Edinburgh Research Explorer

Noboru Komiyama

Senior Lecturer

  1. 2020
  2. Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1 , NLGN3 , DLGAP1 , DLGAP2 and SHANK2

    Horner, A. E., Norris, R. H., Mclaren‐jones, R., Alexander, L., Komiyama, N. H., Grant, S. G. N., Nithianantharajah, J. & Kopanitsa, M. V., 21 Dec 2020, In: Genes, Brain and Behavior.

    Research output: Contribution to journalArticlepeer-review

  3. A brainwide atlas of synapses across the mouse life span

    Cizeron, M., Qiu, Z., Koniaris, B., Gokhale, R., Komiyama, N. H., Fransén, E. & Grant, S. G. N., 17 Jul 2020, In: Science. 369, 6501, p. 270-275 6 p.

    Research output: Contribution to journalArticlepeer-review

  4. 2019
  5. Cell‐type specific visualization and biochemical isolation of endogenous synaptic proteins in mice

    Zhu, F., Collins, M. O., Harmse, J., Choudhary, J. S., Grant, S. G. N. & Komiyama, N. H., 16 Oct 2019, In: European Journal of Neuroscience.

    Research output: Contribution to journalArticlepeer-review

  6. Comprehensive behavioral analysis of heterozygous Syngap1knockout mice

    Nakajima, R., Takao, K., Hattori, S., Shoji, H., Komiyama, N. H., Grant, S. G. N. & Miyakawa, T., 19 Jul 2019, In: Neuropsychopharmacology Reports.

    Research output: Contribution to journalArticlepeer-review

  7. Computational geometry analysis of dendritic spines by structured illumination microscopy

    Kashiwagi, Y., Higashi, T., Obashi, K., Sato, Y., Komiyama, N. H., Grant, S. G. N. & Okabe, S., 20 Mar 2019, In: Nature Communications. 10, 1

    Research output: Contribution to journalArticlepeer-review

  8. 2018
  9. Biphasic Modulation of NMDA Receptor Function by Metabotropic Glutamate Receptors

    O'Neill, N., McLaughlin, C., Komiyama, N. & Sylantyev, S., 14 Nov 2018, In: JOURNAL OF NEUROSCIENCE . 38, 46, p. 9840-9855 16 p.

    Research output: Contribution to journalArticlepeer-review

  10. The developmental shift of NMDA receptor composition proceeds independently of GluN2 subunit-specific GluN2 C-terminal sequences

    Mckay, S., Ryan, T. J., Mcqueen, J., Indersmitten, T., Marwick, K., Hasel, P., Kopanitsa, M. V., Baxter, P., Martel, M-A., Kind, P., Wyllie, D., O'Dell, T. J., Grant, S., Hardingham, G. & Komiyama, N., 23 Oct 2018, In: Cell Reports. 25, 4, p. 841-851.e4

    Research output: Contribution to journalArticlepeer-review

  11. Architecture of the Mouse Brain Synaptome

    Zhu, F., Cizeron, M., Qiu, Z., Benavides-Piccione, R., Kopanitsa, M. V., Skene, N. G., Koniaris, B., DeFelipe, J., Fransén, E., Komiyama, N. H. & Grant, S. G. N., 22 Aug 2018, In: Neuron. 99, 4, p. 781-799.e10 29 p.

    Research output: Contribution to journalArticlepeer-review

  12. Chronic treatment with a MEK inhibitor reverses enhanced excitatory field potentials in Syngap1 mice

    Kopanitsa, M. V., Gou, G., Afinowi, N. O., Bayés, À., Grant, S. G. N. & Komiyama, N. H., Aug 2018, In: Pharmacological reports. 70, 4, p. 777-783 7 p.

