Edinburgh Research Explorer

Dr Paul Brennan

Senior Clinical Lecturer in Neurosurgery

Profile photo

Willingness to take Ph.D. students: Yes

Education/Academic qualification

Doctor of Philosophy (PhD), University of Edinburgh
Using Novel Models of Glioma for Cancer Discovery Science
Bachelor of Medicine and Bachelor of Surgery, University of Cambridge
Bachelor of Science, University of Edinburgh

Professional Qualifications

FRCS (Surgical Neurology), FRCSEd
MRCS

Biography

Paul is Senior Clinical Lecturer and Honorary Consultant Neurosurgeon at the University of Edinburgh and NHS Lothian. 

He combines an active neurosurgical practice with clinical and laboratory research. His clinical work focuses on operative management of people with brain tumours.

His research is focused on improving the clinical care of patients. He uses data science to understand relevant clinical problems, the solutions to which he develops through a combination of discovery science and clinical trials. He is part of the CRUK Adult Brain Tumour Centre of Excellence, based on Edinburgh. 

 

Paul’s research focus includes:

- Speeding up the diagnosis of brain tumours using symptom-based referral pathways and novel blood tests. 

- Developing novel strategies for delivering chemotherapy focally in management of brain tumours. In collaboration with Dr Unciti-Broceta he is developing a palladium activated prodrug where the palladium catalyst will be implanted in the brain at surgery, better targeting drug activation. 

- Understanding the cellular and molecular biology of the malignant transformation of low grade glioma. 

- Since 2014 Paul  has been working with Professor Sir Graham Teasdale, co-developer of the Glasgow Coma Scale, on a number of projects to enhance the use of the GCS, which is already the most widely used tool for assessment of consciousness in the world. Along with Professor Gordon Murray, Paul and Sir Graham published two papers in 2018 that introduced 1) a new scale to complement the GCS, the GCS Pupils Score, providing a rapid assessment of patient prognosis, and 2) the GCS prognostic charts for enhancing prognostication on the clinic. Data science underpins both projects. www.glasgowcomascale.org

 

 

He has an active involvement in clinical research and is co-applicant on a number of multi-centre studies. He was co-founder of the British Neurosurgical Trainee Research Collaborative that he helped found as Chair of the British Neurosurgical Trainees Association in 2012. He has led a UK collaborative study on management of chronic subdural haematoma and is interested in optimising the peri-operative care of these patients. 

Complementing his clinical work, Paul founded eoSurgical Ltd in 2012 along with co-founders Roland Partridge and Mark Hughes. The University spin-out now provides surgical simulation training around the world.  

In 2014 Paul helped in the foundation of the Compassion Initiative at the University of Edinburgh and is a co-Director, working in close collaboration with Prof Jim Doty's Centre for Compassion and Altruism Research at the University of Stanford.

Paul is a member of the Young Academy of Scotland and was co-chair between September 2015 and August 2017.  

    

 

Research activities & awards

  1. British Neuro-oncology conference 2017

    Activity: OtherTypes of Public engagement and outreach - Festival/Exhibition

  2. The Brain Tumour Charity (External organisation)

    Activity: MembershipMembership of peer review panel or committee

  3. BMJ Case Reports (Journal)

    Activity: Publication peer-review and editorial workPublication peer-review

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