Edinburgh Research Explorer

Miss Emily Sena

Research Fellow

  1. Chapter (peer-reviewed) › Research › Peer-reviewed
  2. Design of Meta-Analysis Studies

    MacLeod, M., Tanriver Ayder, E., Hair, K. & Sena, E., 17 Oct 2019, Handbook of Experimental Pharmacology . Springer

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  3. Article › Research › Peer-reviewed
  4. A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

    Hair, K., Macleod, M. R. & Sena, E. S., 12 Jun 2019, In : Research integrity and peer review. 4, 1

    Research output: Contribution to journalArticle

  5. A systematic review and meta-analysis of erythropoietin in experimental stroke

    Jerndal, M., Forsberg, K., Sena, E. S., Macleod, M. R., O'Collins, V. E., Linden, T., Nilsson, M. & Howells, D. W., May 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 5, p. 961-968 8 p.

    Research output: Contribution to journalArticle

  6. A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?

    Hirst, T. C., Vesterinen, H. M., Conlin, S., Egan, K. J., Antonic, A., Lawson Mclean, A., Macleod, M. R., Grant, R., Brennan, P. M., Sena, E. S. & Whittle, I. R., 1 Dec 2014, In : Evidence-based Preclinical Medicine. 1, 1, p. 21-33

    Research output: Contribution to journalArticle

  7. A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models

    Jue, T. R., Sena, E. S., Macleod, M. R., McDonald, K. L. & Hirst, T. C., 29 Jan 2018, In : Oncotarget. 9, 13, p. 11387-11401 15 p.

    Research output: Contribution to journalArticle

  8. An Enriched Environment Improves Sensorimotor Function Post-Ischemic Stroke

    Janssen, H., Bernhardt, J., Collier, J. M., Sena, E. S., McElduff, P., Attia, J., Pollack, M., Howells, D. W., Nilsson, M., Calford, M. B. & Spratt, N. J., 2010, In : Neurorehabilitation and Neural Repair. 24, 9, p. 802-813 12 p.

    Research output: Contribution to journalArticle

  9. Animal models of bone cancer pain: systematic review and meta-analyses: Systematic review and meta-analyses

    Currie, G. L., Delaney, A., Bennett, M. I., Dickenson, A. H., Egan, K. J., Vesterinen, H. M., Sena, E. S., Macleod, M. R., Colvin, L. A. & Fallon, M. T., 7 Mar 2013, In : Pain. 154, 6, p. 917-26 10 p.

    Research output: Contribution to journalArticle

  10. Attitudes towards animal study registries and their characteristics: An online survey of three cohorts of animal researchers

    Wieschowski, S., Laser, H., Sena, E. S., Bleich, A., Tolba, R., Strech, D. & Lopes, L. C. (ed.), 6 Jan 2020, In : PLoS ONE. 15, 1, p. e0226443

    Research output: Contribution to journalArticle

  11. Can Animal Models of Disease Reliably Inform Human Studies?

    van der Worp, H. B., Howells, D. W., Sena, E. S., Porritt, M. J., Rewell, S., O'Collins, V. & Macleod, M. R., Mar 2010, In : PLOS Medicine. 7, 3, p. - 8 p., e1000245.

    Research output: Contribution to journalArticle

  12. Cardiac Stem Cell Treatment in Myocardial Infarction: A Systematic Review and Meta-Analysis of Preclinical Studies

    Zwetsloot, P. P., Végh, A. M., Jansen Of Lorkeers, S. J., van Hout, G. P., Currie, G. L., Sena, E. S., Gremmels, H., Buikema, J. W., Goumans, M-J., Macleod, M. R., Doevendans, P. A., Chamuleau, S. A. & Sluijter, J. P., 17 Feb 2016, In : Circulation Research. 118, 8, p. 1223-1232

    Research output: Contribution to journalArticle

  13. Comparison of treatment effects between animal experiments and clinical trials: systematic review

    Perel, P., Roberts, I., Sena, E., Wheble, P., Briscoe, C., Sandercock, P., Macleod, M., Mignini, L. E., Jayaram, P. & Khan, K. S., 27 Jan 2007, In : BMJ. 334, 7586, p. 197-197

    Research output: Contribution to journalArticle

  14. Determinants of the Efficacy of Cardiac Ischemic Preconditioning: A Systematic Review and Meta-Analysis of Animal Studies

    Wever, K. E., Hooijmans, C. R., Riksen, N. P., Sterenborg, T. B., Sena, E. S., Ritskes-Hoitinga, M. & Warlé, M. C., 18 Nov 2015, In : PLoS ONE. 10, 11, p. e0142021

    Research output: Contribution to journalArticle

  15. Did a change in Nature journals’ editorial policy for life sciences research improve reporting?

    The NPQIP Collaborative group, MacLeod, M., Sena, E. & Howells, D. W., 1 Feb 2019, In : BMJ Open Science. 3, 1, p. e000035

    Research output: Contribution to journalArticle

  16. Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis

    Vesterinen, H. M., Connick, P., Irvine, C. M. J., Sena, E. S., Egan, K. J., Carmichael, G. G., Tariq, A., Pavitt, S., Chataway, J., Macleod, M. R. & Chandran, S., 9 Apr 2015, In : PLoS ONE. 10, 4, e0117705.

