Edinburgh Research Explorer

Prof Moira Whyte

Vice-Principal & Head of College of Medicine & Vet Medicine

  1. A Bayesian approach to copy-number-polymorphism analysis in nuclear pedigrees

    Kosta, K., Sabroe, I., Goeke, J., Nibbs, R. J., Tsanakas, J., Whyte, M. K. & Teare, M. D., Oct 2007, In : American Journal of Human Genetics. 81, 4, p. 808-812 5 p.

    Research output: Contribution to journalArticle

  2. A Cardinal Role for Cathepsin D in Co-Ordinating the Host-Mediated Apoptosis of Macrophages and Killing of Pneumococci

    Bewley, M. A., Marriott, H. M., Tulone, C., Francis, S. E., Mitchell, T. J., Read, R. C., Chain, B., Kroemer, G., Whyte, M. K. B. & Dockrell, D., 27 Jan 2011, In : Plos Pathogens. 7, 1, 17 p., 1001262.

    Research output: Contribution to journalArticle

  3. A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism

    Robertson, A. L., Holmes, G. R., Bojarczuk, A. N., Burgon, J., Loynes, C. A., Chimen, M., Sawtell, A. K., Hamza, B., Willson, J., Walmsley, S. R., Anderson, S. R., Coles, M. C., Farrow, S. N., Solari, R., Jones, S., Prince, L. R., Irimia, D., Rainger, G. E., Kadirkamanathan, V., Whyte, M. K. B. & 1 others, Renshaw, S. A., 26 Feb 2014, In : Science Translational Medicine. 6, 225, 10 p., 225ra29.

    Research output: Contribution to journalArticle

  4. A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia

    Marriott, H. M., Daigneault, M., Thompson, A. A. R., Walmsley, S. R., Gill, S. K., Witcher, D. R., Wroblewski, V. J., Hellewell, P. G., Whyte, M. K. B. & Dockrell, D., Nov 2012, In : Thorax. 67, 11, p. 985-992 8 p.

    Research output: Contribution to journalArticle

  5. A large-scale, consortium-based genomewide association study of asthma

    Moffatt, M. F., Gut, I. G., Demenais, F., Strachan, D. P., Bouzigon, E., Heath, S., von Mutius, E., Farrall, M., Lathrop, M., GABRIEL Consortium, Whyte, M. & Cookson, W. O. C. M., 23 Sep 2010, In : New England Journal of Medicine. 363, 13, p. 1211-21 11 p.

    Research output: Contribution to journalArticle

  6. A local circadian clock calls time on lung inflammation

    Thompson, A. A. R., Walmsley, S. R. & Whyte, M. K. B., Aug 2014, In : Nature Medicine. 20, 8, p. 809-811 3 p.

    Research output: Contribution to journalEditorial

  7. A method for the in vivo measurement of zebrafish tissue neutrophil lifespan

    Dixon, G., Elks, P. M., Loynes, C. A., Whyte, M. K. B. & Renshaw, S. A., 2012, In : ISRN hematology. 2012, 915868.

    Research output: Contribution to journalArticle

  8. A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension

    Arnold, N. D., Pickworth, J. A., West, L. E., Dawson, S., Carvalho, J. A., Casbolt, H., Braithwaite, A. T., Iremonger, J., Renshall, L., Germaschewski, V., McCourt, M., Bland-Ward, P., Kowash, H., Hameed, A. G., Rothman, A. M. K., Frid, M. G., Roger Thompson, A. A., Evans, H. R., Southwood, M., Morrell, N. W. & 7 others, Crossman, D. C., Whyte, M. K. B., Stenmark, K. R., Newman, C. M., Kiely, D. G., Francis, S. E. & Lawrie, A., 15 Nov 2019, In : Nature Communications. 10, 1, p. 5183

    Research output: Contribution to journalArticle

  9. Activation of hypoxia-inducible factor-1 alpha (Hif-1 alpha) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model

    Elks, P. M., van Eeden, F. J., Dixon, G., Wang, X., Reyes-Aldasoro, C. C., Ingham, P. W., Whyte, M. K. B., Walmsley, S. R. & Renshaw, S. A., 21 Jul 2011, In : Blood. 118, 3, p. 712-722 11 p.

    Research output: Contribution to journalArticle

  10. Alpha-nicotinic acetylcholine receptor and tobacco smoke exposure: effects on bronchial hyperresponsiveness in children

    Torjussen, T. M., Lødrup Carlsen, K. C., Munthe-Kaas, M. C., Mowinckel, P., Carlsen, K-H., Helms, P. J., Gerritsen, J., Whyte, M. K., Lenney, W., Undlien, D. E., Shianna, K. V., Zhu, G. & Pillai, S. G., Feb 2012, In : Pediatric Allergy and Immunology. 23, 1, p. 40-9 10 p.

