Edinburgh Research Explorer

Dr Luke Boulter

Chancellor's Fellow

  1. TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

    Bird, T., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W-Y., Jamieson, T., Govaere, O., Campbell, A. D., Ferreira Gonzalez, S., Cole, A. M., Hay, T., Simpson, K. J., Clark, W., Hedley, A., Clarke, M., Gentaz, P., Nixon, C., Bryce, S. & 14 others, Kiourtis, C., Sprangers, J., Nibbs, R. J. B., van Rooijen, N., Bartholin, L., McGreal, S. R., Apte, U., Barry, S. T., Iredale, J., Clarke, A. R., Serrano, M., Roskams, T. A., Sansom, O. J. & Forbes, S., 16 Aug 2018, In : Science translational medicine.

    Research output: Contribution to journalArticle

  2. A NOVEL MODEL OF HEPATIC PROGENITOR CELL ACTIVATION USING HEPATOCYTE SPECIFIC MDM2 DELETION DEMONSTRATES COMPLETE PARENCHYMAL REGENERATION FROM PROGENITOR CELLS IN A TWEAK/FN14 DEPENDENT MANNER

    Bird, T. G., Cole, A., Hay, T., Boulter, L. G., Iredale, J. P., Clarke, A. R., Sansom, O. J. & Forbes, S. J., Oct 2010, In : Hepatology. 52, 4, p. 970A-970A 1 p.

    Research output: Contribution to journalMeeting abstract

  3. Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

    Bird, T. G., Lu, W-Y., Boulter, L., Gordon-Keylock, S., Ridgway, R. A., Williams, M. J., Taube, J., Thomas, J. A., Wojtacha, D., Gambardella, A., Sansom, O. J., Iredale, J. P. & Forbes, S. J., 16 Apr 2013, In : Proceedings of the National Academy of Sciences. 110, 16, p. 6542-6547 6 p.

    Research output: Contribution to journalArticle

  4. Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

    Boulter, L., Govaere, O., Bird, T. G., Radulescu, S., Ramachandran, P., Pellicoro, A., Ridgway, R. A., Seo, S. S., Spee, B., Van Rooijen, N., Sansom, O. J., Iredale, J. P., Lowell, S., Roskams, T. & Forbes, S. J., Apr 2012, In : Nature Medicine. 18, 4, p. 572-579 8 p.

    Research output: Contribution to journalArticle

  5. Differentiation of progenitors in the liver: a matter of local choice

    Boulter, L., Lu, W-Y. & Forbes, S. J., 1 May 2013, In : Journal of Clinical Investigation. 123, 5, p. 1867-1873 7 p.

    Research output: Contribution to journalArticle

  6. NOTCH SIGNALLING IS AN IMPORTANT MEDIATOR OF CELL FATE SPECIFICATION DURING HEPATIC PROGENITOR CELL MEDIATED REGENERATION

    Boulter, L. G., Lowell, S. & Forbes, S. J., Apr 2009, In : Journal of Hepatology. 50, Supplement 1, p. S305-S305 1 p.

    Research output: Contribution to journalMeeting abstract

  7. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.

    Boulter, L., Guest, R. V., Kendall, T. J., Wilson, D. H., Wojtacha, D., Robson, A. J., Ridgway, R. A., Samuel, K., Van Rooijen, N., Barry, S. T., Wigmore, S. J., Sansom, O. J. & Forbes, S. J., 3 Mar 2015, In : Journal of Clinical Investigation. 125, 3, p. 1269–1285

    Research output: Contribution to journalArticle

  8. Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers

    Carotenuto, P., Fassan, M., Pandolfo, R., Lampis, A., Vicentini, C., Cascione, L., Paulus-Hock, V., Boulter, L., Guest, R., Quagliata, L., Hahne, J. C., Ridgway, R., Jamieson, T., Athineos, D., Veronese, A., Visone, R., Murgia, C., Ferrari, G., Guzzardo, V., Evans, T. R. J. & 12 others, MacLeod, M., Feng, G. J., Dale, T., Negrini, M., Forbes, S. J., Terracciano, L., Scarpa, A., Patel, T., Valeri, N., Workman, P., Sansom, O. & Braconi, C., Jul 2017, In : Gut.

