Edinburgh Research Explorer

Dr Jose Garcia-Perez

Chancellor's Fellow

  1. 2019
  2. LINE-1 Evasion of Epigenetic Repression in Humans

    Sanchez-luque, F. J., Kempen, M. H. C., Gerdes, P., Vargas-landin, D. B., Richardson, S. R., Troskie, R., Jesuadian, J. S., Cheetham, S. W., Carreira, P. E., Salvador-palomeque, C., García-cañadas, M., Muñoz-lopez, M., Sanchez, L., Lundberg, M., Macia, A., Heras, S. R., Brennan, P. M., Lister, R., Garcia-perez, J. L., Ewing, A. D. & 1 others, Faulkner, G. J., 20 Jun 2019, In : Molecular Cell.

    Research output: Contribution to journalArticle

  3. 2018
  4. Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s

    Warkocki, Z., Krawczyk, P. S., Adamska, D., Bijata, K., Garcia-Perez, J. L. & Dziembowski, A., 6 Sep 2018, In : Cell. 174, 6, p. 1537-+ 41 p.

    Research output: Contribution to journalArticle

  5. Impact of non-LTR retrotransposons in the differentiation and evolution of anatomically modern humans

    Guichard, E., Peona, V., Tagliazucchi, G. M., Abitante, L., Jagoda, E., Musella, M., Ricci, M., Rubio-Roldan, A., Sarno, S., Luiselli, D., Pettener, D., Taccioli, C., Pagani, L., Luis Garcia-Perez, J. & Boattini, A., 15 Aug 2018, In : Mobile DNA. 9, 19 p., 28.

    Research output: Contribution to journalArticle

  6. Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

    Mayer, J., Harz, C., Sanchez, L., Pereira, G. C., Maldener, E., Heras, S. R., Ostrow, L. W., Ravits, J., Batra, R., Meese, E., Luis Garcia-Perez, J. & Goodier, J. L., 2 Aug 2018, In : Molecular Neurodegeneration. 13, 25 p., 39.

    Research output: Contribution to journalArticle

  7. RNase H2, mutated in Aicardi-Goutières syndrome, promotes LINE-1 retrotransposition

    Benitez-Guijarro, M., Lopez-Ruiz, C., Tamauskaite, Z., Murina, O., Mohammad, M. M., Williams, T. C., Fluteau, A., Sanchez, L., Vilar-Astasio, R., Garcia-Cañadas, M., Cano, D., Kempen, M-J., Sanchez-Pozo, A., Heras, S. R., Jackson, A. P., Reijns, M. A. M. & Garcia-Perez, J. L., 29 Jun 2018, In : EMBO Journal.

    Research output: Contribution to journalArticle

  8. 2017
  9. L1 Mosaicism in Mammals: Extent, Effects, and Evolution

    Faulkner, G. J. & Garcia-Perez, J. L., 1 Nov 2017, In : Trends in Genetics.

    Research output: Contribution to journalReview article

  10. The TREX1 Dinosaur Bites the Brain through the LINE

    García Pérez, J. L. & Alarcón-Riquelme, M. E., 7 Sep 2017, In : Cell Stem Cell. 21, 3, p. 287-288 2 p.

    Research output: Contribution to journalReview article

  11. Heritable L1 retrotransposition in the mouse primordial germline and early embryo

    Richardson, S. R., Gerdes, P., Gerhardt, D. J., Sanchez-Luque, F. J., Bodea, G-O., Munoz-Lopez, M., Jesuadian, J. S., Kempen, M-J. H. C., Carreira, P. E., Jeddeloh, J. A., Garcia-Perez, J. L., Kazazian, H. H., Ewing, A. D. & Faulkner, G. J., 27 Aug 2017, In : Genome Research.

    Research output: Contribution to journalArticle

  12. Mobilization of LINE-1 Retrotransposons is Restricted by Tex19.1 in Mouse Embryonic Stem Cells

    Maclennan, M., Garcia-Cañadas, M., Reichmann, J., Khazina, E., Wagner, G., Playfoot, C., Salvador-Palomeque, C., Mann, A., Peressini, P., Sanchez, L., Dobie, K., Read, D., Hung, C-C., Eskeland, R., Meehan, R. R., Weichenrieder, O., García-Pérez, J. L. & Adams, I. R., 14 Aug 2017, In : eLIFE. 26152.