    Research output: Contribution to journalArticle

  11. Alveolar Macrophage Apoptosis-Associated Bacterial Killing Helps Prevent Murine Pneumonia

    Preston, J. A., Bewley, M. A., Marriott, H. M., Houghton, A. M., Mohasin, M., Jubrail, J., Morris, L., Stephenson, Y. L., Cross, S., Greaves, D. R., Craig, R. W., van Rooijen, N., Bingle, C. D., Read, R. C., Mitchell, T. J., Whyte, M. K. B., Shapiro, S. D. & Dockrell, D. H., 16 Jan 2019, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

  12. Association of PTGDR gene polymorphisms with asthma in two Caucasian populations

    Zhu, G., Vestbo, J., Lenney, W., Silverman, M., Whyte, M., Helms, P., Anderson, W. H. & Pillai, S. G., Jul 2007, In : Genes and Immunity. 8, 5, p. 398-403 6 p.

    Research output: Contribution to journalArticle

  13. Coeliac disease and risk of tuberculosis: a population-based cohort study

    Sanders, D. S., West, J. & Whyte, M. K. B., Jan 2007, In : Thorax. 62, 1, p. 1-2 2 p.

    Research output: Contribution to journalEditorial

  14. Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae

    Marriott, H. M., Hellewell, P. G., Whyte, M. K. B. & Dockrell, D., 22 Mar 2007, In : Vaccine. 25, 13, p. 2485-2490 6 p.

    Research output: Contribution to journalArticle

  15. Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages

    COPDMAP consortium, 10 Oct 2019, In : European Respiratory Journal. 54, 4

    Research output: Contribution to journalArticle

  16. Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis

    McGrath, E. E., Lawrie, A., Marriott, H. M., Mercer, P., Cross, S. S., Arnold, N., Singleton, V., Thompson, A. A. R., Walmsley, S. R., Renshaw, S. A., Sabroe, I., Chambers, R. C., Dockrell, D. & Whyte, M. K. B., Sep 2012, In : Thorax. 67, 9, p. 796-803 8 p.

    Research output: Contribution to journalArticle

  17. Delayed Neutrophil Apoptosis Enhances NET Formation in Cystic Fibrosis

    Gray, R. D., Hardisty, G., Regan, K. H., Smith, M., Robb, C. T., Duffin, R., Mackellar, A., Felton, J. M., Paemka, L., McCullagh, B. N., Lucas, C. D., David, D., McKone, E. F., Cooke, G., Donnelly, S. C., Singh, P. K., Stoltz, D. A., Haslett, C., McCray, P. B., Whyte, M. K. B. & 2 others, Rossi, A. G. & Davidson, D. J., 15 Sep 2017, In : Thorax.

    Research output: Contribution to journalArticle

  18. Development of a Consensus Statement for the Definition, Diagnosis, and Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis Using the Delphi Technique

    Maher, T. M., Whyte, M. K. B., Hoyles, R. K., Parfrey, H., Ochiai, Y., Mathieson, N., Turnbull, A., Williamson, N. & Bennett, B. M., 23 Oct 2015, In : Journal of cancer research and therapeutics.

    Research output: Contribution to journalArticle

  19. Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD

    Bewley, M. A., Belchamber, K. B. R., Chana, K. K., Budd, R. C., Donaldson, G., Wedzicha, J. A., Brightling, C. E., Kilty, I., Donnelly, L. E., Barnes, P. J., Singh, D., Whyte, M. K. B., Dockrell, D. & COPDMAP, 28 Sep 2016, In : PLoS ONE. 11, 9, p. e0163139

    Research output: Contribution to journalArticle

  20. Distinct Cell Death Programs in Monocytes Regulate Innate Responses Following Challenge with Common Causes of Invasive Bacterial Disease

    Webster, S. J., Daigneault, M., Bewley, M. A., Preston, J. A., Marriott, H. M., Walmsley, S. R., Read, R. C., Whyte, M. K. B. & Dockrell, D., 1 Sep 2010, In : Journal of Immunology. 185, 5, p. 2968-2979 12 p.

    Research output: Contribution to journalArticle

  21. Drift-diffusion analysis of neutrophil migration during inflammation resolution in a zebrafish model

    Holmes, G. R., Dixon, G., Anderson, S. R., Reyes-Aldasoro, C. C., Elks, P. M., Billings, S. A., Whyte, M. K. B., Kadirkamanathan, V. & Renshaw, S. A., 17 Aug 2012, In : Advances in Hematology. 2012, 792163.

    Research output: Contribution to journalArticle

  22. Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance

    Marriott, H. M., Bingle, C. D., Read, R. C., Braley, K. E., Kroemer, G., Hellewell, P. G., Craig, R. W., Whyte, M. K. B. & Dockrell, D. H., Feb 2005, In : Journal of Clinical Investigation. 115, 2, p. 359-68 10 p.

    Research output: Contribution to journalArticle

  23. Effective Caspase Inhibition Blocks Neutrophil Apoptosis and Reveals Mcl-1 as Both a Regulator and a Target of Neutrophil Caspase Activation

    Wardle, D. J., Burgon, J., Sabroe, I., Bingle, C. D., Whyte, M. K. B. & Renshaw, S. A., 6 Jan 2011, In : PLoS ONE. 6, 1, 7 p., 15768.

    Research output: Contribution to journalArticle

  24. Experimental validation of the hyperpolarized (129) Xe chemical shift saturation recovery technique in healthy volunteers and subjects with interstitial lung disease

    Stewart, N. J., Leung, G., Norquay, G., Marshall, H., Parra-Robles, J., Murphy, P. S., Schulte, R. F., Elliot, C., Condliffe, R., Griffiths, P. D., Kiely, D. G., Whyte, M. K., Wolber, J. & Wild, J. M., 8 Aug 2014, In : Magnetic Resonance in Medicine.

