Edinburgh Research Explorer

Prof Helen Sang

Personal Chair of Vertebrate Molecular Development

  1. 2019
  2. In vivo generation of haematopoietic stem/progenitor cells from bone marrow-derived haemogenic endothelium

    Yvernogeau, L., Gautier, R., Petit, L., Khoury, H., Relaix, F., Ribes, V., Sang, H., Charbord, P., Souyri, M., Robin, C. & Jaffredo, T., 4 Nov 2019, In : Nature Cell Biology.

    Research output: Contribution to journalArticle

  3. Species specific differences in use of ANP32 proteins by influenza A virus

    Long, J. S., Idoko-akoh, A., Mistry, B., Goldhill, D. H., Staller, E., Schreyer, J., Ross, C., Goodbourn, S., Shelton, H., Skinner, M. A., Sang, H., McGrew, M. & Barclay, W. S., 4 Jun 2019, In : eLIFE.

    Research output: Contribution to journalArticle

  4. Feather arrays are patterned by interacting signalling and cell density waves

    Ho, W., Freem, L., Zhao, D., Painter, K. J., Woolley, T. E., Gaffney, E. A., McGrew, M., Tzika, A., Milinkovitch, M. C., Schneider, P., Drusko, A., Matthäus, F., Glover, J., Wells, K., Johansson, J., Davey, M., Sang, H., Clinton, M. & Headon, D., 21 Feb 2019, In : PLoS Biology.

    Research output: Contribution to journalArticle

  5. 2018
  6. A chicken bioreactor for efficient production of functional cytokines

    Herron, L. R., Pridans, C., Turnbull, M. L., Smith, N., Lillico, S., Sherman, A., Gilhooley, H. J., Wear, M., Kurian, D., Papadakos, G., Digard, P., Hume, D. A., Gill, A. C. & Sang, H. M., 29 Dec 2018, In : BMC Biotechnology. 18, 1, p. 82

    Research output: Contribution to journalArticle

  7. High fidelity CRISPR/Cas9 increases precise monoallelic and biallelic editing events in primordial germ cells

    Idoko-akoh, A., Taylor, L., Sang, H. & McGrew, M., 11 Oct 2018, In : Scientific Reports. 8, 1, 15126.

    Research output: Contribution to journalArticle

  8. Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination

    Baek, C., Freem, L., Goïame, R., Sang, H., Morin, X. & Tozer, S., 30 Apr 2018, In : PLoS Biology. 16, 4, p. e2004162

    Research output: Contribution to journalArticle

  9. Illuminating the chicken model through genetic modification

    Davey, M., Balic, A., Rainger, J., Sang, H. & McGrew, M., 31 Mar 2018, In : The International journal of developmental biology. 62, 1-3, p. 257-264

    Research output: Contribution to journalArticle

  10. 2017
  11. Asymmetrical morphogenesis and microcavities in the axial mesoderm of the chick

    Pieper, T., Carpaij, M., Sang, H., Viebahn, C. & Tsikolia, N., Jul 2017, In : Mechanisms of Development. 145, Suppt., p. S79 Abstract PS2.90.

    Research output: Contribution to journalMeeting abstract

  12. Genome Editing and the Future of Farming meeting report

    Hoyos-Flight, M., Brady, E., Sang, H. & Whitelaw, B., Apr 2017, In : Transgenic Research. 26, 2, p. 319-321

    Research output: Contribution to journalArticle

  13. 2016
  14. New horizons in chicken bioreactor technology

    Herron, L. R., Sherman, A., Gilhooley, H., Song, F., Pridans, C., Turnbull, M., Smith, N., Hume, D. A., Gill, A. C. & Sang, H. M., 2016, In : Transgenic Research. 25, 1, p. 110 1 p.