    Research output: Contribution to journalArticle

  13. Engineered LINE-1 retrotransposition in nondividing human neurons

    Macia, A., Widmann, T. J., Heras, S. R., Ayllon, V., Sanchez, L., Benkaddour-boumzaouad, M., Muñoz-lopez, M., Rubio, A., Amador-cubero, S., Blanco-jimenez, E., Garcia-castro, J., Menendez, P., Ng, P., Muotri, A. R., Goodier, J. L. & Garcia-perez, J. L., Mar 2017, In : Genome Research. 27, 3, p. 335-348

    Research output: Contribution to journalArticle

  14. 2016
  15. The impact of transposable elements on mammalian development

    Garcia-Perez, J. L., Widmann, T. J. & Adams, I. R., 15 Nov 2016, In : Development. 143, 22, p. 4101-4114 14 p.

    Research output: Contribution to journalReview article

  16. Characterization of Engineered L1 Retrotransposition Events: The Recovery Method

    Cano, D., Morell, S., Pulgarin, A. J., Amador, S. & Garcia-Pérez, J. L., 20 Feb 2016, Transposons and Retrotransposons. Springer, Vol. 1400. p. 165-82 18 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

  17. Study of Transposable Elements and Their Genomic Impact

    Muñoz-Lopez, M., Vilar-Astasio, R., Tristan-Ramos, P., Lopez-Ruiz, C. & Garcia-Pérez, J. L., 20 Feb 2016, Transposons and Retrotransposons. Springer, Vol. 1400. p. 1-19 19 p. (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  18. Alu retrotransposons promote differentiation of human carcinoma cells through the aryl hydrocarbon receptor

    Morales-Hernández, A., González-Rico, F. J., Román, A. C., Rico-Leo, E., Alvarez-Barrientos, A., Sánchez, L., Macia, Á., Heras, S. R., García-Pérez, J. L., Merino, J. M. & Fernández-Salguero, P. M., 15 Feb 2016, In : Nucleic Acids Research.

    Research output: Contribution to journalArticle

  19. Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

    Klawitter, S., Fuchs, N. V., Upton, K. R., Muñoz-Lopez, M., Shukla, R., Wang, J., Garcia-Cañadas, M., Lopez-Ruiz, C., Gerhardt, D. J., Sebe, A., Grabundzija, I., Merkert, S., Gerdes, P., Pulgarin, J. A., Bock, A., Held, U., Witthuhn, A., Haase, A., Sarkadi, B., Löwer, J. & 7 others, Wolvetang, E. J., Martin, U., Ivics, Z., Izsvák, Z., Garcia-Perez, J. L., Faulkner, G. J. & Schumann, G. G., 8 Jan 2016, In : Nature Communications. 7, p. 10286

    Research output: Contribution to journalArticle

  20. 2015
  21. Localization of a bacterial group II intron-encoded protein in human cells

    Reinoso-Colacio, M., García-Rodríguez, F. M., García-Cañadas, M., Amador-Cubero, S., García Pérez, J. L. & Toro, N., 5 Aug 2015, In : Scientific Reports. 5, p. 12716

    Research output: Contribution to journalArticle

  22. Retrotransposons in pluripotent cells: Impact and new roles in cellular plasticity

    Macia, A., Blanco-Jimenez, E. & García-Pérez, J. L., Apr 2015, In : Biochimica et biophysica acta-Bioenergetics. 1849, 4, p. 417-26 10 p.

    Research output: Contribution to journalArticle

  23. The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes

    Richardson, S. R., Doucet, A. J., Kopera, H. C., Moldovan, J. B., Garcia-Perez, J. L. & Moran, J. V., Apr 2015, In : Microbiology Spectrum. 3, 2, p. MDNA3-0061-2014

    Research output: Contribution to journalArticle

  24. 2014
  25. Role of BRD4 in hematopoietic differentiation of embryonic stem cells

    Rodriguez, R. M., Suarez-Alvarez, B., Salvanés, R., Huidobro, C., Toraño, E. G., Garcia-Perez, J., Lopez-Larrea, C., Fernandez, A. F., Bueno, C., Menendez, P. & Fraga, M. F., Apr 2014, In : Epigenetics. 9, 4, p. 566-78 13 p.