    Research output: Contribution to journalArticlepeer-review

  13. Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability

    Coba, M. P., Ramaker, M. J., Ho, E. V., Thompson, S. L., Komiyama, N. H., Grant, S. G. N., Knowles, J. A. & Dulawa, S. C., 2 Feb 2018, In: Scientific Reports. 8, 1

    Research output: Contribution to journalArticlepeer-review

  14. 2017
  15. Enhanced cognition and dysregulated hippocampal synaptic physiology in mice with a heterozygous deletion of PSD-95

    Horner, A. E., McLaughlin, C. L., Afinowi, N. O., Bussey, T. J., Saksida, L. M., Komiyama, N. H., Grant, S. G. N. & Kopanitsa, M. V., 13 Dec 2017, In: European Journal of Neuroscience.

    Research output: Contribution to journalArticlepeer-review

  16. Arc requires PSD95 for assembly into postsynaptic complexes involved with brain disease and intelligence

    Fernandez, E., Collins, M. O., Frank, R. A. W., Zhu, F., Kopanitsa, M. V., Nithianantharajah, J., Lempriere, S., Fricker, D. G., Elsegood, K. A., McLaughlin, C., Croning, M. D. R., McLean, C., Armstrong, J. D., Hill, W. D., Deary, I., Cencelli, G., Bagni, C., Fromer, M., Purcell, S. M., Pocklington, A. J. & 3 others, Choudhary, J. S., Komiyama, N. & Grant, S., 17 Oct 2017, In: Cell Reports. 21, 3, p. 679-691

    Research output: Contribution to journalArticlepeer-review

  17. Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1

    Mcqueen, J., Ryan, T. J., Mckay, S., Marwick, K., Baxter, P., Carpanini, S. M., Wishart, T., Gillingwater, T., Manson, J., Wyllie, D., Grant, S., McColl, B., Komiyama, N. & Hardingham, G., 21 Jul 2017, In: eLIFE.

    Research output: Contribution to journalArticlepeer-review

  18. Hierarchical organisation and genetically separable subfamilies of PSD95 postsynaptic supercomplexes

    Frank, R. A. W., Zhu, F., Komiyama, N. H. & Grant, S. G. N., 28 Apr 2017, In: Journal of Neurochemistry.

    Research output: Contribution to journalArticlepeer-review

  19. 2016
  20. Standardised experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds

    van de Lagemaat, L. N., Stanford, L. E., Pettit, C., Strathdee, D. J., Strathdee, K. E., Elsegood, K. A., Fricker, D. G., Croning, M. D. R., Komiyama, N. H. & Grant, S. G. N., 25 Nov 2016, In: Genes, Brain and Behavior.

    Research output: Contribution to journalArticlepeer-review

  21. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation

    Frank, R. A. W., Komiyama, N. H., Ryan, T. J., Zhu, F., O'Dell, T. J. & Grant, S. G. N., 27 Apr 2016, In: Nature Communications. 7, 13 p., 11264.

    Research output: Contribution to journalArticlepeer-review

  22. PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits

    Broadhead, M. J., Horrocks, M. H., Zhu, F., Muresan, L., Benavides-Piccione, R., DeFelipe, J., Fricker, D., Kopanitsa, M. V., Duncan, R. R., Klenerman, D., Komiyama, N. H., Lee, S. F. & Grant, S. G. N., 25 Apr 2016, In: Scientific Reports. 6, p. 24626

    Research output: Contribution to journalArticlepeer-review

  23. 2015
  24. Convergence of hippocampal pathophysiology in Syngap+/- and Fmr1-/y mice

    Barnes, S., Wijetunge, L., Jackson, A. D., Katsanevaki, D., Osterweil, E., Komiyama, N., Grant, S., Bear, M. F., Nägerl, U. V., Kind, P. & Wyllie, D., 11 Nov 2015, In: Journal of Neuroscience. 35, 45, p. 15073-15081

    Research output: Contribution to journalArticlepeer-review

  25. Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns

    Charlesworth, P., Morton, A., Eglen, S. J., Komiyama, N. H. & Grant, S. G. N., 26 Jul 2015, In: Neuropharmacology.