    Research output: Contribution to journalMeeting abstract

  15. 2015
  16. Myosin-II-mediated cell shape changes and cell intercalation contribute to primitive streak formation

    Rozbicki, E., Chuai, M., Karjalainen, A. I., Song, F., Sang, H. M., Martin, R., Knölker, H-J., MacDonald, M. P. & Weijer, C. J., 27 Mar 2015, In : Nature Cell Biology. 17, 4, p. 397-408 12 p.

    Research output: Contribution to journalArticle

  17. Cell-Autonomous Sex Differences in Gene Expression in Chicken Bone Marrow-Derived Macrophages

    Garcia-Morales, C., Nandi, S., Zhao, D., Sauter, K. A., Vervelde, L., McBride, D., Sang, H. M., Clinton, M. & Hume, D. A., 30 Jan 2015, In : Journal of Immunology. 194, 5, p. 2338-2344

    Research output: Contribution to journalArticle

  18. 2014
  19. Generating transgenic chickens

    Sherman, A. & Sang, H., Oct 2014, In : Transgenic Research. 23, 5, p. 837-837 1 p.

    Research output: Contribution to journalMeeting abstract

  20. Lentiviral and transposon methods for fluorescent transgenic chicken production

    Freem, L., Gilhooley, H., Sherman, A. & Sang, H., Oct 2014, In : Transgenic Research. 23, 5, p. 854-854 1 p.

    Research output: Contribution to journalMeeting abstract

  21. Culturing avian primordial germ cells and novel transposon vectors for transgenesis

    Glover, J., Whyte, J., Brzeszczynska, J., Taylor, L., Sang, H. M. & McGrew, M. J., Feb 2014, In : Transgenic Research. 23, 1, p. 193-193 1 p.

    Research output: Contribution to journalMeeting abstract

  22. Pharmaceutical protein production in the egg white of transgenic hens

    Herron, L. R., Song, F., Sherman, A., Gilhooley, H., Hume, D. A. & Sang, H. M., Feb 2014, In : Transgenic Research. 23, 1, p. 207-208 2 p.

    Research output: Contribution to journalMeeting abstract

  23. 2013
  24. A novel piggybac transposon inducible expression system identifies a role for akt signalling in primordial germ cell migration

    Glover, J., Taylor, L., Sherman, A., Zeiger-Poli, C., Sang, H. M. & McGrew, M., 4 Nov 2013, In : PLoS ONE. 8, 11, e77222.

    Research output: Contribution to journalArticle

  25. Disease resistance and other applications of transgenesis in the chicken

    Sang, H., 2013, In : Reproduction, Fertility and Development. 25, 1, p. 320 1 p.

    Research output: Contribution to journalMeeting abstract

  26. 2012
  27. Efficient genetic modification and germ-line transmission of primordial germ cells using piggyBac and Tol2 transposons

    Macdonald, J., Taylor, L., Sherman, A., Kawakami, K., Takahashi, Y., Sang, H. M. & McGrew, M. J., Jun 2012, In : Proceedings of the National Academy of Sciences. 109, 23, p. E1466-E1472

    Research output: Contribution to journalArticle

  28. Genetic Modification of the chicken genome using transposable elements

    Macdonald, J., Taylor, L., Sang, H. M. & McGrew, M. J., 2012, In : Transgenic Research. 21, 4, p. 912-913 2 p.

    Research output: Contribution to journalMeeting abstract

  29. Genetic modification for disease resistance: transgenic chickens that do not transmit avian influenza

    Sang, H., Lyall, J., Sherman, A., Brown, I. & Tiley, L., 2012, In : Transgenic Research. 21, 4, p. 906-907 2 p.

    Research output: Contribution to journalMeeting abstract

  30. New approaches of generating transgenic chicken lines

    Song, F., Sherman, A. & Sang, H. M., 2012, In : Transgenic Research. 21, 4, p. 915-916 2 p.

    Research output: Contribution to journalMeeting abstract

  31. 2011
  32. FGF-dependent midline-derived progenitor cells in hypothalamic infundibular development

    Pearson, C. A., Ohyama, K., Manning, L., Aghamohammadzadeh, S., Sang, H. & Placzek, M., Jun 2011, In : Development. 138, p. 2613-2624 12 p.