    Research output: Contribution to journalArticle

  25. Factor analysis in the Genetics of Asthma International Network family study identifies five major quantitative asthma phenotypes

    Pillai, S. G., Tang, Y., van den Oord, E., Klotsman, M., Barnes, K., Carlsen, K., Gerritsen, J., Lenney, W., Silverman, M., Sly, P., Sundy, J., Tsanakas, J., von Berg, A., Whyte, M., Ortega, H. G., Anderson, W. H. & Helms, P. J., Mar 2008, In : Clinical and Experimental Allergy. 38, 3, p. 421-429 9 p.

    Research output: Contribution to journalArticle

  26. Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study

    Allen, R. J., Porte, J., Braybrooke, R., Flores, C., Fingerlin, T. E., Oldham, J. M., Guillen-Guio, B., Ma, S-F., Okamoto, T., John, A. E., Obeidat, M., Yang, I. V., Henry, A., Hubbard, R. B., Navaratnam, V., Saini, G., Thompson, N., Booth, H. L., Hart, S. P., Hill, M. R. & 23 others, Hirani, N., Maher, T. M., McAnulty, R. J., Millar, A. B., Molyneaux, P. L., Parfrey, H., Rassl, D. M., Whyte, M. K. B., Fahy, W. A., Marshall, R. P., Oballa, E., Bossé, Y., Nickle, D. C., Sin, D. D., Timens, W., Shrine, N., Sayers, I., Hall, I. P., Noth, I., Schwartz, D. A., Tobin, M. D., Wain, L. V. & Jenkins, R. G., Nov 2017, In : The Lancet Respiratory Medicine. 5, 11, p. 869-880 12 p.

    Research output: Contribution to journalArticle

  27. Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

    Allen, R. J., Guillen-Guio, B., Oldham, J. M., Ma, S-F., Dressen, A., Paynton, M. L., Kraven, L. M., Obeidat, M., Li, X., Ng, M., Braybrooke, R., Molina-Molina, M., Hobbs, B. D., Putman, R. K., Sakornsakolpat, P., Booth, H. L., Fahy, W. A., Hart, S. P., Hill, M. R., Hirani, N. & 46 others, Hubbard, R. B., McAnulty, R. J., Millar, A. B., Navaratnam, V., Oballa, E., Parfrey, H., Saini, G., Whyte, M. K. B., Zhang, Y., Kaminski, N., Adegunsoye, A., Strek, M. E., Neighbors, M., Sheng, X. R., Gudmundsson, G., Gudnason, V., Hatabu, H., Lederer, D. J., Manichaikul, A., Newell, J. D., O'Connor, G. T., Ortega, V. E., Xu, H., Fingerlin, T. E., Bossé, Y., Hao, K., Joubert, P., Nickle, D. C., Sin, D. D., Timens, W., Furniss, D., Morris, A. P., Zondervan, K., Hall, I. P., Sayers, I., Tobin, M. D., Maher, T. M., Cho, M. H., Hunninghake, G. M., Schwartz, D. A., Yaspan, B. L., Molyneaux, P. L., Flores, C., Noth, I., Jenkins, R. G. & Wain, L. V., 11 Nov 2019, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

  28. HIF-mediated innate immune responses: cell signaling and therapeutic implications

    AJ, H., Thompson, A. A. R., Whyte, M. & Walmsley, S., May 2014, In : Hypoxia. 2, p. 47-58

    Research output: Contribution to journalLiterature review

  29. Hypoxia Hypoxia, hypoxia inducible factor and myeloid cell function

    Walmsley, S. R., Chilvers, E. R. & Whyte, M. K. B., 2009, In : Arthritis research & therapy. 11, 2, 7 p., 219.

    Research output: Contribution to journalLiterature review

  30. Hypoxia Selectively Inhibits Respiratory Burst Activity and Killing of Staphylococcus aureus in Human Neutrophils

    McGovern, N. N., Cowburn, A. S., Porter, L., Walmsley, S. R., Summers, C., Thompson, A. A. R., Anwar, S., Willcocks, L. C., Whyte, M. K. B., Condliffe, A. M. & Chilvers, E. R., Jan 2011, In : Journal of Immunology. 186, 1, p. 453-463 11 p.

    Research output: Contribution to journalArticle

  31. Hypoxia and reprogramming of host pathogen interactions

    Ryan, E. M., Whyte, M. K. & Walmsley, S. R., 27 Nov 2018, In : Current opinion in physiology. 7, p. 15-20

    Research output: Contribution to journalArticle

  32. Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism

    Thompson, A. A. R., Dickinson, R., Murphy, F., Thomson, J. P., Marriott, H. M., Tavares, A., Willson, J. A., Williams, L., Lewis, A., Mirchandani, A., Dos Santos Coelho, P., Doherty, C., Ryan, E., Watts, E., Morton, N. M., Forbes, S., Stimson, R. H., Hameed, A. G., Arnold, N., Preston, J. A. & 15 others, Lawrie, A., Finisguerra, V., Mazzone, M., Sadiku, P., Goveia, J., Taverna, F., Carmeliet, P., Foster, S. J., Chilvers, E. R., Cowburn, A. S., Dockrell, D. H., Johnson, R. S., Meehan, R. R., Whyte, M. K. B. & Walmsley, S. R., 10 Feb 2017, In : Science Immunology. 2, 8, eaal2861.

