
  51. A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?

    Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., Lawson Mclean, A., Macleod, M. R., Grant, R., Brennan, P. M., Sena, E. S. & Whittle, I. R., 1 Dec 2014, In : Evidence-based Preclinical Medicine. 1, 1, p. 21-33

    Research output: Contribution to journalArticle

  52. Efficacy of antidepressants in animal models of ischemic stroke: a systematic review and meta-analysis

    McCann, S. K., Irvine, C., Mead, G. E., Sena, E. S., Currie, G. L., Egan, K. E., Macleod, M. R. & Howells, D. W., Oct 2014, In : Stroke. 45, 10, p. 3055-3063 9 p.

    Research output: Contribution to journalArticle

  53. Exercise Reduces Infarct Volume and Facilitates Neurobehavioral Recovery: Results From a Systematic Review and Meta-analysis of Exercise in Experimental Models of Focal Ischemia

    Egan, K. J., Janssen, H., Sena, E. S., Longley, L., Speare, S., Howells, D. W., Spratt, N. J., Macleod, M. R., Mead, G. E. & Bernhardt, J., Oct 2014, In : Neurorehabilitation and Neural Repair. 28, 8, p. 800-812 13 p.

    Research output: Contribution to journalArticle

  54. WHY ANIMAL MODELS OF GENE THERAPY HAVE LET GLIOMA PATIENTS DOWN

    Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., McLean, A. L., Macleod, M. R., Whittle, I. R., Grant, R., Brennan, P. M. & Sena, E. S., Oct 2014, In : Neuro-oncology. 16, 1 p.

    Research output: Contribution to journalMeeting abstract

  55. Using animal models to understand cancer pain in humans

    Currie, G. L., Sena, E. S., Fallon, M. T., Macleod, M. R. & Colvin, L. A., Jun 2014, In : Current pain and headache reports. 18, 6, 8 p., 423.

    Research output: Contribution to journalLiterature review

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