    Research output: Contribution to journalArticle

  33. Comparative Analysis of 3D Expression Patterns of Transcription Factor Genes and Digit Fate Maps in the Developing Chick Wing

    Fisher, M., Downie, H., Welten, M. C. M., Delgado, I., Bain, A., Planzer, T., Sherman, A., Sang, H. & Tickle, C., 22 Apr 2011, In : PLoS ONE. 6, 4, p. - 14 p., e18661.

    Research output: Contribution to journalArticle

  34. Suppression of avian influenza transmission in genetically modified chickens

    Lyall, J., Irvine, R. M., Sherman, A., McKinley, T. J., Nunez, A., Purdie, A., Outtrim, L., Brown, I. H., Rolleston-Smith, G., Sang, H. & Tiley, L., Jan 2011, In : Science. 331, 6014, p. 223-226 4 p.

    Research output: Contribution to journalArticle

  35. Analysis of chicken DMRT1 expression

    Zhao, D., Nandi, S., McBride, D., Sang, H. & Clinton, M., 2011, p. 26 Abstract 7.

    Research output: Contribution to conferenceAbstract

  36. CASI [cell autonomous sex identity] and development of the sexual phenotype in birds

    Clinton, M., Zhao, D., Nandi, S., Yu, L., Burt, D., Sang, H. & McBride, D., 2011, p. 31 Abstract 17.

    Research output: Contribution to conferenceAbstract

  37. Cellular and molecular investigations into the development of the pectoral girdle

    Valasek, P., Theis, S., DeLaurier, A., Hinits, Y., Luke, G. N., Otto, A. M., Minchin, J., He, L. W., Christ, B., Brooks, G., Sang, H., Evans, D. J., Logan, M., Huang, R. J. & Patel, K., 2011, In : Developmental Biology. 357, 1, p. 108-116 9 p.

    Research output: Contribution to journalArticle

  38. Control and mechanism of collective cell movement during chick gastrulation

    Weijer, C., Chuai, M., Song, F. & Sang, H., 2011, p. 90 Abstract 131.

    Research output: Contribution to conferenceAbstract

  39. GM and disease resistance - inhibition of influenza virus in transgenic chickens

    Tiley, L. & Sang, H., 2011, p. 29. 1 p.

    Research output: Contribution to conferencePaper

  40. Insights into bird wing evolution and digit specification from polarizing region fate maps

    Towers, M., Signolet, J., Sherman, A., Sang, H. & Tickle, C., 2011, In : Nature Communications. 2, 426.

    Research output: Contribution to journalArticle

  41. Notch regulates contribution of chick stem-like cells from the node to the floor plate and notochord

    Dale, K. J., Gray, S. D. & Sang, H., 2011, p. 68 Abstract 86.

    Research output: Contribution to conferenceAbstract

  42. Primordial germ cell culture and genetic manipulation in vitro

    Macdonald, J., Taylor, L., Sang, H. & McGrew, M., 2011, p. 71 Abstract 92.

    Research output: Contribution to conferenceAbstract

  43. Suppression of bird flu transmission in transgenic chickens

    Sang, H., Lyall, J., Sherman, A., Brown, I. & Tiley, L., 2011. 2 p.

    Research output: Contribution to conferenceAbstract

  44. The chicken polydactyly (Po) locus causes allelic imbalance and ectopic expression of Shh during limb development

    Dunn, I. C., Paton, I. R., Clelland, A. K., Sebastian, S., Johnson, E. J., McTeir, L., Windsor, D., Sherman, A., Sang, H., Burt, D. W., Tickle, C. & Davey, M. G., 2011, In : Developmental Dynamics. 240, 5, p. 1163-72 10 p.

