Edinburgh Research Explorer

Dr Noboru Komiyama

Senior Lecturer

  1. The developmental shift of NMDA receptor composition proceeds independently of GluN2 subunit-specific GluN2 C-terminal sequences

    Mckay, S., Ryan, T. J., Mcqueen, J., Indersmitten, T., Marwick, K., Hasel, P., Kopanitsa, M. V., Baxter, P., Martel, M-A., Kind, P., Wyllie, D., O'Dell, T. J., Grant, S., Hardingham, G. & Komiyama, N., 23 Oct 2018, In : Cell Reports. 25, 4, p. 841-851.e4

    Research output: Contribution to journalArticle

  2. The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults

    Martel, M-A., Ryan, T. J., Bell, K. F. S., Fowler, J. H., McMahon, A., Al-Mubarak, B., Komiyama, N., Horsburgh, K., Kind, P. C., Grant, S. G. N., Wyllie, D. J. A. & Hardingham, G. E., May 2012, In : Neuron. 74, 3, p. 543-556 14 p.

    Research output: Contribution to journalArticle

  3. TNiK Is Required for Postsynaptic and Nuclear Signaling Pathways and Cognitive Function

    Coba, M. P., Komiyama, N. H., Nithianantharajah, J., Kopanitsa, M. V., Indersmitten, T., Skene, N. G., Tuck, E. J., Fricker, D. G., Elsegood, K. A., Stanford, L. E., Afinowi, N. O., Saksida, L. M., Bussey, T. J., O'Dell, T. J. & Grant, S. G. N., 3 Oct 2012, In : Journal of Neuroscience. 32, 40, p. 13987-13999 13 p.

    Research output: Contribution to journalArticle

  4. Synaptic scaffold evolution generated components of vertebrate cognitive complexity

    Nithianantharajah, J., Komiyama, N., McKechanie, A., Johnstone, M., Blackwood, D. H., Clair, D. S., Emes, R. D., van de Lagemaat, L. N., Saksida, L. M., Bussey, T. J. & Grant, S. G. N., Jan 2013, In : Nature Neuroscience. 16, 1, p. 16-24 9 p.

    Research output: Contribution to journalArticle

  5. Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies

    Cuthbert, P. C., Stanford, L. E., Coba, M. P., Ainge, J. A., Fink, A. E., Opazo, P., Delgado, J. Y., Komiyama, N. H., O'Dell, T. J. & Grant, S. G. N., 7 Mar 2007, In : Journal of Neuroscience. 27, 10, p. 2673-82 10 p.

    Research output: Contribution to journalArticle

  6. SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor

    Komiyama, N. H., Watabe, A. M., Carlisle, H. J., Porter, K., Charlesworth, P., Monti, J., Strathdee, D. J. C., O'Carroll, C. M., Martin, S. J., Morris, R. G. M., O'Dell, T. J. & Grant, S. G. N., 15 Nov 2002, In : Journal of Neuroscience. 22, 22, p. 9721-32 12 p.

    Research output: Contribution to journalArticle

  7. Standardised experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds

    van de Lagemaat, L. N., Stanford, L. E., Pettit, C., Strathdee, D. J., Strathdee, K. E., Elsegood, K. A., Fricker, D. G., Croning, M. D. R., Komiyama, N. H. & Grant, S. G. N., 25 Nov 2016, In : Genes, Brain and Behavior.

    Research output: Contribution to journalArticle

  8. Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression

    McLean, G. W., Komiyama, N. H., Serrels, B., Asano, H., Reynolds, L., Conti, F., Hodivala-Dilke, K., Metzger, D., Chambon, P., Grant, S. G. N. & Frame, M. C., 15 Dec 2004, In : Genes & Development. 18, 24, p. 2998-3003 6 p.