    Research output: Contribution to journalArticle

  33. Hypoxia, the HIF pathway and neutrophilic inflammatory responses

    Thompson, A. A. R., Binham, J., Plant, T., Whyte, M. K. B. & Walmsley, S. R., Apr 2013, In : Biological Chemistry. 394, 4, p. 471-477 7 p.

    Research output: Contribution to journalLiterature review

  34. Hypoxia-inducible factor 2 alpha regulates key neutrophil functions in humans, mice, and zebrafish

    Thompson, A. A. R., Elks, P. M., Marriott, H. M., Eamsamarng, S., Higgins, K. R., Lewis, A., Williams, L., Parmar, S., Shaw, G., McGrath, E. E., Formenti, F., Van Eeden, F. J., Kinnula, V. L., Pugh, C. W., Sabroe, I., Dockrell, D. H., Chilvers, E. R., Robbins, P. A., Percy, M. J., Simon, M. C. & 4 others, Johnson, R. S., Renshaw, S. A., Whyte, M. K. B. & Walmsley, S. R., 16 Jan 2014, In : Blood. 123, 3, p. 366-376 11 p.

    Research output: Contribution to journalArticle

  35. IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo.

    Harris, A. J., Mirchandani, A. S., Lynch, R. W., Murphy, F., Delaney, L., Small, D., Coelho, P., Watts, E. R., Sadiku, P., Griffith, D., Dickinson, R. S., Clark, E., Willson, J. A., Morrison, T., Mazzone, M., Carmeliet, P., Ghesquiere, B., O'kane, C., Mcauley, D., Jenkins, S. J. & 2 others, Whyte, M. K. B. & Walmsley, S. R., 8 Mar 2019, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

  36. Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation

    White, J. H., Chiano, M., Wigglesworth, M., Geske, R., Riley, J., White, N., Hall, S., Zhu, G., Maurio, F., Savage, T., Anderson, W., Cordy, J., Ducceschi, M., GAIN investigators, Whyte, M., Vestbo, J. & Pillai, S. G., 1 Jul 2008, In : Human Molecular Genetics. 17, 13, p. 1890-903 14 p.

    Research output: Contribution to journalArticle

  37. Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

    Robertson, A. L., Ogryzko, N. V., Henry, K. M., Loynes, C. A., Foulkes, M. J., Meloni, M. M., Wang, X., Ford, C., Jackson, M., Ingham, P. W., Wilson, H. L., Farrow, S. N., Solari, R., Flower, R. J., Jones, S., Whyte, M. K. B. & Renshaw, S. A., 14 Apr 2016, In : Disease Models & Mechanisms.

    Research output: Contribution to journalArticle

  38. Idiopathic pulmonary fibrosis

    Hoo, Z. H. & Whyte, M. K. B., Aug 2012, In : Thorax. 67, 8, p. 742-746 5 p.

    Research output: Contribution to journalLiterature review

  39. Impaired mitochondrial microbicidal responses in chronic obstructive pulmonary disease macrophages

    Bewley, M. A., Preston, J. A., Mohasin, M., Marriott, H. M., Budd, R. C., Swales, J., Collini, P., Greaves, D. R., Craig, R. W., Brightling, C. E., Donnelly, L. E., Barnes, P. J., Singh, D., Shapiro, S. D., Whyte, M. K. B. & Dockrell, D. H., 30 May 2017, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

  40. Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa

    Bianchi, S. M., Prince, L. R., McPhillips, K., Allen, L., Marriott, H. M., Taylor, G. W., Hellewell, P. G., Sabroe, I., Dockrell, D., Henson, P. W. & Whyte, M. K. B., 1 Jan 2008, In : American Journal of Respiratory and Critical Care Medicine. 177, 1, p. 35-43 9 p.

    Research output: Contribution to journalArticle

  41. Incapacitating the immune system in cystic fibrosis

    Sabroe, I. & Whyte, M. K. B., Dec 2007, In : Nature Medicine. 13, 12, p. 1417-1418 3 p.

    Research output: Contribution to journalEditorial

  42. Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

    Rahman, A., Henry, K. M., Herman, K. D., Thompson, A. A., Isles, H. M., Tulotta, C., Sammut, D., Rougeot, J. J., Khoshaein, N., Reese, A. E., Higgins, K., Tabor, C., Sabroe, I., Zuercher, W. J., Savage, C. O., Meijer, A. H., Whyte, M. K., Dockrell, D. H., Renshaw, S. A. & Prince, L. R., 15 Oct 2019, In : eLIFE. 8

    Research output: Contribution to journalArticle

  43. Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y(11) receptor

    Vaughan, K. R., Stokes, L., Prince, L. R., Marriott, H. M., Meis, S., Kassack, M. U., Bingle, C. D., Sabroe, I., Surprenant, A. & Whyte, M. K. B., 15 Dec 2007, In : Journal of Immunology. 179, 12, p. 8544-8553 10 p.

