Edinburgh Research Explorer

Miss Emily Sena

Research Fellow

  1. Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations

    Andrews, N. A., Latrémolière, A., Basbaum, A. I., Mogil, J. S., Porreca, F., Rice, A. S. C., Woolf, C. J., Currie, G. L., Dworkin, R. H., Eisenach, J. C., Evans, S., Gewandter, J. S., Gover, T. D., Handwerker, H., Huang, W., Iyengar, S., Jensen, M. P., Kennedy, J. D., Lee, N., Levine, J. & 14 others, Lidster, K., Machin, I., McDermott, M. P., McMahon, S. B., Price, T. J., Ross, S. E., Scherrer, G., Seal, R. P., Sena, E. S., Silva, E., Stone, L., Svensson, C. I., Turk, D. C. & Whiteside, G., Apr 2016, In : Pain. 157, 4, p. 901-9 9 p.

    Research output: Contribution to journalArticle

  2. Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies

    Antonic, A., Sena, E. S., Lees, J. S., Wills, T. E., Skeers, P., Batchelor, P. E., Macleod, M. R. & Howells, D. W., Dec 2013, In : PLoS Biology. 11, 12, e1001738.

    Research output: Contribution to journalArticle

  3. Risk of bias reporting in the recent animal focal cerebral ischaemia literature

    Bahor, Z., Liao, J., MacLeod, M., Bannach-brown, A., Mccann, S., Wever, K., Thomas, J., Ottavi, T., Howells, D., Rice, A., Ananiadou, S. & Sena, E., 13 Oct 2017, In : Clinical science. 131, 20, p. 2525-2532 8 p.

    Research output: Contribution to journalArticle

  4. Systematic Review and Stratified Meta-analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke

    Banwell, V., Sena, E. S. & Macleod, M. R., 2009, In : Journal of Stroke and Cerebrovascular Diseases. 18, 4, p. 269-276 8 p.

    Research output: Contribution to journalLiterature review

  5. Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure

    Batchelor, P. E., Wills, T. E., Skeers, P., Battistuzzo, C. R., Macleod, M. R., Howells, D. W. & Sena, E. S., 2013, In : PLoS ONE. 8, 8, p. e72659

    Research output: Contribution to journalArticle

  6. Systematic review and meta-analysis of therapeutic hypothermia in animal models of spinal cord injury

    Batchelor, P. E., Skeers, P., Antonic, A., Wills, T. E., Howells, D. W., Macleod, M. R. & Sena, E. S., 2013, In : PLoS ONE. 8, 8, p. e71317

    Research output: Contribution to journalArticle

  7. The Efficacy of Trastuzumab in Animal Models of Breast Cancer: A Systematic Review and Meta-Analysis

    Chen, J., Yang, C., Guo, B., Sena, E. S., Macleod, M. R., Yuan, Y. & Hirst, T. C., 27 Jul 2016, In : PLoS ONE. 11, 7, e0158240.

    Research output: Contribution to journalArticle

  8. Protocol for a retrospective, controlled cohort study of the impact of a change in Nature journals' editorial policy for life sciences research on the completeness of reporting study design and execution

    Cramond, F., Irvine, C., Liao, J., Howells, D., Sena, E., Currie, G. & Macleod, M., 9 Jul 2016, In : Scientometrics. 108, p. 315-328 14 p.

    Research output: Contribution to journalArticle

  9. Empirical evidence of bias in the design of experimental stroke studies - A metaepidemiologic approach

    Crossley, N. A., Sena, E., Goehler, J., Horn, J., van der Worp, B., Bath, P. M. W., Macleod, M. & Dirnagl, U., Mar 2008, In : Stroke. 39, 3, p. 929-934 6 p.

    Research output: Contribution to journalArticle

  10. The Missing Medians: Exclusion of Ordinal Data from Meta-Analyses

    Cumming, T. B., Churilov, L. & Sena, E. S., 23 Dec 2015, In : PLoS ONE. 10, 12, e0145580.

    Research output: Contribution to journalArticle

  11. Using animal models to understand cancer pain in humans

    Currie, G. L., Sena, E. S., Fallon, M. T., Macleod, M. R. & Colvin, L. A., Jun 2014, In : Current pain and headache reports. 18, 6, 8 p., 423.

