Edinburgh Research Explorer

Prof Evelyn Telfer

Personal Chair in Reproductive Biology

Evelyn Telfer

  • School of Biological Sciences
Postal address:
George Square
Institute of Cell Biology
EH8 9XE
Edinburgh
United Kingdom

Research output

Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response

Maidarti, M., Clarkson, Y. L., McLaughlin, M., Anderson, R. & Telfer, E. 6 Dec 2018 In : Human Reproduction. 11 p.

Being a good egg in the 21st century

Anderson, R. & Telfer, E. 31 Jul 2018 In : British Medical Bulletin.

Initial characterisation of adult human ovarian cell populations isolated by DDX4 expression and aldehyde dehydrogenase activity

Clarkson, Y., McLaughlin, M., Waterfall, M., Dunlop, C. E., Skehel, P., Anderson, R. & Telfer, E. 3 May 2018 In : Scientific Reports. 8, 11 p., 6953

Metaphase II oocytes from human unilaminar follicles grown in a multi-step culture system

McLaughlin, M., Albertini, D. F., Wallace, W. H. B., Anderson, R. & Telfer, E. 1 Mar 2018 In : Molecular Human Reproduction. 24, 3, p. 135–142 8 p.

Ovarian tissue cryopreservation for fertility preservation: clinical and research perspectives

Anderson, R., Wallace, W. H. B. & Telfer, E. 29 Mar 2017 In : Human Reproduction.

Non-growing follicle density is increased following adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy in the adult human ovary

McLaughlin, M., Kelsey, T. W., Wallace, W. H. B., Anderson, R. & Telfer, E. 5 Dec 2016 In : Human Reproduction.

Re-implantation of cryopreserved ovarian cortex resulting in restoration of ovarian function, natural conception and successful pregnancy after haematopoietic stem cell transplantation for Wilms tumour

Dunlop, C., Brady, B. M., McLaughlin, M., Telfer, E., White, J., Cowie, F., Zahra, S., Wallace, W. H. B. & Anderson, R. 17 Sep 2016 In : Journal of Assisted Reproduction and Genetics. p. 1-6

Deconstructing the winding path to the recapitulation of mammalian oogenesis ex vivo

Albertini, D. F. & Telfer, E. E. 6 Sep 2016 In : Proceedings of the National Academy of Sciences. 113, 36, p. 9956-7 2 p.

Important steps towards materializing the dream of developing an artificial ovary

Telfer, E. E. & Fauser, B. C. J. M. 1 Sep 2016 In : Reproductive BioMedicine Online. 33, 3, p. 333-4 2 p.

Replenishing the adult ovarian follicle population: a fresh look at dogma

Anderson, R. & Telfer, E. 24 Mar 2016 In : Human Reproduction.

Creating a Global Community of Practice for Oncofertility

Ataman, L. M. , Rodrigues, J. K. , Marinho, R. M. , Caetano, J. P. J. , Chehin, M. B. , Alves Da Motta, E. L. , Serafini, P. , Suzuki, N. , Furui, T. , Takae, S. , Sugishita, Y. , Morishige, K. , Almeida-santos, T. , Melo, C. , Buzaglo, K. , Irwin, K. , Wallace, H. , Anderson, R. A. , Mitchell, R. T. , Telfer, E. E. & 30 others Adiga, S. K., Anazodo, A., Stern, C., Sullivan, E., Jayasinghe, Y., Orme, L., Cohn, R., Mclachlan, R., Deans, R., Agresta, F., Gerstl, B., Ledger, W. L., Robker, R. L., De Meneses E Silva, J. M., Melo E Silva, L. H. F., Lunardi, F. O., Lee, J. R., Suh, C. S., De Vos, M., Van Moer, E., Stoop, D., Vloeberghs, V., Smitz, J., Tournaye, H., Wildt, L., Winkler-crepaz, K., Andersen, C. Y., Smith, B. M., Smith, K. & Woodruff, T. K. 23 Dec 2015 In : Journal of Global Oncology.

The controversial existence and functional potential of oogonial stem cells

Grieve, K. M., McLaughlin, M., Dunlop, C. E., Telfer, E. E. & Anderson, R. Nov 2015 In : Maturitas. 82, 3, p. 278–281 4 p.

Cancer treatment and gonadal function: Experimental and established strategies for fertility preservation in children and young adults

Anderson, R., Mitchell, R. T., Kelsey, T. W., Spears, N., Telfer, E. E. & Wallace, H. Jul 2015 In : The Lancet Diabetes and Endocrinology.

An externally validated age-related model of mean follicle density in the cortex of the human ovary

McLaughlin, M., Kelsey, T. W., Wallace, H., Anderson, R. A. & Telfer, E. E. 5 Jun 2015 In : Journal of Assisted Reproduction and Genetics. 32, 7, p. 1089-1095 7 p.