    Research output: Contribution to journalArticle

  26. Control of mammalian retrotransposons by cellular RNA processing activities

    Heras, S. R., Macias, S., Cáceres, J. F. & Garcia-Perez, J., 2014, In : Mobile Genetic Elements. 4, p. e28439

    Research output: Contribution to journalArticle

  27. 2013
  28. Wiping DNA methylation: Wip1 regulates genomic fluidity on cancer

    Muñoz-Lopez, M., Medina, P. P. & Garcia-Perez, J. L., 14 Oct 2013, In : Cancer cell. 24, 4, p. 405-7 3 p.

    Research output: Contribution to journalArticle

  29. The Microprocessor controls the activity of mammalian retrotransposons

    Heras, S. R., Macias, S., Plass, M., Fernandez, N., Cano, D., Eyras, E., Garcia-Perez, J. & Cáceres, J. F., Oct 2013, In : Nature Structural & Molecular Biology. 20, 10, p. 1173-1181 9 p.

    Research output: Contribution to journalArticle

  30. Endogenous Retrotransposition Activates Oncogenic Pathways in Hepatocellular Carcinoma

    Shukla, R., Upton, K. R., Munoz-Lopez, M., Gerhardt, D. J., Fisher, M. E., Thu Nguyen, N. V., Brennan, P. M., Baillie, J. K., Collino, A., Ghisletti, S., Sinha, S., Iannelli, F., Radaelli, E., Dos Santos, A., Rapoud, D., Guettier, C., Samuel, D., Natoli, G., Carninci, P., Ciccarelli, F. D. & 3 others, Garcia-Perez, J., Faivre, J. & Faulkner, G. J., 28 Mar 2013, In : Cell. 153, 1, p. 101-111 11 p.

    Research output: Contribution to journalArticle

  31. 2012
  32. Microcephaly, intellectual impairment, bilateral vesicoureteral reflux, distichiasis, and glomuvenous malformations associated with a 16q24.3 contiguous gene deletion and a Glomulin mutation

    Butler, M. G., Dagenais, S. L., Garcia-Perez, J. L., Brouillard, P., Vikkula, M., Strouse, P., Innis, J. W. & Glover, T. W., Apr 2012, In : American Journal of Medical Genetics Part A. 158A, 4, p. 839-49 11 p.

    Research output: Contribution to journalArticle

  33. Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobility

    Wissing, S., Muñoz-Lopez, M., Macia, A., Yang, Z., Montano, M., Collins, W., Garcia-Perez, J. L., Moran, J. V. & Greene, W. C., 1 Jan 2012, In : Human Molecular Genetics. 21, 1, p. 208-18 11 p.

    Research output: Contribution to journalArticle

  34. Analysis of LINE-1 expression in human pluripotent cells

    Muñoz-Lopez, M., Garcia-Cañadas, M., Macia, A., Morell, S. & Garcia-Perez, J. L., 2012, In : Methods in Molecular Biology. 873, p. 113-25 13 p.

    Research output: Contribution to journalArticle

  35. Microarray analysis of LTR retrotransposon silencing identifies Hdac1 as a regulator of retrotransposon expression in mouse embryonic stem cells

    Reichmann, J., Crichton, J. H., Madej, M. J., Taggart, M., Gautier, P., Garcia-Perez, J., Meehan, R. & Adams, I. R., 2012, In : PLoS Computational Biology. 8, 4, 21 p., e1002486.

    Research output: Contribution to journalArticle

  36. 2011
  37. Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells

    Coufal, N. G., Garcia-Perez, J. L., Peng, G. E., Marchetto, M. C. N., Muotri, A. R., Mu, Y., Carson, C. T., Macia, A., Moran, J. V. & Gage, F. H., 20 Dec 2011, In : Proceedings of the National Academy of Sciences. 108, 51, p. 20382-7 6 p.

    Research output: Contribution to journalArticle

  38. Similarities between long interspersed element-1 (LINE-1) reverse transcriptase and telomerase

    Kopera, H. C., Moldovan, J. B., Morrish, T. A., Garcia-Perez, J. L. & Moran, J. V., 20 Dec 2011, In : Proceedings of the National Academy of Sciences. 108, 51, p. 20345-50 6 p.

