Edinburgh Research Explorer

Dr Robert Menzies

(Former employee or visitor)

Profile photo

Willingness to take PhD students: Yes

There are a number of possible projects in the lab, please get in touch using the above email address.

Professional Qualifications

Winner of the APS IECPT Award, San Diego 2012
Winner of the Oliver Wrong Prize UCL/UCH, London 2015

Qualifications

Master of Physics with Honours (MPhys), University of Edinburgh

Master of Cardiovascular Biology by Research (MSc), University of Edinburgh

Doctor of Philosophy (PhD),  University of Edinburgh

My research in a nutshell

Hypertension is a leading cause of cardiovascular mortality globally, yet strategies to lower blood pressure alone have not sufficiently obviated cardiovascular risk. This is partly due to contributions from the growing epidemics of diabetes, obesity, and aging where damage and repair mechanisms become dampened over time.

My research is focused on the identification of macrovascular and microvascular damage and repair mechanisms that arise during hypertension and diabetes to perpetuate disease. This basic research utilises multi-disciplinary approaches to develop vital capabilities and technologies including; cell models, ex vivo preparations, gene-targeted models, signal analysis technques, machine-learning analysis pipelines, and in vivo physiological assays. 

A key result from this research has been the identification of a major therapeutic candidate, vascular purinergic P2X7 receptors (P2X7R). Antagonism of P2X7R lowers blood pressure and improves target organ perfusion in a hypertensive model. This work has subsequently blossomed into an exciting cross-functional research effort with a team of globally recognised scientists and clinicians pursuing an overarching strategy to bring new and improved treatments to patients.

Research activities & awards

  1. Europhysiology 2018

    Activity: Participating in or organising an event typesParticipation in conference

  2. Cardiovascular & renal disease insights from the rat

    Activity: Academic talk or presentation typesInvited talk

  3. H3 symposium on renal purinergic signaling in obesity and renal physiology

    Activity: Participating in or organising an event typesParticipation in conference

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Latest prizes

  1. International Early Career Physiologist

    Prize: Prize (including medals and awards)

  2. Travel Award

    Prize: Prize (including medals and awards)

  3. Travel Award

    Prize: Prize (including medals and awards)

View all (7) »

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