Stem cells, progenitor cells and lineage decisions in the ovary

Hummitzsch, K., Anderson, R. A., Wilhelm, D., Wu, J., Telfer, E. E., Russell, D. L., Robertson, S. A. & Rodgers, R. J. 26 Dec 2014 In : Endocrine Reviews. p. er20141079

Ovarian germline stem cells

Dunlop, C., Telfer, E. E. & Anderson, R. 18 Aug 2014 In : Current stem cell research & therapy. 5, 4, p. 98

Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles

McLaughlin, M., Kinnell, H. L., Anderson, R. A. & Telfer, E. E. 1 Jan 2014 In : Molecular Human Reproduction. 20, 8, p. 736-744 9 p., gau037

The immature human ovary shows loss of abnormal follicles and increasing follicle developmental competence through childhood and adolescence

Anderson, R. A., McLaughlin, M., Wallace, W. H. B., Albertini, D. F. & Telfer, E. E. Jan 2014 In : Human Reproduction. 29, 1, p. 97-106

Ovarian stem cells—Potential roles in infertility treatment and fertility preservation

Dunlop, C., Telfer, E. E. & Anderson, R. A. Nov 2013 In : Maturitas. 76, 3, p. 279-83 5 p.

Ovarian follicle culture: advances and challenges for human and nonhuman primates

Zelinski M May 2013 In : Fertility and Sterility. 99, 6, p. 1523-1533 11 p.

The ageing ovary and uterus: new biological insights

Nelson, S. M., Telfer, E. E. & Anderson, R. A. 2013 In : Human Reproduction Update. 19, 1, p. 67-83 17 p.

Oocyte family trees: Old branches or new stems?

Woods, D. C., Telfer, E. E. & Tilly, J. L. 1 Jul 2012 In : PLoS Genetics. 8, 7, 3 p., e1002848

The quest for human ovarian stem cells

Telfer, E. E. & Albertini, D. F. Mar 2012 In : Nature Medicine. 18, 3, p. 353-354 2 p.

Strategies to support human oocyte development in vitro

Telfer, E. & McLaughlin, M. 2012 In : The International journal of developmental biology. 56, p. 901 907 p.

mTOR kinase inhibition results in oocyte loss characterized by empty follicles in human ovarian cortical strips cultured in vitro

McLaughlin, M., Patrizio, P., Kayisli, U., Luk, J., Thomson, T. C., Anderson, R. A., Telfer, E. E. & Johnson, J. Nov 2011 In : Fertility and Sterility. 96, 5, p. 1154-1159.e1 7 p.

mTOR Inhibition Results in Oocyte Loss in Human Ovarian Cortex

Johnson, J., McLaughlin, M., Anderson, R., Luk, J., Kayisli, U., Patrizio, P. & Telfer, E. Jul 2011 In : Biology of Reproduction. 85, 1 p.

In Vitro Development of Ovarian Follicles

Telfer, E. E. & McLaughlin, M. 2011 In : Seminars in Reproductive Medicine. 29, 1, p. 15-23 9 p.

In vitro growth (IVG) systems for human oocytes: from primordial to maturation

Telfer, E. & McLaughlin, M. 2011 Principles and Practice in Fertility Preservation. Eds S.Kim and J. Donnez. Cambridge University Press

Human oocytes express ATP-sensitive K+ channels

Du, Q., Jovanovic, S., Sukhodub, A., Barratt, E., Drew, E., Whalley, K. M., Kay, V., McLaughlin, M., Telfer, E. E., Barratt, C. L. R. & Jovanovic, A. Nov 2010 In : Human Reproduction. 25, 11, p. 2774-2782 9 p.

Activin promotes follicular integrity and oogenesis in cultured pre-antral bovine follicles

McLaughlin, M., Bromfield, J. J., Albertini, D. F. & Telfer, E. E. Sep 2010 In : Molecular Human Reproduction. 16, 9, p. 644-653 10 p.

Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation

Smitz, J., Dolmans, M. M., Donnez, J., Fortune, J. E., Hovatta, O., Jewgenow, K., Picton, H. M., Plancha, C., Shea, L. D., Stouffer, R. L., Telfer, E. E., Woodruff, T. K. & Zelinski, M. B. Jul 2010 In : Human Reproduction Update. 16, 4, p. 395-414 20 p.

In vitro follicle growth in thawed sarcoma-contaminated human ovarian cortex

McLaughlin, M., Fineron, P., Anderson, R. A., Wallace, W. H. B. & Telfer, E. E. Jun 2010 In : Human Reproduction. 25, p. I264-I264 1 p.