    Research output: Contribution to journalLiterature review

  12. Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis

    Currie, G. L., Angel-scott, H. N., Colvin, L., Cramond, F., Hair, K., Khandoker, L., Liao, J., Macleod, M., Mccann, S. K., Morland, R., Sherratt, N., Stewart, R., Tanriver-ayder, E., Thomas, J., Wang, Q., Wodarski, R., Xiong, R., Rice, A. S. C., Sena, E. S. & Lalu, M., 20 May 2019, In : PLoS Biology. 17, 5, p. e3000243

    Research output: Contribution to journalLetter

  13. Animal models of bone cancer pain: systematic review and meta-analyses: Systematic review and meta-analyses

    Currie, G. L., Delaney, A., Bennett, M. I., Dickenson, A. H., Egan, K. J., Vesterinen, H. M., Sena, E. S., Macleod, M. R., Colvin, L. A. & Fallon, M. T., 7 Mar 2013, In : Pain. 154, 6, p. 917-26 10 p.

    Research output: Contribution to journalArticle

  14. Making the most of animal data – improving the prospect of success in pragmatic trials in the neurosciences

    Egan, K. J., Sena, E. S., Vesterinen, H. M. & Macleod, M. R., 1 Jan 2011, In : Trials. 12, Suppl 1, p. A102

    Research output: Contribution to journalArticle

  15. Exercise Reduces Infarct Volume and Facilitates Neurobehavioral Recovery: Results From a Systematic Review and Meta-analysis of Exercise in Experimental Models of Focal Ischemia

    Egan, K. J., Janssen, H., Sena, E. S., Longley, L., Speare, S., Howells, D. W., Spratt, N. J., Macleod, M. R., Mead, G. E. & Bernhardt, J., Oct 2014, In : Neurorehabilitation and Neural Repair. 28, 8, p. 800-812 13 p.

    Research output: Contribution to journalArticle

  16. Developing our understanding of the pathogenesis of Alzheimer's disease using a systematically identified dataset of interventions tested in transgenic mouse models

    Egan, K. J., Sena, E. S., Vesterinen, H. M. & Macleod, M. R., Sep 2012, In : European Journal of Neurology. 19, p. 460-460 1 p.

    Research output: Contribution to journalMeeting abstract

  17. The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease: Database on interventions for Alzheimer's disease

    Egan, K. J., Vesterinen, H. M., Mccann, S. K., Sena, E. S. & Macleod, M. R., 1 Aug 2015, In : Evidence-based Preclinical Medicine. 2, 1, p. 20-26

    Research output: Contribution to journalArticle

  18. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

    Finnerup, N. B., Attal, N., Haroutounian, S., McNicol, E., Baron, R., Dworkin, R. H., Gilron, I., Haanpää, M., Hansson, P., Jensen, T. S., Kamerman, P. R., Lund, K., Moore, A., Raja, S. N., Rice, A. S. C., Rowbotham, M., Sena, E., Siddall, P., Smith, B. H. & Wallace, M., Feb 2015, In : Lancet Neurology. 14, 2, p. 162-73 12 p.

    Research output: Contribution to journalArticle

  19. Neuropathic pain clinical trials: factors associated with decreases in estimated drug efficacy

    Finnerup, N. B., Haroutounian, S., Baron, R., Dworkin, R. H., Gilron, I., Haanpaa, M., Jensen, T. S., Kamerman, P. R., Mcnicol, E., Moore, A., Raja, S. N., Andersen, N. T., Sena, E. S., Smith, B. H., Rice, A. S. C. & Attal, N., 1 Nov 2018, In : Pain. 159, 11, p. 2339-2346

    Research output: Contribution to journalReview article

  20. Prevalence and natural history of pain in adults with multiple sclerosis: Systematic review and meta-analysis

    Foley, P. L., Vesterinen, H. M., Laird, B. J., Sena, E. S., Colvin, L. A., Chandran, S., Macleod, M. R. & Fallon, M. T., May 2013, In : Pain. 154, 5, p. 632-642 11 p.

    Research output: Contribution to journalArticle

  21. A Systematic Review Of Erythropoietin In Experimental Stroke

    Forsberg, K. O., Jerndal, M. J., Sena, E. S., O'Collins, V. E., Macleod, M. R., Linden, T., Nilsson, M. & Howells, D. W., Apr 2009, In : Stroke. 40, 4, p. E215-E215 1 p.

    Research output: Contribution to journalMeeting abstract

  22. Treatment of intracerebral hemorrhage in animal models: Meta-analysis

    Frantzias, J., Sena, E. S., Macleod, M. R. & Salman, R. A-S., Feb 2011, In : Annals of Neurology. 69, 2, p. 389-399 11 p.

    Research output: Contribution to journalArticle

  23. A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

    Hair, K., Macleod, M. R. & Sena, E. S., 12 Jun 2019, In : Research integrity and peer review. 4, 1

    Research output: Contribution to journalArticle

  24. WHY ANIMAL MODELS OF GENE THERAPY HAVE LET GLIOMA PATIENTS DOWN

    Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., McLean, A. L., Macleod, M. R., Whittle, I. R., Grant, R., Brennan, P. M. & Sena, E. S., Oct 2014, In : Neuro-oncology. 16, 1 p.