    Research output: Contribution to journalArticle

  17. Edaravone improves functional and structural outcomes in animal models of focal cerebral ischemia: A systematic review

    Wu, S., Sena, E., Egan, K., Macleod, M. & Mead, G., Jan 2014, In : International Journal of Stroke. 9, 1, p. 101-106 6 p.

    Research output: Contribution to journalArticle

  18. Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis

    Watzlawick, R., Sena, E. S., Dirnagl, U., Brommer, B., Kopp, M. A., Macleod, M. R., Howells, D. W. & Schwab, J. M., Jan 2014, In : JAMA Neurology. 71, 1, p. 91-9 9 p.

    Research output: Contribution to journalArticle

  19. Effect of endothelin receptor antagonists on clinically relevant outcomes after experimental subarachnoid hemorrhage: a systematic review and meta-analysis

    Laban, K. G., Vergouwen, M. D. I., Dijkhuizen, R. M., Sena, E. S., Macleod, M. R., Rinkel, G. J. E. & van der Worp, H. B., Jul 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, 7, p. 1085-1089 5 p.

    Research output: Contribution to journalArticle

  20. Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review

    Kashangura, R., Sena, E. S., Young, T. & Garner, P., 1 Dec 2015, In : International Journal of Epidemiology. 44, 6, p. 1970–1981

    Research output: Contribution to journalArticle

  21. Efficacy of antidepressants in animal models of ischemic stroke: a systematic review and meta-analysis

    McCann, S. K., Irvine, C., Mead, G. E., Sena, E. S., Currie, G. L., Egan, K. E., Macleod, M. R. & Howells, D. W., Oct 2014, In : Stroke. 45, 10, p. 3055-3063 9 p.

    Research output: Contribution to journalArticle

  22. Empirical evidence of bias in the design of experimental stroke studies - A metaepidemiologic approach

    Crossley, N. A., Sena, E., Goehler, J., Horn, J., van der Worp, B., Bath, P. M. W., Macleod, M. & Dirnagl, U., Mar 2008, In : Stroke. 39, 3, p. 929-934 6 p.

    Research output: Contribution to journalArticle

  23. Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations

    Andrews, N. A., Latrémolière, A., Basbaum, A. I., Mogil, J. S., Porreca, F., Rice, A. S. C., Woolf, C. J., Currie, G. L., Dworkin, R. H., Eisenach, J. C., Evans, S., Gewandter, J. S., Gover, T. D., Handwerker, H., Huang, W., Iyengar, S., Jensen, M. P., Kennedy, J. D., Lee, N., Levine, J. & 14 others, Lidster, K., Machin, I., McDermott, M. P., McMahon, S. B., Price, T. J., Ross, S. E., Scherrer, G., Seal, R. P., Sena, E. S., Silva, E., Stone, L., Svensson, C. I., Turk, D. C. & Whiteside, G., Apr 2016, In : Pain. 157, 4, p. 901-9 9 p.

    Research output: Contribution to journalArticle

  24. Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

    Tsilidis, K. K., Panagiotou, O. A., Sena, E. S., Aretouli, E., Evangelou, E., Howells, D. W., Al-Shahi Salman, R., Macleod, M. R. & Ioannidis, J. P. A., Jul 2013, In : PLoS Biology. 11, 7, p. e1001609

    Research output: Contribution to journalArticle

  25. Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality

    Macleod, M. R., van der Worp, H. B., Sena, E. S., Howells, D. W., Dirnagl, U. & Donnan, G. A., Oct 2008, In : Stroke. 39, 10, p. 2824-2829 6 p.

    Research output: Contribution to journalArticle

  26. Exercise Reduces Infarct Volume and Facilitates Neurobehavioral Recovery: Results From a Systematic Review and Meta-analysis of Exercise in Experimental Models of Focal Ischemia

    Egan, K. J., Janssen, H., Sena, E. S., Longley, L., Speare, S., Howells, D. W., Spratt, N. J., Macleod, M. R., Mead, G. E. & Bernhardt, J., Oct 2014, In : Neurorehabilitation and Neural Repair. 28, 8, p. 800-812 13 p.