    Research output: Contribution to journalArticle

  39. Endogenous APOBEC3B restricts LINE-1 retrotransposition in transformed cells and human embryonic stem cells

    Wissing, S., Montano, M., Garcia-Perez, J. L., Moran, J. V. & Greene, W. C., 21 Oct 2011, In : Journal of Biological Chemistry. 286, 42, p. 36427-37 11 p.

    Research output: Contribution to journalArticle

  40. An epi [c] genetic battle: LINE-1 retrotransposons and intragenomic conflict in humans

    Muñoz-Lopez, M., Macia, A., Garcia-Cañadas, M., Badge, R. M. & Garcia-Perez, J. L., Jul 2011, In : Mobile Genetic Elements. 1, 2, p. 122-127 6 p.

    Research output: Contribution to journalArticle

  41. Enrichment of human ESC-derived multipotent mesenchymal stem cells with immunosuppressive and anti-inflammatory properties capable to protect against experimental inflammatory bowel disease

    Sánchez, L., Gutierrez-Aranda, I., Ligero, G., Rubio, R., Muñoz-López, M., García-Pérez, J. L., Ramos, V., Real, P. J., Bueno, C., Rodríguez, R., Delgado, M. & Menendez, P., Feb 2011, In : Stem Cells. 29, 2, p. 251-62 12 p.

    Research output: Contribution to journalArticle

  42. Epigenetic control of retrotransposon expression in human embryonic stem cells

    Macia, A., Muñoz-Lopez, M., Cortes, J. L., Hastings, R. K., Morell, S., Lucena-Aguilar, G., Marchal, J. A., Badge, R. M. & Garcia-Perez, J. L., Jan 2011, In : Molecular and Cellular Biology. 31, 2, p. 300-16 17 p.

    Research output: Contribution to journalArticle

  43. LINE-1 elements in structural variation and disease

    Beck, C. R., Garcia-Perez, J. L., Badge, R. M. & Moran, J. V., 2011, In : Annual review of genomics and human genetics. 12, p. 187-215 29 p.

    Research output: Contribution to journalArticle

  44. 2010
  45. Enhanced transfection efficiency of human embryonic stem cells by the incorporation of DNA liposomes in extracellular matrix

    Villa-Diaz, L. G., Garcia-Perez, J. L. & Krebsbach, P. H., Dec 2010, In : Stem Cells and Development. 19, 12, p. 1949-57 9 p.

    Research output: Contribution to journalArticle

  46. iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to genomic instability

    Ramos-Mejia, V., Muñoz-Lopez, M., Garcia-Perez, J. L. & Menendez, P., Oct 2010, In : Cell Research . 20, 10, p. 1092-5 4 p.

    Research output: Contribution to journalArticle

  47. Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells

    Garcia-Perez, J. L., Morell, M., Scheys, J. O., Kulpa, D. A., Morell, S., Carter, C. C., Hammer, G. D., Collins, K. L., O'Shea, K. S., Menendez, P. & Moran, J. V., 5 Aug 2010, In : Nature. 466, 7307, p. 769-73 5 p.

    Research output: Contribution to journalArticle

  48. DNA transposons: nature and applications in genomics

    Muñoz-López, M. & García-Pérez, J. L., Apr 2010, In : Current Genomics. 11, 2, p. 115-28 14 p.

    Research output: Contribution to journalArticle

  49. 2009
  50. Etoposide induces MLL rearrangements and other chromosomal abnormalities in human embryonic stem cells

    Bueno, C., Catalina, P., Melen, G. J., Montes, R., Sánchez, L., Ligero, G., García-Pérez, J. L. & Menendez, P., Sep 2009, In : Carcinogenesis. 30, 9, p. 1628-37 10 p.

    Research output: Contribution to journalArticle

  51. L1 retrotransposition in human neural progenitor cells

    Coufal, N. G., Garcia-Perez, J. L., Peng, G. E., Yeo, G. W., Mu, Y., Lovci, M. T., Morell, M., O'Shea, K. S., Moran, J. V. & Gage, F. H., 27 Aug 2009, In : Nature. 460, 7259, p. 1127-31 5 p.