    Research output: Contribution to journalMeeting abstract

  25. A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?

    Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., Lawson Mclean, A., Macleod, M. R., Grant, R., Brennan, P. M., Sena, E. S. & Whittle, I. R., 1 Dec 2014, In : Evidence-based Preclinical Medicine. 1, 1, p. 21-33

    Research output: Contribution to journalArticle

  26. Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted?

    Hirst, T. C., Vesterinen, H. M., Sena, E. S., Egan, K. J., Macleod, M. R. & Whittle, I. R., 15 Jan 2013, In : British Journal of Cancer. 108, 1, p. 64-71 8 p.

    Research output: Contribution to journalArticle

  27. Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies

    Hooijmans, C. R., De Vries, R. B. M., Ritskes-hoitinga, M., Rovers, M. M., Leeflang, M. M., Inthout, J., Wever, K. E., Hooft, L., De Beer, H., Kuijpers, T., Macleod, M. R., Sena, E. S., Ter Riet, G., Morgan, R. L., Thayer, K. A., Rooney, A. A., Guyatt, G. H., Schünemann, H. J., Langendam, M. W. & Minnerup, J. (ed.), 11 Jan 2018, In : PLoS ONE. 13, 1, p. e0187271

    Research output: Contribution to journalArticle

  28. Bringing rigour to translational medicine

    Howells, D. W., Sena, E. S. & Macleod, M. R., Jan 2014, In : Nature Reviews Neurology. 10, 1, p. 37-43 7 p.

    Research output: Contribution to journalLiterature review

  29. Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia

    Howells, D. W., Porritt, M. J., Rewell, S. S. J., O'Collins, V., Sena, E. S., van der Worp, H. B., Traystman, R. J. & Macleod, M. R., Aug 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 8, p. 1412-1431 20 p.

    Research output: Contribution to journalLiterature review

  30. Improving the efficiency of the development of drugs for stroke

    Howells, D. W., Sena, E. S., O'Collins, V. & Macleod, M. R., Jul 2012, In : International Journal of Stroke. 7, 5, p. 371-377 7 p.

    Research output: Contribution to journalLiterature review

  31. Similar effect of autologous and allogeneic cell therapy for ischemic heart disease: systematic review and meta-analysis of large animal studies

    Jansen Of Lorkeers, S. J., Eding, J. E. C., Vesterinen, H. M., van der Spoel, T. I. G., Sena, E. S., Duckers, H. J., Doevendans, P. A., Macleod, M. R. & Chamuleau, S. A. J., 2 Jan 2015, In : Circulation Research. 116, 1, p. 80-6 7 p.

    Research output: Contribution to journalArticle

  32. An Enriched Environment Improves Sensorimotor Function Post-Ischemic Stroke

    Janssen, H., Bernhardt, J., Collier, J. M., Sena, E. S., McElduff, P., Attia, J., Pollack, M., Howells, D. W., Nilsson, M., Calford, M. B. & Spratt, N. J., 2010, In : Neurorehabilitation and Neural Repair. 24, 9, p. 802-813 12 p.

    Research output: Contribution to journalArticle

  33. Exploring the Efficacy of Constraint in Animal Models of Stroke: Meta-analysis and Systematic Review of the Current Evidence

    Janssen, H., Speare, S., Spratt, N. J., Sena, E. S., Ada, L., Hannan, A. J., McElduff, P. & Bernhardt, J., 2012, In : Neurorehabilitation and Neural Repair.

    Research output: Contribution to journalArticle

  34. A systematic review and meta-analysis of erythropoietin in experimental stroke

    Jerndal, M., Forsberg, K., Sena, E. S., Macleod, M. R., O'Collins, V. E., Linden, T., Nilsson, M. & Howells, D. W., May 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 5, p. 961-968 8 p.

    Research output: Contribution to journalArticle

  35. A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models

    Jue, T. R., Sena, E. S., Macleod, M. R., McDonald, K. L. & Hirst, T. C., 29 Jan 2018, In : Oncotarget. 9, 13, p. 11387-11401 15 p.

    Research output: Contribution to journalArticle

  36. Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review

    Kashangura, R., Sena, E. S., Young, T. & Garner, P., 1 Dec 2015, In : International Journal of Epidemiology. 44, 6, p. 1970–1981

    Research output: Contribution to journalArticle

  37. Effect of endothelin receptor antagonists on clinically relevant outcomes after experimental subarachnoid hemorrhage: a systematic review and meta-analysis

    Laban, K. G., Vergouwen, M. D. I., Dijkhuizen, R. M., Sena, E. S., Macleod, M. R., Rinkel, G. J. E. & van der Worp, H. B., Jul 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, 7, p. 1085-1089 5 p.

