Edinburgh Research Explorer

James Dear

Personal Chair of Clinical Pharmacology

  1. 2021
  2. Evaluating the sensitivity and specificity of promising circulating biomarkers to diagnose liver injury in humans

    Llewellyn, H. P., Vaidya, V. S., Wang, Z., Peng, Q., Hyde, C., Potter, D., Wang, J., Zong, Q., Arat, S., Martin, M., Masek-Hammerman, K., Warner, R., Johnson, K., Kullak-Ublick, G. A., Aithal, G. P., Dear, J. W. & Ramaiah, S. K., 23 Jan 2021, In: Toxicological Sciences.

    Research output: Contribution to journalArticlepeer-review

  3. MicroRNA-122 and cytokeratin-18 have potential as a biomarkers of drug-induced liver injury in European and African patients on treatment for mycobacterial infection

    Rupprechter, S. AE., Sloan, D. J., Oosthuyzen, W., Bachmann, T. T., Hill, A. T., Dhaliwal, K., Templeton, K., Matovu, J., Sekaggya-Wiltshire, C. & Dear, J. W., 11 Jan 2021, In: British Journal of Clinical Pharmacology.

    Research output: Contribution to journalArticlepeer-review

  4. 2020
  5. Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells

    Matthews, O., Morrison, E., Tranter, J., Starkey Lewis, P., Toor, I., Srivastava, A. H., Sargeant, R. J. E., Rollison, H., Matchett, K., Kendall, T. J., Gray, G. A., Goldring, C. E., Park, K., Denby, L., Dhaun, N., Bailey, M. A., Henderson, N. C., Williams, D. & Dear, J. W., 1 Dec 2020, In: EBioMedicine. 62, 103092.

    Research output: Contribution to journalArticlepeer-review

  6. Association of baseline hematoma and edema volumes with one-year outcome and long-term survival after spontaneous intracerebral hemorrhage: A community-based inception cohort study

    Loan, J. J., Gane, A. B., Moullaali, T. J., Rodrigues, M. A., Wardlaw, J., Salman, R. A., Samarasekera, N. & Lothian Audit of the Treatment of Cerebral Haemorrhage (LATCH) collaborators, 25 Nov 2020, In: International Journal of Stroke. p. 174749302097428

    Research output: Contribution to journalArticlepeer-review

  7. Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial

    FAST Study Group, 9 Nov 2020, In: The Lancet. 396, 10264, p. 1745-1757

    Research output: Contribution to journalArticlepeer-review


    Osinski, K., Ross, H., Clarke, L., Dear, J. W. & Veiraiah, A., 6 Nov 2020, In: Clinical Toxicology.

    Research output: Contribution to journalArticlepeer-review

  9. Mathematical modelling and statistical analysis of indocyanine green and other biomarkers of hepatic function and drug-induced liver injury

    Leedale, J., Mason, C. L., Brillant, N., Webb, S. D. & Dear, J. W., Nov 2020, In: Computational Toxicology. 16

    Research output: Contribution to journalArticlepeer-review

  10. Comment on fomepizole as an adjunctive treatment in severe acetaminophen ingestions

    Bateman, D. N., Dear, J. W., Eddleston, M. & Vale, J. A., 7 Jul 2020, In: Clinical Toxicology. p. 1-1

    Research output: Contribution to journalArticlepeer-review

  11. Amplification-free profiling of microRNA-122 biomarker in DILI patient serums, using the Luminex MAGPIX system

    Marín-romero, A., Tabraue-chávez, M., Dear, J. W., Sánchez-martín, R. M., Ilyine, H., Guardia-monteagudo, J. J., Fara, M. A., López-delgado, F. J., Díaz-mochón, J. J. & Pernagallo, S., 29 Jun 2020

    Research output: Other contribution

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