Edinburgh Research Explorer

Prof Moira Whyte

Vice-Principal & Head of College of Medicine & Vet Medicine

  1. 2019
  2. A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension

    Arnold, N. D., Pickworth, J. A., West, L. E., Dawson, S., Carvalho, J. A., Casbolt, H., Braithwaite, A. T., Iremonger, J., Renshall, L., Germaschewski, V., McCourt, M., Bland-Ward, P., Kowash, H., Hameed, A. G., Rothman, A. M. K., Frid, M. G., Roger Thompson, A. A., Evans, H. R., Southwood, M., Morrell, N. W. & 7 others, Crossman, D. C., Whyte, M. K. B., Stenmark, K. R., Newman, C. M., Kiely, D. G., Francis, S. E. & Lawrie, A., 15 Nov 2019, In : Nature Communications. 10, 1, p. 5183

    Research output: Contribution to journalArticle

  3. Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

    Allen, R. J., Guillen-Guio, B., Oldham, J. M., Ma, S-F., Dressen, A., Paynton, M. L., Kraven, L. M., Obeidat, M., Li, X., Ng, M., Braybrooke, R., Molina-Molina, M., Hobbs, B. D., Putman, R. K., Sakornsakolpat, P., Booth, H. L., Fahy, W. A., Hart, S. P., Hill, M. R., Hirani, N. & 46 others, Hubbard, R. B., McAnulty, R. J., Millar, A. B., Navaratnam, V., Oballa, E., Parfrey, H., Saini, G., Whyte, M. K. B., Zhang, Y., Kaminski, N., Adegunsoye, A., Strek, M. E., Neighbors, M., Sheng, X. R., Gudmundsson, G., Gudnason, V., Hatabu, H., Lederer, D. J., Manichaikul, A., Newell, J. D., O'Connor, G. T., Ortega, V. E., Xu, H., Fingerlin, T. E., Bossé, Y., Hao, K., Joubert, P., Nickle, D. C., Sin, D. D., Timens, W., Furniss, D., Morris, A. P., Zondervan, K., Hall, I. P., Sayers, I., Tobin, M. D., Maher, T. M., Cho, M. H., Hunninghake, G. M., Schwartz, D. A., Yaspan, B. L., Molyneaux, P. L., Flores, C., Noth, I., Jenkins, R. G. & Wain, L. V., 11 Nov 2019, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

  4. Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

    Rahman, A., Henry, K. M., Herman, K. D., Thompson, A. A., Isles, H. M., Tulotta, C., Sammut, D., Rougeot, J. J., Khoshaein, N., Reese, A. E., Higgins, K., Tabor, C., Sabroe, I., Zuercher, W. J., Savage, C. O., Meijer, A. H., Whyte, M. K., Dockrell, D. H., Renshaw, S. A. & Prince, L. R., 15 Oct 2019, In : eLIFE. 8

    Research output: Contribution to journalArticle

  5. Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages

    COPDMAP consortium, 10 Oct 2019, In : European Respiratory Journal. 54, 4

    Research output: Contribution to journalArticle

  6. IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo.

    Harris, A. J., Mirchandani, A. S., Lynch, R. W., Murphy, F., Delaney, L., Small, D., Coelho, P., Watts, E. R., Sadiku, P., Griffith, D., Dickinson, R. S., Clark, E., Willson, J. A., Morrison, T., Mazzone, M., Carmeliet, P., Ghesquiere, B., O'kane, C., Mcauley, D., Jenkins, S. J. & 2 others, Whyte, M. K. B. & Walmsley, S. R., 8 Mar 2019, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

  7. Alveolar Macrophage Apoptosis-Associated Bacterial Killing Helps Prevent Murine Pneumonia

    Preston, J. A., Bewley, M. A., Marriott, H. M., Houghton, A. M., Mohasin, M., Jubrail, J., Morris, L., Stephenson, Y. L., Cross, S., Greaves, D. R., Craig, R. W., van Rooijen, N., Bingle, C. D., Read, R. C., Mitchell, T. J., Whyte, M. K. B., Shapiro, S. D. & Dockrell, D. H., 16 Jan 2019, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

  8. 2018
  9. RESPIRE: The National Institute for Health Research's (NIHR) Global Respiratory Health Unit

    Sheikh, A., Campbell, H., Balharry, D., Baqui, A. H., Bogaert, D., Cresswell, K., Cunningham, S., Dockerell, D., El Arifeen, S., Fletcher, M., Grant, M., Shariff Ghazali, S., Habib, G. M. M., Hazir, T., Isaac, R., Juvekar, S., Khoo, E. M., McKinstry, B., Morris, A., Nair, H. & 17 others, Norrie, J., Nwaru, B., Pinnock, H., Robertson, D., Saha, S. K., Salvi, S., Schwarze, J., Simpson, C., Sridhar, D., Stoddart, A., Weller, D., Whyte, M., Worth, A., Williams, S., Yusuf, O., Zumla, A. & Rudan, I., Dec 2018, In : Journal of Global Health. 8, 2, p. 020314

    Research output: Contribution to journalEditorial

  10. Hypoxia and reprogramming of host pathogen interactions

    Ryan, E. M., Whyte, M. K. & Walmsley, S. R., 27 Nov 2018, In : Current opinion in physiology. 7, p. 15-20

    Research output: Contribution to journalArticle

  11. PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

    Loynes, C. A., Lee, J. A., Robertson, A. L., Steel, M. J. G., Ellett, F., Feng, Y., Levy, B. D., Whyte, M. & Renshaw, S. A., 5 Sep 2018, In : Science Advances.