    Research output: Contribution to journalArticle

  45. The function of macrophages in avian development

    Balic, A., Garcia-Morales, C., Garceau, V., Sang, H. & Hume, D., 2011, p. 80 Abstract 111.

    Research output: Contribution to conferenceAbstract

  46. The use of site-specific zinc finger nucleases for modification of the chicken genome

    Smith, S., Song, F., McGrew, M. & Sang, H., 2011, p. 85 Abstract 121.

    Research output: Contribution to conferenceAbstract

  47. 2010
  48. Characterisation and germline transmission of cultured avian primordial germ cells

    Macdonald, J., Glover, J., Taylor, L., Sang, H. M. & McGrew, M., Nov 2010, In : PLoS ONE. 5, 11, 10 p., e15518.

    Research output: Contribution to journalArticle

  49. Applications of lentiviral transgenesis in the chick

    Song, F., Sherman, A., Worthington, I., McGrew, M. J., Lillico, S. G. & Sang, H. M., Apr 2010, In : Transgenic Research. 19, 2, p. 350-350 1 p.

    Research output: Contribution to journalMeeting abstract

  50. Somatic sex identity is cell autonomous in the chicken

    Zhao, D., McBride, D., Nandi, S., McQueen, H. A., McGrew, M., Hocking, P. M., Lewis, P. D., Sang, H. M. & Clinton, M., Mar 2010, In : Nature. 464, 7286, p. 237-242 6 p.

    Research output: Contribution to journalArticle

  51. Functional conservation between rodents and chicken of regulatory sequences driving skeletal muscle gene expression in transgenic chickens

    McGrew, M., Sherman, A., Lillico, S. G., Taylor, L. & Sang, H., 25 Feb 2010, In : BMC Developmental Biology. 10, n/a, p. - 10 p., 26.

    Research output: Contribution to journalArticle

  52. The Roslin Institute Transgenic Chicken Facility: developments in chicken transgenesis

    Sherman, A., McGrew, M., Macdonald, J., Mitchell, R., Thomson, F., Hutchison, M. & Sang, H., Feb 2010, In : Transgenic Research. 19, 1, p. 151-151 1 p.

    Research output: Contribution to journalMeeting abstract

  53. 2009
  54. CMV enhancer-promoter is preferentially active in exocrine cells in vivo

    Vasey, D. B., Lillico, S. G., Sang, H. M., King, T. J. & Whitelaw, C. B. A., Apr 2009, In : Transgenic Research. 18, 2, p. 309-14 6 p.

    Research output: Contribution to journalArticle

  55. Applications of lentiviral transgenesis in the chick

    Song, F. F., Sherman, A., Worthington, I., McGrew, M. & Sang, H., 2009, In : Mechanisms of Development. 126, Suppt 1, p. S143-S143, abstract 07-P022

    Research output: Contribution to journalMeeting abstract

  56. Cell autonomous sexual development in birds

    Clinton, M., Zhao, D. B. A., McQueen, H., Nandi, S., Hocking, P., McGrew, M., Sang, H. & McBride, D., 2009, In : Mechanisms of Development. 126, Suppt. 1, p. S253, abstract 15-P020

    Research output: Contribution to journalMeeting abstract

  57. Contributions of polarizing region cells to digit pattern

    Towers, M., Signolet, J., Downie, H., Delgado, I., Sherman, A., Sang, H. & Tickle, C., 2009, In : Mechanisms of Development. 126, Suppt. 1, p. S211-S212, abstract 12-P056

    Research output: Contribution to journalMeeting abstract

  58. Genetic modification of the chicken: New technologies with potential applications in poultry production

    Sang, H. M., 2009, Biology of breeding poultry. Hocking, P. M. (ed.). Wallingford, Oxon: CAB Publishing, p. 45-53 9 p.