    Research output: Contribution to journalArticle

  27. Exploring the Efficacy of Constraint in Animal Models of Stroke: Meta-analysis and Systematic Review of the Current Evidence

    Janssen, H., Speare, S., Spratt, N. J., Sena, E. S., Ada, L., Hannan, A. J., McElduff, P. & Bernhardt, J., 2012, In : Neurorehabilitation and Neural Repair.

    Research output: Contribution to journalArticle

  28. Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies

    Hooijmans, C. R., De Vries, R. B. M., Ritskes-hoitinga, M., Rovers, M. M., Leeflang, M. M., Inthout, J., Wever, K. E., Hooft, L., De Beer, H., Kuijpers, T., Macleod, M. R., Sena, E. S., Ter Riet, G., Morgan, R. L., Thayer, K. A., Rooney, A. A., Guyatt, G. H., Schünemann, H. J., Langendam, M. W. & Minnerup, J. (ed.), 11 Jan 2018, In : PLoS ONE. 13, 1, p. e0187271

    Research output: Contribution to journalArticle

  29. Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis

    Sena, E. S., Briscoe, C. L., Howells, D. W., Donnan, G. A., Sandercock, P. A. G. & Macleod, M. R., Dec 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 12, p. 1905-13 9 p.

    Research output: Contribution to journalArticle

  30. Good Laboratory Practice Preventing Introduction of Bias at the Bench

    Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., van der Worp, H. B., Traystman, R., Minematsu, K., Donnan, G. A. & Howells, D. W., Mar 2009, In : Stroke. 40, 3, p. E50-E52 3 p.

    Research output: Contribution to journalArticle

  31. How our approaches to assessing benefits and harms can be improved

    Sena, E. & Currie, G., 1 Feb 2019, In : Animal Welfare. 28, 1, p. 107-115

    Research output: Contribution to journalArticle

  32. Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE

    Simonato, M., Iyengar, S., Brooks-Kayal, A., Collins, S., Depaulis, A., Howells, D. W., Jensen, F., Liao, J., Macleod, M. R., Patel, M., Potschka, H., Walker, M., Whittemore, V. & Sena, E. S., Nov 2017, In : Epilepsia. 58 Suppl 4, p. 68-77 10 p.

    Research output: Contribution to journalArticle

  33. Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis

    Lalu, M. M., Fergusson, D. A., Cheng, W., Avey, M. T., Corbett, D., Dowlatshahi, D., Macleod, M. R., Sena, E. S., Moher, D., Shorr, R., Mccann, S. K., Gray, L. J., Hill, M. D., O'connor, A., Thayer, K., Haggar, F., Dobriyal, A., Chung, H. S., Welton, N. J. & Hutton, B., 3 Jan 2019, In : F1000Research. 8, p. 11

    Research output: Contribution to journalArticle

  34. Improving the translational hit of experimental treatments in multiple sclerosis

    Vesterinen, H. M., Sena, E. S., Ffrench-Constant, C., Williams, A., Chandran, S. & Macleod, M. R., Sep 2010, In : Multiple Sclerosis Journal. 16, 9, p. 1044-1055 12 p.

    Research output: Contribution to journalArticle

  35. Magnetic resonance imaging in experimental stroke and comparison with histology: systematic review and meta-analysis

    Milidonis, X., Marshall, I., Macleod, M. R. & Sena, E. S., Mar 2015, In : Stroke; a journal of cerebral circulation. 46, 3, p. 843-851 9 p.

    Research output: Contribution to journalArticle

  36. Making the most of animal data – improving the prospect of success in pragmatic trials in the neurosciences

    Egan, K. J., Sena, E. S., Vesterinen, H. M. & Macleod, M. R., 1 Jan 2011, In : Trials. 12, Suppl 1, p. A102

    Research output: Contribution to journalArticle

  37. Meta-analysis of data from animal studies: A practical guide

    Vesterinen, H. M., Sena, E. S., Egan, K. J., Hirst, T., Churolov, L., Currie, G., Antonic, A., Howells, D. W. & Macleod, M. R., 15 Jan 2014, In : Journal of Neuroscience Methods. 221, p. 92-102 11 p.

    Research output: Contribution to journalArticle

  38. Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure

    Batchelor, P. E., Wills, T. E., Skeers, P., Battistuzzo, C. R., Macleod, M. R., Howells, D. W. & Sena, E. S., 2013, In : PLoS ONE. 8, 8, p. e72659

    Research output: Contribution to journalArticle

  39. Multicenter Evaluation of Geometric Accuracy of MRI Protocols Used in Experimental Stroke

    Milidonis, X., Lennen, R. J., Jansen, M., Mueller, S., Boehm-Sturm, P., Holmes, W. M., Sena, E., MacLeod, M. & Marshall, I., 7 Sep 2016, In : PLoS ONE.

