Edinburgh Research Explorer

Dr Luke Boulter

Chancellor's Fellow

  1. 2020
  2. Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

    Wilson, D. H., Jarman, EJ., Mellin, RP., Wilson, M., Waddell, S., Tsokkou, P., Younger, N., Raven, A., Bhalla, SR., Noll, ATR., Olde Damink, S. W. M., Schaap, FG., Chen, P., Bates, D. O., Banales, J. M., Dean, CH., Henderson, D., Sansom, O. J., Kendall, T. & Boulter, L., 23 Jan 2020, In : Nature Communications. 11, 445.

    Research output: Contribution to journalArticle

  3. 2019
  4. Modulation of biliary cancer chemo-resistance through microRNA-mediated rewiring of the expansion of CD133+ cells

    Carotenuto, P., Hedayat, S., Fassan, M., Cardinale, V., Lampis, A., Guzzardo, V., Vicentini, C., Scarpa, A., Cascione, L., Costantini, D., Carpino, G., Alvaro, D., Ghidini, M., Trevisani, F., Te Poele, R., Salati, M., Ventura, S., Vlachogiannis, G., Hahne, J. C., Boulter, L. & 16 others, Forbes, S. J., Guest, R., Cillo, U., Said-Huntingford, I., Begum, R., Smyth, E., Michalarea, V., Cunningham, D., Rimassa, L., Santoro, A., Roncalli, M., Kirnkin, V., Clarke, P., Workman, P., Valeri, N. & Braconi, C., 26 Dec 2019, In : Hepatology.

    Research output: Contribution to journalArticle

  5. The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

    Hari, P., Millar, F., Tarrats, N., Quintanilla, A., Rink, C., Fernández duran, I., Muir, M., Finch, A., Brunton, V., Passos, J. F., Morton, J. P., Boulter, L. & Acosta, J., 5 Jun 2019, In : Science Advances.

    Research output: Contribution to journalArticle

  6. 2018
  7. A cell/cilia cycle biosensor for single cell kinetics reveals persistence of cilia after the G1/ S transition is a general property in cells and mice

    Ford, M. J., Yeyati, P., Mali, G., Keighren, M., Waddell, S., Mjoseng, H. K., Douglas, A. T., Hall, E., Sakaue-Sawano, A., Miyawaki, A., Meehan, R., Boulter, L., Jackson, I., Mill, P. & Mort, R., 19 Nov 2018, In : Developmental Cell.

    Research output: Contribution to journalArticle

  8. TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

    Bird, T., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W-Y., Jamieson, T., Govaere, O., Campbell, A. D., Ferreira Gonzalez, S., Cole, A. M., Hay, T., Simpson, K. J., Clark, W., Hedley, A., Clarke, M., Gentaz, P., Nixon, C., Bryce, S. & 14 others, Kiourtis, C., Sprangers, J., Nibbs, R. J. B., van Rooijen, N., Bartholin, L., McGreal, S. R., Apte, U., Barry, S. T., Iredale, J., Clarke, A. R., Serrano, M., Roskams, T. A., Sansom, O. J. & Forbes, S., 16 Aug 2018, In : Science translational medicine.

    Research output: Contribution to journalArticle

  9. 2017
  10. Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers

    Carotenuto, P., Fassan, M., Pandolfo, R., Lampis, A., Vicentini, C., Cascione, L., Paulus-Hock, V., Boulter, L., Guest, R., Quagliata, L., Hahne, J. C., Ridgway, R., Jamieson, T., Athineos, D., Veronese, A., Visone, R., Murgia, C., Ferrari, G., Guzzardo, V., Evans, T. R. J. & 12 others, MacLeod, M., Feng, G. J., Dale, T., Negrini, M., Forbes, S. J., Terracciano, L., Scarpa, A., Patel, T., Valeri, N., Workman, P., Sansom, O. & Braconi, C., Jul 2017, In : Gut.

    Research output: Contribution to journalArticle

  11. Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma

    Guest, R., Boulter, L., Dwyer, B. & Forbes, S., 22 May 2017, In : npj Regenerative Medicine.