    Research output: Contribution to journalArticle

  52. Mesenchymal stem cells facilitate the derivation of human embryonic stem cells from cryopreserved poor-quality embryos

    Cortes, J. L., Sanchez, L., Ligero, G., Gutierrez-Aranda, I., Catalina, P., Elosua, C., Leone, P. E., Montes, R., Bueno, C., Ramos-Mejía, V., Maleno, I., García-Pérez, J. L. & Menendez, P., Aug 2009, In : Human Reproduction. 24, 8, p. 1844-51 8 p.

    Research output: Contribution to journalArticle

  53. 2007
  54. LINE-1 retrotransposition in human embryonic stem cells

    Garcia-Perez, J. L., Marchetto, M. C. N., Muotri, A. R., Coufal, N. G., Gage, F. H., O'Shea, K. S. & Moran, J. V., 1 Jul 2007, In : Human Molecular Genetics. 16, 13, p. 1569-77 9 p.

    Research output: Contribution to journalArticle

  55. Distinct mechanisms for trans-mediated mobilization of cellular RNAs by the LINE-1 reverse transcriptase

    Garcia-Perez, J. L., Doucet, A. J., Bucheton, A., Moran, J. V. & Gilbert, N., May 2007, In : Genome Research. 17, 5, p. 602-11 10 p.

    Research output: Contribution to journalArticle

  56. Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres

    Morrish, T. A., Garcia-Perez, J. L., Stamato, T. D., Taccioli, G. E., Sekiguchi, J. & Moran, J. V., 8 Mar 2007, In : Nature. 446, 7132, p. 208-12 5 p.

    Research output: Contribution to journalArticle

  57. 2006
  58. Cellular inhibitors of long interspersed element 1 and Alu retrotransposition

    Bogerd, H. P., Wiegand, H. L., Hulme, A. E., Garcia-Perez, J. L., O'Shea, K. S., Moran, J. V. & Cullen, B. R., 6 Jun 2006, In : Proceedings of the National Academy of Sciences. 103, 23, p. 8780-5 6 p.

    Research output: Contribution to journalArticle

  59. L1Tc non-LTR retrotransposons from Trypanosoma cruzi contain a functional viral-like self-cleaving 2A sequence in frame with the active proteins they encode

    Heras, S. R., Thomas, M. C., García-Canadas, M., de Felipe, P., García-Pérez, J. L., Ryan, M. D. & López, M. C., Jun 2006, In : Cellular and Molecular Life Sciences. 63, 12, p. 1449-60 12 p.

    Research output: Contribution to journalArticle

  60. Unconventional translation of mammalian LINE-1 retrotransposons

    Alisch, R. S., Garcia-Perez, J. L., Muotri, A. R., Gage, F. H. & Moran, J. V., 15 Jan 2006, In : Genes & Development. 20, 2, p. 210-24 15 p.

    Research output: Contribution to journalArticle

  61. 2005
  62. The L1Tc C-terminal domain from Trypanosoma cruzi non-long terminal repeat retrotransposon codes for a protein that bears two C2H2 zinc finger motifs and is endowed with nucleic acid chaperone activity

    Heras, S. R., López, M. C., García-Pérez, J. L., Martin, S. L. & Thomas, M. C., Nov 2005, In : Molecular and Cellular Biology. 25, 21, p. 9209-20 12 p.

    Research output: Contribution to journalArticle

  63. 2003
  64. Characterization of reverse transcriptase activity of the L1Tc retroelement from Trypanosoma cruzi

    García-Pérez, J. L., González, C. I., Thomas, M. C., Olivares, M. & López, M. C., Dec 2003, In : Cellular and Molecular Life Sciences. 60, 12, p. 2692-701 10 p.

    Research output: Contribution to journalArticle

  65. The endonuclease NL1Tc encoded by the LINE L1Tc from Trypanosoma cruzi protects parasites from daunorubicin DNA damage

    Olivares, M., López, M. C., García-Pérez, J. L., Briones, P., Pulgar, M. & Thomas, M. C., 15 Apr 2003, In : Biochimica et biophysica acta-Bioenergetics. 1626, 1-3, p. 25-32 8 p.

    Research output: Contribution to journalArticle

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