    Research output: Contribution to journalArticle

  40. Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis

    Watzlawick, R., Rind, J., Sena, E. S., Brommer, B., Zhang, T., Kopp, M. A., Dirnagl, U., Macleod, M. R., Howells, D. W. & Schwab, J. M., 31 May 2016, In : PLoS Biology. 14, 5, p. e1002468

    Research output: Contribution to journalArticle

  41. Optimization of large animal MI models; a systematic analysis of control groups from preclinical studies

    Zwetsloot, P. P., Kouwenberg, L. H. J. A., Sena, E. S., Eding, J. E., Den Ruijter, H. M., Sluijter, J. P. G., Pasterkamp, G., Doevendans, P. A., Hoefer, I. E., Chamuleau, S. A. J., Van Hout, G. P. J. & Jansen Of Lorkeers, S. J., 27 Oct 2017, In : Scientific Reports. 7, 1

    Research output: Contribution to journalArticle

  42. Outcome heterogeneity and bias in acute experimental Spinal Cord Injury – a meta-analysis

    Watzlawick, R., Antonic, A., Sena, E., Kopp, M. A., Rind, J., Dirnagl, U., MacLeod, M., Howells, D. W. & Schwab, J. M., 2 Jul 2019, In : Neurology.

    Research output: Contribution to journalArticle

  43. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

    Finnerup, N. B., Attal, N., Haroutounian, S., McNicol, E., Baron, R., Dworkin, R. H., Gilron, I., Haanpää, M., Hansson, P., Jensen, T. S., Kamerman, P. R., Lund, K., Moore, A., Raja, S. N., Rice, A. S. C., Rowbotham, M., Sena, E., Siddall, P., Smith, B. H. & Wallace, M., Feb 2015, In : Lancet Neurology. 14, 2, p. 162-73 12 p.

    Research output: Contribution to journalArticle

  44. Prevalence and natural history of pain in adults with multiple sclerosis: Systematic review and meta-analysis

    Foley, P. L., Vesterinen, H. M., Laird, B. J., Sena, E. S., Colvin, L. A., Chandran, S., Macleod, M. R. & Fallon, M. T., May 2013, In : Pain. 154, 5, p. 632-642 11 p.

    Research output: Contribution to journalArticle

  45. Protocol for a retrospective, controlled cohort study of the impact of a change in Nature journals' editorial policy for life sciences research on the completeness of reporting study design and execution

    Cramond, F., Irvine, C., Liao, J., Howells, D., Sena, E., Currie, G. & Macleod, M., 9 Jul 2016, In : Scientometrics. 108, p. 315-328 14 p.

    Research output: Contribution to journalArticle

  46. Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

    Sena, E. S., van der Worp, H. B., Bath, P. M. W., Howells, D. W. & Macleod, M. R., Mar 2010, In : PLoS Biology. 8, 3, 8 p., e1000344.

    Research output: Contribution to journalArticle

  47. REPRINT: Good laboratory practice: Preventing introduction of bias at the bench

    Macleod, M. R., Fisher, M., O'collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., Van Der Worp, H. B., Traystman, R. J., Minematsu, K., Donnan, G. A. & Howells, D. W., 25 Feb 2009, In : International Journal of Stroke. 4, 1, p. 3-5 3 p.

    Research output: Contribution to journalArticle

  48. Reproducibility of preclinical animal research improves with heterogeneity of study samples

    Voelkl, B., Vogt, L., Sena, E. S. & Würbel, H., 22 Feb 2018, In : PLoS Biology. 16, 2, p. e2003693

    Research output: Contribution to journalArticle

  49. Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

    Macleod, M. R., Lawson Mclean, A., Kyriakopoulou, A., Serghiou, S., De Wilde, A., Sherratt, N., Hirst, T., Hemblade, R., Bahor, Z., Nunes-fonseca, C., Potluru, A., Thomson, A., Baginskitae, J., Egan, K., Vesterinen, H., Currie, G. L., Churilov, L., Howells, D. W. & Sena, E. S., 13 Oct 2015, In : PLoS Biology. 13, 10, p. e1002273

    Research output: Contribution to journalArticle

  50. Risk of bias reporting in the recent animal focal cerebral ischaemia literature

    Bahor, Z., Liao, J., MacLeod, M., Bannach-brown, A., Mccann, S., Wever, K., Thomas, J., Ottavi, T., Howells, D., Rice, A., Ananiadou, S. & Sena, E., 13 Oct 2017, In : Clinical science. 131, 20, p. 2525-2532 8 p.

    Research output: Contribution to journalArticle

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