Oocyte development in bovine primordial follicles is promoted by activin and FSH within a two-step serum-free culture system

McLaughlin, M. & Telfer, E. E. Jun 2010 In : Reproduction. 139, 6, p. 971-978 8 p.

Activin A inhibits activation of human primordial follicles in vitro

Ding, C. C., Thong, K. J., Krishna, A. & Telfer, E. E. Apr 2010 In : Journal of Assisted Reproduction and Genetics. 27, 4, p. 141-147 7 p.

Purification of germline stem cells from adult mammalian ovaries: a step closer towards control of the female biological clock?

Tilly, J. L. & Telfer, E. E. Jul 2009 In : Molecular Human Reproduction. 15, 7, p. 393-398 6 p.

Inhibition of mTOR Kinase in Cultured Bovine Ovarian Cortex Results in Altered Follicle Dynamics

Johnson, J., McLaughlin, M., Yu, J. & Telfer, E. E. Mar 2009 In : Reproductive Sciences. 16, 3, p. 367A-367A 1 p.

Germline Stem Cells and adult ovarian function

Telfer, E. 2009 Stem Cells in Human Reproduction.

A two-step serum-free culture system supports development of human oocytes from primordial follicles in the presence of activin

Telfer, E. E., McLaughlin, M., Ding, C. & Thong, K. J. May 2008 In : Human Reproduction. 23, 5, p. 1151-1158 8 p.

Expression of anti-Mullerian hormone protein during early follicular development in the primate ovary in vivo is influenced by suppression of gonadotropin secretion and inhibition of vascular endothelial growth factor

Thomas, F. H., Telfer, E. E. & Fraser, H. M. 2007 In : Endocrinology . 148, 5, p. 2273-81 9 p.

On regenerating the ovary and generating controversy

Telfer, E. E., Gosden, R. G., Byskov, A. G., Spears, N., Albertini, D., Andersen, C. Y., Anderson, R., Braw-Tal, R., Clarke, H., Gougeon, A., McLaughlin, E., McLaren, A., McNatty, K., Schatten, G., Silber, S. & Tsafriri, A. 2005 In : Cell. 122, 6, p. 821-2 2 p.

Effect of ovary holding temperature and time on equine granulosa cell apoptosis, oocyte chromatin configuration and cumulus morphology

Pedersen, H. G., Watson, E. D. & Telfer, E. E. 2004 In : Theriogenology. 62, 3-4, p. 468-80 13 p.

Evidence of a role for follicle-stimulating hormone in controlling the rate of preantral follicle development in sheep

Campbell, B. K., Telfer, E. E., Webb, R. & Baird, D. T. 2004 In : Endocrinology . 145, 4, p. 1870-9 10 p.

Long-term ovarian function in sheep after ovariectomy and autotransplantation of cryopreserved cortical strips

Baird, D. T., Campbell, B., de Souza, C. & Telfer, E. 2004 In : European journal of obstetrics, gynecology, and reproductive biology. 113 Suppl 1, p. S55-9

Polyploid cells in the mouse ovary

Keighren, M. A., Macfadyen, L. P., Hill, A. S., Patek, C. E., Telfer, E. E. & West, J. D. Jun 2003 In : Journal of Anatomy. 202, 6, p. 563-71 9 p.

Domestic ruminants as models for the elucidation of the mechanisms controlling ovarian follicle development in humans

Campbell, B. K., Souza, C., Gong, J., Webb, R., Kendall, N., Marsters, P., Robinson, G., Mitchell, A., Telfer, E. E. & Baird, D. T. 2003 In : Reproduction (Cambridge, England) Supplement. 61, p. 429-43 15 p.

Effect of ascorbic acid on health and morphology of bovine preantral follicles during long-term culture

Thomas, F. H., Leask, R., Srsen, V., Riley, S. C., Spears, N. & Telfer, E. E. Sep 2001 In : Reproduction. 122, 3, p. 487-495 9 p.

Culture of bovine preantral follicles in a serum-free system: markers for assessment of growth and development

McCaffery, F. H., Leask, R., Riley, S. C. & Telfer, E. E. Jul 2000 In : Biology of Reproduction. 63, 1, p. 267-273 7 p.

Growth and antrum formation of bovine preantral follicles in long-term culture.

Guiterrez, C., Ralph, J. H., Telfer, E. E. & Webb, R. 2000 In : Biology of Reproduction. 62, p. 1322-1328 7 p.

Improving the efficiency of in vitro matured pig oocyte activation.

Zhu, J., De Sousa, P. A., Dobrinsky, J. R. & Telfer, E. E. 2000 In : Theriogenology. 53

Improving efficiency of in vitro matured pig oocyte activation.

Zhu, J., DeSousa, P. A., Drobrinsky, J. R. & Telfer, E. E. 1999 In : Theriogenology. 53, p. 445-445 1 p.