    Research output: Contribution to journalArticle

  44. Interleukin 18 receptor 1 gene polymorphisms are associated with asthma

    Zhu, G., Whyte, M. K. B., Vestbo, J., Carlsen, K., Carlsen, K-H., Lenney, W., Silverman, M., Helms, P. & Pillai, S. G., Sep 2008, In : European Journal of Human Genetics. 16, 9, p. 1083-1090 8 p.

    Research output: Contribution to journalArticle

  45. Interleukin-1 beta Regulates CXCL8 Release and Influences Disease Outcome in Response to Streptococcus pneumoniae, Defining Intercellular Cooperation between Pulmonary Epithelial Cells and Macrophages

    Marriott, H. M., Gascoyne, K. A., Gowda, R., Geary, I., Nicklin, M. J. H., Iannelli, F., Pozzi, G., Mitchell, T. J., Whyte, M. K. B., Sabroe, I. & Dockrell, D., Mar 2012, In : Infection and Immunity. 80, 3, p. 1140-1149 10 p.

    Research output: Contribution to journalArticle

  46. Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society

    Bradley, B., Branley, H. M., Egan, J. J., Greaves, M. S., Hansell, D. M., Harrison, N. K., Hirani, N., Hubbard, R., Lake, F., Millar, A. B., Wallace, W. A. H., Wells, A. U., Whyte, M., Wilsher, M. L. & British Thoracic Society Interstitial Lung Disease Guideline Group, British Thoracic Society Standards of Care Committee, 2008, In : Thorax. 63 Suppl 5, p. v1-58

    Research output: Contribution to journalArticle

  47. Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis

    Kiss, J., Mollenhauer, M., Walmsley, S. R., Kirchberg, J., Radhakrishnan, P., Niemietz, T., Dudda, J., Steinert, G., Whyte, M. K. B., Carmeliet, P., Mazzone, M., Weitz, J. & Schneider, M., 15 Aug 2012, In : Journal of Immunology. 189, 4, p. 1955-1965 11 p.

    Research output: Contribution to journalArticle

  48. Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease

    Prince, L. R., Maxwell, N. C., Gill, S. K., Dockrell, D. H., Sabroe, I., McGreal, E. P., Kotecha, S. & Whyte, M. K., 12 Aug 2014, In : PLoS ONE. 9, 8, p. e103059

    Research output: Contribution to journalArticle

  49. Modeling inflammation in the Zebrafish: How a fish can help us understand lung disease

    Renshaw, S. A., Loynes, C. A., Elworthy, S., Ingham, P. W. & Whyte, M. K. B., Dec 2007, In : Experimental Lung Research. 33, 10, p. 549-554 6 p.

    Research output: Contribution to journalArticle

  50. Monocytes Regulate the Mechanism of T-cell Death by Inducing Fas-Mediated Apoptosis during Bacterial Infection

    Daigneault, M., De Silva, T. I., Bewley, M. A., Preston, J. A., Marriott, H. M., Mitchell, A. M., Mitchell, T. J., Read, R. C., Whyte, M. K. B. & Dockrell, D., 19 Jul 2012, In : Plos Pathogens. 8, 7, 16 p., 1002814.

    Research output: Contribution to journalArticle

  51. Mutations in Succinate Dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1alpha expression

    Jones, R., McDonald, K. E., Willson, J. A., Ghesquiere, B., Sammut, D., Daniel, E., Harris, A., Lewis, A., Thompson, A. A. R., Dickinson, R., Plant, T., Murphy, F., Sadiku, P., Keevil, B. G., Carmeliet, P., Whyte, M. K. B., Newell-Price, J. & Walmsley, S. R., 26 May 2016, In : Blood.

    Research output: Contribution to journalArticle

  52. NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival

    Prince, L. R., Dannewitz Prosseda, S., Higgins, K., Carlring, J., Prestwich, E. C., Ogryzko, N. V., Rahman, A., Basran, A., Falciani, F., Taylor, P., Renshaw, S. A., Whyte, M. K. B. & Sabroe, I., 21 Jun 2017, In : Blood.

    Research output: Contribution to journalArticle

  53. Neutrophil apoptosis in infectious disease

    Anwar, S. & Whyte, M. K. B., Dec 2007, In : Experimental Lung Research. 33, 10, p. 519-528 10 p.

    Research output: Contribution to journalLiterature review

  54. Neutrophil energetics and oxygen sensing

    Walmsley, S. R. & Whyte, M. K. B., 1 May 2014, In : Blood. 123, 18, p. 2753-2754 4 p.

    Research output: Contribution to journalEditorial

  55. Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis

    Walmsley, S. R., Cowburn, A. S., Clatworthy, M. R., Morrell, N. W., Roper, E. C., Singleton, V., Maxwell, P., Whyte, M. K. B. & Chilvers, E. R., 1 Nov 2006, In : Blood. 108, 9, p. 3176-3178 3 p.

    Research output: Contribution to journalArticle

  56. Opinion - Identifying and hurdling obstacles to translational research

    Sabroe, I., Dockrell, D., Vogel, S. N., Renshaw, S. A., Whyte, M. K. B. & Dower, S. K., Jan 2007, In : Nature Reviews Immunology. 7, 1, p. 77-82 6 p.

