Edinburgh Research Explorer

Dr Paul Brennan

Senior Clinical Lecturer in Neurosurgery

Profile photo

Willingness to take Ph.D. students: Yes

Education / Academic qualification

Doctor of Philosophy (PhD), University of Edinburgh
Using Novel Models of Glioma for Cancer Discovery Science
Bachelor of Science, University of Edinburgh
Bachelor of Medicine and Bachelor of Surgery, University of Cambridge

Professional Qualifications

FRCS (Surgical Neurology), FRCSEd


Paul is Senior Clinical Lecturer and Honorary Consultant Neurosurgeon at the University of Edinburgh and NHS Lothian. 

His clinical work focuses on operative management of people with brain tumours. He complements this work with clinical and laboratory research, principally into brain tumours. 

Paul’s research focus includes:

-      Speeding up the diagnosis of brain tumours using symptom-based referral pathways and novel blood tests. 

-       Developing novel strategies for delivering chemotherapy focally in management of brain tumours. In collaboration with Dr Unciti-Broceta he is developing a palladium activated prodrug where the palladium catalyst will be implanted in the brain at surgery, better targeting drug activation. 

-      Understanding the cellular and molecular biology of the malignant transformation of low grade glioma. 

He has an active involvement in clinical research and is co-applicant on a number of multi-centre studies. He was co-founder of the British Neurosurgical Trainee Research Collaborative that he helped found as Chair of the British Neurosurgical Trainees Association in 2012. He has led a UK collaborative study on management of chronic subdural haematoma and is interested in optimising the peri-operative care of these patients. 

Complementing his clinical work, Paul founded eoSurgical Ltd in 2012 along with co-founders Roland Partridge and Mark Hughes. The University spin-out now provides surgical simulation training around the world.  

In 2014 Paul helped in the foundation of the Compassion Initiative at the University of Edinburgh and is a co-Director, working in close collaboration with Prof Jim Doty's Centre for Compassion and Altruism Research at the University of Stanford.

Paul is a member of the Young Academy of Scotland and was co-chair between September 2015 and August 2017.  



Research activities & awards

  1. British Neuro-oncology conference 2017

    Activity: OtherTypes of Public engagement and outreach - Festival/Exhibition

  2. Undergraduate Awards (External organisation)

    Activity: MembershipMembership of peer review panel or committee

  3. BMJ Case Reports (Journal)

    Activity: Publication peer-review and editorial workPublication peer-review

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