    Research output: Contribution to journalArticle

  12. The role of neutrophils in cancer

    Grecian, R., Whyte, M. & Walmsley, S., 22 Aug 2018, In : British Medical Bulletin.

    Research output: Contribution to journalArticle

  13. Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists

    Bewley, M. A., Budd, R. C., Ryan, E., Cole, J., Collini, P., Marshall, J., Kolsum, U., Beech, G., Emes, R. D., Tcherniaeva, I., Berbers, G. A. M., Walmsley, S. R., Donaldson, G., Wedzicha, J. A., Kilty, I., Rumsey, W., Sanchez, Y., Brightling, C. E., Donnelly, L. E., Barnes, P. J. & 4 others, Singh, D., Whyte, M. K. B., Dockrell, D. H. & COPDMAP, 16 Mar 2018, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

  14. The Efficacy and Mechanism Evaluation of Treating Idiopathic Pulmonary fibrosis with the Addition of Co-trimoxazole (EME-TIPAC): study protocol for a randomised controlled trial

    Hammond, M., Clark, A. B., Cahn, A. P., Chilvers, E. R., Fraser, W. D., Livermore, D. M., Maher, T. M., Parfrey, H., Swart, A. M., Stirling, S., Thickett, D. R., Whyte, M. & Wilson, A., 5 Feb 2018, In : Trials. 19, 1, p. 89

    Research output: Contribution to journalArticle

  15. 2017
  16. Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study

    Allen, R. J., Porte, J., Braybrooke, R., Flores, C., Fingerlin, T. E., Oldham, J. M., Guillen-Guio, B., Ma, S-F., Okamoto, T., John, A. E., Obeidat, M., Yang, I. V., Henry, A., Hubbard, R. B., Navaratnam, V., Saini, G., Thompson, N., Booth, H. L., Hart, S. P., Hill, M. R. & 23 others, Hirani, N., Maher, T. M., McAnulty, R. J., Millar, A. B., Molyneaux, P. L., Parfrey, H., Rassl, D. M., Whyte, M. K. B., Fahy, W. A., Marshall, R. P., Oballa, E., Bossé, Y., Nickle, D. C., Sin, D. D., Timens, W., Shrine, N., Sayers, I., Hall, I. P., Noth, I., Schwartz, D. A., Tobin, M. D., Wain, L. V. & Jenkins, R. G., Nov 2017, In : The Lancet Respiratory Medicine. 5, 11, p. 869-880 12 p.

    Research output: Contribution to journalArticle

  17. Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo

    Dickinson, R. S., Murphy, F., Doherty, C., Williams, S., Mirchandani, A., Willson, J. A., Scotti, J. S., Preston, G., Schofield, C. J., Whyte, M. K. B. & Walmsley, S. R., 26 Oct 2017, In : Wellcome Open Research . 2, p. 104

    Research output: Contribution to journalArticle

  18. Delayed Neutrophil Apoptosis Enhances NET Formation in Cystic Fibrosis

    Gray, R., Hardisty, G., Regan, K. H., Smith, M., Robb, C. T., Duffin, R., Mackellar, A., Felton, J., Paemka, L., McCullagh, B. N., Lucas, C., David, D., McKone, E. F., Cooke, G., Donnelly, S., Singh, P. K., Stoltz, D. A., Haslett, C., McCray, P. B., Whyte, M. & 2 others, Rossi, A. & Davidson, D., 15 Sep 2017, In : Thorax.

    Research output: Contribution to journalArticle

  19. Phd2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

    Sadiku, P., Willson, J. A., Dickinson, R., Murphy, F., Harris, A., Lewis, A., Sammut, D., Mirchandani Thanwerdas, A., Ryan, E., Watts, E., Thompson, A. A. R., Marriott, H. M., Dockrell, D., Taylor, C. T., Schneider, M., Maxwell, P. H., Ratcliffe, P. J., Schofield, C. J., Ghesquiere, B., Carmeliet, P. & 2 others, Whyte, M. & Walmsley, S., Sep 2017, In : Journal of Clinical Investigation.

    Research output: Contribution to journalArticle

  20. The identification of Staphylococcus aureus factors required for pathogenicity and growth in human blood

    Connolly, J., Boldock, E., Prince, L. R., Renshaw, S. A., Whyte, M. K. & Foster, S. J., 14 Aug 2017, In : Infection and Immunity.

    Research output: Contribution to journalArticle

  21. NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival

    Prince, L. R., Dannewitz Prosseda, S., Higgins, K., Carlring, J., Prestwich, E. C., Ogryzko, N. V., Rahman, A., Basran, A., Falciani, F., Taylor, P., Renshaw, S. A., Whyte, M. K. B. & Sabroe, I., 21 Jun 2017, In : Blood.

    Research output: Contribution to journalArticle

  22. Impaired mitochondrial microbicidal responses in chronic obstructive pulmonary disease macrophages

    Bewley, M. A., Preston, J. A., Mohasin, M., Marriott, H. M., Budd, R. C., Swales, J., Collini, P., Greaves, D. R., Craig, R. W., Brightling, C. E., Donnelly, L. E., Barnes, P. J., Singh, D., Shapiro, S. D., Whyte, M. & Dockrell, D., 30 May 2017, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

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