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

  59. Identification and characterisation of chicken DMRT1 transcript isoforms

    Zhao, D., Nandi, S., McBride, D., Sang, H. & Clinton, M., 2009, In : Mechanisms of Development. 126, Supplement 1, p. S167, 09-P056

    Research output: Contribution to journalMeeting abstract

  60. The role of micro-RNAs in the development of the chick gonads

    McBride, D., Carre, W., Nandi, S., Zhao, D. B., Law, A., Sang, H. & Clinton, M., 2009, In : Mechanisms of Development. 126, Suppt. 1, p. S54, abstract 01-P012

    Research output: Contribution to journalMeeting abstract

  61. 2008
  62. Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts

    Bru, T., Clarke, C., McGrew, M., Sang, H. M., Wilmut, I. & Blow, J. J., Aug 2008, In : Experimental Cell Research. 314, 14, p. 2634-42 9 p.

    Research output: Contribution to journalArticle

  63. Localised axial progenitor cell populations in the avian tail bud are not committed to a posterior Hox identity

    McGrew, M., Sherman, A., Lillico, S., Ellard, F. M., Radcliffe, P. A., Gilhooley, H., Mitrophanous, K. A., Cambray, N., Wilson, V. & Sang, H., Jul 2008, In : Development. 135, 13, p. 2289-2299 11 p.

    Research output: Contribution to journalArticle

  64. 2007
  65. The Oct4 homologue PouV and Nanog regulate pluripotency in chicken embryonic stem cells

    Lavial, F., Acloque, H., Bertocchini, F., Macleod, D. J., Boast, S., Bachelard, E., Montillet, G., Thenot, S., Sang, H. M., Stern, C. D., Samarut, J. & Pain, B., Oct 2007, In : Development. 134, 19, p. 3549-63 15 p.

    Research output: Contribution to journalArticle

  66. Oviduct-specific expression of two therapeutic proteins in transgenic hens

    Lillico, S. G., Sherman, A., McGrew, M. J., Robertson, C. D., Smith, J., Haslam, C., Barnard, P., Radcliffe, P. A., Mitrophanous, K. A., Elliot, E. A. & Sang, H. M., 6 Feb 2007, In : Proceedings of the National Academy of Sciences. 104, 6, p. 1771-6 6 p.

    Research output: Contribution to journalArticle

  67. 2006
  68. A robust system for RNA interference in the chicken using a modified microRNA operon

    Das, R. M., Van Hateren, N. J., Howell, G. R., Farrell, E. R., Bangs, F. K., Porteous, V. C., Manning, E. M., McGrew, M., Ohyama, K., Sacco, M. A., Halley, P. A., Sang, H. M., Storey, K. G., Placzek, M., Tickle, C., Nair, V. K. & Wilson, S. A., 15 Jun 2006, In : Developmental Biology. 294, 2, p. 554-63 10 p.

    Research output: Contribution to journalArticle

  69. 2005
  70. Developments in transgenic technology: applications for medicine

    Hunter, C. V., Tiley, L. S. & Sang, H. M., Jun 2005, In : Trends in Molecular Medicine. 11, 6, p. 293-8 6 p.

    Research output: Contribution to journalArticle

  71. Disease-resistant genetically modified animals

    Whitelaw, C. B. A. & Sang, H. M., Apr 2005, In : Revue scientifique et technique-Office international des epizooties. 24, 1, p. 275-83 9 p.

    Research output: Contribution to journalArticle

  72. Transgenic chickens as bioreactors for protein-based drugs

    Lillico, S. G., McGrew, M., Sherman, A. & Sang, H. M., 1 Feb 2005, In : Drug Discovery Today. 10, 3, p. 191-196

    Research output: Contribution to journalArticle

  73. Increased gp130 signaling in combination with inhibition of the MEK/ERK pathway facilitates embryonic stem cell isolation from normally refractory murine CBA blastocysts

    Lodge, P., McWhir, J., Gallagher, E. & Sang, H., 2005, In : Cloning and Stem Cells. 7, 1, p. 2-7 6 p.

    Research output: Contribution to journalArticle

  74. 2004
  75. What is the value of another method for making transgenic animals?

