Edinburgh Research Explorer

Riccardo Marioni

Senior Research Fellow

Profile photo

Willingness to take PhD students: Yes

Education/Academic qualification

Doctor of Philosophy (PhD), University of Edinburgh
Inflammation and cognition: the association between biomarker levels, their genetic determinants, and age-related cognitive decline

Research Interests

My group’s primary research goal is to use computational models to understand the molecular mechanisms that underlie Alzheimer’s disease and to enhance prediction of the disease. We have a passion for research into ageing and, in particular, examining the genetic and environmental contributions to health, cognitive ageing, and dementia. Our work is at the intersection of the biomedical and social sciences.

We work with data from large, population-based cohorts including Generation Scotland, UK Biobank, and the Lothian Birth Cohorts of 1921 and 1936.


2005 - 2006 MSc with distinction in Operational Research
The University of Edinburgh, Edinburgh, UK.
The School of Mathematics
Thesis: `A model describing the value of a gain in productivity among persons with rheumatoid arthritis.'

2001 - 2005 BSc (Hons) in Mathematics and Statistics (First Class)
The University of Aberdeen, Aberdeen, UK.



I am a University of Edinburgh Chancellor's Fellow based in the Centre for Genomic and Experimental Medicine and the Centre for Cognitive Ageing and Cognitive Epidemiology. 

My fellowship was part-funded by the University of Queensland where I was an Adjunct Research Fellow between 2013-2016.

My postdoctoral research included a year at the Department of Public Health and Primary Care at the University of Cambridge (2009-2010).  Whilst there, I was awarded an Alzheimer's Research UK fellowship (2010-2013) in conjunction with the Medical Research Council Biostatistics Unit, Cambridge, the Department of Biostatistics, INSERM U897, Bordeaux and the University of Edinburgh Department of Psychology, to develop and apply longitudinal statistical methods for cognitive ageing. 

I completed my PhD (2006-2009) in Genetic and Cognitive Epidemiology at the University of Edinburgh. My thesis title was "Inflammation and cognition:  The association between biomarker levels, their genetic determinants, and age-related cognitive decline".



Collaborative Activity

Local Collaborators:

Ian Deary, Andrew McIntosh, Kathy Evans, Craig Ritchie, Tamir Chandra, Kristin Nicodemus, David Porteous

National and international collaborators:

Caroline Relton and Laura Howe (Bristol), Steve Horvath (UCLA), Peter Visscher and Naomi Wray (University of Queensland), Sara Hagg (Karolinska Institutet), Matt Robinson (Lausanne)

Current Research Interests

Epi/genetic epidemiology

Biostatistics and longitudinal data analysis


Alzheimer's disease


Highlighted research outputs

  1. Bayesian reassessment of the epigenetic architecture of complex traits

    Research output: Contribution to journalArticle

  2. DNA methylation Aging Clocks: Challenges & Recommendations

    Research output: Contribution to journalArticle

  3. Epigenetic prediction of complex traits and death

    Research output: Contribution to journalArticle

  4. GWAS on family history of Alzheimer’s disease

    Research output: Contribution to journalArticle

View all (161) »

Research activities & awards

  1. Jim Sikela

    Activity: Hosting a visitor typesHosting an academic visitor

  2. Epigenetic prediction of age and modifiable lifestyle factors

    Activity: Academic talk or presentation typesInvited talk

  3. The epigenetic clock and biological ageing

    Activity: Academic talk or presentation typesInvited talk

View all (45) »

ID: 4791904