    Research output: Contribution to journalArticle

  12. 2016
  13. Notch3 drives development and progression of cholangiocarcinoma

    Guest, R. V., Boulter, L., Dwyer, B. J., Kendall, T. J., Man, T., Minnis-lyons, S. E., Lu, W., Robson, A. J., Gonzalez, S. F., Raven, A., Wojtacha, D., Morton, J. P., Komuta, M., Roskams, T., Wigmore, S. J., Sansom, O. J. & Forbes, S. J., 25 Oct 2016, In : Proceedings of the National Academy of Sciences. 113, 43, p. 12250-12255 5 p.

    Research output: Contribution to journalArticle

  14. The RSPO-LGR4/5-ZNRF3/RNF43 module controls 1 liver zonation and size

    Plana-Paz, L., Orsini, V., Boulter, L., Calabrese, D., Pikiolek, M., Nigsch, F., Xie, Y., Roma, G., Donovan, A., Marti, P., Beckmann, N., Dill, MT., Carbone, W., Bergling, S., Isken, A., Mueller, M., Kinzel, B., Yang, Y., Mao, X., Nicholson, TB. & 13 others, Zamponi, R., Capodieci, P., Valdez, R., Rivera, D., Loew, A., Ukomadu, C., Terracciano, LM., Bouwmeester, T., Cong, F., Heim, MH., Forbes, S., Ruffner, H. & Tchorz, JS., 18 Apr 2016, In : Nature Cell Biology.

    Research output: Contribution to journalArticle

  15. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin

    Long, K. R., Moss, L., Laursen, L., Boulter, L. & ffrench-Constant, C., 3 Feb 2016, In : Nature Communications. 10354.

    Research output: Contribution to journalArticle

  16. 2015
  17. Galectin-3 regulates hepatic progenitor cell expansion during liver injury

    Hsieh, W. C., Mackinnon, A. C., Lu, W. Y., Jung, J., Boulter, L., Henderson, N. C., Simpson, K. J., Schotanus, B., Wojtacha, D., Bird, T. G., Medine, C. N., Hay, D. C., Sethi, T., Iredale, J. P. & Forbes, S. J., 8 Aug 2015, In : Gut. 64, 2, p. 312-321 10 p.

    Research output: Contribution to journalArticle

  18. Hepatic progenitor cells of biliary origin with liver repopulation capacity

    Lu, W-Y., Bird, T., Boulter, L., Tsuchiya, A., Cole, A. M., Hay, T., Guest, R., Wojtacha, D., Man, T. Y., MacKinnon, A., Ridgway, R. A., Kendall, T., Williams, M., Jamieson, T., Raven, A., Hay, D., Iredale, J., Clarke, A., Sansom, O. J. & Forbes, S., Aug 2015, In : Nature Cell Biology. 17, 8

    Research output: Contribution to journalArticle

  19. Next generation of ALDH substrates and their potential to study maturational lineage biology in stem and progenitor cells

    Dollé, L., Boulter, L., Leclercq, I. A. & van Grunsven, L. A., 1 Apr 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 308, 7, p. G573-8

    Research output: Contribution to journalArticle

  20. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.

    Boulter, L., Guest, R. V., Kendall, T. J., Wilson, D. H., Wojtacha, D., Robson, A. J., Ridgway, R. A., Samuel, K., Van Rooijen, N., Barry, S. T., Wigmore, S. J., Sansom, O. J. & Forbes, S. J., 3 Mar 2015, In : Journal of Clinical Investigation. 125, 3, p. 1269–1285

    Research output: Contribution to journalArticle

  21. EpCAM and the biology of hepatic stem/progenitor cells

    Dollé, L., Theise, N. D., Schmelzer, E., Boulter, L., Gires, O. & van Grunsven, L. A., 15 Feb 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 308, 4, p. G233-G250

    Research output: Contribution to journalArticle

  22. 2014
  23. Polysialic Acid/Neural Cell Adhesion Molecule Modulates the Formation of Ductular Reactions in Liver Injury

    Tsuchiya, A., Lu, W-Y., Weinhold, B., Boulter, L., Stutchfield, B. M., Williams, M. J., Guest, R. V., Minnis-Lyons, S. E., MacKinnon, A. C., Schwarzer, D., Ichida, T., Nomoto, M., Aoyagi, Y., Gerardy-Schahn, R. & Forbes, S. J., Nov 2014, In : Hepatology. 60, 5, p. 1727-1740 14 p.

    Research output: Contribution to journalArticle

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