    Research output: Contribution to journalArticle

  9. Modulation of biliary cancer chemo-resistance through microRNA-mediated rewiring of the expansion of CD133+ cells

    Carotenuto, P., Hedayat, S., Fassan, M., Cardinale, V., Lampis, A., Guzzardo, V., Vicentini, C., Scarpa, A., Cascione, L., Costantini, D., Carpino, G., Alvaro, D., Ghidini, M., Trevisani, F., Te Poele, R., Salati, M., Ventura, S., Vlachogiannis, G., Hahne, J. C., Boulter, L. & 16 others, Forbes, S. J., Guest, R., Cillo, U., Said-Huntingford, I., Begum, R., Smyth, E., Michalarea, V., Cunningham, D., Rimassa, L., Santoro, A., Roncalli, M., Kirnkin, V., Clarke, P., Workman, P., Valeri, N. & Braconi, C., 26 Dec 2019, In : Hepatology.

    Research output: Contribution to journalArticle

  10. Next generation of ALDH substrates and their potential to study maturational lineage biology in stem and progenitor cells

    Dollé, L., Boulter, L., Leclercq, I. A. & van Grunsven, L. A., 1 Apr 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 308, 7, p. G573-8

    Research output: Contribution to journalArticle

  11. EpCAM and the biology of hepatic stem/progenitor cells

    Dollé, L., Theise, N. D., Schmelzer, E., Boulter, L., Gires, O. & van Grunsven, L. A., 15 Feb 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 308, 4, p. G233-G250

    Research output: Contribution to journalArticle

  12. A cell/cilia cycle biosensor for single cell kinetics reveals persistence of cilia after the G1/ S transition is a general property in cells and mice

    Ford, M. J., Yeyati, P., Mali, G., Keighren, M., Waddell, S., Mjoseng, H. K., Douglas, A. T., Hall, E., Sakaue-Sawano, A., Miyawaki, A., Meehan, R., Boulter, L., Jackson, I., Mill, P. & Mort, R., 19 Nov 2018, In : Developmental Cell.

    Research output: Contribution to journalArticle

  13. Cell Lineage Tracing Reveals a Biliary Origin of Intrahepatic Cholangiocarcinoma

    Guest, R. V., Boulter, L., Kendall, T. J., Minnis-Lyons, S., Walker, R., Wigmore, S. J., Sansom, O. J. & Forbes, S. J., 15 Feb 2014, In : Cancer Research. p. 1005-1010

    Research output: Contribution to journalArticle

  14. Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma

    Guest, R., Boulter, L., Dwyer, B. & Forbes, S., 22 May 2017, In : npj Regenerative Medicine.

    Research output: Contribution to journalArticle

  15. Notch3 drives development and progression of cholangiocarcinoma

    Guest, R. V., Boulter, L., Dwyer, B. J., Kendall, T. J., Man, T., Minnis-lyons, S. E., Lu, W., Robson, A. J., Gonzalez, S. F., Raven, A., Wojtacha, D., Morton, J. P., Komuta, M., Roskams, T., Wigmore, S. J., Sansom, O. J. & Forbes, S. J., 25 Oct 2016, In : Proceedings of the National Academy of Sciences. 113, 43, p. 12250-12255 5 p.

    Research output: Contribution to journalArticle

  16. Endogenous notch-driven tumorigenesis functions via notch3 to promote PI3k/AKT mediated cell survival in intrahepatic cholangiocarcinoma

    Guest, R. V., Boulter, L., Kendall, T., Lu, W. -Y., Robson, A., Komuta, M., McKinnon, A., Wotjacha, D., Minnis-Lyons, S. E., Walker, R., Lowell, S., Roskams, T., Wigmore, S., Sansom, O. & Forbes, S. J., May 2014, In : British Journal of Surgery. 101, p. 47-47 1 p.