    Research output: Contribution to journalArticle

  9. PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits

    Broadhead, M. J., Horrocks, M. H., Zhu, F., Muresan, L., Benavides-Piccione, R., DeFelipe, J., Fricker, D., Kopanitsa, M. V., Duncan, R. R., Klenerman, D., Komiyama, N. H., Lee, S. F. & Grant, S. G. N., 25 Apr 2016, In : Scientific Reports. 6, p. 24626

    Research output: Contribution to journalArticle

  10. Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption

    Milner, L. C., Shirley, R. L., Kozell, L. B., Walter, N. A., Kruse, L. C., Komiyama, N. H., Grant, S. G. N. & Buck, K. J., Jan 2015, In : Addiction Biology. 20, 1, p. 143-147 5 p.

    Research output: Contribution to journalArticle

  11. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation

    Frank, R. A. W., Komiyama, N. H., Ryan, T. J., Zhu, F., O'Dell, T. J. & Grant, S. G. N., 27 Apr 2016, In : Nature Communications. 7, p. 11264

    Research output: Contribution to journalArticle

  12. Hierarchical organisation and genetically separable subfamilies of PSD95 postsynaptic supercomplexes

    Frank, R. A. W., Zhu, F., Komiyama, N. H. & Grant, S. G. N., 28 Apr 2017, In : Journal of Neurochemistry.

    Research output: Contribution to journalArticle

  13. Genetic Dissection Of Cognition In Humans And Mice Carrying Mutations: Evidence That Vertebrate Genomic Evolution Produced Susceptibility To Mental Illnesses

    Nithianantharajah, J., McKechanie, A., Komiyama, N., Emes, R. D., Saksida, L. M., Bussey, T. J. & Grant, S., 18 Jul 2012, p. 641.

    Research output: Contribution to conferencePoster

  14. Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes

    Ryan, T. J., Emes, R. D., Grant, S. G. & Komiyama, N. H., 2008, In : BMC Neuroscience. 9, p. 6

    Research output: Contribution to journalArticle

  15. Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior

    Ryan, T. J., Kopanitsa, M. V., Indersmitten, T., Nithianantharajah, J., Afinowi, N. O., Pettit, C., Stanford, L. E., Sprengel, R., Saksida, L. M., Bussey, T. J., O'Dell, T. J., Grant, S. G. N. & Komiyama, N., 2013, In : Nature Neuroscience. 16, 1, p. 25-32 8 p.

    Research output: Contribution to journalArticle

  16. Enhanced cognition and dysregulated hippocampal synaptic physiology in mice with a heterozygous deletion of PSD-95

    Horner, A. E., McLaughlin, C. L., Afinowi, N. O., Bussey, T. J., Saksida, L. M., Komiyama, N. H., Grant, S. G. N. & Kopanitsa, M. V., 13 Dec 2017, In : European Journal of Neuroscience.

    Research output: Contribution to journalArticle

  17. Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability

    Coba, M. P., Ramaker, M. J., Ho, E. V., Thompson, S. L., Komiyama, N. H., Grant, S. G. N., Knowles, J. A. & Dulawa, S. C., 2 Feb 2018, In : Scientific Reports. 8, 1

    Research output: Contribution to journalArticle

  18. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

    Kirov, G., Pocklington, A. J., Holmans, P., Ivanov, D., Ikeda, M., Ruderfer, D., Moran, J., Chambert, K., Toncheva, D., Georgieva, L., Grozeva, D., Fjodorova, M., Wollerton, R., Rees, E., Nikolov, I., Van De Lagemaat, L., Bayés, A., Fernandez, E., Olason, P. I., Böttcher, Y. & 10 others, Komiyama, N. H., Collins, M. O., Choudhary, J., Stefansson, K., Stefansson, H., Grant, S. G. N., Purcell, S., Sklar, P., O'Donovan, M. C. & Owen, M. J., Feb 2012, In : Molecular Psychiatry. 17, 2, p. 142-153 12 p.

    Research output: Contribution to journalArticle

  19. Convergence of hippocampal pathophysiology in Syngap+/- and Fmr1-/y mice

    Barnes, S., Wijetunge, L., Jackson, A. D., Katsanevaki, D., Osterweil, E., Komiyama, N., Grant, S., Bear, M. F., Nägerl, U. V., Kind, P. & Wyllie, D., 11 Nov 2015, In : Journal of Neuroscience. 35, 45, p. 15073-15081

    Research output: Contribution to journalArticle

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