Edinburgh Research Explorer

Dr. Sari Pennings

Senior Lecturer

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Phone: 0131 242 6145

My research in a nutshell

Our research is focused on nuclear chromatin control of gene expression in mammalian and vertebrate embryos, stem cells, reprogrammed cells and yeast-based models. We investigate the dynamics of epigenetic DNA methylation and histone modifications essential for early development, differentiation and chromatin-mediated gene regulation. In addition, we study epigenetic mechanisms in tissue specification, including cardiovascular development and reprogramming. Our research interests include cell fate reprogramming, chromatin remodelling, and chromatin-based gene repression mechanisms. We have discovered that heterochromatin matures late in development but is induced early in mouse embryonic stem cells; and that epigenetic marks can rapidly adapt to cell culture.

Research outputs

  1. DNA methylation as a genomic marker of exposure to chemical and environmental agents.

    Research output: Contribution to journalReview article

  2. Antibody based detection of global nuclear DNA methylation in cells, tissue sections and mammalian embryos

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  3. Shoring up DNA methylation and H3K27me3 domain demarcation at developmental genes

    Research output: Contribution to journalReview article

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Research activities & awards

  1. Amazing Bodies From Science to Future Medicine public engagement activity at Edinburgh International Science Festival

    Activity: OtherTypes of Public engagement and outreach - Festival/Exhibition

  2. Edinburgh Chromatin, Epigenetics and Transcriptional Regulation Network

    Activity: Participating in or organising an eventParticipation in conference

  3. External Examiner BSc/MSc course - Newcastle University

    Activity: ExaminationExternal Examiner or Assessor

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Research projects

  1. BBSRC EASTBIO Doctoral Training Partnership

    Project: Other ProjectOther (Non-Funded/Miscellaneous)

  2. Chromatin, Epigenetics and Transcriptional Regulation - UoE Network 2018

    Project: Other ProjectUniversity Awarded Project Funding

  3. Summer Vacation Scholarship - The Carnegie Trust for the Universities of Scotland

    Project: Other ProjectOther (Non-Funded/Miscellaneous)

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