Edinburgh Research Explorer

Dr Karen Mackenzie

ECAT SCREDS Clinical Lecturer in Clinical Genetics

  1. 2017
  2. cGAS surveillance of micronuclei links genome instability to innate immunity

    Mackenzie, K., Carroll, P., Martin, C-A., Murina, O., Fluteau, A., Simpson, D., Olova, N., Sutcliffe, H., Rainger, J. K., Robertson, A., Wheeler, A., Nowotny, M., Gilbert, N., Chandra, T., Reijns, M. & Jackson, A., 24 Aug 2017, In : Nature.

    Research output: Contribution to journalArticle

  3. 2016
  4. Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis

    The DDD Study, Wood, A., Vagnarelli, P. & Jackson, A., Oct 2016, In : Genes & Development.

    Research output: Contribution to journalArticle

  5. Ribonuclease H2 mutations induce a cGASSTING-dependent innate immune response

    Mackenzie, K., Carroll, P., Lettice, L., Tarnauskaite, Z., Reddy, K., Dix, F., Revuelta, A., Abbondati, E., Rigby, R. E., Rabe, B., Kilanowski, F., Grimes, G. R., Fluteau, A., Devenney, P. S., Hill, R., Reijns, M. & Jackson, A., 15 Apr 2016, In : EMBO Journal.

    Research output: Contribution to journalArticle

  6. TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

    MacDonald, M., Murina, O., Leitch, A., Higgs, M., Bicknell, L., Yigit, G., Blackford, A., Zlatanou, A., Mackenzie, K., Reddy, K., Halachev, M., McGlasson, S., Reijns, M., Fluteau, A., Martin, C-A., Sabbioneda, S., Elcioglu, N., Altmuller, J., Thiele, H., Greenhalge, L. & 10 others, Chessa, L., Maghnie, M., Salim, M., Bober, M. B., Nurnberg, P., Jackson, S. P., Hurles, M., Wollnik, B., Stewart, G. S. & Jackson, A., Jan 2016, In : Nature Genetics.

    Research output: Contribution to journalArticle

  7. 2014
  8. Effector and central memory T helper 2 cells respond differently to peptide immunotherapy

    Mackenzie, K. J., Nowakowska, D. J., Leech, M. D., McFarlane, A., Wilson, C., Fitch, P. M., O'connor, R. A., Howie, S. E. M., Schwarze, J. & Anderton, S. M., 25 Feb 2014, In : Proceedings of the National Academy of Sciences. 111, 8, p. E784-93

    Research output: Contribution to journalArticle

  9. RNA: DNA hybrids are a novel molecular pattern sensed by TLR9

    Rigby, R. E., Webb, L. M., Mackenzie, K. J., Li, Y., Leitch, A., Reijns, M. A. M., Lundie, R. J., Revuelta, A., Davidson, D. J., Diebold, S., Modis, Y., Macdonald, A. S. & Jackson, A. P., 10 Feb 2014, In : EMBO Journal. 33, 7, p. 665 - 779

    Research output: Contribution to journalArticle

  10. Viral respiratory tract infections and asthma in early life: cause and effect?

    Mackenzie, K. J., Anderton, S. M. & Schwarze, J., Jan 2014, In : Clinical and Experimental Allergy. 44, 1, p. 9-19 11 p.

    Research output: Contribution to journalLiterature review

  11. 2013
  12. Novel insights into immune and inflammatory responses to respiratory viruses

    Schwarze, J. & Mackenzie, K. J., Jan 2013, In : Thorax. 68, 1, p. 108-110 3 p.

    Research output: Contribution to journalArticle

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