Edinburgh Research Explorer

Dr Melanie Leech

(Former employee or visitor)

  1. 2019
  2. PD-1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state

    Mair, I., Besusso, D., Saul, L., Patel, S. D., Ravindran, R., McPherson, R. C., Leech, M. D., O'Connor, R. A., Anderton, S. M. & Mellanby, R. J., Jan 2019, In : European Journal of Immunology. 49, 1, p. 112-120

    Research output: Contribution to journalArticle

  3. 2018
  4. A Context-Dependent Role for αv Integrins in Regulatory T Cell Accumulation at Sites of Inflammation

    Mair, I., Zandee, S. E. J., Toor, I. S., Saul, L., Mcpherson, R. C., Leech, M. D., Smyth, D. J., O’connor, R. A., Henderson, N. C. & Anderton, S. M., 26 Feb 2018, In : Frontiers in Immunology. 9

    Research output: Contribution to journalArticle

  5. 2017
  6. IL-10-producing, ST2-expressing Foxp3(+) T cells in multiple sclerosis brain lesions

    Zandee, S. E. J., O'Connor, R. A., Mair, I., Leech, M. D., Williams, A. & Anderton, S. M., 7 Feb 2017, In : Immunology and Cell Biology.

    Research output: Contribution to journalArticle

  7. 2015
  8. 1,25-Dihydroxyvitamin D3-Conditioned CD11c+ Dendritic Cells are Effective Initiators of CNS Autoimmune Disease

    Besusso, D., Saul, L., Leech, M. D., O'Connor, R. A., Macdonald, A. S., Anderton, S. M. & Mellanby, R. J., 18 Nov 2015, In : Frontiers in Immunology. 6, 575.

    Research output: Contribution to journalArticle

  9. Methods for Ex Vivo Analysis of Immune Cell Function from the Central Nervous System

    Turner, D. G., Leech, M. D., O'Connor, R. A. & Anderton, S. M., Apr 2015, Multiple Sclerosis: Methods and Protocols. SpringerLink, Vol. 1304. p. 81-90 10 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  10. 2014
  11. Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4(+) T cells tolerized by peptide immunotherapy

    McPherson, R. C., Konkel, J. E., Prendergast, C. T., Thomson, J. P., Ottaviano, R., Leech, M. D., Kay, O., Zandee, S. E. J., Sweenie, C. H., Wraith, D. C., Meehan, R. R., Drake, A. J. & Anderton, S. M., 29 Dec 2014, In : eLIFE. 3, 37 p.

    Research output: Contribution to journalArticle

  12. Characterisation of immune cell infiltrates in the lesions of multiple sclerosis patients

    Zandee, S. E., Leech, M. D., Williams, A. & Anderton, S. M., Dec 2014, In : Immunology . 143, p. 140-140 1 p.

    Research output: Contribution to journalMeeting abstract

  13. Epigenetic modification of the PD-1 promoter in antigen-experienced autoreactive T-cells following peptide-immunotherapy

    McPherson, R. C., Konkel, J. E., Leech, M. D., Thomson, J. P., Ottaviano, R., Meehan, R. R., Drake, A. J. & Anderton, S. M., Dec 2014, In : Immunology . 143, p. 141-141 1 p.

    Research output: Contribution to journalMeeting abstract

  14. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

    Shen, P., Roch, T., Lampropoulou, V., O'Connor, R. A., Stervbo, U., Hilgenberg, E., Ries, S., Van Duc Dang, N. V., Jaimes, Y., Daridon, C., Li, R., Jouneau, L., Boudinot, P., Wilantri, S., Sakwa, I., Miyazaki, Y., Leech, M. D., McPherson, R. C., Wirtz, S., Neurath, M. & 11 othersHoehlig, K., Meinl, E., Gruetzkau, A., Gruen, J. R., Horn, K., Kuehl, A. A., Doerner, T., Bar-Or, A., Kaufmann, S. H. E., Anderton, S. M. & Fillatreau, S., 20 Mar 2014, In : Nature. 507, 7492, p. 366-+ 23 p.

    Research output: Contribution to journalArticle

  15. Effector and central memory T helper 2 cells respond differently to peptide immunotherapy

    Mackenzie, K. J., Nowakowska, D. J., Leech, M. D., McFarlane, A., Wilson, C., Fitch, P. M., O'connor, R. A., Howie, S. E. M., Schwarze, J. & Anderton, S. M., 25 Feb 2014, In : Proceedings of the National Academy of Sciences. 111, 8, p. E784-93

    Research output: Contribution to journalArticle

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