Edinburgh Research Explorer

Prof John Fazakerley

(Former employee or visitor)

Current Research Interests

Pathogenesis of infections with RNA viruses, focusing on arboviruses and virus infections of the central nervous system.

Highlighted research outputs

  1. Phenoloxidase Activity Acts as a Mosquito Innate Immune Response against Infection with Semliki Forest Virus

    Research output: Contribution to journal › Article

  2. Semliki forest virus-induced endoplasmic reticulum stress accelerates apoptotic death of mammalian cells

    Research output: Contribution to journal › Article

  3. PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response

    Research output: Contribution to journal › Article

  4. In Semliki Forest virus encephalitis, antibody rapidly clears infectious virus and is required to eliminate viral material from the brain, but is not required to generate lesions of demyelination

    Research output: Contribution to journal › Article

  5. RNA integrity in post mortem human variant Creutzfeldt-Jakob disease (vCJD) and control brain tissue

    Research output: Contribution to journal › Article

View all (103) »

Research projects

  1. The impact of sytematic vira infections on the innate immune response in the brain in chronic neurodegeneration

    Project: Research

  2. Integration of chikungunya research (ICRES)

    Project: Research

  3. POSTICK: post-graduate training network for capacity building to control ticks and tick-borne diseases

    Project: Research

View all (21) »

Research press coverage

  1. Professor John Fazakerley appointed new director of the Institute for Animal Health

    Press/Media: Research

  2. Launch of Roslin Wellcome Trust Tick Cell Biobank at The Roslin Institute

    Press/Media: Research

View all (2) »

Latest datasets

  1. Small interfering RNAs (siRNA) genome-scale screen data for investigating host factors (HFs) involved in Herpes Simplex Virus Type 1 Replication

    Dataset

View all (1) »

ID: 7677