    Research output: Contribution to journalArticlepeer-review

  26. Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption

    Milner, L. C., Shirley, R. L., Kozell, L. B., Walter, N. A., Kruse, L. C., Komiyama, N. H., Grant, S. G. N. & Buck, K. J., Jan 2015, In: Addiction Biology. 20, 1, p. 143-147 5 p.

    Research output: Contribution to journalArticlepeer-review

  27. 2014
  28. A polygenic burden of rare disruptive mutations in schizophrenia

    Purcell, S. M., Moran, J. L., Fromer, M., Ruderfer, D., Solovieff, N., Roussos, P., O'Dushlaine, C., Chambert, K., Bergen, S. E., Kahler, A., Duncan, L., Stahl, E., Genovese, G., Fernandez, E., Collins, M. O., Komiyama, N. H., Choudhary, J. S., Magnusson, P. K. E., Banks, E., Shakir, K. & 12 others, Garimella, K., Fennell, T., DePristo, M., Grant, S. G. N., Haggarty, S. J., Gabriel, S., Scolnick, E. M., Lander, E. S., Hultman, C. M., Sullivan, P. F., McCarroll, S. A. & Sklar, P., 13 Feb 2014, In: Nature. 506, 7487, p. 185-190 17 p.

    Research output: Contribution to journalArticlepeer-review

  29. 2013
  30. CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation

    De Rubeis, S., Pasciuto, E., Li, K. W., Fernández, E., Di Marino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., Grant, S. G. N., Poujol, C., Choquet, D., Achsel, T., Posthuma, D., Smit, A. B. & Bagni, C., 18 Sep 2013, In: Neuron. 79, 6, p. 1169-82 14 p.

    Research output: Contribution to journalArticlepeer-review

  31. Synaptic scaffold evolution generated components of vertebrate cognitive complexity

    Nithianantharajah, J., Komiyama, N., McKechanie, A., Johnstone, M., Blackwood, D. H., Clair, D. S., Emes, R. D., van de Lagemaat, L. N., Saksida, L. M., Bussey, T. J. & Grant, S. G. N., Jan 2013, In: Nature Neuroscience. 16, 1, p. 16-24 9 p.

    Research output: Contribution to journalArticlepeer-review

  32. Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior

    Ryan, T. J., Kopanitsa, M. V., Indersmitten, T., Nithianantharajah, J., Afinowi, N. O., Pettit, C., Stanford, L. E., Sprengel, R., Saksida, L. M., Bussey, T. J., O'Dell, T. J., Grant, S. G. N. & Komiyama, N., 2013, In: Nature Neuroscience. 16, 1, p. 25-32 8 p.

    Research output: Contribution to journalArticlepeer-review

  33. 2012
  34. TNiK Is Required for Postsynaptic and Nuclear Signaling Pathways and Cognitive Function

    Coba, M. P., Komiyama, N. H., Nithianantharajah, J., Kopanitsa, M. V., Indersmitten, T., Skene, N. G., Tuck, E. J., Fricker, D. G., Elsegood, K. A., Stanford, L. E., Afinowi, N. O., Saksida, L. M., Bussey, T. J., O'Dell, T. J. & Grant, S. G. N., 3 Oct 2012, In: Journal of Neuroscience. 32, 40, p. 13987-13999 13 p.

    Research output: Contribution to journalArticlepeer-review

  35. Genetic Dissection Of Cognition In Humans And Mice Carrying Mutations: Evidence That Vertebrate Genomic Evolution Produced Susceptibility To Mental Illnesses

    Nithianantharajah, J., McKechanie, A., Komiyama, N., Emes, R. D., Saksida, L. M., Bussey, T. J. & Grant, S., 18 Jul 2012, p. 641.

