Edinburgh Research Explorer

Dr. Sari Pennings

Senior Lecturer

Profile photo
Phone: 0131 242 6145

My research in a nutshell

Our research is focused on nuclear chromatin control of gene expression in mammalian and vertebrate embryos, stem cells, reprogrammed cells and yeast-based models. We investigate the dynamics of epigenetic DNA methylation and histone modifications essential for early development, differentiation and chromatin-mediated gene regulation. In addition, we study epigenetic mechanisms in tissue specification, including cardiovascular development and reprogramming. Our research interests include cell fate reprogramming, chromatin remodelling, and chromatin-based gene repression mechanisms. We have discovered that heterochromatin matures late in development but is induced early in mouse embryonic stem cells; and that epigenetic marks can rapidly adapt to cell culture.

Research outputs

  1. Dynamics and Mechanisms of DNA Methylation Reprogramming

    Research output: Chapter in Book/Report/Conference proceedingChapter

  2. The Stem Cell Niche: Interactions between Stem Cells and Their Environment

    Research output: Contribution to journalEditorial

  3. DNA methylation as a genomic marker of exposure to chemical and environmental agents.

    Research output: Contribution to journalReview article

View all (41) »

Research activities & awards

  1. Edinburgh Chromatin, Epigenetics and Transcriptional Regulation Network

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

  2. Edinburgh Chromatin, Epigenetics and Transcriptional Regulation Network

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

  3. Edinburgh Chromatin, Epigenetics and Transcriptional Regulation Network

    Activity: Participating in or organising an event typesParticipation in conference

View all (40) »

ID: 17688