Edinburgh Research Explorer

Gwo-Tzer Ho

Clinician Scientist

Profile photo

Willingness to take PhD students: Yes

Area of Expertise

Research expertiseGastroenterology, Inflammatory Bowel Disease, Endoscopy, Mucosal Biology

Biography

 

My research is focused on 2 main questions:

1. What are the molecular factors that drive and maintain the abnormal mucosal inflammation in Crohn’s disease (CD) and Ulcerative Colitis (UC)?

2. How do we translate this understanding into new and better medical treatments for CD and UC?

 

 

My overarching research aim is to translate new knowledge of immune and inflammatory mucosal mechanisms into new therapeutic approaches in IBD. I work very closely with dedicated IBD clinicians, biologists, immunologists and drug development teams with a strong focus on direct studies on human IBD along with in vivo experimental work. Major mechanistic themes are:

 

1. Gut derived mucosal damage-associated molecular patterns (DAMPs)

2. Mitochondrial dysfunction and ROS-signalling

3. Metabolic programing of the mucosal immune response

 

Qualifications

 

QUALIFICATIONS/AWARDS

Fellow of Royal College of Physicians (Edinburgh)

Medical Research Council (MRC) Clinician Scientist Award

Faculty IBD F1000 section member and Editorial Board IBD Monitor

Doctor of Philosophy (PhD) University of Edinburgh: Clinical and genetic determinants of severe ulcerative colitis

British Society of Gastroenterology CORE Research Prize

European Gastreonterology Rising Star Award

American Gastroenterology Association (3 distinction awards)

European Crohn's and Colitis Organisation Young Investigators Award

Member of Royal College of Physicians Edinburgh

MBChB University of Glasgow

 

Highlighted research outputs

  1. Resolution of Inflammation and Gut Repair in IBD: Translational Steps Towards Complete Mucosal Healing

    Research output: Contribution to journalArticlepeer-review

  2. Ulcerative colitis: Recent advances in the understanding of disease pathogenesis

    Research output: Contribution to journalArticlepeer-review

  3. Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD

    Research output: Contribution to journalArticlepeer-review

  4. MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

    Research output: Contribution to journalArticlepeer-review

  5. Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases

    Research output: Contribution to journalArticlepeer-review

  6. Gut mucosal DAMPs in IBD: From mechanisms to therapeutic implications

    Research output: Contribution to journalLiterature reviewpeer-review

View all (40) »

Research activities & awards

  1. Mary Erskine's School visit MRC Centre for Inflammation Research

    Activity: Participating in or organising an event typesPublic Engagement – Schools engagement

  2. BBC Radio Scotland Interview with Mhairi Stuart

    Activity: Other activity typesTypes of Public engagement and outreach - Media article or participation

View all (2) »

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