    Research output: Contribution to journalMeeting abstract

  17. The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

    Hari, P., Millar, F., Tarrats, N., Quintanilla, A., Rink, C., Fernández duran, I., Muir, M., Finch, A., Brunton, V., Passos, J. F., Morton, J. P., Boulter, L. & Acosta, J., 5 Jun 2019, In : Science Advances.

    Research output: Contribution to journalArticle

  18. Galectin-3 regulates hepatic progenitor cell expansion during liver injury

    Hsieh, W. C., Mackinnon, A. C., Lu, W. Y., Jung, J., Boulter, L., Henderson, N. C., Simpson, K. J., Schotanus, B., Wojtacha, D., Bird, T. G., Medine, C. N., Hay, D. C., Sethi, T., Iredale, J. P. & Forbes, S. J., 8 Aug 2015, In : Gut. 64, 2, p. 312-321 10 p.

    Research output: Contribution to journalArticle

  19. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin

    Long, K. R., Moss, L., Laursen, L., Boulter, L. & ffrench-Constant, C., 3 Feb 2016, In : Nature Communications. 10354.

    Research output: Contribution to journalArticle

  20. Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver

    Lorenzini, S., Bird, T. G., Boulter, L., Bellamy, C., Samuel, K., Aucott, R., Clayton, E., Andreone, P., Bernardi, M., Golding, M., Alison, M. R., Iredale, J. P. & Forbes, S. J., 2010, In : Gut. 59, 5, p. 645-654 10 p.

    Research output: Contribution to journalArticle

  21. NOVEL METHOD TO ISOLATE AND EXPAND EPCAM+CD24+CD133+ADULT HEPATIC PROGENITOR CELLS WITH LIVER REPOPULATION CAPACITY

    Lu, W. Y., Tsuchiya, A., Boulter, L., Guest, R. V., Bird, T. G., Williams, M. J., Hay, D. C., Iredale, J. P. & Forbes, S. J., Apr 2013, In : Journal of Hepatology. 58, p. S14-S14 1 p.

    Research output: Contribution to journalMeeting abstract

  22. Hepatic progenitor cells of biliary origin with liver repopulation capacity

    Lu, W-Y., Bird, T., Boulter, L., Tsuchiya, A., Cole, A. M., Hay, T., Guest, R., Wojtacha, D., Man, T. Y., MacKinnon, A., Ridgway, R. A., Kendall, T., Williams, M., Jamieson, T., Raven, A., Hay, D., Iredale, J., Clarke, A., Sansom, O. J. & Forbes, S., Aug 2015, In : Nature Cell Biology. 17, 8

    Research output: Contribution to journalArticle

  23. Galectin-3 Regulates Hepatic Progenitor Cell Expansion During Liver Injury

    Mackinnon, A. C., Hsieh, W. -C., Boulter, L., Wojtacha, D., Lu, W. -Y., Bird, T. G., Hay, D., Jung, J., Sethi, T., Iredale, J. P. & Forbes, S. J., Apr 2013, In : Journal of Hepatology. 58, S1, p. S16-S16 1 p.

    Research output: Contribution to journalMeeting abstract

  24. IMPAIRED MACROPHAGE MEDIATED ELASTIN TURNOVER LIMITS REVERSIBILITY OF LIVER CIRRHOSIS

    Pellicoro, A., Aucott, R., Ramachandran, P., Fallowfield, J., Hartland, S. N., Boulter, L. G., Vernon, M. A., Duffield, J. S., Forbes, S. J. & Iredale, J. P., Oct 2010, In : Hepatology. 52, 4, p. 417A-418A 2 p.