    Research output: Contribution to journalComment/debate

  57. Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists

    Bewley, M. A., Budd, R. C., Ryan, E., Cole, J., Collini, P., Marshall, J., Kolsum, U., Beech, G., Emes, R. D., Tcherniaeva, I., Berbers, G. A. M., Walmsley, S. R., Donaldson, G., Wedzicha, J. A., Kilty, I., Rumsey, W., Sanchez, Y., Brightling, C. E., Donnelly, L. E., Barnes, P. J. & 4 others, Singh, D., Whyte, M. K. B., Dockrell, D. H. & COPDMAP, 16 Mar 2018, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

  58. PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

    Loynes, C. A., Lee, J. A., Robertson, A. L., Steel, M. J. G., Ellett, F., Feng, Y., Levy, B. D., Whyte, M. & Renshaw, S. A., 5 Sep 2018, In : Science Advances.

    Research output: Contribution to journalArticle

  59. Pathological networking: a new approach to understanding COPD

    Sabroe, I., Parker, L. C., Calverley, P. M. A., Dower, S. K. & Whyte, M. K. B., May 2008, In : Postgraduate Medical Journal. 84, 991, p. 259-264 6 p.

    Research output: Contribution to journalLiterature review

  60. Pathological networking: A new approach to understanding COPD

    Sabroe, I., Parker, L. C., Calverley, P. M. A., Dower, S. K. & Whyte, M. K. B., Aug 2007, In : Thorax. 62, 8, p. 733-738 6 p.

    Research output: Contribution to journalLiterature review

  61. Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils

    Dick, E. P., Prince, L. R., Prestwich, E. C., Renshaw, S. A., Whyte, M. K. B. & Sabroe, I., Jun 2009, In : Immunology . 127, 2, p. 249-255 7 p.

    Research output: Contribution to journalArticle

  62. Pellino-1 selectively regulates epithelial cell responses to rhinovirus

    Bennett, J. A., Prince, L. R., Parker, L. C., Stokes, C. A., de Bruin, H. G., van den Berge, M., Heijink, I. H., Whyte, M. K. & Sabroe, I., Jun 2012, In : Journal of Virology. 86, 12, p. 6595-604 10 p.

    Research output: Contribution to journalArticle

  63. Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish

    Loynes, C. A., Martin, J. S., Robertson, A., Trushell, D. M. I., Ingham, P. W., Whyte, M. K. B. & Renshaw, S. A., Feb 2010, In : Journal of Leukocyte Biology. 87, 2, p. 203-212 10 p.

    Research output: Contribution to journalArticle

  64. Phd2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

    Sadiku, P., Willson, J. A., Dickinson, R., Murphy, F., Harris, A., Lewis, A., Sammut, D., Mirchandani, A. S., Ryan, E., Watts, E., Thompson, A. A. R., Marriott, H. M., Dockrell, D. H., Taylor, C. T., Schneider, M., Maxwell, P. H., Ratcliffe, P. J., Schofield, C. J., Ghesquiere, B., Carmeliet, P. & 2 others, Whyte, M. K. B. & Walmsley, S. R., Sep 2017, In : Journal of Clinical Investigation.

    Research output: Contribution to journalArticle

  65. Pneumococcal Pneumonia Mechanisms of Infection and Resolution

    Dockrell, D., Whyte, M. K. B. & Mitchell, T. J., Aug 2012, In : Chest. 142, 2, p. 482-491 10 p.

    Research output: Contribution to journalLiterature review

  66. Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation

    Bewley, M. A., Naughton, M., Preston, J., Mitchell, A., Holmes, A., Marriott, H. M., Read, R. C., Mitchell, T. J., Whyte, M. K. B. & Dockrell, D. H., 7 Oct 2014, In : mBio. 5, 5

    Research output: Contribution to journalArticle

  67. Polymorphisms in the endothelin-1 (EDN1) are associated with asthma in two populations

    Zhu, G., Carlsen, K., Carlsen, K-H., Lenney, W., Silverman, M., Whyte, M. K., Hosking, L., Helms, P., Roses, A. D., Hay, D. W., Barnes, M. R., Anderson, W. H. & Pillai, S. G., Jan 2008, In : Genes and Immunity. 9, 1, p. 23-29 7 p.

    Research output: Contribution to journalArticle

  68. Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

    Walmsley, S. R., Chilvers, E. R., Thompson, A. A., Vaughan, K., Marriott, H. M., Parker, L. C., Shaw, G., Parmar, S., Schneider, M., Sabroe, I., Dockrell, D., Milo, M., Taylor, C. T., Johnson, R. S., Pugh, C. W., Ratcliffe, P. J., Maxwell, P. H., Carmeliet, P. & Whyte, M. K. B., Mar 2011, In : Journal of Clinical Investigation. 121, 3, p. 1053-1063 11 p.

    Research output: Contribution to journalArticle

  69. Proteomic Evaluation and Validation of Cathepsin D Regulated Proteins in Macrophages Exposed to Streptococcus pneumoniae

    Bewley, M. A., Pham, T. K., Marriott, H. M., Noirel, J., Chu, H-P., Ow, S. Y., Ryazanov, A. G., Read, R. C., Whyte, M. K. B., Chain, B., Wright, P. C. & Dockrell, D., Jun 2011, In : Molecular and Cellular Proteomics. 10, 6, 14 p.