    Research output: Contribution to conferencePosterpeer-review

  36. The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults

    Martel, M-A., Ryan, T. J., Bell, K. F. S., Fowler, J. H., McMahon, A., Al-Mubarak, B., Komiyama, N., Horsburgh, K., Kind, P. C., Grant, S. G. N., Wyllie, D. J. A. & Hardingham, G. E., May 2012, In: Neuron. 74, 3, p. 543-556 14 p.

    Research output: Contribution to journalArticlepeer-review

  37. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

    Kirov, G., Pocklington, A. J., Holmans, P., Ivanov, D., Ikeda, M., Ruderfer, D., Moran, J., Chambert, K., Toncheva, D., Georgieva, L., Grozeva, D., Fjodorova, M., Wollerton, R., Rees, E., Nikolov, I., Van De Lagemaat, L., Bayés, A., Fernandez, E., Olason, P. I., Böttcher, Y. & 10 others, Komiyama, N. H., Collins, M. O., Choudhary, J., Stefansson, K., Stefansson, H., Grant, S. G. N., Purcell, S., Sklar, P., O'Donovan, M. C. & Owen, M. J., Feb 2012, In: Molecular Psychiatry. 17, 2, p. 142-153 12 p.

    Research output: Contribution to journalArticlepeer-review

  38. 2011
  39. Beta-adrenergic receptor activation rescues theta frequency stimulation-induced LTP deficits in mice expressing C-terminally truncated NMDA receptor GluN2A subunits

    Moody, T. D., Watabe, A. M., Indersmitten, T., Komiyama, N. H., Grant, S. G. N. & O'Dell, T. J., Feb 2011, In: Learning & Memory. 18, 2, p. 118-27 10 p.

    Research output: Contribution to journalArticlepeer-review

  40. 2010
  41. In Vivo Composition of NMDA Receptor Signaling Complexes Differs between Membrane Subdomains and Is Modulated by PSD-95 And PSD-93

    Delint-Ramirez, I., Fernandez, E., Bayes, A., Kicsi, E., Komiyama, N. & Grant, S. G. N., 16 Jun 2010, In: The Journal of Neuroscience. 30, 24, p. 8162-8170 9 p.

    Research output: Contribution to journalArticlepeer-review

  42. Automated design of genomic Southern blot probes

    Croning, M. D. R., Fricker, D. G., Komiyama, N. H. & Grant, S. G. N., 2010, In: BMC Genomics. 11, p. 74

    Research output: Contribution to journalArticlepeer-review

  43. 2008
  44. Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes

    Ryan, T. J., Emes, R. D., Grant, S. G. & Komiyama, N. H., 2008, In: BMC Neuroscience. 9, p. 6

    Research output: Contribution to journalArticlepeer-review

  45. 2007
  46. Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies

    Cuthbert, P. C., Stanford, L. E., Coba, M. P., Ainge, J. A., Fink, A. E., Opazo, P., Delgado, J. Y., Komiyama, N. H., O'Dell, T. J. & Grant, S. G. N., 7 Mar 2007, In: Journal of Neuroscience. 27, 10, p. 2673-82 10 p.

    Research output: Contribution to journalArticlepeer-review

  47. 2004
  48. Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression

    McLean, G. W., Komiyama, N. H., Serrels, B., Asano, H., Reynolds, L., Conti, F., Hodivala-Dilke, K., Metzger, D., Chambon, P., Grant, S. G. N. & Frame, M. C., 15 Dec 2004, In: Genes & Development. 18, 24, p. 2998-3003 6 p.

    Research output: Contribution to journalArticlepeer-review

  49. 2002
  50. SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor

    Komiyama, N. H., Watabe, A. M., Carlisle, H. J., Porter, K., Charlesworth, P., Monti, J., Strathdee, D. J. C., O'Carroll, C. M., Martin, S. J., Morris, R. G. M., O'Dell, T. J. & Grant, S. G. N., 15 Nov 2002, In: Journal of Neuroscience. 22, 22, p. 9721-32 12 p.

    Research output: Contribution to journalArticlepeer-review