    Sang, H., 1 Dec 2004, In : Transgenic Research. 13, 6, p. 511-512

    Research output: Contribution to journalArticle

  76. Prospects for transgenesis in the chick

    Sang, H., Sep 2004, In : Mechanisms of Development. 121, 9, p. 1179-86 8 p.

    Research output: Contribution to journalArticle

  77. Efficient production of germline transgenic chickens using lentiviral vectors

    McGrew, M., Sherman, A., Ellard, F. M., Lillico, S. G., Gilhooley, H. J., Kingsman, A. J., Mitrophanous, K. A. & Sang, H., 1 Jul 2004, In : EMBO Reports. 5, 7, p. 728-733

    Research output: Contribution to journalArticle

  78. 2003
  79. Genetically modified livestock and poultry and their potential effects on human health and nutrition

    Sang, H., 1 May 2003, In : Trends in Food Science & Technology. 14, 5-8, p. 253-263

    Research output: Contribution to journalArticle

  80. 1998
  81. Transposition of the Drosophila element mariner into the chicken germ line

    Sherman, A., Dawson, A., Mather, C., Gilhooley, H., Li, Y., Mitchell, R., Finnegan, D. & Sang, H., Nov 1998, In : Nature Biotechnology. 16, 11, p. 1050-3 4 p.

    Research output: Contribution to journalArticle

  82. Chronology of events in the first cell cycle of the polyspermic egg of the domestic fowl (Gallus domesticus)

    Waddington, D., Gribbin, C., Stering, R. J., Sang, H. & Perry, M. M., May 1998, In : The International journal of developmental biology. 42, 4, p. 625-28 4 p.

    Research output: Contribution to journalArticle

  83. 1997
  84. Expression of Sry-related genes in the developing genital ridge/mesonephros of the chick embryo

    McBride, D., Sang, H. & Clinton, M., 1997, In : Journal of reproduction and fertility. 109, 1, p. 59-63 5 p.

    Research output: Contribution to journalArticle

  85. 1996
  86. Regulation of Chicken Gonadotropin-Releasing Hormone-I mRNA in Incubating, Nest-Deprived and Laying Bantam Hens

    Dunn, I. C., Beattie, K. K., Maney, D., Sang, H. M., Talbot, R. T., Wilson, P. W. & Sharp, P. J., 1 Jan 1996, In : Neuroendocrinology. 63, 6, p. 504-513 10 p.

    Research output: Contribution to journalArticle

  87. Genetic and physical mapping of the chicken IGF1 gene to chromosome 1 and conservation of synteny with other vertebrate genomes

    Klein, S., Morrice, D. R., Sang, H., Crittenden, L. B. & Burt, D. W., 1996, In : Journal of Heredity. 87, 1, p. 10-4 5 p.

    Research output: Contribution to journalArticle

  88. 1994
  89. Effect of active immunization against recombinant-derived chicken prolactin fusion protein on the onset of broodiness and photoinduced egg laying in bantam hens

    March, J. B., Sharp, P. J., Wilson, P. W. & Sang, H., May 1994, In : Journal of reproduction and fertility. 101, 1, p. 227-33 7 p.

    Research output: Contribution to journalArticle

  90. 1984
  91. Molecular lesions associated with white gene mutations induced by I-R hybrid dysgenesis in Drosophila melanogaster

    Sang, H., Pelisson, A., Bucheton, A. & Finnegan, D., 20 Dec 1984, In : EMBO Journal. 3, 13, p. 3079-85 7 p.

    Research output: Contribution to journalArticle

  92. 1983
  93. Genetic Recombination at the Buff Spore Color Locus in SORDARIA BREVICOLLIS. II. Analysis of Flanking Marker Behavior in Crosses between Buff Mutants

    Sang, H. & Whitehouse, H. L. K., Feb 1983, In : Genetics. 103, 2, p. 161-78 18 p.

    Research output: Contribution to journalArticle