    Research output: Contribution to journalArticle

  38. Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis

    Lalu, M. M., Fergusson, D. A., Cheng, W., Avey, M. T., Corbett, D., Dowlatshahi, D., Macleod, M. R., Sena, E. S., Moher, D., Shorr, R., Mccann, S. K., Gray, L. J., Hill, M. D., O'connor, A., Thayer, K., Haggar, F., Dobriyal, A., Chung, H. S., Welton, N. J. & Hutton, B., 3 Jan 2019, In : F1000Research. 8, p. 11

    Research output: Contribution to journalArticle

  39. Stem cell-based therapy for experimental stroke: A systematic review and meta-analysis

    Lees, J. S., Sena, E. S., Egan, K. J., Antonic, A., Koblar, S. A., Howells, D. W. & Macleod, M. R., Oct 2012, In : International Journal of Stroke. 7, 7, p. 582-588 7 p.

    Research output: Contribution to journalArticle

  40. Similar effect of autologous and allogeneic cell therapy for ischaemic heart disease: systematic review and meta-analysis of large animal studies

    Lorkeers, S. J. J. O., Eding, J. E. C., van der Spoel, T. I. G., Vesterinen, H. M., Sena, E. S., Duckers, H. J., Doevendans, P. A., Macleod, M. R. & Chamuleau, S. A. J., May 2014, In : European journal of clinical investigation. 44, p. 5-6 2 p.

    Research output: Contribution to journalMeeting abstract

  41. Design of Meta-Analysis Studies

    MacLeod, M., Tanriver Ayder, E., Hair, K. & Sena, E., 17 Oct 2019, Handbook of Experimental Pharmacology . Springer

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  42. Reprint: Good laboratory practice: preventing introduction of bias at the bench

    Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., van der Worp, H. B., Traystman, R. J., Minematsu, K., Donnan, G. A. & Howells, D. W., Feb 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 2, p. 221-223 3 p.

    Research output: Contribution to journalLiterature review

  43. Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality

    Macleod, M. R., van der Worp, H. B., Sena, E. S., Howells, D. W., Dirnagl, U. & Donnan, G. A., Oct 2008, In : Stroke. 39, 10, p. 2824-2829 6 p.

    Research output: Contribution to journalArticle

  44. REPRINT: Good laboratory practice: Preventing introduction of bias at the bench

    Macleod, M. R., Fisher, M., O'collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., Van Der Worp, H. B., Traystman, R. J., Minematsu, K., Donnan, G. A. & Howells, D. W., 25 Feb 2009, In : International Journal of Stroke. 4, 1, p. 3-5 3 p.

    Research output: Contribution to journalArticle

  45. Good Laboratory Practice Preventing Introduction of Bias at the Bench

    Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., van der Worp, H. B., Traystman, R., Minematsu, K., Donnan, G. A. & Howells, D. W., Mar 2009, In : Stroke. 40, 3, p. E50-E52 3 p.

    Research output: Contribution to journalArticle

  46. How to avoid bumping into the translational roadblock

    Macleod, M. R. & Sena, E., 1 Jan 2016, Neuromethods. HUMANA PRESS INC, p. 7-17 11 p. (Neuromethods; vol. 120).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  47. Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

    Macleod, M. R., Lawson Mclean, A., Kyriakopoulou, A., Serghiou, S., De Wilde, A., Sherratt, N., Hirst, T., Hemblade, R., Bahor, Z., Nunes-fonseca, C., Potluru, A., Thomson, A., Baginskitae, J., Egan, K., Vesterinen, H., Currie, G. L., Churilov, L., Howells, D. W. & Sena, E. S., 13 Oct 2015, In : PLoS Biology. 13, 10, p. e1002273

    Research output: Contribution to journalArticle

  48. Efficacy of antidepressants in animal models of ischemic stroke: a systematic review and meta-analysis

    McCann, S. K., Irvine, C., Mead, G. E., Sena, E. S., Currie, G. L., Egan, K. E., Macleod, M. R. & Howells, D. W., Oct 2014, In : Stroke. 45, 10, p. 3055-3063 9 p.

    Research output: Contribution to journalArticle

  49. Systematic review and meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke: an update

    McCann, S. K., Cramond, F., MacLeod, M. & Sena, E., 15 Aug 2016, In : Translational Stroke Research.

    Research output: Contribution to journalArticle

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