    Research output: Contribution to journalArticle

  70. Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo

    Dickinson, R. S., Murphy, F., Doherty, C., Williams, S., Mirchandani, A., Willson, J. A., Scotti, J. S., Preston, G., Schofield, C. J., Whyte, M. K. B. & Walmsley, S. R., 26 Oct 2017, In : Wellcome Open Research . 2, p. 104

    Research output: Contribution to journalArticle

  71. Quantitative linkage genome scan for atopy in a large collection of Caucasian families

    Webb, B. T., van den Oord, E., Akkari, A., Wilton, S., Ly, T., Duv, R., Barnes, K. C., Carlsen, K., Gerritsen, J., Lenney, W., Silverman, M., Sly, P., Sundy, J., Tsanakas, J., von Berg, A., Whyte, M., Blumenthal, M., Vestbo, J., Middleton, L., Helms, P. J. & 2 others, Anderson, W. H. & Pillai, S. G., Mar 2007, In : Human Genetics. 121, 1, p. 83-92 10 p.

    Research output: Contribution to journalArticle

  72. RESPIRE: The National Institute for Health Research's (NIHR) Global Respiratory Health Unit

    Sheikh, A., Campbell, H., Balharry, D., Baqui, A. H., Bogaert, D., Cresswell, K., Cunningham, S., Dockerell, D., El Arifeen, S., Fletcher, M., Grant, M., Shariff Ghazali, S., Habib, G. M. M., Hazir, T., Isaac, R., Juvekar, S., Khoo, E. M., McKinstry, B., Morris, A., Nair, H. & 17 others, Norrie, J., Nwaru, B., Pinnock, H., Robertson, D., Saha, S. K., Salvi, S., Schwarze, J., Simpson, C., Sridhar, D., Stoddart, A., Weller, D., Whyte, M., Worth, A., Williams, S., Yusuf, O., Zumla, A. & Rudan, I., Dec 2018, In : Journal of Global Health. 8, 2, p. 020314

    Research output: Contribution to journalEditorial

  73. Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

    Marriott, H. M., Jackson, L. E., Wilkinson, T. S., Simpson, A. J., Mitchell, T. J., Buttle, D. J., Cross, S. S., Ince, P. G., Hellewell, P. G., Whyte, M. & Dockrell, D., 15 Apr 2008, In : American Journal of Respiratory and Critical Care Medicine. 177, 8, p. 887-895 9 p.

    Research output: Contribution to journalArticle

  74. Reducing the toll of inflammatory lung disease

    Chaudhuri, N., Whyte, M. K. B. & Sabroe, I., May 2007, In : Chest. 131, 5, p. 1550-1556 7 p.

    Research output: Contribution to journalLiterature review

  75. Regulation of Neutrophil Senescence by MicroRNAs

    Ward, J. R., Heath, P. R., Catto, J. W., Whyte, M. K. B., Milo, M. & Renshaw, S. A., 19 Jan 2011, In : PLoS ONE. 6, 1, 9 p., 15810.

    Research output: Contribution to journalArticle

  76. Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines

    Basran, A., Jabeen, M., Bingle, L., Stokes, C. A., Dockrell, D., Whyte, M. K. B., Walmsley, S. R., Higgins, K. R., Vogel, S. N., Wilson, H. L., Prince, L. R., Prestwich, E. C., Sabroe, R. A., Parker, L. C. & Sabroe, I., Jan 2013, In : Journal of Leukocyte Biology. 93, 1, p. 7-19 13 p.

    Research output: Contribution to journalArticle

  77. Semaphorin 3F signaling actively retains neutrophils at sites of inflammation

    Plant, T., Eamsamarng, S., Sanchez-garcia, M. A., Reyes, L., Renshaw, S. A., Coelho, P., Mirchandani, A. S., Morgan, J., Ellett, F. E., Morrison, T., Humphries, D., Watts, E. R., Murphy, F., Raffo-iraolagoitia, X. L., Zhang, A., Cash, J. L., Loynes, C., Elks, P. M., Van Eeden, F., Carlin, L. M. & 3 others, Furley, A. J. W., Whyte, M. K. B. & Walmsley, S. R., 19 Mar 2020, In : Journal of Clinical Investigation.

    Research output: Contribution to journalArticle

  78. Serum and Glucocorticoid-Regulated Kinase 1 Regulates Neutrophil Clearance during Inflammation Resolution

    Burgon, J., Robertson, A. L., Sadiku, P., Wang, X., Hooper-Greenhill, E., Prince, L. R., Walker, P., Hoggett, E. E., Ward, J. R., Farrow, S. N., Zuercher, W. J., Jeffrey, P., Savage, C. O., Ingham, P. W., Hurlstone, A. F., Whyte, M. K. B. & Renshaw, S. A., 15 Feb 2014, In : Journal of Immunology. 192, 4, p. 1796-1805 10 p.

    Research output: Contribution to journalArticle

  79. Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish

    Gray, C., Loynes, C. A., Whyte, M. K. B., Crossman, D. C., Renshaw, S. A. & Chico, T. J. A., May 2011, In : Thrombosis and Haemostasis. 105, 5, p. 811-819 9 p.