Projects

Activation of human ovarian follicles and derivation of competent oocytes

Telfer, E. & Anderson, R.

1/07/1030/10/13

£610,375, MRC

Control of somatic cell differentiation and oocyte development during early folliculogenesis - a new hypothesis

Telfer, E.

1/04/0131/03/04

£20,428, BBSRC

Determinants of oocyte quality: expression patterns of specific cell factors

Baird, D. & Telfer, E.

1/11/9931/12/02

£347,220, MRC

Dev of an Experimental System

Spears, N. & Telfer, E.

1/04/0031/03/01

£33,784, UK-based charities

Developmental and meiotic potential of oocytes derived from human ovarian germ cells (OSCs) in vitro

Telfer, E.

1/11/1328/05/16

£253,046, MRC

Developmental potential of oocytes derived from bovine ovarian germ line stem cells (bOSCs)

Telfer, E.

21/07/1431/01/16

£203,492, Non-EU industry, commerce and public corporations

EggPC Maturation and Development

Telfer, E.

31/01/1631/08/17

£467,433, Non-EU industry, commerce and public corporations

Exploration of the oogenic potential of putative germ line stem cells isolated from the ovaries of girls and adult women

Telfer, E. & Anderson, R.

1/10/1730/09/20

£961,943, MRC

Regulation of oocyte development - cooperative group grant

Spears, N., Hillier, S., Meehan, R. & Telfer, E.

11/10/9930/09/03

£762,055, MRC

Systematic investigation of the effect of chemotherapeutic agents on the ovary using ovarian follicle culture systems

Spears, N., Telfer, E., Gourley, C. & Anderson, R.

26/09/1131/12/14

£884,762, MRC

Press clippings

Breakthrough means girls left infertile by cancer could one day have kids

Evelyn Telfer & Richard Anderson

22/05/11

1 item of media coverage

Dr Evelyn Telfer comments on drug saving fertility in mice receiving chemotherapy

Evelyn Telfer

15/05/13

1 item of media coverage

Dr Evelyn Telfer comments on female egg-making stem cells

Evelyn Telfer

10/07/12

1 item of media coverage

Dr Evelyn Telfer comments on latest artificial egg cell treatment in Japan

Evelyn Telfer

5/10/12

2 items of media coverage

Dr Evelyn Telfer finds ovaries produce new eggs in adulthood

Evelyn Telfer

28/07/12

3 items of media coverage

Dr Evelyn Telfer part of team investigating female infertility

Evelyn Telfer

16/10/13

2 items of media coverage

Dr Evelyn Telfer questions idea of biological clock in women

Evelyn Telfer

27/07/12

1 item of media coverage

Dr Evelyn Telfer seeks to develop ovarian stem cells towards fertilisation

Evelyn Telfer

7/04/12

61 items of media coverage

Dr Evelyn Telfer teams up with US scientists to create human eggs from stem cells

Evelyn Telfer

26/02/12

11 items of media coverage

Evelyn Telfer (BioSciences) finds type of chemotherapy may improve condition of ovaries

Evelyn Telfer

1/04/17

1 item of media coverage

Evelyn Telfer (BioSciences) grows human eggs in lab to help boost fertility treatments

Evelyn Telfer

12/03/18

1 item of media coverage

Evelyn Telfer comments on study into women giving birth later in life

Evelyn Telfer

29/09/14

1 item of media coverage

Growing Human eggs in vitro

Evelyn Telfer

8/02/18

1 item of media coverage

Lab-grown eggs could pave way towards new fertility treatments

Evelyn Telfer

9/02/1810/02/18

22 items of media coverage, 1 media contribution

Prof Evelyn Telfer (BioSciences) comments on study where sterilised female mice produced babies

Evelyn Telfer

18/06/17

1 item of media coverage

Prof Evelyn Telfer (BioSciences) finds that a type of chemotherapy may enable women to grow new eggs

Evelyn Telfer

6/01/1612/12/16

43 items of media coverage

Prof Evelyn Telfer comments on ovaries produced from newborn mice stem cells

Evelyn Telfer

8/03/16

1 item of media coverage

Prof Evelyn Telfer comments on research into women giving birth later in life

Evelyn Telfer

20/10/14

1 item of media coverage

Prof Evelyn Telfer discusses how replacing ovarian tissue could improve fertility

Evelyn Telfer

5/04/16

1 item of media coverage

Prof Evelyn Telfer hails healthy birth after ovarian tissue graft

Evelyn Telfer

10/06/15

1 item of media coverage

Prof Evelyn Telfer’s finds women can grow new eggs in ovaries, contrary to popular belief

Evelyn Telfer

8/10/16

12 items of media coverage