Edinburgh Research Explorer

Prof Malcolm Walkinshaw

Chair of Structural Biochemistry

  1. 2019
  2. Pyruvate Kinase regulates the Pentose-Phosphate pathway in Response to Hypoxia in Mycobacterium tuberculosis

    Zhong, W., Guo, J., Cui, L., Chionh, Y. H., Li, K., El Sahili, A., Cai, Q., Yuan, M., Michels, P. A. M., Fothergill-Gilmore, L. A., Walkinshaw, M. D., Mu, Y., Lescar, J. & Dedon, P. C., 2 Aug 2019, In : Journal of Molecular Biology.

    Research output: Contribution to journalArticle

  3. Allosteric effects in cyclophilin mutants may be explained by changes in nano-microsecond time scale motions

    Wapeesittipan, P., Mey, A. S. J. S., Walkinshaw, M. D. & Michel, J., 29 Mar 2019, In : Communications Chemistry. 2, 1, 41.

    Research output: Contribution to journalArticle

  4. The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction

    Fernandes, P. M., Kinkead, J. R., McNae, I. W., Michels, P. A. & Walkinshaw, M. D., 18 Jan 2019, In : Biochemical Journal. 476, 2, p. 179-191 13 p.

    Research output: Contribution to journalArticle

  5. Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing

    Rojas, F., Silvester, E., Young, J., Milne, R., Tettey, M., Houston, D. R., Walkinshaw, M. D., Pérez-Pi, I., Auer, M., Denton, H., Smith, T. K., Thompson, J. & Matthews, K. R., 10 Jan 2019, In : Cell. 176, 1-2, p. 306-317.e16 28 p.

    Research output: Contribution to journalArticle

  6. 2018
  7. Demonstration of the Anthelmintic Potency of Marimastat in the Heligmosomoides Polygyrus Rodent Model

    Robertson, E., Harcus, Y., Johnston, C. J. C., Page, A. P., Walkinshaw, M. D., Maizels, R. M. & Houston, D., 1 Dec 2018, In : Journal of parasitology. 104, 6, p. 705-709 5 p.

    Research output: Contribution to journalArticle

  8. Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation

    Mitchell, A. R., Yuan, M., Morgan, H. P., McNae, I. W., Blackburn, E. A., LeBihan, T., Homem, R. A., Yu, M., Loake, G. J., Michels, P. A., Wear, M. A. & Walkinshaw, M. D., 31 Oct 2018, In : Biochemical Journal. 475, 20, p. 3275-3291 17 p.

    Research output: Contribution to journalArticle

  9. An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

    Yuan, M., McNae, I. W., Chen, Y., Blackburn, E. A., Wear, M. A., Michels, P. A. M., Fothergill-Gilmore, L. A., Hupp, T. & Walkinshaw, M. D., 31 May 2018, In : Biochemical Journal. 475, 10, p. 1821-1837 17 p.

    Research output: Contribution to journalArticle

  10. Molecular Dynamics Simulations of Site Point Mutations in the TPR domain of Cyclophilin 40 Identify Conformational States with Distinct Dynamic and Enzymatic Properties

    Gur, M., Blackburn, E., Ning, J., Narayan, V., Ball, K., Walkinshaw, M. & Erman, B., 9 Apr 2018, In : The Journal of Chemical Physics. 148, 145101.

    Research output: Contribution to journalArticle

  11. 2017
  12. Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis

    Zhong, W., Cui, L., Goh, B. C., Cai, Q., Ho, P., Chionh, Y. H., Yuan, M., Sahili, A. E., Fothergill-Gilmore, L. A., Walkinshaw, M. D., Lescar, J. & Dedon, P. C., 7 Dec 2017, In : Nature Communications. 8, 1, 14 p., 1986.

    Research output: Contribution to journalArticle

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