    Research output: Contribution to journalArticle

  80. Staphylococcus aureus Induces Eosinophil Cell Death Mediated by alpha-hemolysin

    Prince, L. R., Graham, K. J., Connolly, J., Anwar, S., Ridley, R., Sabroe, I., Foster, S. J. & Whyte, M. K. B., 15 Feb 2012, In : PLoS ONE. 7, 2, p. e31506 11 p., 31506.

    Research output: Contribution to journalArticle

  81. Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin

    Prince, L. R., Bianchi, S. M., Vaughan, K. M., Bewley, M. A., Marriott, H. M., Walmsley, S. R., Taylor, G. W., Buttle, D. J., Sabroe, I., Dockrell, D. & Whyte, M. K. B., 1 Mar 2008, In : Journal of Immunology. 180, 5, p. 3502-3511 10 p.

    Research output: Contribution to journalArticle

  82. Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha

    Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., Zheng, L., Gardet, A., Tong, Z., Jany, S. S., Corr, S. C., Haneklaus, M., Caffrey, B. E., Pierce, K., Walmsley, S., Beasley, F. C. & 12 others, Cummins, E., Nizet, V., Whyte, M., Taylor, C. T., Lin, H., Masters, S. L., Gottlieb, E., Kelly, V. P., Clish, C., Auron, P. E., Xavier, R. J. & O'Neill, L. A. J., 11 Apr 2013, In : Nature. 496, 7444, p. 238-242 6 p.

    Research output: Contribution to journalArticle

  83. TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation

    McGrath, E. E., Marriott, H. M., Lawrie, A., Francis, S. E., Sabroe, I., Renshaw, S. A., Dockrell, D. & Whyte, M. K. B., Nov 2011, In : Journal of Leukocyte Biology. 90, 5, p. 855-865 11 p.

    Research output: Contribution to journalArticle

  84. Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease

    Sabroe, I., Parker, L. C., Dockrell, D., Davies, D. E., Dower, S. K. & Whyte, M. K. B., 15 Feb 2007, In : American Journal of Respiratory and Critical Care Medicine. 175, 4, p. 306-311 6 p.

    Research output: Contribution to journalLiterature review

  85. The Anti-Apoptotic Effect of Respiratory Syncytial Virus on Human Peripheral Blood Neutrophils is Mediated by a Monocyte Derived Soluble Factor

    Coleman, C. M., Plant, K., Newton, S., Hobson, L., Whyte, M. K. B. & Everard, M. L., 2011, In : The Open Virology Journal. 5, p. 114-23 10 p.

    Research output: Contribution to journalArticle

  86. The Efficacy and Mechanism Evaluation of Treating Idiopathic Pulmonary fibrosis with the Addition of Co-trimoxazole (EME-TIPAC): study protocol for a randomised controlled trial

    Hammond, M., Clark, A. B., Cahn, A. P., Chilvers, E. R., Fraser, W. D., Livermore, D. M., Maher, T. M., Parfrey, H., Swart, A. M., Stirling, S., Thickett, D. R., Whyte, M. & Wilson, A., 5 Feb 2018, In : Trials. 19, 1, p. 89

    Research output: Contribution to journalArticle

  87. The HIF/VHL pathway - From oxygen sensing to innate immunity

    Walmsley, S. R., McGovern, N. N., Whyte, M. K. B. & Chilvers, E. R., Mar 2008, In : American Journal of Respiratory Cell and Molecular Biology. 38, 3, p. 251-255 5 p.

    Research output: Contribution to journalLiterature review

  88. The Identification of Markers of Macrophage Differentiation in PMA-Stimulated THP-1 Cells and Monocyte-Derived Macrophages

    Daigneault, M., Preston, J. A., Marriott, H. M., Whyte, M. K. B. & Dockrell, D., 13 Jan 2010, In : PLoS ONE. 5, 1, 10 p., 8668.

    Research output: Contribution to journalArticle

  89. The identification of Staphylococcus aureus factors required for pathogenicity and growth in human blood

    Connolly, J., Boldock, E., Prince, L. R., Renshaw, S. A., Whyte, M. K. & Foster, S. J., 14 Aug 2017, In : Infection and Immunity.

    Research output: Contribution to journalArticle

  90. The role of TLR activation in inflammation

    Sabroe, I., Parker, L. C., Dower, S. K. & Whyte, M. K. B., Jan 2008, In : The Journal of Pathology. 214, 2, p. 126-135 10 p.

    Research output: Contribution to journalLiterature review

  91. The role of neutrophils in cancer

    Grecian, R., Whyte, M. & Walmsley, S., 22 Aug 2018, In : British Medical Bulletin.

    Research output: Contribution to journalArticle

  92. Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation in respiratory disease

    Sabroe, I. & Whyte, M. K. B., Dec 2007, In : Biochemical Society Transactions. 35, p. 1492-1495 4 p.

    Research output: Contribution to journalLiterature review

  93. Zebrafish as a model for the study of neutrophil biology

    Henry, K. M., Loynes, C. A., Whyte, M. K. B. & Renshaw, S. A., Oct 2013, In : Journal of Leukocyte Biology. 94, 4, p. 633-642 10 p.

    Research output: Contribution to journalLiterature review