    Research output: Contribution to journalMeeting abstract

  25. The RSPO-LGR4/5-ZNRF3/RNF43 module controls 1 liver zonation and size

    Plana-Paz, L., Orsini, V., Boulter, L., Calabrese, D., Pikiolek, M., Nigsch, F., Xie, Y., Roma, G., Donovan, A., Marti, P., Beckmann, N., Dill, MT., Carbone, W., Bergling, S., Isken, A., Mueller, M., Kinzel, B., Yang, Y., Mao, X., Nicholson, TB. & 13 others, Zamponi, R., Capodieci, P., Valdez, R., Rivera, D., Loew, A., Ukomadu, C., Terracciano, LM., Bouwmeester, T., Cong, F., Heim, MH., Forbes, S., Ruffner, H. & Tchorz, JS., 18 Apr 2016, In : Nature Cell Biology.

    Research output: Contribution to journalArticle

  26. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

    Ramachandran, P., Pellicoro, A., Vernon, M. A., Boulter, L., Aucott, R. L., Ali, A., Hartland, S. N., Snowdon, V. K., Cappon, A., Gordon-Walker, T. T., Williams, M. J., Dunbar, D. R., Manning, J., van Rooijen, N., Fallowfield, J. A., Forbes, S. J. & Iredale, J. P., 2012, In : Proceedings of the National Academy of Sciences. 109, 46, p. E3186-E3195

    Research output: Contribution to journalArticle

  27. NOTCH SIGNALLING WITHIN THE TUMOUR-STROMAL MICROENVIRONMENT DRIVES PROGRESSION OF CHOLANGIOCARCINOMA WHILST PATHWAY INHIBITION ENHANCES CHEMOSENSITIVITY

    Robson, A., Guest, R. V., Boulter, L., Pellicoro, A., Sansom, O. & Forbes, S., Apr 2012, In : Journal of Hepatology. 56, p. S15-S15 1 p.

    Research output: Contribution to journalMeeting abstract

  28. The role of notch signalling within the tumour-stromal microenvironment in cholangiocarcinoma

    Robson, A. J., Guest, R. V., Boulter, L., Iredale, J. P. & Forbes, S. J., 2012, In : British Journal of Surgery. 99, p. 3-3 1 p.

    Research output: Contribution to journalMeeting abstract

  29. Polysialic Acid/Neural Cell Adhesion Molecule Modulates the Formation of Ductular Reactions in Liver Injury

    Tsuchiya, A., Lu, W-Y., Weinhold, B., Boulter, L., Stutchfield, B. M., Williams, M. J., Guest, R. V., Minnis-Lyons, S. E., MacKinnon, A. C., Schwarzer, D., Ichida, T., Nomoto, M., Aoyagi, Y., Gerardy-Schahn, R. & Forbes, S. J., Nov 2014, In : Hepatology. 60, 5, p. 1727-1740 14 p.

    Research output: Contribution to journalArticle

  30. Defining the functional role of laminin isoforms in the adult hepatic progenitor cell response

    Williams, M. J., Boulter, L. G., Bird, T. G., Fujiwara, H., Watt, F., Ffrench-Constant, C. & Forbes, S. J., 27 Feb 2013, In : The Lancet. 381, p. 115-115 1 p.

    Research output: Contribution to journalMeeting abstract

  31. THE EXTRACELLULAR MATRIX PROTEIN LAMININ ALPHA 5 REGULATES THE BEHAVIOUR OF HEPATIC PROGENITOR CELLS IN REGENERATING MOUSE LIVER

    Williams, M. J., Boulter, L. G., Lu, W. -Y., Bird, T. G., Fujiwara, H., Watt, F. M., Ffrench-Constant, C. & Forbes, S. J., Apr 2013, In : Journal of Hepatology. 58, p. S2-S3 2 p.

    Research output: Contribution to journalMeeting abstract

  32. Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

    Wilson, D. H., Jarman, EJ., Mellin, RP., Wilson, M., Waddell, S., Tsokkou, P., Younger, N., Raven, A., Bhalla, SR., Noll, ATR., Olde Damink, S. W. M., Schaap, FG., Chen, P., Bates, D. O., Banales, J. M., Dean, CH., Henderson, D., Sansom, O. J., Kendall, T. & Boulter, L., 23 Jan 2020, In : Nature Communications. 11, 445.

    Research output: Contribution to journalArticle