Edinburgh Research Explorer

Dr Peter Hohenstein

(Former employee or visitor)

Profile photo

Willingness to take PhD students: Yes

Education/Academic qualification

1995Doctor of Philosophy (PhD), Leiden University Medical Center
1991Master in Science, Catholic University Nijmegen, the Netherlands
1987Bachelor of Science, Hoge School Zeeland, Vlissingen, the Netherlands
HLO

Professional Qualifications

2010Introductory Diploma Management, Northampton Business School

Current Research Interests

Kidney development, stem cells and disease in mouse models.

Research Interests

In our lab we study the link between normal kidney development and kidney disease, especially the development of Wilms’ tumours. Much work is done on the role of the Wt1 and β-catenin genes in this, and their involvement in embryonic kidney progenitor cells, but also later stages of kidney development and function are being studied. We are also interested in using the understanding of kidney development from this work to develop ways to generate early kidney progenitor cells from other cells types for kidney replacement therapy.

The use of transgenic mouse models is central in our work, and we use models that we import from other labs or generate ourselves. Besides our kidney work we also try to improve the possibilities and efficiency of transgenic techniques in mice, and the possibility of transferring them to other species.

Biography

Peter Hohenstein did a PhD in mouse models for cancer genetics at the Leiden University Medical Center, Leiden, the Netherlands, generating and studying Brca1 and Smad4 mouse models. In December 2001 he moved on an EU Marie Curie-funded fellowship to the lab of Prof Nick Hastie at the MRC Human Genetics Unit in Edinburgh. Here he started working on the role of Wt1 and β-catenin in the origins of Wilms' tumours and in normal kidney development. He worked on this as post-doctoral fellow until March 2007, after which he got an appointment as Senior Investigative Scientist in the same lab with the main responsibility for the projects on Wt1 in cancer and kidney development. In October 2012 he moved with his group and projects to an independent PI position in The Roslin Institute. Besides running the laboratory for kidney development and disease, he is closely involved here in the management of the transgenic mouse facility. 

Websites

Research activities & awards

  1. visit undergrad students Wyoming

    Activity: Participating in or organising an event typesPublic Engagement – Schools engagement

  2. Midlothian Science Festival 2017

    Activity: Participating in or organising an event typesPublic Engagement – Festival/Exhibition

  3. LUMC Human Genetics seminar series

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

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ID: 2950196